JP2008511337A - ヘテロ多量体分子 - Google Patents

ヘテロ多量体分子 Download PDF

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Publication number
JP2008511337A
JP2008511337A JP2007530373A JP2007530373A JP2008511337A JP 2008511337 A JP2008511337 A JP 2008511337A JP 2007530373 A JP2007530373 A JP 2007530373A JP 2007530373 A JP2007530373 A JP 2007530373A JP 2008511337 A JP2008511337 A JP 2008511337A
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antibody
polypeptide
polypeptides
light chain
pair
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Japanese (ja)
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JP2008511337A5 (https=
Inventor
アーサー ジェイ． ヒャング，
バーバラ モファット，
ダニエル ジー． ヤンスラ，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2007530373A 2004-09-02 2005-09-01 ヘテロ多量体分子 Pending JP2008511337A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60717204P 2004-09-02 2004-09-02
PCT/US2005/031226 WO2006028936A2 (en) 2004-09-02 2005-09-01 Heteromultimeric molecules

Publications (2)

Publication Number Publication Date
JP2008511337A true JP2008511337A (ja) 2008-04-17
JP2008511337A5 JP2008511337A5 (https=) 2008-10-16

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JP2007530373A Pending JP2008511337A (ja) 2004-09-02 2005-09-01 ヘテロ多量体分子

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US (1) US20060204493A1 (https=)
EP (1) EP1789446A2 (https=)
JP (1) JP2008511337A (https=)
AU (1) AU2005282700A1 (https=)
CA (1) CA2577082A1 (https=)
MX (1) MX2007002856A (https=)
WO (1) WO2006028936A2 (https=)

Cited By (10)

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JP2013516965A (ja) * 2010-01-14 2013-05-16 ユセベ ファルマ ソシエテ アノニム 変異体ｓｐｒ遺伝子及び野生型Ｔｓｐ遺伝子を含む細菌宿主系統
JP2013516966A (ja) * 2010-01-14 2013-05-16 ユセベ ファルマ ソシエテ アノニム 組換えＤｓｂＣを発現し、低減したＴｓｐ活性を有する細菌宿主系統
JP2013529190A (ja) * 2010-04-23 2013-07-18 ジェネンテック， インコーポレイテッド ヘテロ多量体タンパク質の産生
JP2014521313A (ja) * 2011-07-13 2014-08-28 ユセベ ファルマ ソシエテ アノニム 組換えＤｓｂＣを発現する細菌宿主系統
JP2014534198A (ja) * 2011-10-11 2014-12-18 ジェネンテック， インコーポレイテッド 二重特異性抗体の構築の改善
JP2015537212A (ja) * 2012-11-15 2015-12-24 ジェネンテック， インコーポレイテッド イオン強度媒介のｐｈ勾配イオン交換クロマトグラフィー
JP2016526909A (ja) * 2013-07-31 2016-09-08 アムジエン・インコーポレーテツド Ｆｃ含有ポリペプチドの安定化
WO2020067541A1 (ja) * 2018-09-28 2020-04-02 協和キリン株式会社 抗体組成物
WO2021201236A1 (ja) * 2020-04-01 2021-10-07 協和キリン株式会社 抗体組成物
US12030926B2 (en) 2014-05-06 2024-07-09 Genentech, Inc. Production of heteromultimeric proteins using mammalian cells

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