JP2013531991A5 - - Google Patents
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- Publication number
- JP2013531991A5 JP2013531991A5 JP2013515522A JP2013515522A JP2013531991A5 JP 2013531991 A5 JP2013531991 A5 JP 2013531991A5 JP 2013515522 A JP2013515522 A JP 2013515522A JP 2013515522 A JP2013515522 A JP 2013515522A JP 2013531991 A5 JP2013531991 A5 JP 2013531991A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- seq
- cell
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012634 fragment Substances 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 7
- 241000701022 Cytomegalovirus Species 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35549910P | 2010-06-16 | 2010-06-16 | |
| US61/355,499 | 2010-06-16 | ||
| PCT/US2011/040761 WO2011159938A2 (en) | 2010-06-16 | 2011-06-16 | High affinity human antibodies to human cytomegalovirus (cmv) gb protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016198700A Division JP2017038612A (ja) | 2010-06-16 | 2016-10-07 | ヒトサイトメガロウイルス（ＣＭＶ）ｇＢタンパク質に対する高親和性ヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013531991A JP2013531991A (ja) | 2013-08-15 |
| JP2013531991A5 true JP2013531991A5 (enExample) | 2014-07-31 |
| JP6055763B2 JP6055763B2 (ja) | 2016-12-27 |
Family
ID=45348879
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515522A Active JP6055763B2 (ja) | 2010-06-16 | 2011-06-16 | ヒトサイトメガロウイルス（ＣＭＶ）ｇＢタンパク質に対する高親和性ヒト抗体 |
| JP2016198700A Pending JP2017038612A (ja) | 2010-06-16 | 2016-10-07 | ヒトサイトメガロウイルス（ＣＭＶ）ｇＢタンパク質に対する高親和性ヒト抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016198700A Pending JP2017038612A (ja) | 2010-06-16 | 2016-10-07 | ヒトサイトメガロウイルス（ＣＭＶ）ｇＢタンパク質に対する高親和性ヒト抗体 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9017668B2 (enExample) |
| EP (1) | EP2582389B1 (enExample) |
| JP (2) | JP6055763B2 (enExample) |
| KR (1) | KR101900435B1 (enExample) |
| CN (1) | CN103221063B (enExample) |
| AU (1) | AU2011268277B2 (enExample) |
| BR (1) | BR112012032182A2 (enExample) |
| CA (1) | CA2839420C (enExample) |
| IL (1) | IL223665B (enExample) |
| RU (1) | RU2613421C2 (enExample) |
| WO (1) | WO2011159938A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2542308T3 (es) * | 2008-03-10 | 2015-08-04 | Theraclone Sciences, Inc. | Composiciones y métodos para la terapia y diagnóstico de infecciones por citomegalovirus |
| JP5833565B2 (ja) | 2009-12-23 | 2015-12-16 | ４−アンティボディ・アクチェンゲゼルシャフト４−Ａｎｔｉｂｏｄｙ Ａｇ | ヒトサイトメガロウイルスに対する結合メンバー |
| KR101900435B1 (ko) * | 2010-06-16 | 2018-09-20 | 트렐리스 바이오싸이언스 인코포레이티드 | 인간 사이토메갈로바이러스 gB 단백질에 대한 고친화도 인간 항체 |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| US11440951B2 (en) | 2017-03-13 | 2022-09-13 | The Government Of The United States, As Represented By The Secretary Of The Army | Therapeutic antibodies to Marburg virus |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| CN118465272B (zh) * | 2019-12-04 | 2025-08-19 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
| TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642062B2 (en) | 1998-09-03 | 2003-11-04 | Trellis Bioinformatics, Inc. | Multihued labels |
| US20090042291A1 (en) | 2002-03-01 | 2009-02-12 | Xencor, Inc. | Optimized Fc variants |
| US8420353B2 (en) | 2002-03-22 | 2013-04-16 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| US7427469B2 (en) * | 2002-11-05 | 2008-09-23 | Institut Pasteur | Method of treating cytomegalovirus with DC-SIGN blockers |
| RU2239453C2 (ru) * | 2002-12-03 | 2004-11-10 | Федеральное государственное унитарное предприятие " Научно-производственное объединение по медицинским иммунобиологическим препаратам " Микроген" | Препарат иммуноглобулина человека против цитомегаловируса и способ его получения |
| US7595379B2 (en) * | 2003-05-30 | 2009-09-29 | Agensys, Inc. | Antibodies and related molecules that bind to PSCA proteins |
| US7413868B2 (en) | 2003-11-05 | 2008-08-19 | Trellis Bioscience, Inc. | Use of particulate labels in bioanalyte detection methods |
| ES2526343T3 (es) | 2004-06-03 | 2015-01-09 | Novimmune Sa | Anticuerpos anti-CD3 y métodos de uso de los mismos |
| WO2007094423A1 (ja) | 2006-02-15 | 2007-08-23 | Evec Incorporated | ヒトサイトメガロウイルスに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| JP2009531273A (ja) * | 2006-02-28 | 2009-09-03 | オンコセラピー・サイエンス株式会社 | 抗ＥｐｈＡ４抗体のエフェクター機能を用いて細胞を障害する方法 |
| CA2652976C (en) | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
| CA2657123A1 (en) | 2006-07-12 | 2008-01-17 | Trellis Bioscience, Inc. | Cellspottm applications |
| GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| CN100575361C (zh) * | 2007-04-28 | 2009-12-30 | 中国人民解放军第三军医大学野战外科研究所 | 抗人巨细胞病毒包膜糖蛋白b的人源化单链抗体 |
| US20110171233A1 (en) * | 2007-08-22 | 2011-07-14 | Ribovax Biotechnologies S.A. | Antibodies Against Human Cytomegalovirus (HCMV) |
| RU2364627C2 (ru) * | 2007-11-06 | 2009-08-20 | Власик Татьяна Николаевна | Экспрессионный вектор для синтеза белков в клетках млекопитающих |
| JP2011517320A (ja) | 2008-03-03 | 2011-06-02 | ダイアックス コーポレーション | メタロプロテアーゼ９結合タンパク質およびメタロプロテアーゼ２結合タンパク質 |
| ES2542308T3 (es) | 2008-03-10 | 2015-08-04 | Theraclone Sciences, Inc. | Composiciones y métodos para la terapia y diagnóstico de infecciones por citomegalovirus |
| EP2352759B1 (en) * | 2008-07-16 | 2017-11-01 | Institute for Research in Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| KR101900435B1 (ko) * | 2010-06-16 | 2018-09-20 | 트렐리스 바이오싸이언스 인코포레이티드 | 인간 사이토메갈로바이러스 gB 단백질에 대한 고친화도 인간 항체 |
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2011
- 2011-06-16 KR KR1020137001220A patent/KR101900435B1/ko active Active
- 2011-06-16 US US13/162,497 patent/US9017668B2/en active Active
- 2011-06-16 CN CN201180038472.0A patent/CN103221063B/zh not_active Expired - Fee Related
- 2011-06-16 RU RU2013101769A patent/RU2613421C2/ru not_active IP Right Cessation
- 2011-06-16 BR BR112012032182A patent/BR112012032182A2/pt not_active IP Right Cessation
- 2011-06-16 AU AU2011268277A patent/AU2011268277B2/en active Active
- 2011-06-16 EP EP11796460.1A patent/EP2582389B1/en active Active
- 2011-06-16 CA CA2839420A patent/CA2839420C/en active Active
- 2011-06-16 JP JP2013515522A patent/JP6055763B2/ja active Active
- 2011-06-16 WO PCT/US2011/040761 patent/WO2011159938A2/en not_active Ceased
-
2012
- 2012-12-16 IL IL223665A patent/IL223665B/en active IP Right Grant
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2015
- 2015-04-27 US US14/697,459 patent/US9688744B2/en active Active
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2016
- 2016-10-07 JP JP2016198700A patent/JP2017038612A/ja active Pending
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2017
- 2017-03-20 US US15/464,165 patent/US10030069B2/en active Active