PL3426348T3 - Pochodna 3-dezoksylowa i jej kompozycje farmaceutyczne - Google Patents

Pochodna 3-dezoksylowa i jej kompozycje farmaceutyczne

Info

Publication number
PL3426348T3
PL3426348T3 PL17763922T PL17763922T PL3426348T3 PL 3426348 T3 PL3426348 T3 PL 3426348T3 PL 17763922 T PL17763922 T PL 17763922T PL 17763922 T PL17763922 T PL 17763922T PL 3426348 T3 PL3426348 T3 PL 3426348T3
Authority
PL
Poland
Prior art keywords
pharmaceutical compositions
desoxy derivative
desoxy
derivative
pharmaceutical
Prior art date
Application number
PL17763922T
Other languages
English (en)
Inventor
Roberto Pellicciari
Antimo GIOIELLO
Original Assignee
Intercept Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intercept Pharmaceuticals, Inc. filed Critical Intercept Pharmaceuticals, Inc.
Publication of PL3426348T3 publication Critical patent/PL3426348T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J11/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
PL17763922T 2016-03-11 2017-03-07 Pochodna 3-dezoksylowa i jej kompozycje farmaceutyczne PL3426348T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662306914P 2016-03-11 2016-03-11
EP17763922.6A EP3426348B1 (en) 2016-03-11 2017-03-07 3-desoxy derivative and pharmaceutical compositions thereof
PCT/US2017/021194 WO2017156024A1 (en) 2016-03-11 2017-03-07 3-desoxy derivative and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
PL3426348T3 true PL3426348T3 (pl) 2022-01-03

Family

ID=59787771

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17763922T PL3426348T3 (pl) 2016-03-11 2017-03-07 Pochodna 3-dezoksylowa i jej kompozycje farmaceutyczne

Country Status (20)

Country Link
US (3) US10815267B2 (pl)
EP (1) EP3426348B1 (pl)
JP (1) JP6892457B2 (pl)
KR (1) KR102359191B1 (pl)
CN (1) CN108883305B (pl)
AR (1) AR107864A1 (pl)
AU (1) AU2017229481B2 (pl)
BR (1) BR112018068278B1 (pl)
CA (1) CA3016875C (pl)
EA (1) EA038632B1 (pl)
ES (1) ES2874682T3 (pl)
IL (1) IL261548B (pl)
MX (1) MX384800B (pl)
PH (1) PH12018501956A1 (pl)
PL (1) PL3426348T3 (pl)
PT (1) PT3426348T (pl)
SG (1) SG11201807784SA (pl)
SI (1) SI3426348T1 (pl)
TW (1) TWI772289B (pl)
WO (1) WO2017156024A1 (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015343025A1 (en) 2014-11-06 2017-06-08 Enanta Pharmaceuticals, Inc. Bile acid analogs an FXR/TGR5 agonists and methods of use thereof
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2016086115A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof
MX2017006833A (es) 2014-11-26 2018-02-13 Enanta Pharm Inc Análogos de ácido biliar como agonistas de fxr/tgr5 y métodos para el uso de los mismos.
US10246483B2 (en) 2015-02-11 2019-04-02 Enanta Pharmaceuticals, Inc. Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
JP6785788B2 (ja) 2015-03-31 2020-11-18 エナンタ ファーマシューティカルズ インコーポレイテッド Fxr/tgr5アゴニストとしての胆汁酸誘導体およびその使用方法
BR112018006892B1 (pt) 2015-10-07 2023-04-11 Intercept Pharmaceuticals, Inc Composto, composição farmacêutica do mesmo e seus usos como moduladores do receptor farnesoide x
US10323060B2 (en) 2016-02-23 2019-06-18 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof
US10364267B2 (en) 2016-02-23 2019-07-30 Enanta Pharmaceuticals, Inc. Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
US10323061B2 (en) 2016-02-23 2019-06-18 Enanta Pharmaceuticals, Inc. Heteroaryl containing bile acid analogs as FXR/TGR5 agonists and methods of use thereof
CN108883305B (zh) 2016-03-11 2021-03-16 英特塞普特医药品公司 3-脱氧衍生物及其药物组合物
CA3045023A1 (en) 2016-11-29 2018-06-07 Enanta Pharmaceuticals, Inc. Process for preparation of sulfonylurea bile acid derivatives
US10472386B2 (en) 2017-02-14 2019-11-12 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR agonists and methods of use thereof
JP7136802B2 (ja) 2017-04-07 2022-09-13 エナンタ ファーマシューティカルズ インコーポレイテッド スルホニルカルバマート胆汁酸誘導体の調製のためのプロセス
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
MX2023008364A (es) * 2021-01-14 2023-07-26 Enyo Pharma Metodo para el tratamiento de enfermedades renales cronicas.
WO2023288123A1 (en) 2021-07-16 2023-01-19 Interecept Pharmaceuticals, Inc. Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid
CN119136794A (zh) * 2022-04-21 2024-12-13 英特塞普特医药品公司 法尼醇x受体激动剂的用途
WO2024097247A1 (en) * 2022-10-31 2024-05-10 Intercept Pharmaceuticals, Inc. Uses of farnesoid x receptor agonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE032928T2 (hu) * 2004-03-12 2017-11-28 Intercept Pharmaceuticals Inc Fibrózis kezelése FXR-ligandumok alkalmazásával
US20130261317A1 (en) * 2010-09-27 2013-10-03 Kythera Biopharmaceuticals, Inc. Methods for preparing synthetic bile acids and compositions comprising the same
CN104011064A (zh) 2011-12-29 2014-08-27 诺沃—诺迪斯克有限公司 包含非成蛋白质性的氨基酸的二肽
PT3360881T (pt) * 2013-05-14 2021-02-19 Intercept Pharmaceuticals Inc Derivados de 11-hidroxilo substituídos em 6 de ácidos biliares e conjugados de aminoácidos dos mesmos como moduladores do recetor farnesoide x
MX373721B (es) * 2014-05-29 2020-04-20 Bar Pharmaceuticals S R L Derivados del colano para uso en el tratamiento y/o prevencion de enfermedades en las que intervienen el fxr y el tgr5/gpbar1.
MX2018001491A (es) * 2015-08-07 2018-04-24 Intercept Pharmaceuticals Inc Metodos para la preparacion de acidos biliares y derivados de los mismos.
CN108883305B (zh) 2016-03-11 2021-03-16 英特塞普特医药品公司 3-脱氧衍生物及其药物组合物

Also Published As

Publication number Publication date
HK1259145A1 (zh) 2019-11-29
CN108883305A (zh) 2018-11-23
TWI772289B (zh) 2022-08-01
US10815267B2 (en) 2020-10-27
MX2018010983A (es) 2019-01-21
EA201892007A1 (ru) 2019-01-31
SI3426348T1 (sl) 2021-11-30
CN108883305B (zh) 2021-03-16
WO2017156024A1 (en) 2017-09-14
CA3016875C (en) 2023-08-22
MX384800B (es) 2025-03-14
PH12018501956A1 (en) 2019-06-17
US20170260225A1 (en) 2017-09-14
EP3426348A1 (en) 2019-01-16
US20210101927A1 (en) 2021-04-08
AR107864A1 (es) 2018-06-13
KR20180117702A (ko) 2018-10-29
EP3426348A4 (en) 2019-11-20
US20190002493A1 (en) 2019-01-03
SG11201807784SA (en) 2018-10-30
BR112018068278B1 (pt) 2023-12-19
NZ745980A (en) 2025-03-28
KR102359191B1 (ko) 2022-02-04
JP2019507781A (ja) 2019-03-22
TW201734031A (zh) 2017-10-01
EA038632B1 (ru) 2021-09-27
AU2017229481A1 (en) 2018-09-20
IL261548B (en) 2021-02-28
IL261548A (en) 2018-11-29
US11319337B2 (en) 2022-05-03
AU2017229481B2 (en) 2022-06-16
BR112018068278A2 (pt) 2019-04-02
CA3016875A1 (en) 2017-09-14
PT3426348T (pt) 2021-06-28
ES2874682T3 (es) 2021-11-05
JP6892457B2 (ja) 2021-06-23
EP3426348B1 (en) 2021-05-05

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