JP2015508284A5 - - Google Patents
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- Publication number
- JP2015508284A5 JP2015508284A5 JP2014548019A JP2014548019A JP2015508284A5 JP 2015508284 A5 JP2015508284 A5 JP 2015508284A5 JP 2014548019 A JP2014548019 A JP 2014548019A JP 2014548019 A JP2014548019 A JP 2014548019A JP 2015508284 A5 JP2015508284 A5 JP 2015508284A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- nucleic acid
- homodimeric protein
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 230000000890 antigenic effect Effects 0.000 claims 9
- 241000701806 Human papillomavirus Species 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 5
- 230000008685 targeting Effects 0.000 claims 5
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 4
- 238000006471 dimerization reaction Methods 0.000 claims 4
- 108700019828 Hinge Exons Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000002246 oncogenic effect Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578542P | 2011-12-21 | 2011-12-21 | |
| US61/578,542 | 2011-12-21 | ||
| PCT/EP2012/076404 WO2013092875A1 (en) | 2011-12-21 | 2012-12-20 | Vaccines against hpv |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508284A JP2015508284A (ja) | 2015-03-19 |
| JP2015508284A5 true JP2015508284A5 (enExample) | 2016-02-18 |
| JP6258864B2 JP6258864B2 (ja) | 2018-01-10 |
Family
ID=47471832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548019A Active JP6258864B2 (ja) | 2011-12-21 | 2012-12-20 | Ｈｐｖに対するワクチン |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9901635B2 (enExample) |
| EP (2) | EP2793937B1 (enExample) |
| JP (1) | JP6258864B2 (enExample) |
| KR (1) | KR102057265B1 (enExample) |
| CN (1) | CN104039833B (enExample) |
| AU (1) | AU2012356969B2 (enExample) |
| BR (1) | BR112014015016B1 (enExample) |
| CA (1) | CA2858963C (enExample) |
| DK (1) | DK2793937T3 (enExample) |
| ES (1) | ES2730718T3 (enExample) |
| HU (1) | HUE043361T2 (enExample) |
| IL (1) | IL233217B (enExample) |
| PT (1) | PT2793937T (enExample) |
| RU (1) | RU2644201C2 (enExample) |
| TR (1) | TR201908199T4 (enExample) |
| WO (1) | WO2013092875A1 (enExample) |
| ZA (1) | ZA201404516B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2970466A1 (en) * | 2013-03-15 | 2016-01-20 | Vaccibody AS | Targeting vaccines for veterinary use |
| EP3094652B1 (en) | 2014-01-13 | 2021-09-29 | Baylor Research Institute | Novel vaccines against hpv and hpv-related diseases |
| AU2015302930C1 (en) | 2014-08-15 | 2023-06-01 | Genexine, Inc. | Methods of treating cervical cancer |
| BR112018003019A2 (pt) * | 2015-08-20 | 2018-09-25 | Janssen Vaccines & Prevention Bv | vacinas terapêuticas contra hpv18 |
| KR102833333B1 (ko) * | 2016-01-08 | 2025-07-11 | 니코데 테라퓨틱스 에이에스에이 | 치료적 항암 네오에피토프 백신 |
| JP2020533338A (ja) | 2017-09-07 | 2020-11-19 | ユニバーシティ オブ オスロＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｏｓｌｏ | ワクチン分子 |
| WO2019048936A1 (en) | 2017-09-07 | 2019-03-14 | University Of Oslo | VACCINE MOLECULES |
| JP2023522588A (ja) | 2020-04-09 | 2023-05-31 | ナイコード セラピューティクス アルメン アクスイェ セルスカプ | 個別化された治療用抗がんワクチン |
| US11883479B2 (en) | 2020-04-24 | 2024-01-30 | Genexine, Inc. | Method for treating cervical cancer |
| KR20230005962A (ko) | 2020-05-01 | 2023-01-10 | 니코데 테라퓨틱스 에이에스에이 | 베타코로나바이러스 예방 및 치료요법 |
| CA3212592A1 (en) | 2021-03-26 | 2022-09-29 | Agnete Fredriksen | Therapeutic combination for treating cancer |
| US20250339509A1 (en) | 2021-05-03 | 2025-11-06 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases |
| CA3216720A1 (en) | 2021-05-10 | 2022-11-17 | Agnete Brunsvik Fredriksen | Co-expression of constructs and immunostimulatory compounds |
| JP2024518463A (ja) | 2021-05-10 | 2024-05-01 | ナイコード セラピューティクス アルメン アクスイェ セルスカプ | 構築物及び免疫阻害化合物の共発現 |
| WO2022238363A1 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases |
| WO2022238395A1 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Tolerance-inducing constructs and compositions and their use for the treatment of immune disorders |
| WO2022238381A2 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Immunotherapy constructs for treatment of disease |
| KR20240007235A (ko) | 2021-05-10 | 2024-01-16 | 니코데 테라퓨틱스 에이에스에이 | 관용-유도 컨스트럭트 및 조성물 및 면역 장애의 치료를 위한 그들의 용도 |
| JP2024540322A (ja) | 2021-11-03 | 2024-10-31 | ナイコード セラピューティクス アルメン アクスイェ セルスカプ | ＳＡＲＳ－ＣｏＶ－２によって引き起こされる疾患の予防及び処置に使用するための免疫原性構築物及びワクチン |
| WO2024092025A1 (en) | 2022-10-25 | 2024-05-02 | Nykode Therapeutics ASA | Constructs and their use |
| WO2024100196A1 (en) | 2022-11-09 | 2024-05-16 | Nykode Therapeutics ASA | Co-expression of constructs and polypeptides |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9105383D0 (en) * | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
| AUPN015794A0 (en) | 1994-12-20 | 1995-01-19 | Csl Limited | Variants of human papilloma virus antigens |
| US7223408B2 (en) * | 2002-10-03 | 2007-05-29 | Wyeth Holdings Corporation | Human papillomavirus polypeptides and immunogenic compositions |
| CA2517054C (en) * | 2003-02-25 | 2016-05-10 | Medinnova As | Use of nucleic acids encoding antibody-like molecules for use in medical treatment |
| PT1576967E (pt) * | 2004-03-18 | 2007-12-03 | Pasteur Institut | Proteína recombinante que transporta epitopos do virús do papilloma humano inseridos numa proteína adenilato ciclase, ou no seu fragmento, e seus usos terapêuticos |
| WO2006081323A2 (en) | 2005-01-26 | 2006-08-03 | The Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding mutant oncoprotein antigen and calreticulin |
| KR20130087517A (ko) * | 2010-06-25 | 2013-08-06 | 백시바디 에이에스 | 동종이합체 단백질 구조물 |
-
2012
- 2012-12-20 KR KR1020147020468A patent/KR102057265B1/ko active Active
- 2012-12-20 RU RU2014129788A patent/RU2644201C2/ru active
- 2012-12-20 EP EP12809271.5A patent/EP2793937B1/en active Active
- 2012-12-20 US US14/365,536 patent/US9901635B2/en active Active
- 2012-12-20 HU HUE12809271A patent/HUE043361T2/hu unknown
- 2012-12-20 CA CA2858963A patent/CA2858963C/en active Active
- 2012-12-20 JP JP2014548019A patent/JP6258864B2/ja active Active
- 2012-12-20 DK DK12809271.5T patent/DK2793937T3/da active
- 2012-12-20 WO PCT/EP2012/076404 patent/WO2013092875A1/en not_active Ceased
- 2012-12-20 BR BR112014015016-8A patent/BR112014015016B1/pt active IP Right Grant
- 2012-12-20 CN CN201280064089.7A patent/CN104039833B/zh active Active
- 2012-12-20 EP EP19166523.1A patent/EP3533462A1/en not_active Withdrawn
- 2012-12-20 ES ES12809271T patent/ES2730718T3/es active Active
- 2012-12-20 PT PT12809271T patent/PT2793937T/pt unknown
- 2012-12-20 AU AU2012356969A patent/AU2012356969B2/en active Active
- 2012-12-20 TR TR2019/08199T patent/TR201908199T4/tr unknown
-
2014
- 2014-06-18 IL IL233217A patent/IL233217B/en active IP Right Grant
- 2014-06-19 ZA ZA2014/04516A patent/ZA201404516B/en unknown
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