JP2019533642A5 - - Google Patents

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JP2019533642A5
JP2019533642A5 JP2019513944A JP2019513944A JP2019533642A5 JP 2019533642 A5 JP2019533642 A5 JP 2019533642A5 JP 2019513944 A JP2019513944 A JP 2019513944A JP 2019513944 A JP2019513944 A JP 2019513944A JP 2019533642 A5 JP2019533642 A5 JP 2019533642A5
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JP7065081B2 (ja
JP2019533642A (ja
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Priority claimed from PCT/US2017/050964 external-priority patent/WO2018049328A1/en
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JP2019513944A 2016-09-12 2017-09-11 Gpr120モジュレーターとして有用な二環式化合物 Active JP7065081B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662393619P 2016-09-12 2016-09-12
US62/393,619 2016-09-12
PCT/US2017/050964 WO2018049328A1 (en) 2016-09-12 2017-09-11 Bicyclic compounds useful as gpr120 modulators

Publications (3)

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JP2019533642A JP2019533642A (ja) 2019-11-21
JP2019533642A5 true JP2019533642A5 (https=) 2020-11-12
JP7065081B2 JP7065081B2 (ja) 2022-05-11

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JP2019513944A Active JP7065081B2 (ja) 2016-09-12 2017-09-11 Gpr120モジュレーターとして有用な二環式化合物

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US (2) US10865201B2 (https=)
EP (1) EP3509588B1 (https=)
JP (1) JP7065081B2 (https=)
KR (1) KR102539877B1 (https=)
CN (1) CN110121343B (https=)
WO (1) WO2018049328A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018049324A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Monocyclic compounds useful as gpr120 modulators
EP3509588B1 (en) * 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
AU2019255363A1 (en) * 2018-04-20 2020-11-05 Krish Biotech Research Private Limited Method of treatment of non-alcoholic steatohepatitis, nash
CN111499592B (zh) * 2020-03-14 2023-06-23 江苏省农用激素工程技术研究中心有限公司 5-氨甲基糖精的合成方法
CN111574414A (zh) * 2020-05-20 2020-08-25 上海毕得医药科技有限公司 一种4-溴-2-甲氧基苯磺酰氯的合成方法
CN114671827B (zh) * 2020-12-24 2024-09-20 杭州百新生物医药科技有限公司 邻苯甲酰磺酰亚胺类衍生物及其应用
CN114685395A (zh) * 2020-12-29 2022-07-01 浙江大学 一种2,3-二氢苯并[d]异噻唑类化合物及其应用
WO2024046323A1 (zh) * 2022-08-29 2024-03-07 山东大学 一种苯并五元氮环类化合物、其制备方法及医药用途
CN116730945B (zh) * 2023-08-10 2023-11-17 北京惠宇乐邦环保科技有限公司 糖精的制备方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2735225A (en) 1956-02-21 Table ix p petri dish tests with x-phthalimido-
DE2253251A1 (de) * 1972-10-30 1974-05-09 Thomae Gmbh Dr K Neue phthalimido-sulfonylharnstoffe
DE3474547D1 (en) * 1983-12-02 1988-11-17 Shell Int Research Diphenyl ether herbicides
FR2659327A1 (fr) 1990-03-08 1991-09-13 Centre Nat Rech Scient Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases.
EP0526402B1 (en) 1991-07-30 1998-01-21 Novartis AG Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors
US5334600A (en) * 1991-07-30 1994-08-02 Ciba-Geigy Corporation Isoquinolyl substituted hydroxylamine derivatives
US5350761A (en) * 1991-07-30 1994-09-27 Ciba-Geigy Corporation Indolyl substituted hydroxylamine derivatives
TW219935B (https=) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
US5599811A (en) * 1995-02-21 1997-02-04 Warner-Lambert Company Benzothiazine dioxides as endothelin antagonists
PT891332E (pt) 1996-03-29 2004-07-30 Pfizer Derivados de 6-fenilpiridil-2-amina
US6716836B2 (en) 2001-03-22 2004-04-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
GB0124627D0 (en) * 2001-10-15 2001-12-05 Smithkline Beecham Plc Novel compounds
DE10348022A1 (de) 2003-10-15 2005-05-25 Imtm Gmbh Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
WO2006038594A1 (ja) * 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. N型カルシウムチャネル阻害薬
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
RU2455302C2 (ru) * 2006-12-27 2012-07-10 Санофи-Авентис ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ
JP5175866B2 (ja) * 2007-02-22 2013-04-03 アイアールエム・リミテッド・ライアビリティ・カンパニー Gタンパク質共役受容体を調節するための化合物および方法
US8569378B2 (en) 2007-07-20 2013-10-29 Toshiyuki Sakai p27 protein inducer
NZ592603A (en) * 2008-10-21 2013-02-22 Metabolex Inc Aryl gpr120 receptor agonists and uses thereof
AR074760A1 (es) 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
EP2406248B1 (en) * 2009-03-11 2013-12-25 Msd K.K. Novel isoindolin-1-one derivative
US8314120B2 (en) * 2010-03-30 2012-11-20 Abbott Gmbh & Co. Kg Small molecule potentiators of metabotropic glutamate receptors
US8299117B2 (en) 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
JP5746334B2 (ja) 2010-06-16 2015-07-08 シマベイ セラピューティクス, インコーポレーテッド Gpr120受容体作動薬及びその使用
TW201200505A (en) * 2010-06-17 2012-01-01 Metabolex Inc GPR120 receptor agonists and uses thereof
CA2841757A1 (en) 2011-07-15 2013-01-24 Etzer Darout Gpr 119 modulators
BR112014013136B1 (pt) 2011-11-30 2020-05-26 F. Hoffmann-La Roche Ag Novos derivados de dihidroisoquinolina-1-ona biciclicos
EP2906542B1 (en) 2012-10-11 2019-08-07 Merck Sharp & Dohme Corp. Substituted spiropiperidinyl compounds useful as gpr120 agonists
KR101942752B1 (ko) * 2012-11-05 2019-01-28 주식회사 엘지화학 Gpr120 효능제로서의 티오아릴 유도체
CA2893239A1 (en) * 2012-12-03 2014-06-12 F. Hoffmann-La Roche Ag Substituted triazole and imidazole compounds
WO2014096941A1 (en) * 2012-12-20 2014-06-26 Purdue Pharma L.P. Cyclic sulfonamides as sodium channel blockers
CN105008345A (zh) * 2013-03-14 2015-10-28 詹森药业有限公司 可用作gpr120的激动剂的双环吡咯衍生物
WO2014159061A2 (en) 2013-03-14 2014-10-02 Janssen Pharmaceutica Nv Benzo-fused heterocyclic derivatives useful as agonists of gpr120
WO2014209034A1 (en) 2013-06-27 2014-12-31 Lg Life Sciences Ltd. Biaryl derivatives as gpr120 agonists
AR099937A1 (es) 2014-04-04 2016-08-31 Sanofi Sa Compuestos de isoindolinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados
DK3140296T3 (en) 2014-05-07 2018-07-23 Bristol Myers Squibb Co PYRROLIDIN GPR40 MODULATORS FOR TREATMENT OF DISEASES SUCH AS DIABETES
EP3186241B1 (en) * 2014-08-29 2020-10-07 CHDI Foundation, Inc. Probes for imaging huntington protein
JP6486699B2 (ja) 2015-01-29 2019-03-20 国立大学法人金沢大学 脱水縮合剤
EP3365334B1 (en) * 2015-10-21 2024-07-17 Otsuka Pharmaceutical Co., Ltd. Benzolactam compounds as protein kinase inhibitors
EP3509588B1 (en) * 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
WO2018049324A1 (en) * 2016-09-12 2018-03-15 Numerate, Inc. Monocyclic compounds useful as gpr120 modulators

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