HUP0401735A2 - CCR1 receptor antagonista hatású piperazinszármazékok és ezeket tartalmazó gyógyászati készítmények - Google Patents

CCR1 receptor antagonista hatású piperazinszármazékok és ezeket tartalmazó gyógyászati készítmények

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Publication number
HUP0401735A2
HUP0401735A2 HU0401735A HUP0401735A HUP0401735A2 HU P0401735 A2 HUP0401735 A2 HU P0401735A2 HU 0401735 A HU0401735 A HU 0401735A HU P0401735 A HUP0401735 A HU P0401735A HU P0401735 A2 HUP0401735 A2 HU P0401735A2
Authority
HU
Hungary
Prior art keywords
alkyl
heteroaryl
aryl
piperazine derivatives
pharmaceutical compositions
Prior art date
Application number
HU0401735A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Matthew Frank Brown
Matthew Merrill Hayward
Christopher Stanley Poss
Gregory Dean Lundquist
Andre Shavnya
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0401735A2 publication Critical patent/HUP0401735A2/hu
Publication of HUP0401735A3 publication Critical patent/HUP0401735A3/hu

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
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    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P35/00—Antineoplastic agents
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Oncology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgyát az (I) általános képletű piperazinszármazékok vagyezek gyógyászatilag megfelelő alakjai, továbbá e vegyületekettartalmazó gyógyászati készítmények képezik; a találmány szerinti (I)általános képletű vegyületek alkalmasak olyan rendellenességek ésbetegségek kezelésére, ahol a CCR1 receptor antagonizálása emlősöknélkedvező eredményeket hozhat. Az (I) általános képletben aszubsztituensek jelentése igen sokféle, így például a értéke 0, 1, 2,3, 4 vagy 5; b értéke 0, 1 vagy 2; c értéke 0, 1 vagy 2; d értéke 0,1, 2, 3 vagy 4; X jelentése -O-, -S-, -CH2- vagy -NR6-; Y jelentésearil- vagy heteroarilcsoport; mindegyik R1 jelentése például egymástólfüggetlenül H-, HO-, halogénatom, alkil-, alkil-O-, HO-alkil-, NC-,H2N-, H2N-alkil-, HO-(C=O)-, alkil-(C=O)-, alkil)-C=O)-alkíl-, H2N-(C=O)- vagy H2N-(C=O)-alkil-csoport; mindegyik R2 és R3 jelentésepéldául egymástól függetlenül H-, oxo-, alkil-, cikloalkil-alkil)-,aril-, aril)-alkil)-, HO-alkil-, alkil-O-alkil-, H2N-alkil-, alkil-NH-alkil-, (alkil)2-N-alkil-, heterociklil-alkil-, cikloalkil-NH-alkil-,heteroaril- alkil-, H2N(C=O)- vagy H2N-(C=O)-alkil-csoport; R4jelentése például[HO-(C=O)-][H2N-]-alkil-,[HO-(C=O)][alkil-NH-]-alkil-,[HO-(C=O)-][(alkil)2-N]-alkil-, HO-(C=O)- alkil)-NH-, HO-(C=O)-alkil-NH-alkil-csoport és hasonlók; mindegyik R5 jelentéseegymástól függetlenül például HO-, halogénatom, NC-, HO-(C=O)-, H2N-,aril-, heteroaril-, H2N-(C=O)-, alkil-NH-(C=O)-, alkilcsoport éshasonlók; továbbá R6 jelentése például alkil-, heteroaril-(C=O)-, H2N-(C=O)-, NH-(C=O) vagy SO2-csoport. Ó
HU0401735A 2001-10-22 2002-09-26 Piperazine derivatives with ccr1 receptor antagonist activity and pharmaceutical compositions containing them HUP0401735A3 (en)

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ZA200402090B (en) 2005-05-23
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BG108674A (en) 2005-04-30
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WO2003035627A1 (en) 2003-05-01
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