|
EP1429765A2
(en)
|
2001-09-14 |
2004-06-23 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
US6897220B2
(en)
|
2001-09-14 |
2005-05-24 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
KR20040093692A
(ko)
|
2002-03-13 |
2004-11-08 |
얀센 파마슈티카 엔.브이. |
히스톤 디아세틸라제의 신규한 저해제로서의 피페라지닐-,피페리디닐- 및 모르폴리닐-유도체
|
|
DE60326436D1
(en)
|
2002-03-13 |
2009-04-16 |
Janssen Pharmaceutica Nv |
Aminoderivate als histone-deacetylase-inhibitoren
|
|
OA12793A
(en)
|
2002-03-13 |
2006-07-10 |
Janssen Pharmaceutica Nv |
Sulfonylamino-derivatives as novel inhibitors of histone deacetylase.
|
|
MXPA04008796A
(es)
|
2002-03-13 |
2004-11-26 |
Janssen Pharmaceutica Nv |
Derivados de carbonilamino como novedosos inhibidores de desacetilasa de histona.
|
|
KR101153335B1
(ko)
|
2003-09-24 |
2012-07-05 |
메틸진 인코포레이티드 |
히스톤 데아세틸라제의 억제제
|
|
US7253204B2
(en)
|
2004-03-26 |
2007-08-07 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
US8193205B2
(en)
|
2004-07-28 |
2012-06-05 |
Janssen Pharmaceutica N.V. |
Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
|
|
US7718801B2
(en)
|
2004-08-31 |
2010-05-18 |
Banyu Pharmaceutical Co., Ltd. |
Substituted imidazole derivative
|
|
HN2005000795A
(es)
*
|
2004-10-15 |
2010-08-19 |
Aventis Pharma Inc |
Pirimidinas como antagonistas del receptor de prostaglandina d2
|
|
JP2008524246A
(ja)
|
2004-12-16 |
2008-07-10 |
タケダ サン ディエゴ インコーポレイテッド |
ヒストンデアセチラーゼ阻害剤
|
|
CA2605110A1
(en)
|
2005-04-20 |
2006-11-02 |
Merck & Co., Inc. |
Benzothiophene derivatives
|
|
AU2006240246A1
(en)
|
2005-04-20 |
2006-11-02 |
Merck Sharp & Dohme Corp. |
Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions
|
|
AU2006240248A1
(en)
|
2005-04-20 |
2006-11-02 |
Merck Sharp & Dohme Corp. |
Benzothiophene hydroxamic acid derivatives
|
|
US7642253B2
(en)
|
2005-05-11 |
2010-01-05 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
AU2006248938B2
(en)
|
2005-05-18 |
2011-09-29 |
Janssen Pharmaceutica N.V. |
Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
|
|
CN101796055B
(zh)
|
2005-05-20 |
2013-09-04 |
梅特希尔基因公司 |
Vegf受体和hgf受体信号的抑制剂
|
|
DE102005027274A1
(de)
*
|
2005-06-08 |
2006-12-14 |
Schering Ag |
Inhibitoren der löslichen Adenylatzyklase
|
|
US7417066B2
(en)
|
2005-06-08 |
2008-08-26 |
Schering Ag |
Inhibitors of soluble adenylate cyclase
|
|
JP2008546793A
(ja)
|
2005-06-24 |
2008-12-25 |
メルク エンド カムパニー インコーポレーテッド |
修飾マロン酸誘導体
|
|
EA200800321A1
(ru)
|
2005-07-14 |
2008-06-30 |
Такеда Сан Диего, Инк. |
Ингибиторы гистондеацетилазы
|
|
GB0521244D0
(en)
|
2005-10-19 |
2005-11-30 |
Astrazeneca Ab |
Benzamide compounds
|
|
AR057579A1
(es)
|
2005-11-23 |
2007-12-05 |
Merck & Co Inc |
Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
|
|
EP1973405A4
(en)
*
|
2006-01-12 |
2011-06-01 |
Merck Sharp & Dohme |
HYDROXYALKYLARYLAMID DERIVATIVES
|
|
WO2007084390A2
(en)
*
|
2006-01-13 |
2007-07-26 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
WO2007082880A1
(en)
|
2006-01-19 |
2007-07-26 |
Janssen Pharmaceutica N.V. |
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
|
|
AU2007206942B2
(en)
|
2006-01-19 |
2012-08-23 |
Janssen Pharmaceutica N.V. |
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
|
|
US7834011B2
(en)
|
2006-01-19 |
2010-11-16 |
Janssen Pharmaceutica N.V. |
Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase
|
|
SI1981874T1
(sl)
|
2006-01-19 |
2009-10-31 |
Janssen Pharmaceutica Nv |
Aminofenilni derivati kot novi inhibitorji histon deacetilaze
|
|
AU2007206944B2
(en)
|
2006-01-19 |
2012-08-23 |
Janssen Pharmaceutica N.V. |
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
|
|
JP5137849B2
(ja)
*
|
2006-01-19 |
2013-02-06 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体
|
|
JP2009528354A
(ja)
|
2006-02-28 |
2009-08-06 |
メルク エンド カムパニー インコーポレーテッド |
ヒストン脱アセチル化酵素のインヒビター
|
|
CA2649861A1
(en)
|
2006-04-26 |
2007-11-08 |
Merck & Co., Inc. |
Disubstituted aniline compounds
|
|
CA2651681A1
(en)
*
|
2006-05-18 |
2007-11-29 |
Merck & Co., Inc. |
Aryl-fused spirocyclic compounds
|
|
EP2049124A4
(en)
|
2006-07-20 |
2010-02-10 |
Merck & Co Inc |
PHOSPHOR DERIVATIVES AS HISTONDEACETYLASE HEMMER
|
|
WO2008029152A2
(en)
*
|
2006-09-08 |
2008-03-13 |
Summit Corporation Plc |
Treatment of duchenne muscular dystrophy
|
|
US7977336B2
(en)
|
2006-12-28 |
2011-07-12 |
Banyu Pharmaceutical Co. Ltd |
Aminopyrimidine derivatives as PLK1 inhibitors
|
|
WO2008089436A2
(en)
*
|
2007-01-18 |
2008-07-24 |
Takeda San Diego, Inc. |
Crystalline forms of histone deacetylase inhibitors
|
|
US8030344B2
(en)
*
|
2007-03-13 |
2011-10-04 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
CN103087043A
(zh)
*
|
2007-03-16 |
2013-05-08 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
具有抗增殖活性的苯甲酰胺类衍生物及其药用制剂
|
|
EP2170882A1
(en)
*
|
2007-06-26 |
2010-04-07 |
Gilead Colorado, Inc. |
Imidazopyridinyl thiazolyl histone deacetylase inhibitors
|
|
WO2009005638A2
(en)
|
2007-06-27 |
2009-01-08 |
Merck & Co., Inc. |
Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors
|
|
EP3103791B1
(en)
|
2007-06-27 |
2018-01-31 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
|
WO2009033281A1
(en)
*
|
2007-09-14 |
2009-03-19 |
Methylgene Inc. |
Cancer combination therapy with a selective inhibitor of histone deacetylase hdac1, hdac2 and/or hdac3 and a microtubule stabilizer
|
|
KR101198057B1
(ko)
*
|
2008-01-29 |
2012-11-07 |
에프. 호프만-라 로슈 아게 |
신규한 ｎ-(2-아미노-페닐)-아미드 유도체
|
|
AU2009228931B2
(en)
|
2008-03-27 |
2013-05-23 |
Janssen Pharmaceutica Nv |
Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
|
|
AU2008355098B2
(en)
*
|
2008-04-21 |
2012-11-15 |
Gpcr Therapeutics, Inc |
Heterocyclic compounds
|
|
JP5640005B2
(ja)
|
2008-07-14 |
2014-12-10 |
ギリアード サイエンシーズ， インコーポレイテッド |
Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物
|
|
NZ602832A
(en)
|
2008-07-14 |
2014-04-30 |
Gilead Sciences Inc |
Fused heterocyclic hdac inhibitor compounds
|
|
WO2010009166A1
(en)
*
|
2008-07-14 |
2010-01-21 |
Gilead Colorado, Inc. |
Oxindolyl inhibitor compounds
|
|
JP2011529504A
(ja)
|
2008-07-28 |
2011-12-08 |
ギリアード サイエンシーズ， インコーポレイテッド |
シクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物およびヘテロシクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物
|
|
EP2330894B8
(en)
|
2008-09-03 |
2017-04-19 |
BioMarin Pharmaceutical Inc. |
Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
|
|
EP2340244A4
(en)
|
2008-10-14 |
2012-07-25 |
Ning Xi |
COMPOUNDS AND APPLICATION PROCEDURES
|
|
JP2010111702A
(ja)
|
2009-02-16 |
2010-05-20 |
Tetsuya Nishio |
複素環化合物、その製造法および用途
|
|
CA2751777A1
(en)
*
|
2009-02-23 |
2010-08-26 |
F. Hoffmann-La Roche Ag |
Novel ortho-aminoamides for the treatment of cancer
|
|
MX2011010218A
(es)
*
|
2009-04-02 |
2011-10-10 |
Merck Patent Gmbh |
Inhibidores de autotaxina.
|
|
WO2010144378A2
(en)
|
2009-06-08 |
2010-12-16 |
Gilead Colorado, Inc. |
Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds
|
|
KR20120031170A
(ko)
|
2009-06-08 |
2012-03-30 |
길리애드 사이언시즈, 인코포레이티드 |
알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물
|
|
WO2011053876A1
(en)
|
2009-10-30 |
2011-05-05 |
Massachusetts Institute Of Technology |
The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders
|
|
TWI429628B
(zh)
*
|
2010-03-29 |
2014-03-11 |
Univ Taipei Medical |
吲哚基或吲哚啉基羥肟酸化合物
|
|
US20130029846A1
(en)
|
2010-03-29 |
2013-01-31 |
Basf Se |
Fungicidal Iminoderivatives
|
|
JP6155187B2
(ja)
|
2010-03-30 |
2017-06-28 |
ヴァーセオン コーポレイション |
トロンビンの阻害剤としての多置換芳香族化合物
|
|
AR081331A1
(es)
*
|
2010-04-23 |
2012-08-08 |
Cytokinetics Inc |
Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
|
|
US9133123B2
(en)
|
2010-04-23 |
2015-09-15 |
Cytokinetics, Inc. |
Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
|
|
AR081626A1
(es)
|
2010-04-23 |
2012-10-10 |
Cytokinetics Inc |
Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
|
|
US10059723B2
(en)
|
2011-02-28 |
2018-08-28 |
Biomarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
WO2012118632A1
(en)
|
2011-02-28 |
2012-09-07 |
Ning Xi |
Substituted quinoline compounds and methods of use
|
|
US8957066B2
(en)
*
|
2011-02-28 |
2015-02-17 |
Biomarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
US9540395B2
(en)
*
|
2011-02-28 |
2017-01-10 |
Biomarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
JP6116554B2
(ja)
*
|
2011-07-07 |
2017-04-19 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ |
がんの処置のための置換されたアザ複素環
|
|
CN103764635B
(zh)
*
|
2011-07-08 |
2016-01-20 |
诺华股份有限公司 |
新的三氟甲基-噁二唑衍生物及其在疾病治疗中的用途
|
|
KR20140138293A
(ko)
|
2012-03-16 |
2014-12-03 |
액시킨 파마수티컬스 인코포레이티드 |
3,5-다이아미노피라졸 키나아제 억제제
|
|
UA112897C2
(uk)
|
2012-05-09 |
2016-11-10 |
Байєр Фарма Акцієнгезелльшафт |
Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань
|
|
WO2014022117A1
(en)
|
2012-07-28 |
2014-02-06 |
Calitor Sciences, Llc |
Substituted pyrazolone compounds and methods of use
|
|
TWI574962B
(zh)
|
2012-11-14 |
2017-03-21 |
加拓科學公司 |
作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途
|
|
US9604937B2
(en)
|
2012-11-27 |
2017-03-28 |
Thomas Helledays Stiftelse For Medicinsk Forskning |
Pyrimidine-2,4-diamine derivatives for treatment of cancer
|
|
JP2016511237A
(ja)
*
|
2013-02-01 |
2016-04-14 |
アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
選択的ｈｄａｃ３阻害剤
|
|
MX2015010700A
(es)
|
2013-02-21 |
2017-01-23 |
Calitor Sciences Llc |
Compuestos heteroaromaticos como moduladores de la p13 cinasa.
|
|
CN110179795A
(zh)
|
2013-03-15 |
2019-08-30 |
维颂公司 |
作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途
|
|
WO2014143666A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Biomarin Pharmaceutical Inc. |
Hdac inhibitors
|
|
HK1214252A1
(zh)
*
|
2013-03-15 |
2016-07-22 |
Verseon Corporation |
作為凝血酶抑制劑的鹵代吡唑
|
|
US9878986B2
(en)
|
2013-04-29 |
2018-01-30 |
Chong Kun Dang Pharmaceutical Corp. |
Compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same
|
|
WO2015006875A1
(en)
*
|
2013-07-18 |
2015-01-22 |
Methylgene Inc. |
Process for the preparation of substituted pyrimidines
|
|
NZ631142A
(en)
|
2013-09-18 |
2016-03-31 |
Axikin Pharmaceuticals Inc |
Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
|
|
EP3062783B1
(en)
|
2013-10-18 |
2020-08-12 |
The General Hospital Corporation |
Imaging histone deacetylases with a radiotracer using positron emission tomography
|
|
EP3082819B1
(en)
|
2013-12-20 |
2020-06-17 |
Signal Pharmaceuticals, LLC |
Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
|
|
CN106794181A
(zh)
|
2014-06-04 |
2017-05-31 |
托马斯·黑勒戴药物研究基金会 |
用于治疗炎性和自身免疫性病况的mth1抑制剂
|
|
WO2015187088A1
(en)
|
2014-06-04 |
2015-12-10 |
Thomas Helledays Stiftelse För Medicinsk Forskning |
Mth1 inhibitors for treatment of cancer
|
|
JP6785217B2
(ja)
*
|
2014-07-31 |
2020-11-18 |
インスティチュート パスツール コリア |
２−アミノ−ベンゾイミダゾール誘導体ならびにこれらの５−リポキシゲナーゼおよび／またはプロスタグランジンｅシンターゼ阻害剤としての使用
|
|
US10189810B2
(en)
|
2014-09-17 |
2019-01-29 |
Verseon Corporation |
Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
|
|
US9546163B2
(en)
|
2014-12-23 |
2017-01-17 |
Axikin Pharmaceuticals, Inc. |
3,5-diaminopyrazole kinase inhibitors
|
|
CN107405333A
(zh)
|
2015-02-27 |
2017-11-28 |
维颂公司 |
作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物
|
|
RU2720678C2
(ru)
|
2015-07-02 |
2020-05-12 |
Байомарин Фармасьютикал Инк. |
Ингибиторы гистондеацетилазы
|
|
CN106588943B
(zh)
|
2015-10-19 |
2018-10-16 |
广东东阳光药业有限公司 |
一种egfr抑制剂的盐、晶型及其用途
|
|
KR101838615B1
(ko)
*
|
2016-09-30 |
2018-03-15 |
숙명여자대학교산학협력단 |
신규한 벤조옥사졸 또는 벤조티아졸 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
WO2018165520A1
(en)
|
2017-03-10 |
2018-09-13 |
Vps-3, Inc. |
Metalloenzyme inhibitor compounds
|
|
MX2020003242A
(es)
|
2017-09-22 |
2020-09-18 |
Jubilant Epipad LLC |
Compuestos heterociclicos como inhibidores de pad.
|
|
AU2018352142B2
(en)
|
2017-10-18 |
2022-08-25 |
Jubilant Epipad LLC |
Imidazo-pyridine compounds as PAD inhibitors
|
|
KR20200085836A
(ko)
|
2017-11-06 |
2020-07-15 |
주빌런트 프로델 엘엘씨 |
Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
|
|
BR112020010322A2
(pt)
|
2017-11-24 |
2020-11-17 |
Jubilant Episcribe Llc |
composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer
|
|
SG11202008950PA
(en)
|
2018-03-13 |
2020-10-29 |
Jubilant Prodel LLC |
Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
|
|
GB201820450D0
(en)
|
2018-12-14 |
2019-01-30 |
Z Factor Ltd |
Compound and its use for the treatment of alpha1-antitryspin deficiency
|
|
AU2020321955A1
(en)
|
2019-07-30 |
2022-03-17 |
Eikonizo Therapapeutics, Inc. |
HDAC6 inhibitors and uses thereof
|
|
GB201918404D0
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|
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