JP2006522830A5 - - Google Patents

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JP2006522830A5
JP2006522830A5 JP2006509915A JP2006509915A JP2006522830A5 JP 2006522830 A5 JP2006522830 A5 JP 2006522830A5 JP 2006509915 A JP2006509915 A JP 2006509915A JP 2006509915 A JP2006509915 A JP 2006509915A JP 2006522830 A5 JP2006522830 A5 JP 2006522830A5
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7f3com
antibody
4d4com
cdr
amino acid
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JP2006522830A (ja
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Priority claimed from PCT/US2004/011172 external-priority patent/WO2004091510A2/en
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  1. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4の重鎖可変(VH)ドメインのアミノ酸配列を有するVHドメインを含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  2. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4の軽鎖可変(VL)ドメインのアミノ酸配列を有するVLドメインを含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  3. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4のVLドメインのアミノ酸配列を有するVLドメインをさらに含む、請求項1に記載のIL-9抗体。
  4. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4の相補性決定領域(CDR)のアミノ酸配列を有するCDRを含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  5. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4のVH CDRのアミノ酸配列を有するVH CDRを含む、請求項4に記載のIL-9抗体。
  6. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4のVL CDRのアミノ酸配列を有するVL CDRを含む、請求項4に記載のIL-9抗体。
  7. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4のVL CDRのアミノ酸配列を有するVL CDRをさらに含む、請求項5に記載のIL-9抗体。
  8. VH CDRが4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4のVH CDR3である、請求項5に記載のIL-9抗体。
  9. VL CDRが4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4のVL CDR3である、請求項6に記載のIL-9抗体。
  10. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4のいずれか1つのVH CDR 3及びVL CDR3を示すアミノ酸配列を有するVH CDR3及びVL CDR3を含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  11. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4のいずれか1つのVH CDR 1、2、及び3を示すアミノ酸配列を有するVH CDR 1、2、及び3を含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  12. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4のいずれか1つのVL CDR 1、2、及び3を示すアミノ酸配列を有するVL CDR 1、2、及び3を含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  13. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3co
    m-3H5、または7F3com-3D4のいずれか１つのVH CDR 1、2、3及びVL CDRを示すアミノ酸配列を有するVH CDR 1、2、3及び少なくとも１つのVL CDRを含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  14. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3co
    m-3H5、または7F3com-3D4のいずれか１つのVL CDR 1、2、3及びVH CDRを示すアミノ酸配列を有するVL CDR 1、2、3及び少なくとも１つのVH CDRを含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  15. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3co
    m-3H5、または7F3com-3D4のいずれか１つのVH CDR 1、2、3及びVL CDR3を示すアミノ酸配列を有するVH CDR 1、2、3及びVL CDR3を含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  16. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3co
    m-3H5、または7F3com-3D4のいずれか１つのVL CDR 1、2、3及びVH CDR3を示すアミノ酸配列を有するVL CDR 1、2、3及びVH CDR3を含むIL-9抗体であって、ヒトIL-9ポリペプチドに免疫特異的に結合する抗体。
  17. 4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3co
    m-3H5、または7F3com-3D4のいずれか１つのVH CDR 1、2、3及びVL CDR 1、2、3を示すアミノ酸配列を有するVH CDR 1、2、3及びVL CDR 1、2、3を含むIL-9抗体。
  18. IL-9に特異的に結合し6個のCDRを有する単離抗体または抗体断片であって、
    (a) 単離抗体のVH CDR1は、第２の抗体のVH CDR1と比べて4以下のアミノ酸残基が置換されたアミノ酸配列を含み；
    (b) 単離抗体のVH CDR2は、第２の抗体のVH CDR2と比べて4以下のアミノ酸残基が置換されたアミノ酸配列を含み；
    (c) 単離抗体のVH CDR3は、第２の抗体のVH CDR3と比べて4以下のアミノ酸残基が置換されたアミノ酸配列を含み；
    (d) 単離抗体のVL CDR1は、第２の抗体のVL CDR1と比べて4以下のアミノ酸残基が置換されたアミノ酸配列を含み；
    (e) 単離抗体のVL CDR2は、第２の抗体のVL CDR2と比べて4以下のアミノ酸残基が置換されたアミノ酸配列を含み；及び
    (f) 単離抗体のVL CDR3は、第２の抗体のVL CDR3と比べて4以下のアミノ酸残基が置換されたアミノ酸配列を含み；
    第２の抗体は4D4、4D4 H2-1 D11、4D4com-XF9、4D4com-2F9、7F3、71A10、22D3、7F3com-2H2、7F3com-3H5、または7F3com-3D4である、前記抗体または抗体断片。
  19. ヒト抗体またはヒト化抗体である、請求項1、2、3、17または18のいずれか1項に記載のIL-9抗体。
  20. 検出可能な物質または治療剤にコンジュゲートしている、請求項1、2、3、17または18のいずれか1項に記載のIL-9抗体。
  21. 請求項1、2、3、17または18に記載のIL-9抗体および薬学的に許容できる担体を含む医薬組成物。
  22. 予防または治療有効量の請求項1、2、3、17または18に記載のIL-9抗体を、それを必要とする被験者に投与することにより、IL-9ポリペプチドの異常発現および/もしくは異常活性またはIL-9Rの異常発現および/もしくは異常活性を特徴とする疾患または障害を予防、治療、管理、および/または改善するための医薬の製造における、前記IL-9抗体の使用。
  23. 予防または治療有効量の請求項1、2、3、17または18に記載のIL-9抗体を、それを必要とする被験者に投与することにより、炎症性障害、自己免疫障害、増殖性障害もしくは呼吸器感染症またはそれらの1つもしくは複数の症状を予防、治療、管理、および/または改善するための医薬の製造における、前記IL-9抗体の使用。
  24. 前記呼吸器感染症がウイルスまたは細菌によって引き起こされる、請求項23に記載の使用。
  25. 前記ウイルスが呼吸器合胞体ウイルス、パラインフルエンザウイルスまたはヒトメタニューモウイルスである、請求項23に記載の使用。
  26. 前記IL-9抗体が非経口、経鼻または経口投与される、請求項23に記載の使用。
JP2006509915A 2003-04-11 2004-04-12 組換えｉｌ−９抗体およびその使用 Expired - Fee Related JP4764818B2 (ja)

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US46225903P 2003-04-11 2003-04-11
US60/462,259 2003-04-11
US47779703P 2003-06-10 2003-06-10
US60/477,797 2003-06-10
PCT/US2004/011172 WO2004091510A2 (en) 2003-04-11 2004-04-12 Recombinant il-9 antibodies and uses thereof

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