JP2015508284A5 - - Google Patents
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- Publication number
- JP2015508284A5 JP2015508284A5 JP2014548019A JP2014548019A JP2015508284A5 JP 2015508284 A5 JP2015508284 A5 JP 2015508284A5 JP 2014548019 A JP2014548019 A JP 2014548019A JP 2014548019 A JP2014548019 A JP 2014548019A JP 2015508284 A5 JP2015508284 A5 JP 2015508284A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- nucleic acid
- homodimeric protein
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 230000000890 antigenic effect Effects 0.000 claims 9
- 241000701806 Human papillomavirus Species 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 5
- 230000008685 targeting Effects 0.000 claims 5
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 4
- 238000006471 dimerization reaction Methods 0.000 claims 4
- 108700019828 Hinge Exons Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000002246 oncogenic effect Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578542P | 2011-12-21 | 2011-12-21 | |
| US61/578,542 | 2011-12-21 | ||
| PCT/EP2012/076404 WO2013092875A1 (en) | 2011-12-21 | 2012-12-20 | Vaccines against hpv |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508284A JP2015508284A (ja) | 2015-03-19 |
| JP2015508284A5 true JP2015508284A5 (enExample) | 2016-02-18 |
| JP6258864B2 JP6258864B2 (ja) | 2018-01-10 |
Family
ID=47471832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548019A Active JP6258864B2 (ja) | 2011-12-21 | 2012-12-20 | Ｈｐｖに対するワクチン |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9901635B2 (enExample) |
| EP (2) | EP2793937B1 (enExample) |
| JP (1) | JP6258864B2 (enExample) |
| KR (1) | KR102057265B1 (enExample) |
| CN (1) | CN104039833B (enExample) |
| AU (1) | AU2012356969B2 (enExample) |
| BR (1) | BR112014015016B1 (enExample) |
| CA (1) | CA2858963C (enExample) |
| DK (1) | DK2793937T3 (enExample) |
| ES (1) | ES2730718T3 (enExample) |
| HU (1) | HUE043361T2 (enExample) |
| IL (1) | IL233217B (enExample) |
| PT (1) | PT2793937T (enExample) |
| RU (1) | RU2644201C2 (enExample) |
| TR (1) | TR201908199T4 (enExample) |
| WO (1) | WO2013092875A1 (enExample) |
| ZA (1) | ZA201404516B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014140176A1 (en) * | 2013-03-15 | 2014-09-18 | Vaccibody As | Targeting vaccines for veterinary use |
| US10286058B2 (en) | 2014-01-13 | 2019-05-14 | Baylor Research Institute | Vaccines against HPV and HPV-related diseases |
| WO2016024255A1 (en) | 2014-08-15 | 2016-02-18 | Genexine, Inc. | Methods of treating cervical cancer |
| AU2016309743B2 (en) * | 2015-08-20 | 2019-02-07 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV18 vaccines |
| CA3008437A1 (en) | 2016-01-08 | 2017-07-13 | Vaccibody As | Therapeutic anticancer neoepitope vaccine |
| EP3678699A1 (en) * | 2017-09-07 | 2020-07-15 | University Of Oslo | Vaccine molecules |
| US12268736B2 (en) | 2017-09-07 | 2025-04-08 | University Of Oslo | Vaccine molecules |
| AU2021252155A1 (en) | 2020-04-09 | 2022-12-08 | Nykode Therapeutics ASA | Individualized therapeutic anticancer vaccine |
| CN115551547A (zh) | 2020-04-24 | 2022-12-30 | 格纳西尼有限公司 | 宫颈癌治疗方法 |
| JP2023524054A (ja) | 2020-05-01 | 2023-06-08 | ナイコード セラピューティクス アルメン アクスイェ セルスカプ | ベータコロナウイルスの予防と治療 |
| CA3212592A1 (en) | 2021-03-26 | 2022-09-29 | Agnete Fredriksen | Therapeutic combination for treating cancer |
| EP4333881A1 (en) | 2021-05-03 | 2024-03-13 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases |
| US20250195632A1 (en) | 2021-05-10 | 2025-06-19 | Nykode Therapeutics ASA | Tolerance-inducing constructs and composition and their use for the treatment of immune disorders |
| MX2023013308A (es) | 2021-05-10 | 2024-02-14 | Nykode Therapeutics ASA | Co-expresion de construcciones y compuestos inmunoinhibidores. |
| IL308310A (en) | 2021-05-10 | 2024-01-01 | Nykode Therapeutics ASA | Co-expression of immune-stimulating structures and compounds |
| WO2022238363A1 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases |
| US20250288654A1 (en) | 2021-05-10 | 2025-09-18 | Nykode Therapeutics ASA | Tolerance-inducing constructs and compositions and their use for the treatment of immune disorders |
| WO2022238381A2 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Immunotherapy constructs for treatment of disease |
| EP4426344A1 (en) | 2021-11-03 | 2024-09-11 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of diseases caused by sars-cov-2 |
| WO2024092025A1 (en) | 2022-10-25 | 2024-05-02 | Nykode Therapeutics ASA | Constructs and their use |
| WO2024100196A1 (en) | 2022-11-09 | 2024-05-16 | Nykode Therapeutics ASA | Co-expression of constructs and polypeptides |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9105383D0 (en) * | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
| AUPN015794A0 (en) | 1994-12-20 | 1995-01-19 | Csl Limited | Variants of human papilloma virus antigens |
| BR0314529A (pt) * | 2002-10-03 | 2005-08-09 | Wyeth Corp | Polipeptìdeos de papilomavìrus humano e composições imunogênicas |
| US8932603B2 (en) | 2003-02-25 | 2015-01-13 | Vaccibody As | Modified antibody |
| EP1576967B1 (en) * | 2004-03-18 | 2007-09-12 | Institut Pasteur | Recombinant protein, carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof, therapeutic uses thereof |
| EP1846026A4 (en) | 2005-01-26 | 2008-07-02 | Univ Johns Hopkins | ANTIBODY DNA VACCINE WITH PLASMIDES FOR CODING A MUTATED ONCOPROTEIN ANTIGEN AND CALRETICULIN |
| CN102985109B (zh) * | 2010-06-25 | 2016-05-11 | 瓦西博迪公司 | 同型二聚体蛋白质构建体 |
-
2012
- 2012-12-20 HU HUE12809271A patent/HUE043361T2/hu unknown
- 2012-12-20 CA CA2858963A patent/CA2858963C/en active Active
- 2012-12-20 EP EP12809271.5A patent/EP2793937B1/en active Active
- 2012-12-20 RU RU2014129788A patent/RU2644201C2/ru active
- 2012-12-20 US US14/365,536 patent/US9901635B2/en active Active
- 2012-12-20 EP EP19166523.1A patent/EP3533462A1/en not_active Withdrawn
- 2012-12-20 BR BR112014015016-8A patent/BR112014015016B1/pt active IP Right Grant
- 2012-12-20 KR KR1020147020468A patent/KR102057265B1/ko active Active
- 2012-12-20 ES ES12809271T patent/ES2730718T3/es active Active
- 2012-12-20 CN CN201280064089.7A patent/CN104039833B/zh active Active
- 2012-12-20 PT PT12809271T patent/PT2793937T/pt unknown
- 2012-12-20 TR TR2019/08199T patent/TR201908199T4/tr unknown
- 2012-12-20 AU AU2012356969A patent/AU2012356969B2/en active Active
- 2012-12-20 JP JP2014548019A patent/JP6258864B2/ja active Active
- 2012-12-20 WO PCT/EP2012/076404 patent/WO2013092875A1/en not_active Ceased
- 2012-12-20 DK DK12809271.5T patent/DK2793937T3/da active
-
2014
- 2014-06-18 IL IL233217A patent/IL233217B/en active IP Right Grant
- 2014-06-19 ZA ZA2014/04516A patent/ZA201404516B/en unknown
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