CN101355876B - 一种适用于眼部给药的组合物 - Google Patents
一种适用于眼部给药的组合物 Download PDFInfo
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- CN101355876B CN101355876B CN2006800505921A CN200680050592A CN101355876B CN 101355876 B CN101355876 B CN 101355876B CN 2006800505921 A CN2006800505921 A CN 2006800505921A CN 200680050592 A CN200680050592 A CN 200680050592A CN 101355876 B CN101355876 B CN 101355876B
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73598905P | 2005-11-09 | 2005-11-09 | |
| US60/735,989 | 2005-11-09 | ||
| PCT/US2006/043493 WO2007056457A2 (en) | 2005-11-09 | 2006-11-08 | Methods, compositions, and kits for the treatment of medical conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101355876A CN101355876A (zh) | 2009-01-28 |
| CN101355876B true CN101355876B (zh) | 2012-09-05 |
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ID=38023959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800505921A Expired - Fee Related CN101355876B (zh) | 2005-11-09 | 2006-11-08 | 一种适用于眼部给药的组合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US8067433B2 (enExample) |
| EP (2) | EP2218442A1 (enExample) |
| JP (2) | JP2009514969A (enExample) |
| KR (1) | KR20080065704A (enExample) |
| CN (1) | CN101355876B (enExample) |
| AR (1) | AR058182A1 (enExample) |
| AU (1) | AU2006311577B2 (enExample) |
| BR (1) | BRPI0618643A2 (enExample) |
| CA (1) | CA2628570A1 (enExample) |
| IL (2) | IL191283A (enExample) |
| MX (1) | MX2008006076A (enExample) |
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| RU (1) | RU2008122978A (enExample) |
| TW (1) | TWI435729B (enExample) |
| WO (1) | WO2007056457A2 (enExample) |
| ZA (3) | ZA200804550B (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8916546B2 (en) | 2003-08-29 | 2014-12-23 | Therapeutic Research Llc | Materials and methods for treatment and diagnosis of disorders associated with oxidative stress |
| US7812049B2 (en) * | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
| TWI435729B (zh) | 2005-11-09 | 2014-05-01 | Combinatorx Inc | 治療病症之方法,組合物及套組 |
| US7691811B2 (en) * | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
| US20080146497A1 (en) * | 2006-07-25 | 2008-06-19 | Graham Richard S | Cyclosporin Compositions |
| US9561178B2 (en) * | 2006-07-25 | 2017-02-07 | Allergan, Inc. | Cyclosporin compositions |
| RU2010104916A (ru) * | 2006-08-16 | 2011-08-20 | Михаил В. Благосклонный (US) | Способ профилактики и лечения возрастных заболеваний |
| US8828966B2 (en) | 2006-10-03 | 2014-09-09 | Claire Mitchell | Method for treatment of macular degeneration by modulating P2Y12 or P2X7 receptors |
| WO2008062320A2 (en) * | 2006-10-06 | 2008-05-29 | Eisai R&D Management Co., Ltd | Extended release formulations of a proton pump inhibitor |
| JP5424330B2 (ja) * | 2007-07-26 | 2014-02-26 | 国立大学法人大阪大学 | インターロイキン6受容体阻害剤を有効成分とする眼炎症疾患治療剤 |
| CA2639412A1 (en) * | 2007-09-11 | 2009-03-11 | Universite Laval | Prostaglandin e2 modulation and uses thereof |
| MX2010003364A (es) | 2007-10-08 | 2010-07-06 | Lux Biosciences Inc | Composiciones oftalmicas que comprenden inhibidores de calcineurina o inhibidores de mtor. |
| EP2818184B1 (en) * | 2007-11-16 | 2018-10-31 | Allergan, Inc. | Compositions and methods for treating Purpura |
| JP5728234B2 (ja) * | 2008-02-15 | 2015-06-03 | ボーン・セラピューティクス | 骨関節疾患の治療又は予防において使用するための医薬組成物 |
| PT2252290T (pt) * | 2008-02-15 | 2018-02-14 | Bone Therapeutics Sa | Composição farmacêutica para utilização no tratamento e/ou prevenção de doenças osteoarticulares |
| US8349806B2 (en) * | 2008-07-10 | 2013-01-08 | Inspire Pharmaceuticals, Inc. | Method of treating blepharitis |
| WO2010025266A1 (en) * | 2008-08-27 | 2010-03-04 | University Of Iowa Research Foundation | Inhibitors of phosphodiesterase type 5a for treating or preventing muscle disease or the symptoms thereof in a patient |
| WO2010048264A2 (en) * | 2008-10-23 | 2010-04-29 | Combinatorx, Incorporated | Methods and compositions for the treatment of immunoinflammatory disorders |
| US20100190734A1 (en) * | 2009-01-23 | 2010-07-29 | Romulus Kimbro Brazzell | Method of treating dry eye disease with azithromycin |
| US8870876B2 (en) | 2009-02-13 | 2014-10-28 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| FR2942138A1 (fr) * | 2009-02-16 | 2010-08-20 | Galderma Res & Dev | Association de composes pour le traitement ou la prevention des affections dermatologiques |
| EP2416792A4 (en) * | 2009-04-10 | 2012-10-24 | Haiyan Qi | NOVEL ANTI-AGING AGENTS AND METHODS OF IDENTIFICATION |
| US20110009339A1 (en) * | 2009-04-14 | 2011-01-13 | Allergan, Inc | Method of treating blurred vision and other conditions of the eye with cyclosporin compositions |
| WO2010125416A1 (en) * | 2009-04-27 | 2010-11-04 | Raouf Rekik | Drug delivery to the anterior and posterior segments of the eye |
| WO2010127301A1 (en) * | 2009-05-01 | 2010-11-04 | Allergan, Inc. | Method of treating allergic conjunctivitis with cyclosporin compositions |
| US20120114637A1 (en) * | 2009-05-04 | 2012-05-10 | Santen Pharmaceutical Co., Ltd. | Mtor pathway inhibitors for treating ocular disorders |
| US9017725B2 (en) * | 2009-06-09 | 2015-04-28 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| GB0915319D0 (en) * | 2009-09-03 | 2009-10-07 | Sharma Anant | Combination medicament |
| US8277459B2 (en) | 2009-09-25 | 2012-10-02 | Tarsus Medical Inc. | Methods and devices for treating a structural bone and joint deformity |
| RU2407491C1 (ru) * | 2009-09-29 | 2010-12-27 | Эрнест Витальевич Бойко | Способ лечения внутриглазных инфекций |
| JP2013508295A (ja) * | 2009-10-16 | 2013-03-07 | デューク・ユニヴァーシティ | 薬物誘発性手足症候群を治療するための組成物および方法 |
| EP2493475A4 (en) * | 2009-10-30 | 2014-10-29 | Intratus Inc | COSMETIC METHODS AND PREPARATIONS FOR THE PROLONGED RELEASE OF THERAPEUTIC AGENTS IN THE EYE |
| CA2783699C (en) | 2009-12-08 | 2019-01-15 | Case Western Reserve University | Primary amine compounds for treating ocular disorders |
| DE202009017772U1 (de) * | 2009-12-10 | 2011-04-21 | Orthogen Ag | Kombinationspräparate mit Cytokin-Antagonist und Corticosteroid |
| US10813917B2 (en) * | 2009-12-11 | 2020-10-27 | Medregen, Llc | Treatment methods utilizing stem cell mobilizers and immunosuppressive agents |
| US8652141B2 (en) | 2010-01-21 | 2014-02-18 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| EP2538965B1 (en) | 2010-02-25 | 2017-04-12 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
| US8696719B2 (en) | 2010-06-03 | 2014-04-15 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| WO2012118863A1 (en) * | 2011-02-28 | 2012-09-07 | The Schepens Eye Research Institute, Inc. | Therapies that target autoimmunity for treating glaucoma and optic neuropathy |
| US8865685B2 (en) | 2011-06-30 | 2014-10-21 | Johnson & Johnson Vision Care, Inc. | Esters for treatment of ocular inflammatory conditions |
| JP6224624B2 (ja) * | 2012-02-02 | 2017-11-01 | ザ・ユニバーシティ・オブ・シドニー | 涙膜安定性における改善 |
| WO2013169315A1 (en) * | 2012-05-09 | 2013-11-14 | Hill David W | Method for treating macular degeneration |
| EP3181120A1 (en) | 2012-11-09 | 2017-06-21 | Scidose LLC | Enema composition for treatment of ulcerative colitis having long term stability |
| JP6231857B2 (ja) * | 2012-11-13 | 2017-11-15 | 徳人 ▲高▼村 | 眼房水中アルブミンに結合親和性を有する薬剤の効果を増強する眼科用組み合わせ剤 |
| GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
| WO2014117117A1 (en) * | 2013-01-28 | 2014-07-31 | The Johns Hopkins University | Chronic nsaid treatment for fuchs endothelial corneal dystrophy |
| US9254289B2 (en) | 2013-03-13 | 2016-02-09 | Remedeye Inc. | Methods for treating eye disorders using dipyridamole |
| US20150031712A1 (en) | 2013-03-12 | 2015-01-29 | Moshe Rogosnitzky | Therapeutic Compositions Containing Dipyridamole and Treatment Packs Including Such Compositions and Methods for Producing Same |
| IL225179A (en) * | 2013-03-12 | 2017-01-31 | Rogosnitzky Moshe | Compounds for use in ocular disorders using dipyridamole |
| AU2015269353B2 (en) * | 2014-06-04 | 2020-03-26 | Tersus Pharmaceuticals, LLC | Methods of treating chronic dry eye disease using C16:1n7 palmitoleate and derivatives thereof |
| US9980976B2 (en) * | 2015-02-17 | 2018-05-29 | Northwestern University | Use of REDD1 inhibitors to dissociate therapeutic and adverse atrophogenic effects of glucocorticoid receptor agonists |
| CN113651873B (zh) * | 2015-05-01 | 2025-09-02 | Onl医疗股份有限公司 | 肽组合物和使用方法 |
| AU2016298794A1 (en) | 2015-06-08 | 2018-02-01 | O.D. Ocular Discovery Ltd. | Therapeutic compositions containing dipyridamole, treatment packs and kits including such compositions, and methods for producing same |
| CN108271374B (zh) | 2015-07-07 | 2021-09-21 | 科德克希思公司 | 具有改进的活性的新颖p450-bm3变体 |
| HK1247120A1 (zh) | 2015-07-08 | 2018-09-21 | 艾克瑟罗视觉股份有限公司 | 用於治疗眼部炎性病症含有整联蛋白α4拮抗剂的药物组合物 |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
| US20190008920A1 (en) * | 2017-05-19 | 2019-01-10 | Ocugen, Inc. | Ophthalmic compositions and methods of use |
| WO2018215596A1 (en) * | 2017-05-24 | 2018-11-29 | Koninklijke Philips N.V. | Diagnostics of gingivitis based on salivary il-1beta and hgf |
| EP3639854A4 (en) * | 2017-06-16 | 2021-03-03 | The Doshisha | MTOR INHIBITIVE MEDICINAL PRODUCT FOR THE TREATMENT OR PREVENTION OF OPHTHALMIC SYMPTOMS, DISORDERS, OR DISEASES AND USE THEREOF |
| US20200121652A1 (en) * | 2017-06-16 | 2020-04-23 | The Doshisha | Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent |
| KR20210018193A (ko) * | 2018-03-09 | 2021-02-17 | 포톨라 파마슈티컬스, 인코포레이티드 | 선택적 syk 억제자의 사용 방법 및 약학적 조성물 |
| RU2668713C1 (ru) * | 2018-03-16 | 2018-10-02 | Федеральное государственное бюджетное учреждение "Московский научно-исследовательский институт глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации | Способ лечения центральных язв роговицы бактериальной и герпетической этиологии |
| CN109119165A (zh) * | 2018-08-27 | 2019-01-01 | 珠海为凡医疗信息技术有限公司 | 一种白内障患病风险检测方法、装置及电子设备 |
| CA3115664A1 (en) * | 2018-08-29 | 2020-03-05 | Ocugen, Inc. | Ophthalmic compositions and methods of use |
| JP7430719B2 (ja) * | 2018-10-19 | 2024-02-13 | メディシノバ・インコーポレイテッド | イブジラストを用いて眼疾患/障害または損傷を治療する方法 |
| FR3109524B1 (fr) * | 2020-04-22 | 2022-04-08 | H4 Orphan Pharma | Utilisation d’un ligand multifonctionnel pour traiter l’œil sec et les dysfonctionnements des glandes de Meibomius et des glandes lacrymales. |
| EP4146664A4 (en) | 2020-05-01 | 2024-11-13 | Ripple Therapeutics Corporation | HETERODIMER COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES |
| WO2022061303A1 (en) | 2020-09-21 | 2022-03-24 | Antares Pharma, Inc. | Aqueous pharmaceutical formulation of hydrocortisone sodium phosphate and monothioglycerol |
| EP4236949A4 (en) * | 2020-10-30 | 2024-09-25 | The Board of Trustees of the Leland Stanford Junior University | DRUGS TARGETING INFLAMMATION FOR THE TREATMENT OF OSTEOARTHRITIS AND OTHER INFLAMMATORY DISEASES |
| CN116407499B (zh) * | 2021-12-29 | 2024-10-25 | 辅必成(上海)医药科技有限公司 | 一种他克莫司眼用乳剂及其制备方法 |
| JP2025509955A (ja) | 2022-03-21 | 2025-04-11 | アンタレス・ファーマ・インコーポレーテッド | リン酸ヒドロコルチゾンナトリウム及びモノチオグリセロール水性医薬製剤 |
| CN116966187B (zh) * | 2022-04-22 | 2025-11-21 | 深圳埃格林医药有限公司 | 地昔帕明前药的新用途 |
Family Cites Families (392)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US532248A (en) | 1895-01-08 | powell | ||
| US2554736A (en) | 1951-05-29 | Tertiary aminoalkyl-iminodibenzyls | ||
| US3282942A (en) | 1966-11-01 | Substituted cycloalkanoindoles | ||
| US2868818A (en) | 1953-12-15 | 1959-01-13 | Merck & Co Inc | Alpha methyl phenylalanines |
| US3046283A (en) | 1957-08-19 | 1962-07-24 | Merck & Co Inc | 10-(omega-aminoalkylidene)-thioxanthenes |
| NL110232C (enExample) | 1958-12-06 | |||
| US3409640A (en) | 1959-07-22 | 1968-11-05 | Schering Corp | 5-(3'-dimethylamino-2'-methyl-propyl)dibenzocycloheptenes |
| NL120551C (enExample) | 1959-09-22 | |||
| NL274885A (enExample) | 1960-09-16 | |||
| US3454554A (en) | 1960-10-14 | 1969-07-08 | Colgate Palmolive Co | Aminoalkyliminodibenzyl compounds |
| FR1332145A (enExample) | 1961-06-08 | 1963-12-16 | ||
| US3158648A (en) | 1962-04-09 | 1964-11-24 | Merck & Co Inc | Direct resolution of alpha-methyl-3, 4-dihydroxyphenylalanine |
| US3202660A (en) | 1961-10-09 | 1965-08-24 | Boehringer Sohn Ingelheim | Process for the preparation of 3-arylamino-1, 3-diazacycloalkenes |
| BE674185A (enExample) | 1961-10-10 | |||
| CH426833A (de) | 1962-03-27 | 1966-12-31 | Dumex Ltd As | Verfahren zur Herstellung des N-Oxyds des N-(3-Dimethylamino-propyl)-iminodibenzyls oder seiner Salze |
| US3205264A (en) | 1962-06-15 | 1965-09-07 | Merck & Co Inc | Process for the preparation of 10, 11-dihydro-5-(gamma-methyl-and dimethyl-amino propylidene)-5h-dibenzo[a, d] cycloheptene |
| US3271451A (en) | 1962-07-03 | 1966-09-06 | Merck & Co Inc | Process for preparing 5-(3-methylaminopropyl)-5h-dibenzo [a, d] cycloheptenes |
| US3244748A (en) | 1962-07-03 | 1966-04-05 | Merck & Co Inc | 5h-dibenzo [a, d] cycloheptenes |
| US3922305A (en) | 1962-08-09 | 1975-11-25 | Merck & Co Inc | Chemical compounds |
| NL130095C (enExample) | 1962-08-31 | |||
| US3310553A (en) | 1962-09-25 | 1967-03-21 | Pfizer & Co C | Alkylated thioxathenesulfonamides |
| GB991651A (en) | 1963-02-20 | 1965-05-12 | Dumex Ltd As | Dibenzocycloheptadiene derivatives |
| US3389139A (en) | 1963-06-14 | 1968-06-18 | Wander Ag Dr A | 6-homopiperazino and piperazinomorphanthridines |
| FR88751E (enExample) | 1963-07-09 | 1967-06-07 | ||
| US3978121A (en) | 1963-07-25 | 1976-08-31 | Merck & Co., Inc. | 5H Dibenzo[a,d]cycloheptene derivatives |
| US3981917A (en) | 1963-07-25 | 1976-09-21 | Merck & Co., Inc. | Chemical compounds |
| US3963778A (en) | 1965-11-10 | 1976-06-15 | Bayer Aktiengesellschaft | Basic oximes and their preparation |
| US3505321A (en) | 1965-11-24 | 1970-04-07 | Bayer Ag | Basically substituted oximes of 5h-dibenzo-(a,d)10,11-dihydro-cycloheptenylidene and their preparation |
| NL129434C (enExample) | 1966-03-12 | |||
| GB1192812A (en) | 1966-05-20 | 1970-05-20 | American Cyanamid Co | 2-Chloro-11-(1-Piperazinyl)Dibenz[b,f]-[1,4]Oxazepine, Non-Toxic Acid Addition Salts thereof, and Therapeutic Compositions containing said Oxazepine or Salts |
| FR1532301A (fr) | 1967-01-18 | 1968-07-12 | Rhone Poulenc Sa | Nouveaux dérivés de la dibenzazépine et leur préparation |
| US3539573A (en) | 1967-03-22 | 1970-11-10 | Jean Schmutz | 11-basic substituted dibenzodiazepines and dibenzothiazepines |
| GB1177525A (en) | 1967-04-13 | 1970-01-14 | Leo Ab | New Heterocyclic Aminoketones of Therapeutic Interest |
| CH479559A (de) | 1967-09-26 | 1969-10-15 | Wander Ag Dr A | Verfahren zur Herstellung von Acylguanidinen |
| US3892777A (en) | 1968-05-01 | 1975-07-01 | Hoffmann La Roche | Substituted benzylethylenedicarbamates |
| US3758528A (en) | 1970-03-13 | 1973-09-11 | Science Union & Cie | Tricyclic compounds |
| US4017542A (en) | 1971-02-23 | 1977-04-12 | Ciba-Geigy Corporation | 9-(2-Hydroxy-3-amino-propyl)-9,10-dihydro-9,10-ethano-anthracenes and salts thereof |
| US4045580A (en) | 1971-02-23 | 1977-08-30 | Ciba-Geigy Corporation | Pharmaceutical preparation using 9-(2-hydroxy-3-amino-propyl)-9,10-dihydro-9,10-ethano-anthracenes as antidepressants |
| US4250094A (en) | 1971-04-28 | 1981-02-10 | The Upjohn Company | 1-(Aminoalkyl) substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
| BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US4029792A (en) | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| JPS5229318B2 (enExample) | 1972-03-30 | 1977-08-01 | ||
| CH570401A5 (enExample) | 1972-05-09 | 1975-12-15 | Wander Ag Dr A | |
| GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| US4020096A (en) | 1974-02-01 | 1977-04-26 | Merck & Co., Inc. | 10,11,Dihydro-N-alkoxycarbonyl-10,10,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene-5-methylamines |
| US4193926A (en) | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
| US4097483A (en) | 1974-11-01 | 1978-06-27 | Kyorin Pharmaceutical Co., Ltd. | Pyrazolo 1,5-a!pyridines |
| US4017621A (en) | 1974-12-09 | 1977-04-12 | Sumitomo Chemical Company, Limited | 2-Morpholinyl tricyclic dibenzazepine compounds |
| US3956296A (en) | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
| GB1508669A (en) | 1974-12-13 | 1978-04-26 | Sumitomo Chemical Co | Methanoanthracene derivative and a process for the preparation thereof |
| US4358620A (en) | 1974-12-13 | 1982-11-09 | Sumitomo Chemical Company, Limited | 9-Formyl-9,10-dihydro-9,10-methanoanthracene |
| NL189199C (nl) | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| US4048223A (en) | 1975-04-11 | 1977-09-13 | Merck & Co., Inc. | 3-Dimethylsulfamoyl-5-[amino(alkyl or alkylidene)]-5H-dibenzo [a,d]cycloheptenes |
| US4014335A (en) | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
| JPS527972A (en) | 1975-07-07 | 1977-01-21 | Sumitomo Chem Co Ltd | Process for preparing novel morpholine derivatives |
| FR2319333A1 (fr) | 1975-07-28 | 1977-02-25 | Roussel Uclaf | Nouveaux derives du 7-amino 6,7-dihydro/5h/ benzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments de ces produits |
| US4128641A (en) | 1975-07-31 | 1978-12-05 | Hzi Research Center Inc. | Tetracyclic psychotropic drug |
| GB1531278A (en) | 1975-12-15 | 1978-11-08 | Shionogi & Co | 9,10-dihydro-9,10-methanoanthracene n-oxide derivatives and the production thereof |
| US4088647A (en) | 1976-02-04 | 1978-05-09 | Glushkov Robert Georgievich | Pyrazino (1,2,3-ab)-β-carboline derivatives and salts thereof and method of preparing same |
| NL7610942A (nl) | 1976-10-02 | 1978-04-04 | Akzo Nv | Werkwijze voor het bereiden van 1,4-diazepine derivaten. |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| IE46852B1 (en) | 1977-06-10 | 1983-10-05 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives |
| DE2727481A1 (de) | 1977-06-18 | 1979-01-11 | Basf Ag | Dihydropyridazone und dihydropyridazone enthaltende therapeutische mittel |
| CA1114379A (en) | 1977-11-03 | 1981-12-15 | Pfizer Corporation | Piperidino-phthalazines |
| FI65914C (fi) | 1978-03-07 | 1984-08-10 | Sandoz Ag | Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a |
| NL171194C (nl) | 1978-05-23 | 1983-02-16 | Giesen Metaalgieterij | Warmwater-ketel, bijvoorbeeld een centrale verwarmingsketel. |
| US4287175A (en) | 1978-06-22 | 1981-09-01 | Merck & Co., Inc. | Contact lens wetting agents |
| DE2837161A1 (de) | 1978-08-25 | 1980-03-06 | Thomae Gmbh Dr K | Neue benzimidazole und deren verwendung |
| NL7809726A (nl) | 1978-09-26 | 1980-03-28 | Akzo Nv | Nieuwe tetracyclische verbindingen. |
| JPS6056143B2 (ja) | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | アミジン誘導体ならびにその製造法 |
| PH16099A (en) | 1979-03-06 | 1983-06-24 | Yamanouchi Pharma Co Ltd | Guanidinothiazole compounds,process for preparing them and medical composition containing them |
| US4285958A (en) | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof |
| US4254130A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| US4254129A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| US4285957A (en) | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
| NZ193935A (en) | 1979-06-18 | 1985-05-31 | Richardson Merrell Inc | 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions |
| IL61501A (en) | 1979-11-26 | 1984-06-29 | Sterling Drug Inc | 5-(pyridinyl)-2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them |
| US4300557A (en) | 1980-01-07 | 1981-11-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating intraocular malignancies |
| US4512978A (en) * | 1980-01-24 | 1985-04-23 | Inwood Louis R | Dermatological composition useful in the treatment of psoriasis |
| DE3009034A1 (de) | 1980-03-08 | 1981-09-24 | Basf Ag, 6700 Ludwigshafen | 10-substituierte 5-cyanmethylendibenzo (a,d) -cycloheptne |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4394508A (en) | 1980-06-07 | 1983-07-19 | Bristol-Myers Company | Chemical compounds |
| US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
| EP0056782B1 (en) | 1981-01-09 | 1984-08-01 | Sandoz Ag | Novel cyclosporins |
| US4513002A (en) | 1981-01-16 | 1985-04-23 | Hoffmann-La Roche Inc. | Cycloheptene derivatives |
| US4510309A (en) | 1981-03-03 | 1985-04-09 | Bristol-Myers Company | Histamine H2 -antagonists |
| US4877805A (en) | 1985-07-26 | 1989-10-31 | Kligman Albert M | Methods for treatment of sundamaged human skin with retinoids |
| JPS5851853A (ja) | 1981-09-18 | 1983-03-26 | Kyowa Hakko Kogyo Co Ltd | リン脂質混合物の処理法 |
| PT75625B (en) | 1981-10-08 | 1985-12-09 | Merck & Co Inc | Process for preparing biosoluble ocular insert |
| US4517199A (en) | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4486432A (en) | 1982-09-30 | 1984-12-04 | Eli Lilly And Company | Quinoxalinedione leukotriene release inhibitors |
| DE3241102A1 (de) | 1982-11-06 | 1984-05-10 | A. Nattermann & Cie GmbH, 5000 Köln | Imidazolylalkylthienyl-tetrahydropyridazine und verfahren zu ihrer herstellung |
| FR2541680B1 (fr) | 1983-02-24 | 1985-06-14 | Rhone Poulenc Sante | Nouveaux derives de l'amino-5 dithiole-1,2 one-3, leur preparation et les compositions medicinales qui les contiennent |
| JPS59167590A (ja) | 1983-03-14 | 1984-09-21 | Kyorin Pharmaceut Co Ltd | ピラゾロ〔1,5−a〕ピリジン誘導体、その製法及びそれを含有する治療剤 |
| US4440933A (en) | 1983-03-16 | 1984-04-03 | Bristol-Myers Company | Process for preparing 1,2,5-thiadiazoles |
| US4569935A (en) | 1983-03-17 | 1986-02-11 | University Of Tennessee Research Corp. | Topical treatment of psoriasis with imidazole antibiotics |
| US5169637A (en) | 1983-03-24 | 1992-12-08 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| CA1237671A (en) | 1983-08-01 | 1988-06-07 | Michael W. Fountain | Enhancement of pharmaceutical activity |
| GB8321157D0 (en) | 1983-08-05 | 1983-09-07 | Fordonal Sa | Piperidine derivatives |
| GB8400863D0 (en) | 1984-01-13 | 1984-02-15 | Smith Kline French Lab | Chemical compounds |
| US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5639724A (en) | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| US4582822A (en) | 1984-10-09 | 1986-04-15 | Eli Lilly And Company | Antibiotic A80190, pharmaceutical compositions containing same and method of use |
| US5254562A (en) | 1984-12-03 | 1993-10-19 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| GB8509276D0 (en) | 1985-04-11 | 1985-05-15 | Smith Kline French Lab | Pyridine derivatives |
| US4824863A (en) | 1985-05-28 | 1989-04-25 | Eli Lilly And Company | Antibiotic A80438 |
| US5409704A (en) | 1985-06-26 | 1995-04-25 | The Liposome Company, Inc. | Liposomes comprising aminoglycoside phosphates and methods of production and use |
| US4975282A (en) | 1985-06-26 | 1990-12-04 | The Liposome Company, Inc. | Multilamellar liposomes having improved trapping efficiencies |
| JPS625963A (ja) | 1985-07-02 | 1987-01-12 | Mitsui Toatsu Chem Inc | イソキノリン誘導体 |
| US4655074A (en) | 1985-08-12 | 1987-04-07 | The Babcock & Wilcox Company | Self-zeroing pressure transmitter with automatic pressure manifold |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| ES2031821T3 (es) | 1985-10-17 | 1993-01-01 | Smith Kline & French Laboratories Limited | Procedimiento para preparar derivados de 4(4-oxo-1,4-dihidropiridin-1-il)fenilo. |
| US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| US5023087A (en) | 1986-02-10 | 1991-06-11 | Liposome Technology, Inc. | Efficient method for preparation of prolonged release liposome-based drug delivery system |
| GB8607684D0 (en) | 1986-03-27 | 1986-04-30 | Ici America Inc | Thiazepine compounds |
| US4742175A (en) | 1986-05-07 | 1988-05-03 | Merrell Dow Pharmaceuticals Inc. | Preparation of polymorphically pure terfenadine |
| IE60901B1 (en) | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
| US5049388A (en) | 1986-11-06 | 1991-09-17 | Research Development Foundation | Small particle aerosol liposome and liposome-drug combinations for medical use |
| NZ222843A (en) | 1986-12-22 | 1989-10-27 | Ortho Pharma Corp | Benzoxazinyl- and benzothiazinyl-tetrahydropyridazinones and intermediates, and medicaments |
| US4956388A (en) | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| US4965271A (en) | 1986-12-31 | 1990-10-23 | Hoechst Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| US5096906A (en) | 1986-12-31 | 1992-03-17 | University Of Virginia Alumni Patents Foundation | Method of inhibiting the activity of leukocyte derived cytokines |
| US5272153A (en) | 1986-12-31 | 1993-12-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
| US5032582A (en) | 1987-02-27 | 1991-07-16 | Liposome Technology, Inc. | Method for treating fungal infections with amphotericin B/cholesterol sulfate composition |
| US4798823A (en) | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| JP2577049B2 (ja) | 1987-06-04 | 1997-01-29 | 三共株式会社 | シクロスポリン製剤 |
| AU614965B2 (en) | 1987-06-06 | 1991-09-19 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Thiadiazinones |
| US4925849A (en) | 1987-06-15 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutically useful pyrazolopyridines |
| GB2206880B (en) | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
| US5227467A (en) | 1987-08-03 | 1993-07-13 | Merck & Co., Inc. | Immunosuppressive fluorinated cyclosporin analogs |
| ATE109970T1 (de) * | 1987-09-03 | 1994-09-15 | Univ Georgia Res Found | Cyclosporin-augenmittel. |
| US4839342A (en) | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| US4833138A (en) | 1987-10-23 | 1989-05-23 | Washington University | Phenothiazinealkaneamines for treatment of neurotoxic injury |
| DE68917485T2 (de) | 1988-01-23 | 1995-02-09 | Kyowa Hakko Kogyo Kk | Pyridazinon-Derivate und diese enthaltende pharmazeutische Zubereitungen. |
| US5188826A (en) | 1988-02-08 | 1993-02-23 | Insite Vision Incorporated | Topical ophthalmic suspensions |
| JP2717687B2 (ja) | 1988-02-13 | 1998-02-18 | 日本曹達株式会社 | ピリダジノン誘導体及びその製造方法 |
| US5238959A (en) | 1988-04-08 | 1993-08-24 | Eli Lilly And Company | 3-phenyloxy-3-phenyl propanamines |
| US5314875A (en) | 1988-05-02 | 1994-05-24 | Eli Lilly And Company | Method for treating swine dysentery with the derivatives of the antibiotic A82810 |
| US4994213A (en) | 1988-05-17 | 1991-02-19 | Liposome Technology, Inc. | Method of preparing lipid structures |
| US5342625A (en) | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| US6007840A (en) | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| KR0148748B1 (ko) | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| US4908372A (en) | 1988-10-13 | 1990-03-13 | Merrell Dow Pharmaceuticals Inc. | Antihistaminic piperidinyl benzimidazoles |
| CA2003198C (en) | 1988-11-29 | 1995-03-21 | Anthony J. Dziabo, Jr. | Aqueous ophthalmic solutions and method for preserving same |
| GB8827820D0 (en) | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
| US5098443A (en) | 1989-03-23 | 1992-03-24 | University Of Miami | Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents |
| US5281591A (en) | 1989-05-22 | 1994-01-25 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| US5021410A (en) | 1989-05-22 | 1991-06-04 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| US5180721A (en) | 1989-05-22 | 1993-01-19 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| NZ234186A (en) | 1989-07-07 | 1991-10-25 | Janssen Pharmaceutica Nv | Imidazo quinazolin-one derivatives and pharmaceutical compositions |
| US5284826A (en) | 1989-07-24 | 1994-02-08 | Sandoz Ltd. | 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins |
| US5194266A (en) | 1989-08-08 | 1993-03-16 | Liposome Technology, Inc. | Amphotericin B/cholesterol sulfate composition and method |
| US5231096A (en) | 1989-10-12 | 1993-07-27 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| US5077292A (en) | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
| US5112822A (en) | 1989-10-12 | 1992-05-12 | Allergan, Inc. | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same |
| US5198442A (en) | 1989-10-12 | 1993-03-30 | Allergan, Inc. | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same |
| US5204347A (en) | 1989-10-12 | 1993-04-20 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines |
| US5326763A (en) | 1989-10-12 | 1994-07-05 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| US5356633A (en) | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
| US5208228A (en) | 1989-11-13 | 1993-05-04 | Merck & Co., Inc. | Aminomacrolides and derivatives having immunosuppressive activity |
| US5215991A (en) | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
| US5130441A (en) | 1990-02-06 | 1992-07-14 | Allergan, Inc. | Method for producing amino-2-imidazoline derivatives |
| US5237072A (en) | 1990-02-06 | 1993-08-17 | Allergan, Inc. | Method for producing amino-2-imidazoline derivatives |
| US5122511A (en) | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
| US5252595A (en) | 1990-02-28 | 1993-10-12 | Allergan, Inc. | Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenylamino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines |
| US4963561A (en) | 1990-02-28 | 1990-10-16 | Sterling Drug Inc. | Imidazopyridines, their preparation and use |
| US5124455A (en) | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
| US5091528A (en) | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
| PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
| US5143918A (en) | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
| DE4034218A1 (de) | 1990-10-27 | 1992-04-30 | Merck Patent Gmbh | Verfahren zur herstellung von carebastin |
| US5141931A (en) | 1991-01-03 | 1992-08-25 | Sterling Winthrop Inc. | 5-Quinolinylpyridinones, cardiotonic compositions and methods |
| US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| DE69211691T2 (de) | 1991-04-19 | 1997-01-16 | Nexstar Pharmaceuticals Inc., Boulder, Col. | Pharmazeutische formulierung und pharmazeutisches verfahren |
| US5262533A (en) | 1991-05-13 | 1993-11-16 | Merck & Co., Inc. | Amino O-aryl macrolides having immunosuppressive activity |
| US5250678A (en) | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
| US5162334A (en) | 1991-05-13 | 1992-11-10 | Merck & Co., Inc. | Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity |
| US5120727A (en) | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Rapamycin dimers |
| US5120725A (en) | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Bicyclic rapamycins |
| IL102236A0 (en) | 1991-06-27 | 1993-01-14 | Ltt Inst Co Ltd | Topical preparations containing cyclosporin |
| US5202332A (en) | 1991-08-07 | 1993-04-13 | American Home Products Corporation | Rapamycin analog as immunosuppressant |
| US5169851A (en) | 1991-08-07 | 1992-12-08 | American Home Products Corporation | Rapamycin analog as immunosuppressants and antifungals |
| US5512575A (en) | 1991-08-15 | 1996-04-30 | Zeneca Limited | Methanoanthraceneyl methyl piperidinyl compounds |
| GB9216297D0 (en) | 1991-08-15 | 1992-09-16 | Ici Plc | Therapeutic agents |
| GB9216298D0 (en) | 1991-08-15 | 1992-09-16 | Ici Plc | Piperidine derivatives |
| US5189042A (en) | 1991-08-22 | 1993-02-23 | Merck & Co. Inc. | Fluoromacrolides having immunosuppressive activity |
| US5208241A (en) | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
| US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| US5770592A (en) | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
| US5278150A (en) | 1992-04-24 | 1994-01-11 | Whitby Research, Inc. | 2-hydrazoadenosines and their utility for the treatmeat of vascular conditions |
| SG45449A1 (en) * | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
| US5284840A (en) | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkylidene macrolides having immunosuppressive activity |
| DK0701443T4 (da) | 1992-08-03 | 2000-12-18 | Sepracor Inc | Terfenadinmetabolitter og deres optisk rene isomerer til behandling af allergiske lidelser |
| GR1002207B (en) | 1992-08-06 | 1996-03-27 | Johnson & Johnson Consumer | Skin care compositions containing imidazoles. |
| US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| US5552155A (en) | 1992-12-04 | 1996-09-03 | The Liposome Company, Inc. | Fusogenic lipsomes and methods for making and using same |
| MY113268A (en) | 1992-12-29 | 2002-01-31 | Insite Vision Incorporated | Plasticized bioerodible controlled delivery system |
| US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
| GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| ATE254594T1 (de) | 1993-06-24 | 2003-12-15 | Albany Molecular Res Inc | Verbindungen verwendbar als zwischenprodukte zur herstellung von piperidinderivate |
| US5965595A (en) | 1993-07-01 | 1999-10-12 | The Procter & Gamble Company | 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists |
| CA2148260A1 (en) | 1993-09-10 | 1995-03-16 | Yasutaka Takase | Quinazoline cpompounds |
| US6323204B1 (en) | 1993-10-13 | 2001-11-27 | Allergan | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| ES2187533T3 (es) | 1993-10-13 | 2003-06-16 | Allergan Inc | Usdo de derivados de (2-imidazolin-2-ilamino)quinoxalina. |
| US6022852A (en) | 1993-10-22 | 2000-02-08 | Hexal Ag | Pharmaceutical composition containing cyclosporin A |
| US5580892A (en) | 1993-10-22 | 1996-12-03 | Allergan | Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents |
| KR100327264B1 (ko) | 1993-10-29 | 2002-07-02 | 요시히로 미와 | 인돌유도체,그의염및이를함유하는심질환치료제 |
| US5574173A (en) | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
| US5464840A (en) | 1993-12-06 | 1995-11-07 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
| CZ175496A3 (en) | 1993-12-17 | 1996-11-13 | Procter & Gamble | 6-(2-imidazolinylamino)quinoxaline compounds usable as alpha-2 adrenoceptor agonists |
| US6117871A (en) | 1993-12-17 | 2000-09-12 | The Procter & Gamble Company | 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists |
| US5578607A (en) | 1993-12-17 | 1996-11-26 | The Procter & Gamble Company | 6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists |
| US5478858A (en) | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
| WO1995016683A1 (en) | 1993-12-17 | 1995-06-22 | The Procter & Gamble Company | 6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists |
| US5576437A (en) | 1993-12-17 | 1996-11-19 | The Procter & Gamble Company | 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists |
| GB9514465D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| GB9401090D0 (en) | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| DK0693055T3 (da) | 1994-02-08 | 1997-12-15 | Alcon Lab Inc | Hidtil ukendt fremgangsmåde til fremstilling af clonidinderivater |
| CH687062A5 (de) | 1994-02-14 | 1996-09-13 | Cerbios Pharma Sa | Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten. |
| US5422116A (en) | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
| US5773021A (en) | 1994-03-14 | 1998-06-30 | Vetoquinol S.A. | Bioadhesive ophthalmic insert |
| US5466233A (en) | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| US5877180A (en) | 1994-07-11 | 1999-03-02 | University Of Virginia Patent Foundation | Method for treating inflammatory diseases with A2a adenosine receptor agonists |
| WO1996004270A1 (en) | 1994-08-04 | 1996-02-15 | Synaptic Pharmaceutical Corporation | Novel benzimidazole derivatives |
| NZ290952A (en) | 1994-08-09 | 1998-05-27 | Eisai Co Ltd | Phthalazine derivatives optionally substituted in position-1 by (generally benzyl) amino groups |
| US5693648A (en) | 1994-09-30 | 1997-12-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity |
| US5545504A (en) | 1994-10-03 | 1996-08-13 | Xerox Corporation | Ink jettable toner compositions and processes for making and using |
| US6294563B1 (en) | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
| US5856480A (en) | 1994-11-11 | 1999-01-05 | Nippon Soda Co., Ltd. | Optically active compound |
| GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| US5725493A (en) | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
| US5693646A (en) | 1994-12-22 | 1997-12-02 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| US5698560A (en) | 1995-03-01 | 1997-12-16 | Kyowa Hakko Kogyo Co., Ltd. | Imidazoquinazoline derivatives |
| DE19518082A1 (de) | 1995-05-17 | 1996-11-21 | Merck Patent Gmbh | 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one |
| US6369116B1 (en) * | 1995-06-02 | 2002-04-09 | Oculex Pharmaceuticals, Inc. | Composition and method for treating glaucoma |
| AU5938996A (en) | 1995-06-07 | 1996-12-30 | Nexstar Pharmaceuticals, Inc. | Method for encapsulating pharmaceutical materials |
| US5914342A (en) | 1995-06-07 | 1999-06-22 | The Procter & Gamble Company | 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists |
| US6194415B1 (en) | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US5856329A (en) | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| US5916900A (en) | 1995-06-29 | 1999-06-29 | The Procter & Gamble Company | 7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists |
| US5804587A (en) | 1995-06-29 | 1998-09-08 | The Procter & Gamble Company | 6-(2-imidazolinylamino) quinolines useful as alpha-2 adrenoceptor agonists |
| GB9514464D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Medicaments |
| US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| DE19537012A1 (de) | 1995-10-04 | 1997-04-10 | Dietl Hans | Cyclosporin(e) enhaltende pharmazeutische Zubereitung zur oralen Applikation und Verfahren zu ihrer Herstellung |
| US6153754A (en) | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US6201124B1 (en) | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| CZ358598A3 (cs) | 1996-05-10 | 1999-03-17 | Icos Corporation | Karbolinové deriváty |
| US5709797A (en) | 1996-06-05 | 1998-01-20 | Poli Industria Chimica S.P.A. | Method of isolating cyclosporins |
| US5789416B1 (en) | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
| ES2194217T3 (es) | 1996-10-04 | 2003-11-16 | Novo Nordisk As | Spperazinas 1,4-disustituidas. |
| DE19644228A1 (de) | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| US6306877B1 (en) | 1999-08-09 | 2001-10-23 | The Procter & Gamble Co. | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists |
| HUP9904215A3 (en) | 1996-11-25 | 2002-01-28 | Procter & Gamble | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists |
| CA2272640C (en) | 1996-11-25 | 2003-07-08 | The Procter & Gamble Company | Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists |
| SK74999A3 (en) | 1996-11-25 | 2000-02-14 | Procter & Gamble | 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists |
| US6172095B1 (en) | 1996-11-25 | 2001-01-09 | The Procter & Gamble Company | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists |
| US5888493A (en) | 1996-12-05 | 1999-03-30 | Sawaya; Assad S. | Ophthalmic aqueous gel formulation and related methods |
| US5837713A (en) * | 1997-02-26 | 1998-11-17 | Mayo Foundation For Medical Education And Research | Treatment of eosinophil-associated pathologies by administration of topical anesthetics and glucocorticoids |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| CZ299633B6 (cs) | 1997-04-25 | 2008-09-24 | Pfizer Inc. | Pyrazolopyrimidinony, meziprodukty pro jejich výrobu a farmaceutické a veterinární kompozice na jejich bázi |
| US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| DE69840586D1 (de) | 1997-10-08 | 2009-04-02 | Isotechnika Inc | Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien |
| AU740758B2 (en) | 1997-10-28 | 2001-11-15 | Vivus, Inc. | Treatment of female sexual dysfunction |
| US6156753A (en) | 1997-10-28 | 2000-12-05 | Vivus, Inc. | Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| PL340711A1 (en) | 1997-11-24 | 2001-02-26 | Procter & Gamble | Derivatives of 5-(2-imidazolinamino)-benzimidazole, their production and application of them as antagonists of alpha-adrenergic receptors of improved metabolic stability |
| US6066740A (en) | 1997-11-25 | 2000-05-23 | The Procter & Gamble Company | Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives |
| CA2314993A1 (en) | 1997-12-16 | 1999-06-24 | Pfizer Products Inc. | Combination effective for the treatment of impotence |
| AR014195A1 (es) | 1997-12-29 | 2001-02-07 | Ortho Mcneil Pharm Inc | Compuestos de trifenilpropanamida utiles para el tratamiento de procesos inflamatorios, composiciones anti-inflamatorias que los comprenden, ymetodos para prepararlos |
| US5981607A (en) * | 1998-01-20 | 1999-11-09 | Allergan | Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers |
| US6380207B2 (en) | 1998-02-13 | 2002-04-30 | Abbott Laboratories | Glucocortiocoid-selective antiinflammatory agents |
| US6506766B1 (en) | 1998-02-13 | 2003-01-14 | Abbott Laboratories | Glucocortiocoid-selective antinflammatory agents |
| EP1056454B1 (en) | 1998-02-23 | 2003-05-02 | Fujisawa Pharmaceutical Co., Ltd. | Use of macrolide compounds for treating glaucoma |
| TR200003130T2 (tr) | 1998-04-28 | 2001-01-22 | Arzneimittelwerk Dresden Gmbh | Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler |
| US6235781B1 (en) | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
| US20040152664A1 (en) * | 1998-09-02 | 2004-08-05 | Allergan, Inc. | Prednisolone compositions |
| WO2004073708A1 (en) | 1998-12-17 | 2004-09-02 | Dean Thomas R | Brinzolamide and brimonidine for treating ocular conditions |
| US6869950B1 (en) | 1998-12-24 | 2005-03-22 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
| US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| US20010053780A1 (en) | 1999-04-30 | 2001-12-20 | Whitaker John S. | Daily treatment for erectile dysfunction using a PDE5 inhibitor |
| US6943166B1 (en) | 1999-04-30 | 2005-09-13 | Lilly Icos Llc. | Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction |
| HUP0201243A3 (en) | 1999-04-30 | 2002-11-28 | Pfizer Prod Inc | Glucocorticoid receptor modulators, pharmaceutical compositions containing them and their use |
| SI1176960T1 (en) | 1999-05-04 | 2005-04-30 | Altana Pharma Ag | Synergistic combination comprising roflumilast and a pde-3 inhibitor |
| WO2000068230A1 (en) | 1999-05-05 | 2000-11-16 | Darwin Discovery Limited | 9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7 inhibitors |
| IT1313583B1 (it) | 1999-07-30 | 2002-09-09 | Chiesi Farma Spa | Derivati 2-amminotetralinici per la terapia del glaucoma. |
| US6593480B2 (en) | 1999-09-01 | 2003-07-15 | Abbott Laboratories | Glucocorticoid receptor antagonists for treatment of diabetes |
| US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| US7323496B2 (en) | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| WO2001034632A2 (en) | 1999-11-12 | 2001-05-17 | Merck & Co., Inc. | Aliphatic hydroxy substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents |
| DE60026350T2 (de) | 1999-11-12 | 2006-11-09 | Merck & Co., Inc. | Diaryl piperidyl-pyrrol-derivate als antiprotozoenmittel |
| TWI227143B (en) | 1999-12-15 | 2005-02-01 | Guo-Jiun Sung | In situ gel formation for ophthalmic delivery by combining Pluronic/Carbopol medic composition and its preparing method |
| US6372777B1 (en) | 1999-12-23 | 2002-04-16 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US6258833B1 (en) | 1999-12-23 | 2001-07-10 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| WO2001057025A1 (en) | 2000-01-31 | 2001-08-09 | Pfizer Products Inc. | Pyrimidine carboxamides useful as inhibitors of pde4 isozymes |
| US6555572B2 (en) | 2000-03-16 | 2003-04-29 | Inflazyme Pharmaceuticals Ltd. | Benzylated PDE4 inhibitors |
| GB0008694D0 (en) | 2000-04-07 | 2000-05-31 | Novartis Ag | Organic compounds |
| US6919337B2 (en) | 2000-04-07 | 2005-07-19 | Novartis, Ag | 8-Quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors |
| ES2206363T3 (es) * | 2000-04-07 | 2004-05-16 | Laboratoire Medidom S.A. | Formulaciones oftalmicas a base de ciclosporina, de acido hialuronico y de polisorbato. |
| US7019136B2 (en) | 2000-04-07 | 2006-03-28 | Novartis, Ag | 8-quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors |
| PL358057A1 (en) | 2000-06-05 | 2004-08-09 | Altana Pharma Ag | Compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors |
| EP1301210A2 (en) | 2000-07-14 | 2003-04-16 | Allergan, Inc. | Compositions containing therapeutically active components having enhanced solubility |
| CA2402405C (en) | 2000-07-14 | 2008-02-12 | Allergan Sales, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| KR100586765B1 (ko) | 2000-08-11 | 2006-06-08 | 오노 야꾸힝 고교 가부시키가이샤 | 피페리딘 유도체 및 그 유도체를 유효 성분으로 하는 약제 |
| AU2001271417B2 (en) | 2000-08-30 | 2006-10-05 | Johns Hopkins University | Devices for intraocular drug delivery |
| US6579519B2 (en) | 2000-09-18 | 2003-06-17 | Registrar, University Of Delhi | Sustained release and long residing ophthalmic formulation and the process of preparing the same |
| CA2423449A1 (en) | 2000-09-26 | 2002-04-04 | The Brigham And Women's Hospital, Inc. | Tricyclic antidepressants and their analogues as long-acting local anesthetics and analgesics |
| TWI262920B (en) | 2000-10-27 | 2006-10-01 | Elbion Ag | New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them |
| IL146057A (en) | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
| ES2262612T3 (es) | 2000-10-28 | 2006-12-01 | Pfizer Products Inc. | Moduladpres del receptor de glucocorticoides. |
| ES2271080T3 (es) | 2000-11-06 | 2007-04-16 | Lilly Icos Llc | Derivados de indol como inhibidores de pde5. |
| MXPA03004023A (es) | 2000-11-08 | 2004-02-12 | Lilly Icos Llc | Compuestos quimicos. |
| PL362980A1 (en) | 2000-11-17 | 2004-11-02 | Warner-Lambert Company Llc | Treatment of sexual dysfunction |
| CA2436551A1 (en) | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes |
| PL364135A1 (en) | 2001-01-31 | 2004-12-13 | Pfizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| WO2002060896A1 (en) | 2001-01-31 | 2002-08-08 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
| US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| US6583180B2 (en) | 2001-02-14 | 2003-06-24 | Abbott Laboratories | Glucocorticoid receptor modulators |
| EA200300836A1 (ru) | 2001-02-15 | 2004-02-26 | Алтана Фарма Аг | Производные фталазинон-пиперидина в качестве ингибиторов pde4 |
| US6617357B2 (en) | 2001-03-06 | 2003-09-09 | Smithkline Beecham Corporation | Compounds and their use as PDE inhibitors |
| US6713081B2 (en) | 2001-03-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Ocular therapeutic agent delivery devices and methods for making and using such devices |
| WO2002076953A1 (en) | 2001-03-21 | 2002-10-03 | Warner-Lambert Company Llc | New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors |
| US6958328B2 (en) | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
| CN1520313A (zh) | 2001-05-23 | 2004-08-11 | ������ҩ��ʽ���� | 一种加速骨折愈合的组合物 |
| ES2427930T3 (es) | 2001-05-23 | 2013-11-04 | Mitsubishi Tanabe Pharma Corporation | Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos |
| US6992192B2 (en) | 2001-06-05 | 2006-01-31 | Lilly Icos Llc. | Carboline derivatives as PDE5 inhibitors |
| WO2002102778A1 (en) | 2001-06-15 | 2002-12-27 | Yamanouchi Pharmaceutical Co., Ltd. | Phenylpyridine carbonyl piperazine derivative |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| HUP0402352A2 (hu) | 2001-06-19 | 2005-02-28 | Bristol-Myers Squibb Co. | Foszfodiészteráz (PDE) 7 inhibitorként alkalmazható pirimidinszármazékok és ezeket tartalmazó gyógyszerkészítmények |
| GB0115181D0 (en) * | 2001-06-20 | 2001-08-15 | Glaxo Group Ltd | Novel use |
| ATE335742T1 (de) | 2001-06-21 | 2006-09-15 | Lilly Icos Llc | Carbolinderivate als pdev inhibitoren |
| ES2242036T3 (es) | 2001-06-27 | 2005-11-01 | MERCK FROSST CANADA & CO. | Inhibidores pde4 de arilquinolina 8-sustituida. |
| US6872705B2 (en) * | 2001-07-13 | 2005-03-29 | Allergan, Inc. | Use of antimicrobial peptides as preservatives in ophthalmic preparations, including solutions, emulsions, and suspensions |
| DE60237696D1 (de) | 2001-08-01 | 2010-10-28 | Univ Utah | Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a |
| DE10141212A1 (de) | 2001-08-22 | 2003-03-06 | Bayer Ag | Neue 4-Aminofuropyrimidine und ihre Verwendung |
| US20030176316A1 (en) | 2001-08-24 | 2003-09-18 | Whitehead Clark M. | Methods for treatment of rheumatoid arthritis |
| US6582422B2 (en) | 2001-10-03 | 2003-06-24 | Bausch & Lomb Incorporated | Ophthalmic delivery device |
| US6809077B2 (en) | 2001-10-12 | 2004-10-26 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogs for the treatment of autoimmune diseases |
| EP1304321A3 (en) | 2001-10-17 | 2003-07-30 | Samsung Electronics Co., Ltd. | Process for preparing 3-Hydroxyesters from epoxide derivatives |
| EP1463509A1 (en) * | 2001-10-31 | 2004-10-06 | MERCK PATENT GmbH | Type 4 phosphodiesterase inhibitors and uses thereof |
| FR2832711B1 (fr) | 2001-11-26 | 2004-01-30 | Warner Lambert Co | Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation |
| EP1467730A4 (en) | 2002-01-22 | 2010-03-10 | Univ California | Non-steroid ligands for the glucocorticoid receptor, compositions and uses thereof |
| MXPA04007713A (es) | 2002-02-07 | 2004-11-10 | Pfizer | Uso de inhibidores de la fosfodiesterasa tipo 5, tal como sildenafil, en el tratamiento del sindrome de ovario poliquistico. |
| OA12768A (en) | 2002-02-11 | 2006-07-04 | Pfizer | Nicotinamide derivatives useful as PDE4 inhibitors. |
| CA2477044A1 (en) | 2002-02-22 | 2003-09-04 | Pharmacia Corporation | Ophthalmic formulation with gum system |
| TWI347845B (en) | 2002-03-06 | 2011-09-01 | Nycomed Gmbh | Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| EP1348701A1 (en) | 2002-03-28 | 2003-10-01 | Warner-Lambert Company LLC | (2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors |
| EP1348433A1 (en) | 2002-03-28 | 2003-10-01 | Warner-Lambert Company LLC | Thiazol-2-yl-imine compounds as PDE-7 inhibitors |
| US7084157B2 (en) * | 2002-05-17 | 2006-08-01 | Rajeev Raut | Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation |
| JP2005533829A (ja) | 2002-07-10 | 2005-11-10 | アラクノーバ・セラピューティックス・リミテッド | 機能性腸疾患の処置における4−(2−フルオロフェニル)−6−メチル−2−(1−ピペラジニル)チエノ[2,3−d]ピリミジン |
| JP4254263B2 (ja) * | 2002-08-22 | 2009-04-15 | 日産自動車株式会社 | ガス流量測定装置及びガス流量測定方法 |
| AU2003288901A1 (en) | 2002-09-06 | 2004-03-29 | Merck And Co., Inc. | Treatment of rheumatoid arthritis by inhibition of pde4 |
| KR20050043923A (ko) | 2002-09-16 | 2005-05-11 | 알콘 매뉴팩츄어링, 리미티드 | 혈관신생 치료를 위한 pde-ⅳ 저해제의 용도 |
| CA2506442A1 (en) | 2002-11-18 | 2004-07-01 | Celgene Corporation | Methods of using and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
| US6909002B2 (en) | 2002-11-22 | 2005-06-21 | Merck & Co., Inc. | Method of preparing inhibitors of phosphodiesterase-4 |
| US20040151754A1 (en) * | 2002-12-20 | 2004-08-05 | Control Delivery Systems, Inc. | Steroid suspensions for intraocular use |
| US20060083754A1 (en) | 2003-02-10 | 2006-04-20 | Anthony Winiski | Pharmaceutical combinations comprising corticoids and immunosuppressants for treating corticoid- and/or calcineurin inhibitors-resistant diseases |
| CA2518409A1 (en) | 2003-03-12 | 2004-09-23 | John P. Mullally | Composition and method for treating inflammations by reducing c-reactive protein |
| US20040186046A1 (en) | 2003-03-17 | 2004-09-23 | Pfizer Inc | Treatment of type 1 diabetes with PDE5 inhibitors |
| EP1613747A1 (en) | 2003-03-31 | 2006-01-11 | Pfizer Products Inc. | Crystal structure of 3 ,5 -cyclic nucleotide phosphodiesterase 1b (pde1b) and uses thereof |
| BRPI0409229A (pt) | 2003-04-01 | 2006-03-28 | Applied Research Systems | inibidores das fosfodiesterases na infertilidade |
| CN1809559B (zh) | 2003-04-18 | 2010-06-02 | 记忆药物公司 | 作为磷酸二酯酶4抑制剂的吡唑衍生物 |
| DE10318611A1 (de) | 2003-04-24 | 2004-11-11 | Elbion Ag | 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
| DE10318610A1 (de) | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-Azaindole und deren Verwendung als Therapeutika |
| EP1477166B1 (de) | 2003-04-28 | 2006-08-23 | Biofrontera Bioscience GmbH | Verwendung von Riluzole kombiniert mit geeigneten Hilfs-und Zusatzstoffen zur Behandlung von Krankheiten, die durch eine Hyperproliferation von Keratinozyten gekennzeichnet sind, insbesondere Neurodermitis und Psoriasis |
| US20040242673A1 (en) | 2003-05-16 | 2004-12-02 | Ambit Biosciences Corporation | Heterocyclic compounds and uses thereof |
| US20050042177A1 (en) | 2003-07-23 | 2005-02-24 | Elan Pharma International Ltd. | Novel compositions of sildenafil free base |
| TW200522932A (en) | 2003-09-15 | 2005-07-16 | Combinatorx Inc | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| US20050112199A1 (en) * | 2003-09-24 | 2005-05-26 | Mahesh Padval | Therapeutic regimens for administering drug combinations |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| MY141255A (en) | 2003-12-11 | 2010-03-31 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
| CA2557216A1 (en) | 2004-02-26 | 2005-09-09 | Advanced Ocular Systems Limited | Heparin for the treatment of ocular pathologies |
| JP2007530563A (ja) | 2004-03-22 | 2007-11-01 | ミオゲン インコーポレイティッド | (s)−エノキシモンスルホキシドおよびpde−iii媒介疾患の治療におけるその使用 |
| WO2005092333A1 (en) | 2004-03-22 | 2005-10-06 | Myogen, Inc. | (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
| EA010834B1 (ru) | 2004-03-29 | 2008-12-30 | Инотек Фармасьютикалз Корпорейшн | Пиридилзамещённые порфириновые соединения и способы их применения |
| US20050234018A1 (en) | 2004-04-15 | 2005-10-20 | Allergan, Inc. | Drug delivery to the back of the eye |
| WO2005107463A1 (en) | 2004-05-03 | 2005-11-17 | University Of Virginia Patent Foundation | Agonists of a2a adenosine receptors for treatment of diabetic nephropathy |
| US20050277584A1 (en) | 2004-06-09 | 2005-12-15 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| DE602004022523D1 (de) * | 2004-07-02 | 2009-09-24 | Novagali Pharma Sa | Verwendung von Emulsionen zur intra- und periocularen Injection |
| ATE415400T1 (de) | 2004-07-05 | 2008-12-15 | Astellas Pharma Inc | Pyrazolopyridinderivate |
| AU2005303893A1 (en) | 2004-11-11 | 2006-05-18 | Argenta Discovery Ltd | Pyrimidine compounds as histamine modulators |
| US20060122152A1 (en) | 2004-12-03 | 2006-06-08 | Peyman Gholam A | Heparin for the treatment of ocular pathologies |
| WO2006073786A2 (en) * | 2004-12-30 | 2006-07-13 | Bausch & Lomb Incorporated | Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy |
| TWI435729B (zh) | 2005-11-09 | 2014-05-01 | Combinatorx Inc | 治療病症之方法,組合物及套組 |
| WO2011079778A1 (en) | 2009-12-30 | 2011-07-07 | China Shanghai Fochon Pharmaceutical Co Ltd | 3-(3-aminopiperidin-1-yl)-5-oxo-1,2,4-triazine derivates as dipeptidyl peptidase iv(dpp-iv) inhibitors |
-
2006
- 2006-11-08 TW TW095141282A patent/TWI435729B/zh not_active IP Right Cessation
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- 2006-11-08 MX MX2008006076A patent/MX2008006076A/es active IP Right Grant
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- 2006-11-08 EP EP10001901A patent/EP2218442A1/en not_active Ceased
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- 2006-11-08 CA CA002628570A patent/CA2628570A1/en not_active Abandoned
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- 2006-11-08 US US11/594,436 patent/US20070225217A1/en not_active Abandoned
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- 2008-05-06 IL IL191283A patent/IL191283A/en not_active IP Right Cessation
- 2008-05-29 NO NO20082473A patent/NO20082473L/no not_active Application Discontinuation
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- 2009-05-25 ZA ZA2009/03604A patent/ZA200903604B/en unknown
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- 2011-11-28 US US13/305,391 patent/US8258153B2/en not_active Expired - Fee Related
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- 2012-02-24 ZA ZA2012/01391A patent/ZA201201391B/en unknown
- 2012-08-29 US US13/597,996 patent/US20120322746A1/en not_active Abandoned
-
2013
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2014
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|---|---|
| WO2007056457A3 (en) | 2007-09-13 |
| AU2006311577A1 (en) | 2007-05-18 |
| JP5490292B2 (ja) | 2014-05-14 |
| US20120322746A1 (en) | 2012-12-20 |
| ZA200903604B (en) | 2012-06-27 |
| EP2218442A1 (en) | 2010-08-18 |
| WO2007056457A2 (en) | 2007-05-18 |
| ZA201201391B (en) | 2014-07-30 |
| JP2009514969A (ja) | 2009-04-09 |
| KR20080065704A (ko) | 2008-07-14 |
| US20070105761A1 (en) | 2007-05-10 |
| EP1956906A2 (en) | 2008-08-20 |
| HK1128593A1 (en) | 2009-11-06 |
| IL191283A (en) | 2015-03-31 |
| NZ568694A (en) | 2011-09-30 |
| US8067433B2 (en) | 2011-11-29 |
| US20120077756A1 (en) | 2012-03-29 |
| US20070225217A1 (en) | 2007-09-27 |
| JP2013231047A (ja) | 2013-11-14 |
| AR058182A1 (es) | 2008-01-23 |
| ZA200804550B (en) | 2009-08-26 |
| EP1956906A4 (en) | 2009-12-30 |
| BRPI0618643A2 (pt) | 2011-09-06 |
| IL233634A0 (en) | 2014-08-31 |
| US8258153B2 (en) | 2012-09-04 |
| RU2008122978A (ru) | 2009-12-20 |
| TWI435729B (zh) | 2014-05-01 |
| TW200803887A (en) | 2008-01-16 |
| CA2628570A1 (en) | 2007-05-18 |
| NO20082473L (no) | 2008-08-06 |
| MX2008006076A (es) | 2008-12-16 |
| CN101355876A (zh) | 2009-01-28 |
| AU2006311577B2 (en) | 2013-02-07 |
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