JP2009514969A5 - - Google Patents

Info

Publication number

JP2009514969A5

JP2009514969A5 JP2008540160A JP2008540160A JP2009514969A5 JP 2009514969 A5 JP2009514969 A5 JP 2009514969A5 JP 2008540160 A JP2008540160 A JP 2008540160A JP 2008540160 A JP2008540160 A JP 2008540160A JP 2009514969 A5 JP2009514969 A5 JP 2009514969A5

Authority

JP

Japan

Prior art keywords

composition

drug

disease

agent

ophthalmic

Prior art date

2006-11-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 239000003814 drug Substances 0.000 claims 46
• 239000000203 mixture Substances 0.000 claims 45
• 229940079593 drug Drugs 0.000 claims 41
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 22
• 201000010099 disease Diseases 0.000 claims 21
• 239000003246 corticosteroid Substances 0.000 claims 14
• 150000001875 compounds Chemical class 0.000 claims 12
• 208000010412 Glaucoma Diseases 0.000 claims 10
• 108010074051 C-Reactive Protein Proteins 0.000 claims 9
• 102100032752 C-reactive protein Human genes 0.000 claims 9
• 239000000739 antihistaminic agent Substances 0.000 claims 9
• 206010023332 keratitis Diseases 0.000 claims 9
• 210000002966 serum Anatomy 0.000 claims 8
• 102000000521 Immunophilins Human genes 0.000 claims 7
• 108010016648 Immunophilins Proteins 0.000 claims 7
• 206010046851 Uveitis Diseases 0.000 claims 7
• 230000001419 dependent effect Effects 0.000 claims 7
• 239000003018 immunosuppressive agent Substances 0.000 claims 7
• 208000001344 Macular Edema Diseases 0.000 claims 6
• 208000023178 Musculoskeletal disease Diseases 0.000 claims 6
• GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 6
• 230000001387 anti-histamine Effects 0.000 claims 6
• 201000010666 keratoconjunctivitis Diseases 0.000 claims 6
• 208000028169 periodontal disease Diseases 0.000 claims 6
• 229930105110 Cyclosporin A Natural products 0.000 claims 5
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 5
• 108010036949 Cyclosporine Proteins 0.000 claims 5
• 208000007465 Giant cell arteritis Diseases 0.000 claims 5
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• 208000002205 allergic conjunctivitis Diseases 0.000 claims 5
• 230000000495 immunoinflammatory effect Effects 0.000 claims 5
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 5
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 5
• 229940094443 oxytocics prostaglandins Drugs 0.000 claims 5
• 229960005205 prednisolone Drugs 0.000 claims 5
• OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 5
• 150000003180 prostaglandins Chemical class 0.000 claims 5
• JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical class N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 claims 5
• 206010043207 temporal arteritis Diseases 0.000 claims 5
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• 206010061218 Inflammation Diseases 0.000 claims 4
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• 239000000043 antiallergic agent Substances 0.000 claims 4
• 239000003429 antifungal agent Substances 0.000 claims 4
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• 229960001265 ciclosporin Drugs 0.000 claims 4
• 229960001334 corticosteroids Drugs 0.000 claims 4
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• 208000002780 macular degeneration Diseases 0.000 claims 4
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• 208000003971 Posterior uveitis Diseases 0.000 claims 3
• 239000000150 Sympathomimetic Substances 0.000 claims 3
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• -1 antibiotic Substances 0.000 claims 3
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• 210000001525 retina Anatomy 0.000 claims 3
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• LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 2
• 206010057380 Allergic keratitis Diseases 0.000 claims 2
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• 206010055665 Corneal neovascularisation Diseases 0.000 claims 2
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• 206010018258 Giant papillary conjunctivitis Diseases 0.000 claims 2
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 2
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• HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 2
• 206010029113 Neovascularisation Diseases 0.000 claims 2
• 206010072139 Ocular rosacea Diseases 0.000 claims 2
• 208000003435 Optic Neuritis Diseases 0.000 claims 2
• 201000010183 Papilledema Diseases 0.000 claims 2
• 206010033708 Papillitis Diseases 0.000 claims 2
• 241000721454 Pemphigus Species 0.000 claims 2
• 208000002158 Proliferative Vitreoretinopathy Diseases 0.000 claims 2
• 201000007527 Retinal artery occlusion Diseases 0.000 claims 2
• 206010038848 Retinal detachment Diseases 0.000 claims 2
• 208000017442 Retinal disease Diseases 0.000 claims 2
• 208000007014 Retinitis pigmentosa Diseases 0.000 claims 2
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• 206010038933 Retinopathy of prematurity Diseases 0.000 claims 2
• 206010038934 Retinopathy proliferative Diseases 0.000 claims 2
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• 206010042742 Sympathetic ophthalmia Diseases 0.000 claims 2
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• 208000000208 Wet Macular Degeneration Diseases 0.000 claims 2
• 230000036783 anaphylactic response Effects 0.000 claims 2
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• 230000002491 angiogenic effect Effects 0.000 claims 2
• 239000005557 antagonist Substances 0.000 claims 2
• 201000004612 anterior uveitis Diseases 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 229940125715 antihistaminic agent Drugs 0.000 claims 2
• 210000004087 cornea Anatomy 0.000 claims 2
• 201000000159 corneal neovascularization Diseases 0.000 claims 2
• 201000007717 corneal ulcer Diseases 0.000 claims 2
• 201000003146 cystitis Diseases 0.000 claims 2
• 201000010206 cystoid macular edema Diseases 0.000 claims 2
• 201000011190 diabetic macular edema Diseases 0.000 claims 2
• 230000003511 endothelial effect Effects 0.000 claims 2
• 208000013653 hyalitis Diseases 0.000 claims 2
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 239000012528 membrane Substances 0.000 claims 2
• 201000003142 neovascular glaucoma Diseases 0.000 claims 2
• 208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 claims 2
• 201000002166 optic papillitis Diseases 0.000 claims 2
• 230000002085 persistent effect Effects 0.000 claims 2
• 230000002980 postoperative effect Effects 0.000 claims 2
• 230000002062 proliferating effect Effects 0.000 claims 2
• 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims 2
• 230000006785 proliferative vitreoretinopathy Effects 0.000 claims 2
• ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 claims 2
• 239000000018 receptor agonist Substances 0.000 claims 2
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• 230000004264 retinal detachment Effects 0.000 claims 2
• 208000004644 retinal vein occlusion Diseases 0.000 claims 2
• 201000004700 rosacea Diseases 0.000 claims 2
• 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 2
• 230000003637 steroidlike Effects 0.000 claims 2
• 230000001975 sympathomimetic effect Effects 0.000 claims 2
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• 208000011580 syndromic disease Diseases 0.000 claims 2
• 230000002792 vascular Effects 0.000 claims 2
• 208000018464 vernal keratoconjunctivitis Diseases 0.000 claims 2
• VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 claims 1
• VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims 1
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• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
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• 206010012438 Dermatitis atopic Diseases 0.000 claims 1
• 206010013774 Dry eye Diseases 0.000 claims 1
• HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
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• GZENKSODFLBBHQ-ILSZZQPISA-N Medrysone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@H](C(C)=O)CC[C@H]21 GZENKSODFLBBHQ-ILSZZQPISA-N 0.000 claims 1
• 208000000112 Myalgia Diseases 0.000 claims 1
• HIEKJRVYXXINKH-ADVKXBNGSA-N N1([C@H]2CC[C@H](C[C@H]2OC)/C=C(\C)[C@H]2OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@]3(O)O[C@@H]([C@H](C[C@H]3C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]2C)=O)CC)C=NN=N1 Chemical compound N1([C@H]2CC[C@H](C[C@H]2OC)/C=C(\C)[C@H]2OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@]3(O)O[C@@H]([C@H](C[C@H]3C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]2C)=O)CC)C=NN=N1 HIEKJRVYXXINKH-ADVKXBNGSA-N 0.000 claims 1
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• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
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• 239000000048 adrenergic agonist Substances 0.000 claims 1
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• ZDQSOHOQTUFQEM-PKUCKEGBSA-N ascomycin Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](O)[C@H](OC)C1 ZDQSOHOQTUFQEM-PKUCKEGBSA-N 0.000 claims 1
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• 229930003231 vitamin Natural products 0.000 claims 1
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• 150000003722 vitamin derivatives Chemical class 0.000 claims 1
• 229940075420 xanthine Drugs 0.000 claims 1