BR112023023260A2 - Vetor, métodos para produzir um vetor e para tratar um sujeito tendo uma doença ou uma doença infecciosa, célula hospedeira, e, composição farmacêutica - Google Patents
Vetor, métodos para produzir um vetor e para tratar um sujeito tendo uma doença ou uma doença infecciosa, célula hospedeira, e, composição farmacêuticaInfo
- Publication number
- BR112023023260A2 BR112023023260A2 BR112023023260A BR112023023260A BR112023023260A2 BR 112023023260 A2 BR112023023260 A2 BR 112023023260A2 BR 112023023260 A BR112023023260 A BR 112023023260A BR 112023023260 A BR112023023260 A BR 112023023260A BR 112023023260 A2 BR112023023260 A2 BR 112023023260A2
- Authority
- BR
- Brazil
- Prior art keywords
- vector
- disease
- treating
- subject
- producing
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract 5
- 208000035473 Communicable disease Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006471 dimerization reaction Methods 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
vetor, métodos para produzir um vetor e para tratar um sujeito tendo uma doença ou uma doença infecciosa, célula hospedeira, e, composição farmacêutica. a presente invenção refere-se aos vetores, tais como plasmídeos de dna, compreendendo sequências múltiplas de ácido nucleico engenheiradas para serem coexpressas como moléculas separadas. tais moléculas separadas incluem um primeiro polipeptídeo, em que o primeiro polipeptídeo compreende uma unidade de alvejamento que alveja células que apresentam antígeno, uma unidade de multimerização, tal como unidade de dimerização e uma unidade antigênica compreendendo um ou mais antígenos ou partes dos mesmos e um ou mais compostos imunoestimulatórios.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA202170221 | 2021-05-10 | ||
DKPA202170364 | 2021-07-08 | ||
DKPA202270113 | 2022-03-18 | ||
DKPA202270186 | 2022-04-07 | ||
PCT/EP2022/062665 WO2022238420A2 (en) | 2021-05-10 | 2022-05-10 | Co-expression of constructs and immunostimulatory compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023023260A2 true BR112023023260A2 (pt) | 2024-01-30 |
Family
ID=82016537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023023260A BR112023023260A2 (pt) | 2021-05-10 | 2022-05-10 | Vetor, métodos para produzir um vetor e para tratar um sujeito tendo uma doença ou uma doença infecciosa, célula hospedeira, e, composição farmacêutica |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP4337248A2 (pt) |
JP (1) | JP2024516882A (pt) |
KR (1) | KR20240019135A (pt) |
AU (1) | AU2022274154A1 (pt) |
BR (1) | BR112023023260A2 (pt) |
CA (1) | CA3216720A1 (pt) |
IL (1) | IL308310A (pt) |
WO (1) | WO2022238420A2 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024092025A1 (en) | 2022-10-25 | 2024-05-02 | Nykode Therapeutics ASA | Constructs and their use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8932603B2 (en) | 2003-02-25 | 2015-01-13 | Vaccibody As | Modified antibody |
WO2011161244A1 (en) | 2010-06-25 | 2011-12-29 | Vaccibody As | Homodimeric protein constructs |
AU2012356969B2 (en) | 2011-12-21 | 2017-05-04 | Nykode Therapeutics ASA | Vaccines against HPV |
EP3362103A4 (en) * | 2015-10-12 | 2020-02-05 | Nantomics, LLC | COMPOSITIONS AND METHODS USING VIRAL CANCER NEOEPITOPES |
KR20180100659A (ko) | 2016-01-08 | 2018-09-11 | 백시바디 에이에스 | 치료적 항암 네오에피토프 백신 |
BR112021005702A8 (pt) | 2018-09-27 | 2022-11-08 | Vaccibody As | Método para selecionar neoepítopos |
CN113631185A (zh) | 2019-02-27 | 2021-11-09 | 尼克塔治疗公司 | 用于治疗癌症的免疫治疗组合 |
WO2020221783A1 (en) | 2019-04-29 | 2020-11-05 | Vaccibody As | Methods for pre-selection of neoepitopes |
KR20230004585A (ko) | 2020-04-09 | 2023-01-06 | 니코데 테라퓨틱스 에이에스에이 | 개별화된 치료용 항암 백신 |
JP2023524054A (ja) | 2020-05-01 | 2023-06-08 | ナイコード セラピューティクス アルメン アクスイェ セルスカプ | ベータコロナウイルスの予防と治療 |
EP4181949A1 (en) | 2020-07-14 | 2023-05-24 | Evaxion Biotech A/S | Apc targeting units for immunotherapy |
-
2022
- 2022-05-10 AU AU2022274154A patent/AU2022274154A1/en active Pending
- 2022-05-10 EP EP22729066.5A patent/EP4337248A2/en active Pending
- 2022-05-10 KR KR1020237042659A patent/KR20240019135A/ko unknown
- 2022-05-10 IL IL308310A patent/IL308310A/en unknown
- 2022-05-10 JP JP2023568692A patent/JP2024516882A/ja active Pending
- 2022-05-10 BR BR112023023260A patent/BR112023023260A2/pt unknown
- 2022-05-10 CA CA3216720A patent/CA3216720A1/en active Pending
- 2022-05-10 WO PCT/EP2022/062665 patent/WO2022238420A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP4337248A2 (en) | 2024-03-20 |
IL308310A (en) | 2024-01-01 |
AU2022274154A1 (en) | 2023-11-16 |
CA3216720A1 (en) | 2022-11-17 |
KR20240019135A (ko) | 2024-02-14 |
WO2022238420A3 (en) | 2022-12-22 |
WO2022238420A2 (en) | 2022-11-17 |
JP2024516882A (ja) | 2024-04-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201991440A1 (ru) | ТЕРМОСТАБИЛЬНЫЕ НУКЛЕАЗЫ Cas9 | |
BR112019007433A2 (pt) | sistemas de replicon de vírus recombinante e usos dos mesmos | |
EA201892810A1 (ru) | Гибридные последовательности нуклеиновых кислот для геномной инженерии | |
BR112018076259A2 (pt) | tagmentação usando transposomas imobilizados com ligantes | |
AU2018298422A1 (en) | Novel nucleic acid molecules | |
BR112015023424A2 (pt) | construto de expressão engenheirado, método para aprimoramento de produção de rna ou proteína, vetor, célula, hospedeira bacteriana, sistema de cultura de célula para síntese in vivo de dsrna, composição e método para controlar uma infestação de pragas de invertebrados ou para inibir a propagação de uma doença viral em uma população de plantas, e terminador transcricional | |
BR112017016681A2 (pt) | vetor de coexpressão de vacina e moléculas coestimulatórias | |
MX2018011384A (es) | Arn de replicacion en trans. | |
BR112018013930A2 (pt) | vírus oncolítico, vírus que expressa três genes heterólogos, composição farmacêutica, vírus para o uso, produto de fabricação, método de tratamento de câncer e uso do vírus | |
BR112017026719A8 (pt) | Nucleases cas9 termostáveis | |
BR112018010635A2 (pt) | linhagens celulares estáveis para a produção retroviral | |
BR112015012375A2 (pt) | modificação e regulação de genoma à base de crispr | |
BR112022003740A2 (pt) | Anticorpos anti-cd96 e métodos de uso dos mesmos | |
Kalliomaa-Sanford et al. | Chromosome segregation in Archaea mediated by a hybrid DNA partition machine | |
BR112022021459A2 (pt) | Nucleases guiadas por rna, fragmentos ativos e variantes das mesmas e métodos de uso | |
WO2020030984A3 (en) | Compositions and methods for genome engineering with cas12a proteins | |
BR112023023260A2 (pt) | Vetor, métodos para produzir um vetor e para tratar um sujeito tendo uma doença ou uma doença infecciosa, célula hospedeira, e, composição farmacêutica | |
WO2015009678A3 (en) | Specific targeting of rna expanded repeat sequences | |
WO2016130628A8 (en) | Griffithsin mutants | |
Mairhofer et al. | Advances in host and vector development for the production of plasmid DNA vaccines | |
BR112021023899A2 (pt) | Método para o tratamento da distrofia muscular por direcionamento ao gene da dmpk | |
Aditham et al. | Chemically modified mocRNAs for highly efficient protein expression in mammalian cells | |
Janowski et al. | The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize | |
AR102803A1 (es) | Vacunas de reovirus aviar | |
AR102762A1 (es) | Secuencia de oligonucleótidos para uso en ingeniería de rutas metabólicas |