JP2019507781A5 - - Google Patents
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- Publication number
- JP2019507781A5 JP2019507781A5 JP2018547355A JP2018547355A JP2019507781A5 JP 2019507781 A5 JP2019507781 A5 JP 2019507781A5 JP 2018547355 A JP2018547355 A JP 2018547355A JP 2018547355 A JP2018547355 A JP 2018547355A JP 2019507781 A5 JP2019507781 A5 JP 2019507781A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- compound
- pharmaceutically acceptable
- amino acid
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 208000012902 Nervous system disease Diseases 0.000 claims description 2
- 208000025966 Neurological disease Diseases 0.000 claims description 2
- 108010077895 Sarcosine Proteins 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000017169 kidney disease Diseases 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 208000019423 liver disease Diseases 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229940043230 sarcosine Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 1
- 239000000463 material Substances 0.000 description 3
- 208000010643 digestive system disease Diseases 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662306914P | 2016-03-11 | 2016-03-11 | |
| US62/306,914 | 2016-03-11 | ||
| PCT/US2017/021194 WO2017156024A1 (en) | 2016-03-11 | 2017-03-07 | 3-desoxy derivative and pharmaceutical compositions thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507781A JP2019507781A (ja) | 2019-03-22 |
| JP2019507781A5 true JP2019507781A5 (https=) | 2020-02-06 |
| JP6892457B2 JP6892457B2 (ja) | 2021-06-23 |
Family
ID=59787771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547355A Active JP6892457B2 (ja) | 2016-03-11 | 2017-03-07 | ３−デスオキシ誘導体およびその医薬組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10815267B2 (https=) |
| EP (1) | EP3426348B1 (https=) |
| JP (1) | JP6892457B2 (https=) |
| KR (1) | KR102359191B1 (https=) |
| CN (1) | CN108883305B (https=) |
| AR (1) | AR107864A1 (https=) |
| AU (1) | AU2017229481B2 (https=) |
| BR (1) | BR112018068278B1 (https=) |
| CA (1) | CA3016875C (https=) |
| EA (1) | EA038632B1 (https=) |
| ES (1) | ES2874682T3 (https=) |
| IL (1) | IL261548B (https=) |
| MX (1) | MX384800B (https=) |
| PH (1) | PH12018501956A1 (https=) |
| PL (1) | PL3426348T3 (https=) |
| PT (1) | PT3426348T (https=) |
| SG (1) | SG11201807784SA (https=) |
| SI (1) | SI3426348T1 (https=) |
| TW (1) | TWI772289B (https=) |
| WO (1) | WO2017156024A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016073767A1 (en) | 2014-11-06 | 2016-05-12 | Enanta Pharmaceuticals, Inc. | Bile acid analogs an fxr/tgr5 agonists and methods of use thereof |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| US11578097B2 (en) | 2014-11-26 | 2023-02-14 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof |
| JP2017535570A (ja) | 2014-11-26 | 2017-11-30 | エナンタ ファーマシューティカルズ インコーポレイテッド | Ｆｘｒ／ｔｇｒ５アゴニストとしての胆汁酸類似体およびその使用方法 |
| MX2017010376A (es) | 2015-02-11 | 2017-12-20 | Enanta Pharm Inc | Análogos de ácido biliar como agonistas de fxr/tgr5 y métodos para el uso de los mismos. |
| CA2981503C (en) | 2015-03-31 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| EP3981779A1 (en) | 2015-10-07 | 2022-04-13 | Intercept Pharmaceuticals, Inc. | Farnesoid x receptor modulators |
| WO2017147174A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
| US10323060B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof |
| WO2017147159A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Deuterated bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| EP3426348B1 (en) | 2016-03-11 | 2021-05-05 | Intercept Pharmaceuticals, Inc. | 3-desoxy derivative and pharmaceutical compositions thereof |
| CA3045023A1 (en) | 2016-11-29 | 2018-06-07 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
| US10472386B2 (en) | 2017-02-14 | 2019-11-12 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR agonists and methods of use thereof |
| CA3058754A1 (en) | 2017-04-07 | 2018-10-11 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonyl carbamate bile acid derivatives |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| US20230165853A1 (en) * | 2021-01-14 | 2023-06-01 | Enyo Pharma | Method for treating chronic kidney diseases |
| WO2023288123A1 (en) | 2021-07-16 | 2023-01-19 | Interecept Pharmaceuticals, Inc. | Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid |
| US20250288600A1 (en) * | 2022-04-21 | 2025-09-18 | Intercept Pharmaceuticals, Inc. | Uses of farnesoid x receptor agonists |
| EP4611888A1 (en) * | 2022-10-31 | 2025-09-10 | Intercept Pharmaceuticals, Inc. | Uses of farnesoid x receptor agonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1734970B1 (en) * | 2004-03-12 | 2014-12-31 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using fxr ligands |
| US20130261317A1 (en) * | 2010-09-27 | 2013-10-03 | Kythera Biopharmaceuticals, Inc. | Methods for preparing synthetic bile acids and compositions comprising the same |
| CN110041399B (zh) | 2011-12-29 | 2023-12-12 | 诺沃—诺迪斯克有限公司 | 包含非成蛋白质性的氨基酸的二肽 |
| CA2912139C (en) * | 2013-05-14 | 2021-04-20 | Roberto Pellicciari | 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators |
| US10407462B2 (en) | 2014-05-29 | 2019-09-10 | Bar Pharmaceuticals S.R.L. | Cholane derivatives for use in the treatment and/or prevention of FXR and TGR5/GPBAR1 mediated diseases |
| CN108137643A (zh) | 2015-08-07 | 2018-06-08 | 英特塞普特医药品公司 | 制备胆汁酸及其衍生物的方法 |
| EP3426348B1 (en) | 2016-03-11 | 2021-05-05 | Intercept Pharmaceuticals, Inc. | 3-desoxy derivative and pharmaceutical compositions thereof |
-
2017
- 2017-03-07 EP EP17763922.6A patent/EP3426348B1/en active Active
- 2017-03-07 KR KR1020187028967A patent/KR102359191B1/ko active Active
- 2017-03-07 ES ES17763922T patent/ES2874682T3/es active Active
- 2017-03-07 WO PCT/US2017/021194 patent/WO2017156024A1/en not_active Ceased
- 2017-03-07 MX MX2018010983A patent/MX384800B/es unknown
- 2017-03-07 CA CA3016875A patent/CA3016875C/en active Active
- 2017-03-07 PL PL17763922T patent/PL3426348T3/pl unknown
- 2017-03-07 US US15/451,818 patent/US10815267B2/en active Active
- 2017-03-07 BR BR112018068278-0A patent/BR112018068278B1/pt active IP Right Grant
- 2017-03-07 AU AU2017229481A patent/AU2017229481B2/en active Active
- 2017-03-07 PT PT177639226T patent/PT3426348T/pt unknown
- 2017-03-07 EA EA201892007A patent/EA038632B1/ru unknown
- 2017-03-07 SI SI201730776T patent/SI3426348T1/sl unknown
- 2017-03-07 CN CN201780018432.7A patent/CN108883305B/zh active Active
- 2017-03-07 SG SG11201807784SA patent/SG11201807784SA/en unknown
- 2017-03-07 JP JP2018547355A patent/JP6892457B2/ja active Active
- 2017-03-09 TW TW106107817A patent/TWI772289B/zh active
- 2017-03-13 AR ARP170100619A patent/AR107864A1/es unknown
-
2018
- 2018-09-03 IL IL261548A patent/IL261548B/en active IP Right Grant
- 2018-09-06 US US16/124,122 patent/US20190002493A1/en not_active Abandoned
- 2018-09-11 PH PH12018501956A patent/PH12018501956A1/en unknown
-
2020
- 2020-09-18 US US17/025,475 patent/US11319337B2/en active Active
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