JP6321662B2 - Ｇｓｋ３阻害剤およびその使用の方法 - Google Patents

Ｇｓｋ３阻害剤およびその使用の方法 Download PDF

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Publication number
JP6321662B2
JP6321662B2 JP2015536972A JP2015536972A JP6321662B2 JP 6321662 B2 JP6321662 B2 JP 6321662B2 JP 2015536972 A JP2015536972 A JP 2015536972A JP 2015536972 A JP2015536972 A JP 2015536972A JP 6321662 B2 JP6321662 B2 JP 6321662B2
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optionally substituted
compound
ring
membered saturated
heteroaryl
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Japanese (ja)
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JP2015536307A (ja
JP2015536307A5 (https=
Inventor
ワグナー，フローレンス，フェヴリエ
パン，ジェニファー，キュー．
ダンダパニ，シヴァラマン
ジェルマン，アンドリュー
ホルソン，エドワード
ムニョス，ベニート
ナグ，パーサ，ピー．
ウェイワー，ミシェル
ルイス，マイケル，シー．
ハガーティー，ステファン，ジェイ．
ビショップ，ジョシュア，エー．
ステグマイアー，キンバリー
バナージ，バーシャ
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Broad Institute Inc
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Broad Institute Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2015536972A 2012-10-12 2013-10-11 Ｇｓｋ３阻害剤およびその使用の方法 Active JP6321662B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261713314P 2012-10-12 2012-10-12
US61/713,314 2012-10-12
US201361779394P 2013-03-13 2013-03-13
US61/779,394 2013-03-13
PCT/US2013/064716 WO2014059383A1 (en) 2012-10-12 2013-10-11 Gsk3 inhibitors and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018072831A Division JP6606691B2 (ja) 2012-10-12 2018-04-05 Ｇｓｋ３阻害剤およびその使用の方法

Publications (3)

Publication Number Publication Date
JP2015536307A JP2015536307A (ja) 2015-12-21
JP2015536307A5 JP2015536307A5 (https=) 2016-12-22
JP6321662B2 true JP6321662B2 (ja) 2018-05-09

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JP2015536972A Active JP6321662B2 (ja) 2012-10-12 2013-10-11 Ｇｓｋ３阻害剤およびその使用の方法
JP2018072831A Active JP6606691B2 (ja) 2012-10-12 2018-04-05 Ｇｓｋ３阻害剤およびその使用の方法

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US (4) US9096594B2 (https=)
EP (1) EP2909204B1 (https=)
JP (2) JP6321662B2 (https=)
CA (1) CA2887701C (https=)
CY (1) CY1122601T1 (https=)
DK (1) DK2909204T3 (https=)
ES (1) ES2719776T3 (https=)
HR (1) HRP20190406T1 (https=)
HU (1) HUE043853T2 (https=)
LT (1) LT2909204T (https=)
PL (1) PL2909204T3 (https=)
PT (1) PT2909204T (https=)
RS (1) RS58700B1 (https=)
SI (1) SI2909204T1 (https=)
SM (1) SMT201900136T1 (https=)
WO (1) WO2014059383A1 (https=)

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US20190175584A1 (en) 2019-06-13
HRP20190406T1 (hr) 2019-05-31
US20200061050A9 (en) 2020-02-27
US11052080B2 (en) 2021-07-06
DK2909204T3 (en) 2019-04-01
SI2909204T1 (sl) 2019-06-28
WO2014059383A1 (en) 2014-04-17
JP2015536307A (ja) 2015-12-21
PL2909204T3 (pl) 2019-07-31
US9096594B2 (en) 2015-08-04
CY1122601T1 (el) 2021-03-12
LT2909204T (lt) 2019-05-10
EP2909204B1 (en) 2018-12-05
JP2018150302A (ja) 2018-09-27
PT2909204T (pt) 2019-03-21
CA2887701C (en) 2020-12-15
RS58700B1 (sr) 2019-06-28
US20220160702A1 (en) 2022-05-26
EP2909204A1 (en) 2015-08-26
JP6606691B2 (ja) 2019-11-20
ES2719776T3 (es) 2019-07-16
US10137122B2 (en) 2018-11-27
US20150313890A1 (en) 2015-11-05
US12419885B2 (en) 2025-09-23
HUE043853T2 (hu) 2019-09-30
US20140107141A1 (en) 2014-04-17
CA2887701A1 (en) 2014-04-17
SMT201900136T1 (it) 2019-05-10

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