|
PT2476667E
(pt)
*
|
2003-02-26 |
2014-09-18 |
Sugen Inc |
Compostos de aminoheteroarilo como inibidores da proteína quinase
|
|
WO2005082411A1
(en)
*
|
2004-02-23 |
2005-09-09 |
Sugen, Inc. |
Method of treating abnormal cell growth using c-met and-tor inhibitors
|
|
KR100799534B1
(ko)
|
2004-02-27 |
2008-01-31 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
신규 피리딘 유도체 및 피리미딘 유도체(1)
|
|
WO2005095386A1
(en)
*
|
2004-03-30 |
2005-10-13 |
Chiron Corporation |
Substituted thiophene derivatives as anti-cancer agents
|
|
US8008301B2
(en)
|
2004-04-01 |
2011-08-30 |
Eli Lilly And Company |
Histamine H3 receptor agents, preparation and therapeutic uses
|
|
CA2561628C
(en)
*
|
2004-04-01 |
2012-05-08 |
Eli Lilly And Company |
Histamine h3 receptor agents, preparation and therapeutic uses
|
|
EP1784400B1
(en)
*
|
2004-08-23 |
2015-01-14 |
Eli Lilly And Company |
Histamine h3 receptor agents, preparation and therapeutic uses
|
|
CA2577937C
(en)
*
|
2004-08-26 |
2010-12-21 |
Pfizer Inc. |
Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
|
|
KR20080072105A
(ko)
*
|
2004-08-26 |
2008-08-05 |
화이자 인코포레이티드 |
단백질 티로신 키나제 저해제 중간체의 제조를 위한거울상이성질선택적 생물학적 전환
|
|
EP1786777A1
(en)
*
|
2004-08-26 |
2007-05-23 |
Pfizer, Inc. |
Aminoheteroaryl compounds as protein tyrosine kinase inhibitors
|
|
JP4242911B2
(ja)
|
2004-08-26 |
2009-03-25 |
ファイザー・インク |
プロテインキナーゼ阻害薬としてのエナンチオピュアなアミノヘテロアリール化合物
|
|
GT200600042A
(es)
*
|
2005-02-10 |
2006-09-27 |
Aventis Pharma Inc |
Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
|
|
US20090163476A1
(en)
*
|
2005-03-03 |
2009-06-25 |
Sirtris Pharmaceuticals, Inc. |
N-Phenyl Benzamide Derivatives as Sirtuin Modulators
|
|
CN101193635A
(zh)
*
|
2005-05-13 |
2008-06-04 |
莱西肯医药有限公司 |
多环化合物及其使用方法
|
|
US8093401B2
(en)
*
|
2005-08-04 |
2012-01-10 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US8088928B2
(en)
*
|
2005-08-04 |
2012-01-03 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US7855289B2
(en)
*
|
2005-08-04 |
2010-12-21 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US7345178B2
(en)
*
|
2005-08-04 |
2008-03-18 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
TWI377198B
(en)
*
|
2005-08-24 |
2012-11-21 |
Eisai R&D Man Co Ltd |
Novel pyridine derivatives and pyrimidine derivatives (3)
|
|
PT1963302E
(pt)
*
|
2005-12-05 |
2013-04-09 |
Pfizer Prod Inc |
Polimorfos de um inibidor de c-met/hgfr
|
|
DE602006018354D1
(de)
*
|
2005-12-05 |
2010-12-30 |
Pfizer Prod Inc |
Verfahren zur behandlung von abnormalem zellwachstum
|
|
PE20070978A1
(es)
*
|
2006-02-14 |
2007-11-15 |
Novartis Ag |
COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
|
|
US7723330B2
(en)
|
2006-03-07 |
2010-05-25 |
Array Biopharma Inc. |
Heterobicyclic pyrazole compounds and methods of use
|
|
KR20090007347A
(ko)
*
|
2006-03-22 |
2009-01-16 |
버텍스 파마슈티칼스 인코포레이티드 |
증식성 장애의 치료를 위한 c-MET 단백질 키나제 억제제
|
|
PL2450437T3
(pl)
|
2006-04-14 |
2017-12-29 |
Cell Signaling Technology Inc |
Defekty genu i zmutowana kinaza ALK w ludzkich guzach litych
|
|
US8168383B2
(en)
|
2006-04-14 |
2012-05-01 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
US7601716B2
(en)
|
2006-05-01 |
2009-10-13 |
Cephalon, Inc. |
Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
|
|
US20080045589A1
(en)
*
|
2006-05-26 |
2008-02-21 |
Susan Kelley |
Drug Combinations with Substituted Diaryl Ureas for the Treatment of Cancer
|
|
US20110053931A1
(en)
*
|
2006-06-08 |
2011-03-03 |
John Gaudino |
Quinoline compounds and methods of use
|
|
US7683060B2
(en)
|
2006-08-07 |
2010-03-23 |
Incyte Corporation |
Triazolotriazines as kinase inhibitors
|
|
ATE535520T1
(de)
|
2006-08-23 |
2011-12-15 |
Eisai R&D Man Co Ltd |
Salz eines phenoxypyridinderivats oder kristall davon und verfahren zu dessen herstellung
|
|
US7790885B2
(en)
*
|
2006-08-31 |
2010-09-07 |
Eisai R&D Management Co., Ltd. |
Process for preparing phenoxypyridine derivatives
|
|
WO2008042867A2
(en)
*
|
2006-09-29 |
2008-04-10 |
Emiliem Inc. |
Modulators of multiple kinases
|
|
MX2009004426A
(es)
|
2006-10-23 |
2009-08-12 |
Cephalon Inc |
Derivados biciclicos fusionados de 2,4-diaminopirimidina como inhibidores alk y c-met.
|
|
GB0621607D0
(en)
*
|
2006-10-31 |
2006-12-06 |
Chroma Therapeutics Ltd |
Inhibitors of c-Met
|
|
GEP20125658B
(en)
|
2006-11-22 |
2012-10-10 |
Incyte Corp |
Imidazotriazines and imidazo pyrimidines as kinase inhibitors
|
|
CA2672167C
(en)
|
2006-12-14 |
2016-01-26 |
Bayer Schering Pharma Aktiengesellschaft |
Dihydropyridine derivatives useful as protein kinase inhibitors
|
|
CA2675755C
(en)
*
|
2007-01-19 |
2015-10-06 |
Xcovery, Inc. |
Pyridine and pyridazine derivatives as kinase inhibitors
|
|
EP2123627B1
(en)
*
|
2007-01-19 |
2013-11-20 |
Ube Industries, Ltd. |
Process for producing aromatic amine having aralkyloxy or heteroaralkyloxy group
|
|
CA2683559C
(en)
*
|
2007-04-13 |
2019-09-24 |
Dana Farber Cancer Institute, Inc. |
Methods for treating cancer resistant to erbb therapeutics
|
|
MX2009011210A
(es)
*
|
2007-04-16 |
2009-10-30 |
Abbott Lab |
Inhibidores de mcl1 de indol 7-no sustituido.
|
|
US8263585B2
(en)
|
2007-05-04 |
2012-09-11 |
Novartis Ag |
Organic compounds
|
|
TW200916472A
(en)
*
|
2007-06-20 |
2009-04-16 |
Sirtris Pharmaceuticals Inc |
Sirtuin modulating compounds
|
|
JP2010533729A
(ja)
|
2007-07-17 |
2010-10-28 |
プレキシコン,インコーポレーテッド |
キナーゼ調節のための化合物と方法、及びそのための適応
|
|
MX2010001020A
(es)
*
|
2007-07-26 |
2010-03-01 |
Novartis Ag |
Derivados de pirimidina utiles para el tratamiento de condiciones inflamatorias o alergicas.
|
|
KR101586503B1
(ko)
|
2007-09-13 |
2016-01-18 |
코덱시스, 인코포레이티드 |
아세토페논의 환원을 위한 케토리덕타제 폴리펩티드
|
|
EP2215084B1
(en)
*
|
2007-10-23 |
2016-09-28 |
Allergan, Inc. |
Therapeutic substituted lactams
|
|
EP2215066A1
(en)
*
|
2007-11-01 |
2010-08-11 |
Sirtris Pharmaceuticals, Inc. |
Amide derivatives as sirtuin modulators
|
|
JP2011503066A
(ja)
*
|
2007-11-08 |
2011-01-27 |
サートリス ファーマシューティカルズ, インコーポレイテッド |
可溶化チアゾロピリジン誘導体
|
|
JP2009132660A
(ja)
*
|
2007-11-30 |
2009-06-18 |
Eisai R & D Management Co Ltd |
食道癌治療用組成物
|
|
WO2009073224A1
(en)
*
|
2007-12-07 |
2009-06-11 |
Ambit Biosciences Corp. |
Methods of treating certain diseases using pyrimidine derivatives
|
|
US20090227556A1
(en)
*
|
2008-01-31 |
2009-09-10 |
Eisai R&D Management Co., Ltd. |
Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives
|
|
WO2009096198A1
(ja)
*
|
2008-02-01 |
2009-08-06 |
Pharma Ip Limited Liability Intermediary Corporations |
新規ビアリール誘導体
|
|
JP2011511005A
(ja)
*
|
2008-02-04 |
2011-04-07 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
2−アミノピリジン系キナーゼ阻害薬
|
|
AR070317A1
(es)
*
|
2008-02-06 |
2010-03-31 |
Osi Pharm Inc |
Furo (3,2-c) piridina y tieno (3,2-c) piridinas
|
|
JPWO2009104520A1
(ja)
*
|
2008-02-18 |
2011-06-23 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
フェノキシピリジン誘導体の製造方法(2)
|
|
WO2009111644A2
(en)
*
|
2008-03-05 |
2009-09-11 |
The Regents Of The University Of Michigan |
Compositions and methods for diagnosing and treating pancreatic cancer
|
|
US8268834B2
(en)
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
FR2928923B1
(fr)
|
2008-03-21 |
2010-04-23 |
Sanofi Aventis |
Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
|
|
FR2928922B1
(fr)
|
2008-03-21 |
2010-04-23 |
Sanofi Aventis |
Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
|
|
FR2928924B1
(fr)
|
2008-03-21 |
2010-04-23 |
Sanofi Aventis |
Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
|
|
WO2009151800A1
(en)
*
|
2008-05-07 |
2009-12-17 |
Merck & Co., Inc. |
Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment
|
|
SI2300455T1
(sl)
|
2008-05-21 |
2017-12-29 |
Incyte Holdings Corporation |
Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo
|
|
KR101691640B1
(ko)
*
|
2008-06-19 |
2016-12-30 |
엑스커버리 홀딩 컴퍼니 엘엘씨 |
키나아제 억제제 화합물로서의 치환된 피리다진 카르복사마이드 화합물
|
|
EP2321433A2
(en)
*
|
2008-08-29 |
2011-05-18 |
F. Hoffmann-La Roche AG |
Diagnostics and treatments for vegf-independent tumors
|
|
WO2010046780A2
(en)
*
|
2008-10-22 |
2010-04-29 |
Institut Pasteur Korea |
Anti viral compounds
|
|
AT507187B1
(de)
|
2008-10-23 |
2010-03-15 |
Helmut Dr Buchberger |
Inhalator
|
|
EP2356116A1
(en)
|
2008-11-20 |
2011-08-17 |
OSI Pharmaceuticals, Inc. |
Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
|
|
US8367679B2
(en)
*
|
2008-12-09 |
2013-02-05 |
Merck Sharp & Dohme Corp. |
Biaryl carboxamides
|
|
PL3354650T3
(pl)
|
2008-12-19 |
2022-06-13 |
Vertex Pharmaceuticals Incorporated |
Związki przydatne jako inhibitory kinazy atr
|
|
CN102388054B
(zh)
|
2008-12-19 |
2015-03-04 |
西特里斯药业公司 |
噻唑并吡啶沉默调节蛋白调节剂的化合物
|
|
JP2012102018A
(ja)
*
|
2009-03-03 |
2012-05-31 |
Astellas Pharma Inc |
アミド化合物
|
|
TW201100441A
(en)
|
2009-06-01 |
2011-01-01 |
Osi Pharm Inc |
Amino pyrimidine anticancer compounds
|
|
DE102009056886A1
(de)
|
2009-12-03 |
2011-06-09 |
Bayer Schering Pharma Aktiengesellschaft |
cMet-Inhibitoren zur Behandlung der Endometriose
|
|
MX2012008898A
(es)
|
2010-02-03 |
2012-11-06 |
Incyte Corp |
Imidazo - [1, 2 - b] [1, 2, 4] triazinas como inhibidores de c - met.
|
|
CA2796967C
(en)
*
|
2010-05-04 |
2015-12-01 |
Pfizer Inc. |
Heterocyclic derivatives as alk inhibitors
|
|
WO2011143423A2
(en)
*
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
JP2013526540A
(ja)
|
2010-05-12 |
2013-06-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
JP5836367B2
(ja)
|
2010-05-12 |
2015-12-24 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼ阻害剤として有用な化合物
|
|
AR081039A1
(es)
|
2010-05-14 |
2012-05-30 |
Osi Pharmaceuticals Llc |
Inhibidores biciclicos fusionados de quinasa
|
|
US20130072495A1
(en)
|
2010-05-14 |
2013-03-21 |
OSI Pharmaceuticals, LLC |
Fused bicyclic kinase inhibitors
|
|
US10420665B2
(en)
|
2010-06-13 |
2019-09-24 |
W. L. Gore & Associates, Inc. |
Intragastric device for treating obesity
|
|
US9526648B2
(en)
|
2010-06-13 |
2016-12-27 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
|
US8628554B2
(en)
|
2010-06-13 |
2014-01-14 |
Virender K. Sharma |
Intragastric device for treating obesity
|
|
US10010439B2
(en)
|
2010-06-13 |
2018-07-03 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
|
CN102958523B
(zh)
|
2010-06-25 |
2014-11-19 |
卫材R&D管理有限公司 |
使用具有激酶抑制作用的组合的抗肿瘤剂
|
|
JP2013531687A
(ja)
|
2010-07-16 |
2013-08-08 |
パーデュー、ファーマ、リミテッド、パートナーシップ |
ナトリウムチャネル遮断剤としてのピリジン化合物
|
|
WO2012042421A1
(en)
|
2010-09-29 |
2012-04-05 |
Pfizer Inc. |
Method of treating abnormal cell growth
|
|
EP2625176B1
(en)
|
2010-10-08 |
2016-08-17 |
Xcovery Holding Company LLC |
Substitututed 6-amino-pyridazin-3-yl-carboxamide compounds as protein kinase modulators
|
|
WO2012074951A1
(en)
|
2010-11-29 |
2012-06-07 |
OSI Pharmaceuticals, LLC |
Macrocyclic kinase inhibitors
|
|
GB201021103D0
(en)
|
2010-12-13 |
2011-01-26 |
Univ Leuven Kath |
New compounds for the treatment of neurodegenerative diseases
|
|
CA2824970C
(en)
|
2011-02-11 |
2016-05-03 |
Batmark Limited |
Inhaler component
|
|
CA2826892A1
(en)
*
|
2011-02-24 |
2012-08-30 |
Jiangsu Hansoh Pharmaceutical Co., Ltd. |
Phosphorus containing compounds as protein kinase inhibitors
|
|
US9145390B2
(en)
|
2011-03-03 |
2015-09-29 |
Concert Pharmaceuticals, Inc. |
Derivatives of pyrazole-substituted amino-heteroaryl compounds
|
|
JO3363B1
(ar)
*
|
2011-04-13 |
2019-03-13 |
Epizyme Inc |
مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
|
|
BR112013028895A2
(pt)
|
2011-05-10 |
2016-08-09 |
Bayer Ip Gmbh |
(tio)carbonilamidinas bicíclicas
|
|
JP2014513724A
(ja)
|
2011-05-16 |
2014-06-05 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
融合二環キナーゼ阻害剤
|
|
WO2012178125A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
CA2842841C
(en)
*
|
2011-07-27 |
2016-04-19 |
Nanjing Allgen Pharma Co. Ltd. |
Spirocyclic molecules as protein kinase inhibitors
|
|
US20160206608A1
(en)
|
2011-08-02 |
2016-07-21 |
Pfizer Inc. |
Crizotinib for use in the treatment of cancer
|
|
AU2012315384B2
(en)
|
2011-09-30 |
2017-08-10 |
Vertex Pharmaceuticals Incorporated |
Treating pancreatic cancer and non-small cell lung cancer with ATR inhibitors
|
|
RU2018147217A
(ru)
|
2011-09-30 |
2019-01-18 |
Вертекс Фармасьютикалз Инкорпорейтед |
Способы получения соединений, которые можно использовать в качестве ингибиторов киназы atr
|
|
CA2863892C
(en)
|
2012-03-06 |
2016-08-30 |
Pfizer Inc. |
Macrocyclic derivatives for the treatment of proliferative diseases
|
|
WO2013136170A1
(en)
|
2012-03-16 |
2013-09-19 |
Purdue Pharma L.P. |
Substituted pyridines as sodium channel blockers
|
|
CN104582795B
(zh)
|
2012-04-05 |
2018-04-20 |
沃泰克斯药物股份有限公司 |
可用作atr激酶抑制剂的化合物及其组合疗法
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
EP2836216B1
(en)
*
|
2012-04-13 |
2022-06-08 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
CN103387535B
(zh)
*
|
2012-05-10 |
2016-06-01 |
广东东阳光药业有限公司 |
取代的炔基吡啶化合物及其使用方法和用途
|
|
WO2013177092A1
(en)
*
|
2012-05-23 |
2013-11-28 |
Sunshine Lake Pharma Co., Ltd. |
Substituted alkynyl pyridine compounds and methods of use
|
|
US20150182490A1
(en)
|
2012-06-26 |
2015-07-02 |
Del Mar Pharmaceuticals |
Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
|
|
GB201211310D0
(en)
*
|
2012-06-26 |
2012-08-08 |
Chroma Therapeutics Ltd |
CSF-1R kinase inhibitors
|
|
WO2014046730A1
(en)
|
2012-09-24 |
2014-03-27 |
Ventana Medical Systems, Inc. |
Method of identifying treatment responsive non-small cell lung cancer using anaplastic lymphoma kinase (alk) as a marker
|
|
DK2904406T3
(en)
|
2012-10-04 |
2018-06-18 |
Vertex Pharma |
METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
|
|
WO2014081816A1
(en)
*
|
2012-11-21 |
2014-05-30 |
Concert Pharmaceuticals, Inc. |
Fluoro-derivatives of pyrazole-substituted amino-heteroaryl compounds
|
|
LT3418281T
(lt)
|
2012-12-07 |
2021-01-11 |
Vertex Pharmaceuticals Inc. |
Pirazolo[1,5-a]pirimidinai, naudotini kaip atr kinazės inhibitoriai, skirti vėžinių ligų gydymui
|
|
EP2935257B1
(en)
|
2012-12-20 |
2018-02-07 |
Purdue Pharma LP |
Cyclic sulfonamides as sodium channel blockers
|
|
JPWO2014098176A1
(ja)
|
2012-12-21 |
2017-01-12 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体のアモルファス及びその製造方法
|
|
AU2014211856C1
(en)
*
|
2013-02-02 |
2018-04-12 |
Centaurus Biopharma Co., Ltd. |
Substituted 2-aminopyridine protein kinase inhibitor
|
|
WO2014143240A1
(en)
|
2013-03-15 |
2014-09-18 |
Vertex Pharmaceuticals Incorporated |
Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
|
|
CN105492011A
(zh)
|
2013-04-08 |
2016-04-13 |
丹尼斯·M·布朗 |
不理想给药化学化合物的治疗增效
|
|
CA2912219C
(en)
|
2013-05-14 |
2021-11-16 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
|
WO2015034729A1
(en)
*
|
2013-09-05 |
2015-03-12 |
Calitor Sciences, Llc |
Substituted pyridine compounds and methods of use
|
|
WO2015036898A2
(en)
*
|
2013-09-10 |
2015-03-19 |
Shilpa Medicare Limited |
Novel salts of crizotinib and their preparation
|
|
RU2550346C2
(ru)
|
2013-09-26 |
2015-05-10 |
Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" |
Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
|
|
AU2013402175B2
(en)
|
2013-09-30 |
2017-09-07 |
Handok Inc. |
Novel triazolopyrazine derivative and use thereof
|
|
EP3066118B1
(en)
|
2013-11-06 |
2020-01-08 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Alk antibodies, conjugates, and chimeric antigen receptors, and their use
|
|
HUE046727T2
(hu)
|
2013-12-06 |
2020-03-30 |
Vertex Pharma |
Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai
|
|
CA2934251C
(en)
|
2013-12-20 |
2024-01-02 |
3-V Biosciences, Inc. |
A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer
|
|
CN103755627B
(zh)
*
|
2014-01-09 |
2016-02-17 |
定陶县友帮化工有限公司 |
2-氨基-3-羟基-5-氯吡啶的合成方法
|
|
US10231965B2
(en)
|
2014-02-20 |
2019-03-19 |
Ignyta, Inc. |
Molecules for administration to ROS1 mutant cancer cells
|
|
EP3122900A1
(en)
|
2014-03-24 |
2017-02-01 |
F. Hoffmann-La Roche AG |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
US10730866B2
(en)
|
2014-04-07 |
2020-08-04 |
Purdue Pharma L.P. |
Indole derivatives and use thereof
|
|
WO2015167825A1
(en)
|
2014-04-29 |
2015-11-05 |
Emory University |
Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto
|
|
WO2015172747A1
(en)
*
|
2014-05-16 |
2015-11-19 |
Zhaoyin Wang |
Spirocyclic molecules as mth1 inhibitors
|
|
ES2777608T3
(es)
|
2014-06-05 |
2020-08-05 |
Vertex Pharma |
Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útiles como inhibidores de ATR cinasa, la preparación de dicho compuesto y diferentes formas sólidas del mismo
|
|
US11179394B2
(en)
|
2014-06-17 |
2021-11-23 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of Chk1 and ATR inhibitors
|
|
WO2016019909A1
(zh)
*
|
2014-08-07 |
2016-02-11 |
江苏豪森药业股份有限公司 |
一种抗癌化合物的新晶型及其制备方法和用途
|
|
CN107108581B
(zh)
|
2014-08-21 |
2020-06-23 |
百时美施贵宝公司 |
作为强效rock抑制剂的回接苯甲酰胺衍生物
|
|
EP3187491A4
(en)
|
2014-08-28 |
2018-08-01 |
Eisai R&D Management Co., Ltd. |
High-purity quinoline derivative and method for manufacturing same
|
|
BR112017007708B8
(pt)
|
2014-10-13 |
2023-10-24 |
Atrin Pharmaceuticals LLC |
Composto macrocíclico e composição farmacêutica
|
|
GB2535427A
(en)
|
2014-11-07 |
2016-08-24 |
Nicoventures Holdings Ltd |
Solution
|
|
AR102537A1
(es)
*
|
2014-11-05 |
2017-03-08 |
Flexus Biosciences Inc |
Agentes inmunomoduladores
|
|
EP3215150B1
(en)
|
2014-11-07 |
2022-07-20 |
The Regents of The University of Michigan |
Inhibitors of myocardin-related transcription factor and serum response factor (mrtf/srf)-mediated gene transcription and methods for use of the same
|
|
CN107207471B
(zh)
|
2014-12-02 |
2020-06-26 |
伊尼塔公司 |
用于治疗神经母细胞瘤的组合
|
|
EP3246046A4
(en)
|
2015-01-13 |
2018-12-05 |
Kyoto University |
Agent for preventing and/or treating amyotrophic lateral sclerosis
|
|
US20180028662A1
(en)
|
2015-02-25 |
2018-02-01 |
Eisai R&D Management Co., Ltd. |
Method for Suppressing Bitterness of Quinoline Derivative
|
|
MA41598A
(fr)
*
|
2015-02-25 |
2018-01-02 |
Constellation Pharmaceuticals Inc |
Composés thérapeutiques de pyridazine et leurs utilisations
|
|
KR20240064733A
(ko)
|
2015-03-04 |
2024-05-13 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
|
CN107709314A
(zh)
|
2015-06-11 |
2018-02-16 |
巴斯利尔药物国际股份公司 |
外排泵抑制剂及其治疗性用途
|
|
CA2988707C
(en)
|
2015-06-16 |
2023-10-10 |
Eisai R&D Management Co., Ltd. |
Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
|
|
US10405627B2
(en)
*
|
2015-07-14 |
2019-09-10 |
Michael Charles Boland, III |
Luggage with fold out table
|
|
CN108135894B
(zh)
|
2015-08-20 |
2021-02-19 |
卫材R&D管理有限公司 |
肿瘤治疗剂
|
|
US11464774B2
(en)
|
2015-09-30 |
2022-10-11 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
|
|
GB2542838B
(en)
|
2015-10-01 |
2022-01-12 |
Nicoventures Trading Ltd |
Aerosol provision system
|
|
BR112018012255A2
(pt)
|
2015-12-18 |
2018-12-04 |
Ignyta Inc |
método para tratar câncer
|
|
US11129808B2
(en)
|
2016-03-15 |
2021-09-28 |
University Of South Florida |
PKC-delta-I inhibitor formulations and uses thereof
|
|
WO2017180723A1
(en)
|
2016-04-12 |
2017-10-19 |
Atrin Pharmaceuticals LLC |
Ataxia telengiectasia and rad3-related (atr) inhibitors and methods of their use
|
|
US10779980B2
(en)
|
2016-04-27 |
2020-09-22 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
|
US10933068B2
(en)
*
|
2016-05-26 |
2021-03-02 |
Sonic Master Limited |
Modulators of DUX4 for regulation of muscle function
|
|
TWI646094B
(zh)
*
|
2016-06-01 |
2019-01-01 |
大陸商貝達藥業股份有限公司 |
Crystal form of inhibitory protein kinase active compound and application thereof
|
|
EP3558992A4
(en)
*
|
2016-12-15 |
2020-12-02 |
ONO Pharmaceutical Co., Ltd. |
TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK)
|
|
CN106866627B
(zh)
*
|
2017-01-24 |
2021-09-14 |
南方医科大学 |
3-(1-(氨基吡啶氧基)乙基)苯甲酰胺衍生物及其合成方法和应用
|
|
CN110072528B
(zh)
|
2017-02-08 |
2022-04-26 |
卫材R&D管理有限公司 |
治疗肿瘤的药物组合物
|
|
WO2018212202A1
(en)
|
2017-05-16 |
2018-11-22 |
Eisai R&D Management Co., Ltd. |
Treatment of hepatocellular carcinoma
|
|
JP2020527588A
(ja)
|
2017-07-18 |
2020-09-10 |
ニューベイション・バイオ・インコーポレイテッドNuvation Bio Inc. |
アデノシンアンタゴニストとしてのヘテロ環式化合物
|
|
CA3070073A1
(en)
|
2017-07-18 |
2019-01-24 |
Nuvation Bio Inc. |
1,8-naphthyridinone compounds and uses thereof
|
|
WO2019018570A1
(en)
|
2017-07-19 |
2019-01-24 |
Ignyta, Inc. |
PHARMACEUTICAL COMPOSITIONS CONTAINING ENTRECTINIB
|
|
WO2019077506A1
(en)
|
2017-10-17 |
2019-04-25 |
Ignyta, Inc. |
PHARMACEUTICAL COMPOSITIONS AND SOLID GALENIC FORMS
|
|
CN107794282B
(zh)
*
|
2017-11-20 |
2020-12-25 |
浙江工业大学 |
一种克唑替尼手性中间体的制备方法及菌株
|
|
WO2019154665A1
(en)
*
|
2018-02-07 |
2019-08-15 |
Basf Se |
New pyridine carboxamides
|
|
DK3749646T3
(da)
*
|
2018-03-15 |
2022-05-02 |
Fujian Haixi Pharmaceuticals Co Ltd |
Heteroaryl-forbindelser som kinase-inhibitor
|
|
CN110372664A
(zh)
*
|
2018-04-13 |
2019-10-25 |
华东理工大学 |
选择性jak2抑制剂及其应用
|
|
WO2019206049A1
(en)
*
|
2018-04-25 |
2019-10-31 |
Zhuhai Yufan Biotechnologies Co., Ltd |
Hpk1 inhibitors, preparation method and application thereof
|
|
CN110396087A
(zh)
*
|
2018-04-25 |
2019-11-01 |
珠海宇繁生物科技有限责任公司 |
Hpk1激酶抑制剂、制备方法及其应用
|
|
CN108947895B
(zh)
*
|
2018-08-22 |
2021-09-24 |
肇庆中彩机电技术研发有限公司 |
一种抗癌活性的化合物
|
|
WO2020150674A1
(en)
*
|
2019-01-18 |
2020-07-23 |
Nuvation Bio Inc. |
Heterocyclic compounds as adenosine antagonists
|
|
US11254670B2
(en)
|
2019-01-18 |
2022-02-22 |
Nuvation Bio Inc. |
1,8-naphthyridinone compounds and uses thereof
|
|
CA3126704A1
(en)
*
|
2019-01-18 |
2020-07-23 |
Nuvation Bio Inc. |
Heterocyclic compounds as adenosine antagonists
|
|
WO2020191208A1
(en)
|
2019-03-20 |
2020-09-24 |
Emory University |
Prostaglandin receptor ep2 antagonists, derivatives, and uses related thereto
|
|
KR20220004206A
(ko)
|
2019-05-14 |
2022-01-11 |
텔리진 엘티디. |
키네이스 억제제로 유용한 치환된 거대고리화합물
|
|
CA3149796A1
(en)
|
2019-08-02 |
2021-02-11 |
Onehealthcompany, Inc. |
Anti-cancer agents for the treatment of canine cancers
|
|
KR102426921B1
(ko)
*
|
2019-09-24 |
2022-07-29 |
주식회사 이노보테라퓨틱스 |
헤테로아릴아미도피리딘올 유도체 및 이를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 약학적 조성물
|
|
CN112552293A
(zh)
*
|
2019-09-25 |
2021-03-26 |
珠海宇繁生物科技有限责任公司 |
一种protac小分子化合物及其应用
|
|
KR102344185B1
(ko)
*
|
2020-02-26 |
2021-12-27 |
계명대학교 산학협력단 |
신규한 Pim 키나아제 억제제 및 이의 용도
|
|
WO2021196655A1
(zh)
*
|
2020-04-03 |
2021-10-07 |
中国药科大学 |
含苯并咪唑结构的化合物及其制备方法与用途
|
|
CN113493437B
(zh)
*
|
2020-04-03 |
2022-07-26 |
中国药科大学 |
含苯并咪唑结构的化合物及其制备方法和用途
|
|
WO2023086671A1
(en)
*
|
2021-11-15 |
2023-05-19 |
The Broad Institute, Inc. |
Compounds, compositions, and methods for inducing antimicrobial intracellular activity and for preventing and treating microbial infections
|
|
CN119451699A
(zh)
|
2022-07-04 |
2025-02-14 |
中外制药株式会社 |
并用药物
|
|
TW202425998A
(zh)
|
2022-08-30 |
2024-07-01 |
日商中外製藥股份有限公司 |
併用醫藥
|
|
CN120166992A
(zh)
*
|
2022-10-31 |
2025-06-17 |
上海皓元医药股份有限公司 |
一种((2R,7aS)-2-氟六氢-1H-吡咯嗪-7a-基)甲醇的制备方法
|
|
WO2026071043A1
(en)
*
|
2024-09-30 |
2026-04-02 |
Alivexis, Inc. |
Kit inhibitors, compounds, pharmaceutical compositions, and methods of use thereof
|