JP2009502115A5 - - Google Patents

Info

Publication number

JP2009502115A5

JP2009502115A5 JP2008503310A JP2008503310A JP2009502115A5 JP 2009502115 A5 JP2009502115 A5 JP 2009502115A5 JP 2008503310 A JP2008503310 A JP 2008503310A JP 2008503310 A JP2008503310 A JP 2008503310A JP 2009502115 A5 JP2009502115 A5 JP 2009502115A5

Authority

JP

Japan

Prior art keywords

lung cancer

small cell

cell lung

zic5

gene

Prior art date

2006-07-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
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• 206010041067 Small cell lung cancer Diseases 0.000 claims 17
• 208000000587 small cell lung carcinoma Diseases 0.000 claims 17
• 150000001875 compounds Chemical class 0.000 claims 16
• 238000000034 method Methods 0.000 claims 13
• 239000002773 nucleotide Substances 0.000 claims 13
• 125000003729 nucleotide group Chemical group 0.000 claims 13
• 230000000692 anti-sense effect Effects 0.000 claims 12
• 101000976649 Homo sapiens Zinc finger protein ZIC 5 Proteins 0.000 claims 11
• 108091081021 Sense strand Proteins 0.000 claims 11
• 102100023494 Zinc finger protein ZIC 5 Human genes 0.000 claims 11
• 230000014509 gene expression Effects 0.000 claims 11
• 108091028664 Ribonucleotide Proteins 0.000 claims 9
• 108090000623 proteins and genes Proteins 0.000 claims 9
• 239000002336 ribonucleotide Substances 0.000 claims 9
• 125000002652 ribonucleotide group Chemical group 0.000 claims 9
• 229920001184 polypeptide Polymers 0.000 claims 7
• 102000004196 processed proteins & peptides Human genes 0.000 claims 7
• 108090000765 processed proteins & peptides Proteins 0.000 claims 7
• 210000004027 cell Anatomy 0.000 claims 6
• 230000000295 complement effect Effects 0.000 claims 5
• 238000001514 detection method Methods 0.000 claims 5
• 108700008625 Reporter Genes Proteins 0.000 claims 4
• 108020004459 Small interfering RNA Proteins 0.000 claims 4
• 230000004071 biological effect Effects 0.000 claims 4
• 239000012472 biological sample Substances 0.000 claims 4
• 238000012216 screening Methods 0.000 claims 4
• 239000004055 small Interfering RNA Substances 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 101100545268 Homo sapiens ZIC5 gene Proteins 0.000 claims 2
• 210000002919 epithelial cell Anatomy 0.000 claims 2
• 210000004072 lung Anatomy 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000001105 regulatory effect Effects 0.000 claims 2
• 230000002103 transcriptional effect Effects 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 1
• 235000010469 Glycine max Nutrition 0.000 claims 1
• 244000068988 Glycine max Species 0.000 claims 1
• 101000883798 Homo sapiens Probable ATP-dependent RNA helicase DDX53 Proteins 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 108091034117 Oligonucleotide Proteins 0.000 claims 1
• 102100038236 Probable ATP-dependent RNA helicase DDX53 Human genes 0.000 claims 1
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 230000027455 binding Effects 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 230000007423 decrease Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 230000000144 pharmacologic effect Effects 0.000 claims 1
• 239000000523 sample Substances 0.000 claims 1
• 108700026220 vif Genes Proteins 0.000 claims 1