JP2020505927A5 - - Google Patents

Info

Publication number

JP2020505927A5

JP2020505927A5 JP2019541323A JP2019541323A JP2020505927A5 JP 2020505927 A5 JP2020505927 A5 JP 2020505927A5 JP 2019541323 A JP2019541323 A JP 2019541323A JP 2019541323 A JP2019541323 A JP 2019541323A JP 2020505927 A5 JP2020505927 A5 JP 2020505927A5

Authority

JP

Japan

Prior art keywords

antibody

seq

isolated nucleic

sequence

amino acid

Prior art date

2018-02-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108020004707 nucleic acids Proteins 0.000 claims 93
• 150000007523 nucleic acids Chemical class 0.000 claims 93
• 102000039446 nucleic acids Human genes 0.000 claims 93
• 125000003275 alpha amino acid group Chemical group 0.000 claims 51
• 101000795074 Homo sapiens Tryptase alpha/beta-1 Proteins 0.000 claims 22
• 102100029639 Tryptase alpha/beta-1 Human genes 0.000 claims 22
• 102000001400 Tryptase Human genes 0.000 claims 21
• 108060005989 Tryptase Proteins 0.000 claims 21
• NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 12
• 239000000427 antigen Substances 0.000 claims 6
• 102000036639 antigens Human genes 0.000 claims 6
• 108091007433 antigens Proteins 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 6
• 229960001340 histamine Drugs 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 239000000546 pharmaceutical excipient Substances 0.000 claims 5
• 102000013691 Interleukin-17 Human genes 0.000 claims 4
• 108050003558 Interleukin-17 Proteins 0.000 claims 4
• 102000017761 Interleukin-33 Human genes 0.000 claims 4
• 108010067003 Interleukin-33 Proteins 0.000 claims 4
• 102000004388 Interleukin-4 Human genes 0.000 claims 4
• 108090000978 Interleukin-4 Proteins 0.000 claims 4
• 102000000743 Interleukin-5 Human genes 0.000 claims 4
• 108010002616 Interleukin-5 Proteins 0.000 claims 4
• 241000282567 Macaca fascicularis Species 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 230000002255 enzymatic effect Effects 0.000 claims 4
• 229940028885 interleukin-4 Drugs 0.000 claims 4
• 229940100602 interleukin-5 Drugs 0.000 claims 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
• 239000013598 vector Substances 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 3
• 239000003085 diluting agent Substances 0.000 claims 3
• 239000003937 drug carrier Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 102000008186 Collagen Human genes 0.000 claims 2
• 108010035532 Collagen Proteins 0.000 claims 2
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
• 101000795085 Homo sapiens Tryptase beta-2 Proteins 0.000 claims 2
• 238000010521 absorption reaction Methods 0.000 claims 2
• 210000003678 bronchial smooth muscle cell Anatomy 0.000 claims 2
• 230000004663 cell proliferation Effects 0.000 claims 2
• 229920001436 collagen Polymers 0.000 claims 2
• 230000008602 contraction Effects 0.000 claims 2
• 238000001952 enzyme assay Methods 0.000 claims 2
• 229960002897 heparin Drugs 0.000 claims 2
• 229920000669 heparin Polymers 0.000 claims 2
• 210000003630 histaminocyte Anatomy 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 230000000638 stimulation Effects 0.000 claims 2
• 239000000758 substrate Substances 0.000 claims 2
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
• DZTHIGRZJZPRDV-LBPRGKRZSA-N N-acetyl-L-tryptophan Chemical compound C1=CC=C2C(C[C@H](NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-LBPRGKRZSA-N 0.000 claims 1
• DZTHIGRZJZPRDV-UHFFFAOYSA-N Nalpha-Acetyltryptophan Natural products C1=CC=C2C(CC(NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-UHFFFAOYSA-N 0.000 claims 1
• 239000003963 antioxidant agent Substances 0.000 claims 1
• 230000003078 antioxidant effect Effects 0.000 claims 1
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 229930182817 methionine Natural products 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229940116191 n-acetyltryptophan Drugs 0.000 claims 1
• 229940071643 prefilled syringe Drugs 0.000 claims 1
• 210000001236 prokaryotic cell Anatomy 0.000 claims 1