JP2018150302A5 - - Google Patents
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- Publication number
- JP2018150302A5 JP2018150302A5 JP2018072831A JP2018072831A JP2018150302A5 JP 2018150302 A5 JP2018150302 A5 JP 2018150302A5 JP 2018072831 A JP2018072831 A JP 2018072831A JP 2018072831 A JP2018072831 A JP 2018072831A JP 2018150302 A5 JP2018150302 A5 JP 2018150302A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- ring
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261713314P | 2012-10-12 | 2012-10-12 | |
| US61/713,314 | 2012-10-12 | ||
| US201361779394P | 2013-03-13 | 2013-03-13 | |
| US61/779,394 | 2013-03-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536972A Division JP6321662B2 (ja) | 2012-10-12 | 2013-10-11 | Ｇｓｋ３阻害剤およびその使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018150302A JP2018150302A (ja) | 2018-09-27 |
| JP2018150302A5 true JP2018150302A5 (https=) | 2019-01-10 |
| JP6606691B2 JP6606691B2 (ja) | 2019-11-20 |
Family
ID=49474737
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536972A Active JP6321662B2 (ja) | 2012-10-12 | 2013-10-11 | Ｇｓｋ３阻害剤およびその使用の方法 |
| JP2018072831A Active JP6606691B2 (ja) | 2012-10-12 | 2018-04-05 | Ｇｓｋ３阻害剤およびその使用の方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536972A Active JP6321662B2 (ja) | 2012-10-12 | 2013-10-11 | Ｇｓｋ３阻害剤およびその使用の方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9096594B2 (https=) |
| EP (1) | EP2909204B1 (https=) |
| JP (2) | JP6321662B2 (https=) |
| CA (1) | CA2887701C (https=) |
| CY (1) | CY1122601T1 (https=) |
| DK (1) | DK2909204T3 (https=) |
| ES (1) | ES2719776T3 (https=) |
| HR (1) | HRP20190406T1 (https=) |
| HU (1) | HUE043853T2 (https=) |
| LT (1) | LT2909204T (https=) |
| PL (1) | PL2909204T3 (https=) |
| PT (1) | PT2909204T (https=) |
| RS (1) | RS58700B1 (https=) |
| SI (1) | SI2909204T1 (https=) |
| SM (1) | SMT201900136T1 (https=) |
| WO (1) | WO2014059383A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6321662B2 (ja) | 2012-10-12 | 2018-05-09 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | Ｇｓｋ３阻害剤およびその使用の方法 |
| LT2970890T (lt) | 2013-03-14 | 2020-07-10 | The Brigham And Women`S Hospital, Inc. | Kompozicijos ir būdai, skirti epitelinių kamieninių ląstelių padauginimui ir kultivavimui |
| EP3166637B1 (en) | 2014-07-10 | 2020-01-29 | The J. David Gladstone Institutes | Compositions and methods for treating dengue virus infection |
| WO2016037016A1 (en) | 2014-09-03 | 2016-03-10 | The Brigham And Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| WO2016061344A1 (en) * | 2014-10-15 | 2016-04-21 | Mirx Pharmaceuticals Llc | Gsk3 inhibitors and their uses |
| CN108779437A (zh) | 2016-01-08 | 2018-11-09 | 麻省理工学院 | 分化的肠内分泌细胞和胰岛素产生细胞的制备 |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| US11066419B2 (en) | 2016-12-30 | 2021-07-20 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using same |
| US11203601B2 (en) * | 2017-04-05 | 2021-12-21 | The Broad Institute, Inc. | Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof |
| WO2018217766A1 (en) | 2017-05-22 | 2018-11-29 | Whitehead Institute For Biomedical Research | Kcc2 expression enhancing compounds and uses thereof |
| CN110407769B (zh) * | 2018-04-27 | 2022-11-08 | 复旦大学 | 3,4-二氢-苯并[f][1,4]硫氮杂䓬-5(2H)-酮类化合物及其药物用途 |
| CN112351819B (zh) | 2018-06-05 | 2023-11-10 | 开动疗法公司 | 治疗恶性淋巴增生性疾病的方法 |
| US20210299233A1 (en) * | 2018-07-12 | 2021-09-30 | The Children's Medical Center Corporation | Method for treating cancer |
| CN113195707A (zh) | 2018-08-17 | 2021-07-30 | 频率治疗公司 | 用于通过上调jag-1来生成毛细胞的组合物和方法 |
| US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
| EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
| US20230014430A1 (en) * | 2019-11-20 | 2023-01-19 | Washington University | Methods and Compositions for Generating Functionally Mature Beta Cells and Uses Thereof |
| WO2023056463A1 (en) * | 2021-09-30 | 2023-04-06 | Trustees Of Tufts College | Glycogen synthase kinase 3 (gsk3) inhibitors for treating ctnnb1 syndrome |
| WO2024081939A2 (en) * | 2022-10-13 | 2024-04-18 | The Broad Institute, Inc. | Glycogen synthase kinase 3 inhibitors and uses thereof |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2024259178A1 (en) | 2023-06-14 | 2024-12-19 | The Broad Institute, Inc. | Glycogen synthase kinase 3 inhibitors and uses thereof |
| IL326136A (en) | 2023-08-07 | 2026-03-01 | Revolution Medicines Inc | RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
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| DE2722416A1 (de) | 1977-05-18 | 1978-11-30 | Thomae Gmbh Dr K | Neue thiazolo-pyridine |
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| JP6321662B2 (ja) * | 2012-10-12 | 2018-05-09 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | Ｇｓｋ３阻害剤およびその使用の方法 |
| US20160375006A1 (en) | 2012-10-12 | 2016-12-29 | The Broad Institute, Inc. | Uses of paralog-selective inhibitors of gsk3 kinases |
| JP2014139870A (ja) * | 2013-01-21 | 2014-07-31 | Hitachi Consumer Electronics Co Ltd | 照明装置およびこれを用いた映像表示装置 |
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| KR101602559B1 (ko) | 2014-04-29 | 2016-03-10 | 경북대학교 산학협력단 | 2,5,6,7-사중치환 티아졸로[4,5-b]피리딘 유도체 및 이의 용도 |
| US10437707B2 (en) * | 2015-03-19 | 2019-10-08 | Teachers Insurance And Annuity Association Of America | Evaluating and presenting software testing project status indicators |
| US11203601B2 (en) | 2017-04-05 | 2021-12-21 | The Broad Institute, Inc. | Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof |
-
2013
- 2013-10-11 JP JP2015536972A patent/JP6321662B2/ja active Active
- 2013-10-11 EP EP13780300.3A patent/EP2909204B1/en active Active
- 2013-10-11 HU HUE13780300A patent/HUE043853T2/hu unknown
- 2013-10-11 LT LTEP13780300.3T patent/LT2909204T/lt unknown
- 2013-10-11 SI SI201331368T patent/SI2909204T1/sl unknown
- 2013-10-11 HR HRP20190406TT patent/HRP20190406T1/hr unknown
- 2013-10-11 RS RS20190292A patent/RS58700B1/sr unknown
- 2013-10-11 PT PT13780300T patent/PT2909204T/pt unknown
- 2013-10-11 DK DK13780300.3T patent/DK2909204T3/en active
- 2013-10-11 WO PCT/US2013/064716 patent/WO2014059383A1/en not_active Ceased
- 2013-10-11 PL PL13780300T patent/PL2909204T3/pl unknown
- 2013-10-11 CA CA2887701A patent/CA2887701C/en active Active
- 2013-10-11 ES ES13780300T patent/ES2719776T3/es active Active
- 2013-10-11 SM SM20190136T patent/SMT201900136T1/it unknown
- 2013-10-11 US US14/052,661 patent/US9096594B2/en active Active
-
2015
- 2015-07-14 US US14/799,281 patent/US10137122B2/en active Active
-
2018
- 2018-04-05 JP JP2018072831A patent/JP6606691B2/ja active Active
- 2018-11-21 US US16/198,589 patent/US11052080B2/en active Active
-
2019
- 2019-03-05 CY CY20191100268T patent/CY1122601T1/el unknown
-
2021
- 2021-06-10 US US17/344,830 patent/US12419885B2/en active Active
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