|
TWI372624B
(en)
*
|
2004-03-30 |
2012-09-21 |
Vertex Pharma |
Azaindoles useful as inhibitors of jak and other protein kinases
|
|
WO2006127587A1
(en)
*
|
2005-05-20 |
2006-11-30 |
Vertex Pharmaceuticals Incorporated |
Pyrrolopyridines useful as inhibitors of protein kinase
|
|
EP2270014A1
(en)
|
2005-09-22 |
2011-01-05 |
Incyte Corporation |
Azepine inhibitors of janus kinases
|
|
EP2455382B1
(en)
|
2005-12-13 |
2016-10-26 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
|
TW200801008A
(en)
*
|
2005-12-29 |
2008-01-01 |
Abbott Lab |
Protein kinase inhibitors
|
|
CN102532133A
(zh)
|
2006-01-17 |
2012-07-04 |
沃泰克斯药物股份有限公司 |
适用作詹纳斯激酶抑制剂的吖吲哚类
|
|
JP2009532475A
(ja)
*
|
2006-04-05 |
2009-09-10 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ヤヌスキナーゼの阻害剤として有用なデアザプリン
|
|
MX2009002046A
(es)
|
2006-08-24 |
2009-03-06 |
Astrazeneca Ab |
Derivados de morfolino pirimidina utiles en el tratamiento de trastornos proliferativos.
|
|
AU2007338754A1
(en)
|
2006-12-21 |
2008-07-03 |
Vertex Pharmaceuticals Incorporated |
5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
|
|
EP2121692B1
(en)
|
2006-12-22 |
2013-04-10 |
Incyte Corporation |
Substituted heterocycles as janus kinase inhibitors
|
|
CN101778825A
(zh)
*
|
2007-03-22 |
2010-07-14 |
沃泰克斯药物股份有限公司 |
适用作詹纳斯激酶抑制剂的n-杂环类化合物
|
|
EP3070090B1
(en)
|
2007-06-13 |
2018-12-12 |
Incyte Holdings Corporation |
Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
CN101809002B
(zh)
|
2007-07-09 |
2013-03-27 |
阿斯利康(瑞典)有限公司 |
用于与mtor激酶和/或pi3k相关的疾病中的吗啉代嘧啶衍生物
|
|
NZ586662A
(en)
*
|
2007-12-19 |
2012-08-31 |
Vertex Pharma |
PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JANUS KINASE 2 INHIBITORS
|
|
DE102008005493A1
(de)
*
|
2008-01-22 |
2009-07-23 |
Merck Patent Gmbh |
4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate
|
|
US8158616B2
(en)
|
2008-03-11 |
2012-04-17 |
Incyte Corporation |
Azetidine and cyclobutane derivatives as JAK inhibitors
|
|
EP2276750A2
(en)
*
|
2008-03-27 |
2011-01-26 |
Auckland Uniservices Limited |
Substituted pyrimidines and triazines and their use in cancer therapy
|
|
CN102149695B
(zh)
*
|
2008-07-09 |
2015-02-04 |
日产化学工业株式会社 |
异*唑啉取代的苯甲酰胺化合物的制造方法
|
|
GB2465405A
(en)
*
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
JP5775070B2
(ja)
|
2009-05-22 |
2015-09-09 |
インサイト・コーポレイションIncyte Corporation |
ヤヌスキナーゼ阻害剤としてのピラゾール−4−イル−ピロロ[2,3−d]ピリミジンおよびピロール−3−イル−ピロロ[2,3−d]ピリミジンのN−(ヘテロ)アリール−ピロリジン誘導体
|
|
SG176111A1
(en)
|
2009-05-22 |
2011-12-29 |
Incyte Corp |
3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
|
|
RS57869B1
(sr)
|
2009-06-17 |
2018-12-31 |
Vertex Pharma |
Inhibitori replikacije virusa gripa
|
|
US20120219596A1
(en)
|
2009-07-30 |
2012-08-30 |
Wendelin Stark |
Injectable formulation for treatment and protection of patients having an inflammatory reaction or an ischemia-reperfusion event
|
|
AR078012A1
(es)
|
2009-09-01 |
2011-10-05 |
Incyte Corp |
Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
|
|
KR101921850B1
(ko)
|
2009-10-09 |
2018-11-23 |
인사이트 홀딩스 코포레이션 |
3-(4-(7H-피롤로〔2,3-d〕피리미딘-4-일)-1H-피라졸-1-일)-3-사이클로펜틸프로판니트릴의 하이드록실, 케토 및 글루쿠로나이드 유도체
|
|
CA2776028C
(en)
*
|
2009-10-15 |
2015-12-01 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidine compounds
|
|
UA109775C2
(xx)
*
|
2009-10-29 |
2015-10-12 |
|
N-вмісні гетероарильні похідні як інгібітори jak3-кінази
|
|
ES2461967T3
(es)
*
|
2009-12-18 |
2014-05-21 |
Pfizer Inc. |
Compuestos de pirrolo[2,3-d]pirimidina
|
|
JP2013518112A
(ja)
*
|
2010-01-27 |
2013-05-20 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ピラゾロピリジンキナーゼ阻害剤
|
|
EP2528917B1
(en)
*
|
2010-01-27 |
2016-10-19 |
Vertex Pharmaceuticals Incorporated |
Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
|
|
PT3354652T
(pt)
|
2010-03-10 |
2020-07-20 |
Incyte Holdings Corp |
Derivados de piperidin-4-ilazetidina como inibidores de jak1
|
|
RS54824B1
(sr)
|
2010-05-21 |
2016-10-31 |
Incyte Holdings Corp |
Topikalna formulacija za inhibiciju jak-a
|
|
SA111320519B1
(ar)
|
2010-06-11 |
2014-07-02 |
Astrazeneca Ab |
مركبات بيريميدينيل للاستخدام كمثبطات atr
|
|
CA2818542A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
WO2012068440A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
AU2011343642A1
(en)
|
2010-12-16 |
2013-05-02 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
MX2013006840A
(es)
*
|
2010-12-16 |
2014-01-31 |
Vertex Pharma |
Inhibidores de la replicacion de los virus de la influenza.
|
|
CA2827673C
(en)
|
2011-02-18 |
2020-10-27 |
Novartis Pharma Ag |
Mtor/jak inhibitor combination therapy
|
|
MY165963A
(en)
|
2011-06-20 |
2018-05-18 |
Incyte Holdings Corp |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
|
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
EP2741747A1
(en)
|
2011-08-10 |
2014-06-18 |
Novartis Pharma AG |
JAK P13K/mTOR COMBINATION THERAPY
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
EP2788000B1
(en)
*
|
2011-12-06 |
2018-05-30 |
Merck Sharp & Dohme Corp. |
Pyrrolopyrimidines as janus kinase inhibitors
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
WO2014013014A1
(en)
|
2012-07-18 |
2014-01-23 |
Fundació Privada Centre De Regulació Genòmica (Crg) |
Jak inhibitors for activation of epidermal stem cell populations
|
|
CN113384546A
(zh)
|
2012-11-15 |
2021-09-14 |
因赛特公司 |
鲁索利替尼的缓释剂型
|
|
WO2014138168A1
(en)
|
2013-03-06 |
2014-09-12 |
Incyte Corporation |
Processes and intermediates for making a jak inhibitor
|
|
WO2014145576A2
(en)
|
2013-03-15 |
2014-09-18 |
Northwestern University |
Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer
|
|
SG10201801069QA
(en)
|
2013-08-07 |
2018-03-28 |
Incyte Corp |
Sustained release dosage forms for a jak1 inhibitor
|
|
HRP20181272T1
(hr)
|
2013-11-13 |
2018-10-05 |
Vertex Pharmaceuticals Incorporated |
Postupci priprave inhibitora replikacije virusa influence
|
|
RS59144B1
(sr)
|
2013-11-13 |
2019-09-30 |
Vertex Pharma |
Inhibitori replikacije virusa influence
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
AR101196A1
(es)
|
2014-07-16 |
2016-11-30 |
Gruenenthal Gmbh |
Compuestos de pirimidina sustituidos
|
|
AR101197A1
(es)
*
|
2014-07-16 |
2016-11-30 |
Gruenenthal Gmbh |
Pirimidinas 2,5-sustituidas
|
|
AR101198A1
(es)
|
2014-07-16 |
2016-11-30 |
Gruenenthal Gmbh |
Pirimidinas 2,5-sustituidas como inhibidores de pde4b
|
|
TWI679205B
(zh)
|
2014-09-02 |
2019-12-11 |
日商日本新藥股份有限公司 |
吡唑并噻唑化合物及醫藥
|
|
HUE053595T2
(hu)
*
|
2014-09-08 |
2021-07-28 |
Janssen Sciences Ireland Unlimited Co |
Pirrolopirimidinek influenzavírus-fertõzésnél történõ alkalmazásra
|
|
JP6704416B2
(ja)
|
2015-05-13 |
2020-06-03 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
インフルエンザウイルスの複製の阻害剤を調製する方法
|
|
JP6857617B2
(ja)
|
2015-05-13 |
2021-04-14 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
インフルエンザウイルスの複製の阻害剤
|
|
KR20180087290A
(ko)
|
2015-11-27 |
2018-08-01 |
얀센 사이언시즈 아일랜드 유씨 |
인플루엔자 바이러스 감염에서 사용하기 위한 복소환식 인돌
|
|
WO2017125506A1
(en)
|
2016-01-20 |
2017-07-27 |
Janssen Sciences Ireland Uc |
Aryl substituted pyrimidines for use in influenza virus infection
|
|
WO2017133669A1
(en)
*
|
2016-02-05 |
2017-08-10 |
Savira Pharmaceuticals Gmbh |
5, 7-diazaindole and 5, 7-diazaindazole derivatives and their use in the treatment, amelioration or prevention of influenza
|
|
TWI712604B
(zh)
|
2016-03-01 |
2020-12-11 |
日商日本新藥股份有限公司 |
具jak抑制作用之化合物之結晶
|
|
CN109311882B
(zh)
*
|
2016-05-04 |
2022-02-11 |
Bci制药公司 |
作为蛋白激酶抑制剂的腺嘌呤衍生物
|
|
JP6978097B2
(ja)
*
|
2016-07-26 |
2021-12-08 |
スーヂョウ ロングバイオテック ファーマシューティカルズ カンパニー リミテッドSuzhou Longbiotech Pharmaceuticals Co., Ltd. |
Jak阻害剤としての複素環化合物、該化合物の塩類および治療への使用
|
|
WO2018041989A1
(en)
|
2016-09-02 |
2018-03-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for diagnosing and treating refractory celiac disease type 2
|
|
EA039344B1
(ru)
*
|
2017-01-19 |
2022-01-17 |
Сучжоу Лонгбайотек Фармасьютикалз Ко., Лтд. |
Гетероциклическое соединение в качестве ингибитора jak и его соли и терапевтическое применение
|
|
US10927118B2
(en)
*
|
2017-03-02 |
2021-02-23 |
Sunshine Lake Pharma Co., Ltd. |
Inhibitors of influenza virus replication and uses thereof
|
|
AR113922A1
(es)
|
2017-12-08 |
2020-07-01 |
Incyte Corp |
Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
|
|
EA202091830A1
(ru)
|
2018-01-30 |
2020-12-29 |
Инсайт Корпорейшн |
Способы и промежуточные соединения для получения ингибитора jak
|
|
MD3773593T2
(ro)
|
2018-03-30 |
2024-10-31 |
Incyte Corp |
Tratament hidradenitei supurative utilizând inhibitori ai JAK
|
|
CN109293640B
(zh)
*
|
2018-10-31 |
2020-05-19 |
青岛清原化合物有限公司 |
一种取代的含氮杂芳环甲酰胺衍生物及其除草组合物和用途
|
|
JP2022527972A
(ja)
|
2019-04-02 |
2022-06-07 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
前悪性病変を有する患者において癌を予測及び予防する方法
|
|
US20220202820A1
(en)
|
2019-04-16 |
2022-06-30 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels
|
|
JP7617030B2
(ja)
|
2019-05-08 |
2025-01-17 |
ビマラン バイオサイエンシーズ,インク. |
Jak阻害剤
|
|
KR20220051351A
(ko)
|
2019-08-08 |
2022-04-26 |
비말란 바이오사이언스즈, 인크. |
Jak 억제제
|
|
BR112022005608A2
(pt)
*
|
2019-09-25 |
2022-09-06 |
Vimalan Biosciences Inc |
Inibidores de jak
|
|
CN114761013A
(zh)
|
2019-09-27 |
2022-07-15 |
迪斯克医药公司 |
治疗骨髓纤维化和相关病症的方法
|
|
WO2021231798A1
(en)
|
2020-05-13 |
2021-11-18 |
Disc Medicine, Inc. |
Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
EP4526469A1
(en)
|
2022-05-16 |
2025-03-26 |
Institut National de la Santé et de la Recherche Médicale |
Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation
|