|
US3391142A
(en)
|
1966-02-09 |
1968-07-02 |
Lilly Co Eli |
Adamantyl secondary amines
|
|
US3539573A
(en)
|
1967-03-22 |
1970-11-10 |
Jean Schmutz |
11-basic substituted dibenzodiazepines and dibenzothiazepines
|
|
ES413944A1
(es)
|
1972-04-20 |
1976-06-01 |
Merz & Co |
Procedimiento para la preparacion de compuestos de adamen- tano trisustituidos en las posiciones 1,3,5.
|
|
NL7605526A
(nl)
|
1976-05-24 |
1977-11-28 |
Akzo Nv |
Nieuwe tetracyclische derivaten.
|
|
JPS54130587A
(en)
|
1978-03-30 |
1979-10-09 |
Otsuka Pharmaceut Co Ltd |
Carbostyryl derivative
|
|
DE2856393C2
(de)
|
1978-12-27 |
1983-04-28 |
Merz + Co GmbH & Co, 6000 Frankfurt |
Arzneimittel zur Behandlung von Morbus Parkinson
|
|
US4804663A
(en)
|
1985-03-27 |
1989-02-14 |
Janssen Pharmaceutica N.V. |
3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
|
|
IE58370B1
(en)
|
1985-04-10 |
1993-09-08 |
Lundbeck & Co As H |
Indole derivatives
|
|
GB8607684D0
(en)
|
1986-03-27 |
1986-04-30 |
Ici America Inc |
Thiazepine compounds
|
|
US4816456A
(en)
|
1986-10-01 |
1989-03-28 |
Summers William K |
Administration of monoamine acridines in cholinergic neuronal deficit states
|
|
HU201906B
(en)
|
1987-03-04 |
1991-01-28 |
Sandoz Ag |
Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them
|
|
FI95572C
(fi)
|
1987-06-22 |
1996-02-26 |
Eisai Co Ltd |
Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
|
|
US4831031A
(en)
|
1988-01-22 |
1989-05-16 |
Pfizer Inc. |
Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
|
|
US5006528A
(en)
|
1988-10-31 |
1991-04-09 |
Otsuka Pharmaceutical Co., Ltd. |
Carbostyril derivatives
|
|
CA2000786C
(en)
|
1988-11-07 |
1999-01-26 |
Janssen Pharmaceutica, Naamloze Vennootschap |
3-piperidinyl-1,2-benzisoxazoles
|
|
US5043345A
(en)
|
1989-02-22 |
1991-08-27 |
Novo Nordisk A/S |
Piperidine compounds and their preparation and use
|
|
DE58905637D1
(de)
|
1989-04-14 |
1993-10-21 |
Merz & Co Gmbh & Co |
Verwendung von Adamantan-Derivaten zur Prävention und Behandlung der cerebralen Ischämie.
|
|
ES2076253T3
(es)
|
1989-05-19 |
1995-11-01 |
Hoechst Roussel Pharma |
N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
|
|
US5229382A
(en)
|
1990-04-25 |
1993-07-20 |
Lilly Industries Limited |
2-methyl-thieno-benzodiazepine
|
|
JP2807577B2
(ja)
|
1990-06-15 |
1998-10-08 |
エーザイ株式会社 |
環状アミド誘導体
|
|
JP2800953B2
(ja)
|
1990-07-06 |
1998-09-21 |
住友製薬株式会社 |
新規なイミド誘導体
|
|
ES2131506T3
(es)
*
|
1990-09-21 |
1999-08-01 |
Rohm & Haas |
Dihidropiridacinonas y piridacinonas como fungicidas.
|
|
US5190951A
(en)
|
1990-10-19 |
1993-03-02 |
Ss Pharmaceutical Co., Ltd. |
Quinoline derivatives
|
|
WO1992020682A1
(en)
|
1991-05-24 |
1992-11-26 |
E.I. Du Pont De Nemours And Company |
Arthropodicidal anilides
|
|
US5106856A
(en)
|
1991-06-07 |
1992-04-21 |
Hoechst-Roussel Pharmaceuticals Inc. |
[(Arylalkylpiperidin-4-yl)methyl]-2a,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-ones and related compounds
|
|
TW201311B
(https=)
|
1991-06-17 |
1993-03-01 |
Hoffmann La Roche |
|
|
US5312925A
(en)
|
1992-09-01 |
1994-05-17 |
Pfizer Inc. |
Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
|
|
JP4099224B2
(ja)
|
1994-03-02 |
2008-06-11 |
ナームローゼ・フエンノートチヤツプ・オルガノン |
舌下又はバッカル医薬組成物
|
|
US6479523B1
(en)
|
1997-08-26 |
2002-11-12 |
Emory University |
Pharmacologic drug combination in vagal-induced asystole
|
|
AU1041599A
(en)
|
1997-11-13 |
1999-06-07 |
Jose Luis Castro Pineiro |
Therapeutic uses of triazolo-pyridazine derivatives
|
|
US6391922B1
(en)
|
1998-01-13 |
2002-05-21 |
Synchroneuron, Llc |
Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders
|
|
US6294583B1
(en)
|
1998-01-13 |
2001-09-25 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders
|
|
WO2000027849A2
(en)
|
1998-11-12 |
2000-05-18 |
Merck & Co., Inc. |
Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
|
|
WO2000051985A1
(en)
|
1999-03-03 |
2000-09-08 |
Eisai Co., Ltd. |
Fluorides of 4-substituted piperidine derivatives
|
|
GB9911804D0
(en)
|
1999-05-20 |
1999-07-21 |
Merck Sharp & Dohme |
Therapeutic combination
|
|
GB9911803D0
(en)
|
1999-05-20 |
1999-07-21 |
Merck Sharp & Dohme |
Therapeutic combination
|
|
GB9911802D0
(en)
|
1999-05-20 |
1999-07-21 |
Merck Sharp & Dohme |
Therapeutic combination
|
|
GB9929569D0
(en)
|
1999-12-14 |
2000-02-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0004297D0
(en)
|
2000-02-23 |
2000-04-12 |
Ucb Sa |
2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
|
|
US20020151591A1
(en)
|
2000-10-17 |
2002-10-17 |
Anabella Villalobos |
Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
|
|
TWI239333B
(en)
*
|
2000-11-16 |
2005-09-11 |
Hoffmann La Roche |
Benzodiazepine derivatives as GABA A receptor modulators
|
|
PA8535601A1
(es)
|
2000-12-21 |
2002-11-28 |
Pfizer |
Derivados benzimidazol y piridilimidazol como ligandos para gabaa
|
|
WO2002069948A1
(en)
|
2001-03-01 |
2002-09-12 |
Pfizer Products Inc. |
Use of gabaa inverse agonists in combination with nicotine receptor partial agonists, estrogen, selective estrogen modulators, or vitamin e for the treatment of cognitive disorders
|
|
US6686352B2
(en)
*
|
2001-05-18 |
2004-02-03 |
Hoffmann-La Roche Inc. |
Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
|
|
US20050071088A1
(en)
|
2001-08-13 |
2005-03-31 |
Landfield Philip W |
Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment
|
|
EP1471909A4
(en)
|
2002-01-16 |
2007-07-25 |
Endo Pharmaceuticals Inc |
PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM
|
|
GB0218876D0
(en)
|
2002-08-13 |
2002-09-25 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CA2495285A1
(en)
|
2002-08-13 |
2004-02-19 |
Merck Sharp & Dohme Limited |
Phenylpyridazine derivatives as ligands for gaba receptors
|
|
US7635709B2
(en)
|
2002-09-26 |
2009-12-22 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Compositions and methods for bowel care in individuals with chronic intestinal pseudo-obstruction
|
|
KR100777904B1
(ko)
|
2002-10-24 |
2007-11-28 |
메르츠 파마 게엠베하 운트 코. 카가아 |
1-아미노시클로헥산 유도체 및 아세틸콜린에스테라제 저해제를 포함하는 약학적 제품 및 이를 이용한 복합 치료
|
|
US20040191803A1
(en)
|
2002-11-22 |
2004-09-30 |
Michela Gallagher |
Target for therapy of cognitive impairment
|
|
CN1870984A
(zh)
|
2003-10-22 |
2006-11-29 |
莫茨药物股份两合公司 |
1－氨基环己烷衍生物用于调节淀粉样病变中原纤维生成Aβ肽的沉积的用途
|
|
US20060079582A1
(en)
|
2004-09-23 |
2006-04-13 |
Jeffrey Jonas |
Memantine for the treatment of childhood behavioral disorders
|
|
WO2006040038A1
(en)
*
|
2004-10-12 |
2006-04-20 |
F.Hoffmann-La Roche Ag |
Imidazo [1, 5-a]triazolo[1, 5-d]benzodiazepine derivatives for the treatment of cognitive disorders
|
|
ES2399439T3
(es)
*
|
2004-10-20 |
2013-04-01 |
F. Hoffmann-La Roche Ag |
Derivados de imidazo-benzodiazepina
|
|
AU2005299031B2
(en)
*
|
2004-10-20 |
2011-11-10 |
F. Hoffmann-La Roche Ag |
Halogen substituted benzodiazepine derivatives
|
|
BRPI0515800A
(pt)
|
2004-12-14 |
2008-08-05 |
Hoffmann La Roche |
imidazo-benzodiazepinas tetracìclicas como moduladores de receptores de gaba
|
|
US20060205822A1
(en)
|
2004-12-22 |
2006-09-14 |
Forest Laboratories, Inc. |
1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
|
|
EP1888594A2
(en)
|
2005-05-16 |
2008-02-20 |
Wisys Technology Foundation, Inc. |
Gabaergic agents to treat memory deficits
|
|
EP1924712B1
(en)
|
2005-08-03 |
2018-10-03 |
The Johns Hopkins University |
Methods for characterizing and treating cognitive impairment in aging and disease
|
|
US8510055B2
(en)
|
2005-08-03 |
2013-08-13 |
The Johns Hopkins University |
Methods for characterizing and treating cognitive impairment in aging and disease
|
|
KR101009860B1
(ko)
*
|
2005-10-11 |
2011-01-19 |
에프. 호프만-라 로슈 아게 |
이미다조 벤조다이아제핀 유도체
|
|
US20070112017A1
(en)
|
2005-10-31 |
2007-05-17 |
Braincells, Inc. |
Gaba receptor mediated modulation of neurogenesis
|
|
US8486979B2
(en)
|
2006-12-12 |
2013-07-16 |
Abbvie Inc. |
1,2,4 oxadiazole compounds and methods of use thereof
|
|
US7943619B2
(en)
|
2007-12-04 |
2011-05-17 |
Hoffmann-La Roche Inc. |
Isoxazolo-pyridazine derivatives
|
|
WO2010014220A1
(en)
|
2008-08-01 |
2010-02-04 |
Lixte Biotechnology, Inc. |
Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
|
|
WO2010036553A1
(en)
|
2008-09-24 |
2010-04-01 |
E. I. Du Pont De Nemours And Company |
Fungicidal pyridazines
|
|
BRPI0920515B1
(pt)
|
2008-09-25 |
2018-03-20 |
Vive Nano, Inc. |
Composição compreendendo nanopartícula de polímero e composto ativo agrícola
|
|
US8344028B2
(en)
|
2009-04-17 |
2013-01-01 |
Xenoport, Inc. |
Gamma-amino-butyric acid derivatives as GABAB receptor ligands
|
|
US8853219B2
(en)
|
2010-01-11 |
2014-10-07 |
Neurosolis, Inc. |
Compounds and compositions for cognition-enhancement, methods of making, and methods of treating
|
|
MX341471B
(es)
*
|
2010-11-05 |
2016-08-22 |
Hoffmann La Roche |
Uso de compuestos farmaceuticos activos para el tratamiento de estados patologicos del sistema nervioso central.
|
|
WO2012068149A1
(en)
*
|
2010-11-15 |
2012-05-24 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions and methods for treating cognitive impairment
|
|
EP3034079B1
(en)
|
2010-11-15 |
2018-01-10 |
Agenebio, Inc. |
Pyridazine derivatives, compositions and methods for treating cognitive impairment
|
|
WO2012161133A1
(ja)
|
2011-05-20 |
2012-11-29 |
日産化学工業株式会社 |
置換ピリダジン化合物及び農園芸用殺菌剤
|
|
US20150374705A1
(en)
|
2012-02-14 |
2015-12-31 |
Shanghai Institues for Biological Sciences |
Substances for treatment or relief of pain
|
|
AU2013312240A1
(en)
|
2012-09-10 |
2015-03-19 |
Ophirex Inc. |
Administration of acetylcholinesterase inhibitors to mitigate neurotoxin-induced paralysis and residual neuromuscular blockade
|
|
EP3083569B1
(en)
|
2013-12-20 |
2022-01-26 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
JP6987384B2
(ja)
|
2015-06-19 |
2021-12-22 |
エージンバイオ， インコーポレイテッド |
ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法
|
|
US20180170941A1
(en)
|
2016-12-19 |
2018-06-21 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
CN108567787A
(zh)
|
2017-03-10 |
2018-09-25 |
辛衍雪 |
一种治疗慢性阻塞性肺病的药物组合物
|
|
US11414425B2
(en)
|
2018-06-19 |
2022-08-16 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|