JP2011507913A5 - - Google Patents
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- Publication number
- JP2011507913A5 JP2011507913A5 JP2010539988A JP2010539988A JP2011507913A5 JP 2011507913 A5 JP2011507913 A5 JP 2011507913A5 JP 2010539988 A JP2010539988 A JP 2010539988A JP 2010539988 A JP2010539988 A JP 2010539988A JP 2011507913 A5 JP2011507913 A5 JP 2011507913A5
- Authority
- JP
- Japan
- Prior art keywords
- csf
- group
- type polyethylene
- polyethylene glycolated
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 22
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 22
- 239000004698 Polyethylene Substances 0.000 claims 8
- -1 polyethylene Polymers 0.000 claims 8
- 229920000573 polyethylene Polymers 0.000 claims 8
- 229920001223 polyethylene glycol Polymers 0.000 claims 8
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 201000010000 Agranulocytosis Diseases 0.000 claims 2
- 206010018687 Granulocytopenia Diseases 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 239000012506 Sephacryl® Substances 0.000 claims 1
- 150000001263 acyl chlorides Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000005341 cation exchange Methods 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 150000002605 large molecules Chemical class 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 229920002521 macromolecule Polymers 0.000 claims 1
- 229930014626 natural product Natural products 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 238000011127 radiochemotherapy Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000012064 sodium phosphate buffer Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000011476 stem cell transplantation Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2007/003897 WO2009086656A1 (zh) | 2007-12-29 | 2007-12-29 | Y型聚乙二醇修饰的g-csf及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011507913A JP2011507913A (ja) | 2011-03-10 |
| JP2011507913A5 true JP2011507913A5 (enExample) | 2013-07-18 |
Family
ID=40852740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010539988A Pending JP2011507913A (ja) | 2007-12-29 | 2007-12-29 | Ｙ型ポリエチレングリコール修飾したｇ−ｃｓｆならびにその製造方法および使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8530417B2 (enExample) |
| EP (1) | EP2236521A4 (enExample) |
| JP (1) | JP2011507913A (enExample) |
| CN (1) | CN101627056B (enExample) |
| AU (1) | AU2007363326B2 (enExample) |
| BR (1) | BRPI0722341A2 (enExample) |
| CA (1) | CA2710841C (enExample) |
| WO (1) | WO2009086656A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007363326B2 (en) | 2007-12-29 | 2014-01-30 | Biosteed Gene Expression Tech. Co., Ltd. | Y-type polyethylene glycol modified G-CSF and preparation method and use thereof |
| JP5458416B2 (ja) * | 2008-04-03 | 2014-04-02 | バイオスティード ジーン エクスプレッション テック． カンパニー リミテッド | 二本鎖ポリエチレングリコール化成長ホルモン、その製造方法およびその使用 |
| US8966134B2 (en) | 2011-02-23 | 2015-02-24 | Apple Inc. | Cross-over and bypass configurations for high-speed data transmission |
| ES2657870T3 (es) * | 2012-03-01 | 2018-03-07 | Alcare Co., Ltd. | Apósito para heridas |
| RU2535002C2 (ru) * | 2013-04-04 | 2014-12-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии" Сибирского отделения Российской академии медицинских наук | Средство коррекции отдаленных последствий нарушений сперматогенеза, вызванных цитостатическим воздействием |
| CN106146325B (zh) * | 2015-04-24 | 2019-01-29 | 北京键凯科技股份有限公司 | 一种y型多缩乙二醇衍生物及其制备方法 |
| CN107446908A (zh) * | 2016-06-01 | 2017-12-08 | 湖南华腾制药有限公司 | 分支型聚乙二醇修饰的l‑门冬酰胺酶及其制备方法 |
| CN108525002B (zh) * | 2017-03-01 | 2020-09-29 | 中国科学院化学研究所 | 一种具有高强粘附性能的可注射生物胶水及其制备方法与应用 |
| CN114853872B (zh) * | 2022-04-27 | 2023-11-17 | 山东新时代药业有限公司 | 一种聚乙二醇修饰rhG-CSF的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE522563T1 (de) * | 1999-12-24 | 2011-09-15 | Kyowa Hakko Kirin Co Ltd | Verzweigte polyalkylenglykole |
| US6831158B2 (en) * | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| NZ522847A (en) * | 2000-05-16 | 2004-11-26 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| JP2003248136A (ja) * | 2002-02-25 | 2003-09-05 | Kyoei Senzai Kk | 光ファイバ用複合フェルール及び光ファイバ接続用コネクタ |
| EP1496076B1 (en) * | 2002-03-13 | 2007-07-25 | Beijing Jiankai Technology Co., Ltd. | Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound |
| CN1778821A (zh) * | 2004-10-15 | 2006-05-31 | 北京凯正生物工程发展有限责任公司 | 化学修饰的粒细胞集落刺激因子偶联物及其制备方法 |
| WO2006094530A1 (en) * | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
| WO2007019331A2 (en) * | 2005-08-04 | 2007-02-15 | Nektar Therapeutics Al, Corporation | Conjugates of a g-csf moiety and a polymer |
| AU2007363326B2 (en) | 2007-12-29 | 2014-01-30 | Biosteed Gene Expression Tech. Co., Ltd. | Y-type polyethylene glycol modified G-CSF and preparation method and use thereof |
| WO2012064867A1 (en) * | 2010-11-09 | 2012-05-18 | Nektar Therapeutics | Pharmacologically active polymer-g-csf conjugates |
-
2007
- 2007-12-29 AU AU2007363326A patent/AU2007363326B2/en active Active
- 2007-12-29 JP JP2010539988A patent/JP2011507913A/ja active Pending
- 2007-12-29 CN CN2007800513782A patent/CN101627056B/zh active Active
- 2007-12-29 EP EP07855897.0A patent/EP2236521A4/en not_active Withdrawn
- 2007-12-29 WO PCT/CN2007/003897 patent/WO2009086656A1/zh not_active Ceased
- 2007-12-29 BR BRPI0722341-2A patent/BRPI0722341A2/pt not_active Application Discontinuation
- 2007-12-29 CA CA2710841A patent/CA2710841C/en active Active
- 2007-12-29 US US12/811,103 patent/US8530417B2/en active Active
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