JP2007513633A5 - - Google Patents
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- JP2007513633A5 JP2007513633A5 JP2006544092A JP2006544092A JP2007513633A5 JP 2007513633 A5 JP2007513633 A5 JP 2007513633A5 JP 2006544092 A JP2006544092 A JP 2006544092A JP 2006544092 A JP2006544092 A JP 2006544092A JP 2007513633 A5 JP2007513633 A5 JP 2007513633A5
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- acid sequence
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- 125000003275 alpha amino acid group Chemical group 0.000 description 17
- 210000004602 germ cell Anatomy 0.000 description 9
- 238000009795 derivation Methods 0.000 description 6
- 239000002773 nucleotide Substances 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 101000852870 Homo sapiens Interferon alpha/beta receptor 1 Proteins 0.000 description 1
- 102100036714 Interferon alpha/beta receptor 1 Human genes 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- IFLVGRRVGPXYON-UHFFFAOYSA-N adci Chemical compound C12=CC=CC=C2C2(C(=O)N)C3=CC=CC=C3CC1N2 IFLVGRRVGPXYON-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000006240 deamidation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52875703P | 2003-12-10 | 2003-12-10 | |
| US60/528,757 | 2003-12-10 | ||
| PCT/US2004/041777 WO2005059106A2 (en) | 2003-12-10 | 2004-12-10 | Interferon alpha antibodies and their uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010267571A Division JP2011097943A (ja) | 2003-12-10 | 2010-11-30 | インターフェロンα抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007513633A JP2007513633A (ja) | 2007-05-31 |
| JP2007513633A5 true JP2007513633A5 (cg-RX-API-DMAC7.html) | 2009-09-10 |
| JP5047626B2 JP5047626B2 (ja) | 2012-10-10 |
Family
ID=34699898
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006544092A Expired - Fee Related JP5047626B2 (ja) | 2003-12-10 | 2004-12-10 | インターフェロンα抗体及びその使用 |
| JP2010267571A Pending JP2011097943A (ja) | 2003-12-10 | 2010-11-30 | インターフェロンα抗体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010267571A Pending JP2011097943A (ja) | 2003-12-10 | 2010-11-30 | インターフェロンα抗体及びその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US7741449B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2418220B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5047626B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101151477B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN1889978A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2004299833B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2546054C (cg-RX-API-DMAC7.html) |
| DK (2) | DK1711207T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2399050T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE035520T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL175586A (cg-RX-API-DMAC7.html) |
| IN (1) | IN2009KN02655A (cg-RX-API-DMAC7.html) |
| LT (1) | LT2418220T (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ547157A (cg-RX-API-DMAC7.html) |
| PL (2) | PL2418220T3 (cg-RX-API-DMAC7.html) |
| PT (2) | PT1711207E (cg-RX-API-DMAC7.html) |
| SI (2) | SI1711207T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005059106A2 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8188249B2 (en) | 2003-09-10 | 2012-05-29 | Amgen Fremont Inc. | Nucleic acid molecules encoding antibodies to M-CSF |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2363761T3 (es) * | 2001-01-09 | 2011-08-16 | Baylor Research Institute | Procedimientos para el tratamiento de enfermedades autoinmunitarias en un sujeto y en ensayos de diagnóstico in vitro. |
| CN100409897C (zh) * | 2003-04-23 | 2008-08-13 | 梅达雷克斯公司 | 1型干扰素拮抗剂在制备治疗患有炎症性肠病的患者的药物中的用途 |
| PL2418220T3 (pl) * | 2003-12-10 | 2017-12-29 | E. R. Squibb & Sons, L.L.C. | Przeciwciała przeciwko interferonowi alfa i ich zastosowania |
| KR20150041193A (ko) | 2004-06-21 | 2015-04-15 | 메다렉스, 엘.엘.시. | 인터페론 알파 수용체 1 항체 및 그의 용도 |
| EP1796722A1 (en) * | 2004-10-07 | 2007-06-20 | Universität Zürich | Type i interferon blocking agents for prevention and treatment of psoriasis |
| US7888481B2 (en) | 2005-02-10 | 2011-02-15 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| MX2007009466A (es) | 2005-02-10 | 2007-12-07 | Baylor Res Inst | Anticuerpos monoclonales de anti-interferon alfa y metodos para su uso. |
| EP3623473A1 (en) | 2005-03-31 | 2020-03-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| WO2007002543A2 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
| CA2630483C (en) | 2005-12-08 | 2015-05-19 | Medarex, Inc. | Human monoclonal antibodies to o8e |
| KR101463631B1 (ko) | 2006-03-31 | 2014-11-19 | 추가이 세이야쿠 가부시키가이샤 | 항체의 혈중 동태를 제어하는 방법 |
| EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| CN101473045B (zh) * | 2006-04-24 | 2016-08-03 | 健泰科生物技术公司 | 用于检测自身免疫性病症的方法和组合物 |
| EP2407548A1 (en) | 2006-10-16 | 2012-01-18 | MedImmune, LLC | Molecules with reduced half-lives, compositions and uses thereof |
| EP2077858A4 (en) * | 2006-12-06 | 2011-07-20 | Medimmune Llc | INTERFERON ALPHA-INDUCED PHARMACODYNAMIC MARKERS |
| CN101678100A (zh) | 2006-12-06 | 2010-03-24 | 米迪缪尼有限公司 | 治疗系统性红斑狼疮的方法 |
| JP5456658B2 (ja) * | 2007-03-30 | 2014-04-02 | メディミューン，エルエルシー | 抗体製剤 |
| US20100261172A1 (en) * | 2007-05-03 | 2010-10-14 | Medimmune, Llc | Interferon alpha-induced pharmacodynamic markers |
| EP2076590A4 (en) * | 2007-05-03 | 2011-06-01 | Medimmune Llc | SELF-IMMUNE DISEASE SELF-ANTIBODY MARKERS |
| PT2068927E (pt) | 2007-05-14 | 2016-02-10 | Medimmune Llc | Métodos para reduzir os níveis de eosinófilos |
| PH12021552811A1 (en) | 2007-09-26 | 2022-11-21 | Chugai Pharmaceutical Co Ltd | Modified antibody constant region |
| RU2510400C9 (ru) | 2007-09-26 | 2014-07-20 | Чугаи Сейяку Кабусики Кайся | Способ модификации изоэлектрической точки антитела с помощью аминокислотных замен в cdr |
| WO2009061818A1 (en) | 2007-11-05 | 2009-05-14 | Medimmune, Llc | Methods of treating scleroderma |
| WO2009070642A1 (en) * | 2007-11-28 | 2009-06-04 | Medimmune, Llc | Protein formulation |
| MX2010005830A (es) * | 2007-11-30 | 2010-09-14 | Bristol Myers Squibb Co | Conjugado de anticuerpo monoclonal anti-b7h4 - farmaco y metodos de uso del mismo. |
| KR20110005806A (ko) * | 2008-03-21 | 2011-01-19 | 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 | 인간 인터페론 α 서브타입 α8 및 그 변이 단백질을 특이적으로 인식하는 단일클론 항체 |
| ES2549903T3 (es) | 2008-05-07 | 2015-11-03 | Argos Therapeutics, Inc. | Anticuerpos humanizados contra interferón alfa humano |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| US20110256149A1 (en) * | 2008-10-09 | 2011-10-20 | Medimmune, Llc | Antibody formulation |
| EP3674317B1 (en) | 2009-03-19 | 2024-12-11 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| EP2462158B1 (en) * | 2009-08-06 | 2018-01-10 | F. Hoffmann-La Roche AG | Method to improve virus removal in protein purification |
| RU2012112802A (ru) | 2009-09-03 | 2013-10-10 | МЕДИММЬЮН, ЭлЭлСи | Диагностика интерферона типа 1 |
| US10150808B2 (en) | 2009-09-24 | 2018-12-11 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
| JP5889181B2 (ja) | 2010-03-04 | 2016-03-22 | 中外製薬株式会社 | 抗体定常領域改変体 |
| GB201012784D0 (en) * | 2010-07-29 | 2010-09-15 | Ucb Pharma Sa | Method |
| EP4066826B1 (en) | 2010-09-01 | 2024-03-06 | Thomas Jefferson University | Retinoic acid receptor gamma agonists for muscle repair and regeneration |
| US9334331B2 (en) | 2010-11-17 | 2016-05-10 | Chugai Seiyaku Kabushiki Kaisha | Bispecific antibodies |
| EP2679681B2 (en) | 2011-02-25 | 2023-11-15 | Chugai Seiyaku Kabushiki Kaisha | FcgammaRIIB-specific FC antibody |
| KR20140043402A (ko) * | 2011-05-25 | 2014-04-09 | 메디뮨 엘엘씨 | 인터페론-알파에 대한 항체를 사용하여 전신홍반루푸스, 피부경화증 및 근육염을 치료하는 방법 |
| EP2728002B1 (en) | 2011-06-30 | 2022-01-19 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| EP3388451A1 (en) | 2011-09-29 | 2018-10-17 | Apo-T B.V. | Multi specific binding molecules targeting aberrant cells |
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| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR20230143201A (ko) | 2011-11-30 | 2023-10-11 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| WO2013101771A2 (en) | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| AU2013208364B2 (en) * | 2012-01-13 | 2017-10-26 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| EP2813568B1 (en) | 2012-02-09 | 2025-04-23 | Chugai Seiyaku Kabushiki Kaisha | Modified fc region of antibody |
| WO2013187495A1 (ja) | 2012-06-14 | 2013-12-19 | 中外製薬株式会社 | 改変されたFc領域を含む抗原結合分子 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8188249B2 (en) | 2003-09-10 | 2012-05-29 | Amgen Fremont Inc. | Nucleic acid molecules encoding antibodies to M-CSF |
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