JP2006515836A5 - - Google Patents
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- Publication number
- JP2006515836A5 JP2006515836A5 JP2004553058A JP2004553058A JP2006515836A5 JP 2006515836 A5 JP2006515836 A5 JP 2006515836A5 JP 2004553058 A JP2004553058 A JP 2004553058A JP 2004553058 A JP2004553058 A JP 2004553058A JP 2006515836 A5 JP2006515836 A5 JP 2006515836A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- compound
- negatively charged
- bacteriochlorophyll
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 27
- DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 229910052763 palladium Inorganic materials 0.000 claims 13
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 12
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 12
- 150000001768 cations Chemical class 0.000 claims 10
- 238000002428 photodynamic therapy Methods 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 9
- -1 K + Chemical class 0.000 claims 7
- 230000002378 acidificating effect Effects 0.000 claims 7
- KZNICNPSHKQLFF-UHFFFAOYSA-N dihydromaleimide Natural products O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 claims 7
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 229910052751 metal Inorganic materials 0.000 claims 4
- 239000002184 metal Substances 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229960002317 succinimide Drugs 0.000 claims 4
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 239000011572 manganese Substances 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 claims 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 3
- 239000011701 zinc Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 244000052616 bacterial pathogen Species 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 229910052802 copper Inorganic materials 0.000 claims 2
- 239000010949 copper Substances 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 229910052748 manganese Inorganic materials 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical compound NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 claims 2
- 239000003504 photosensitizing agent Substances 0.000 claims 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 2
- 241001515965 unidentified phage Species 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000004036 bacteriochlorins Chemical class 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical compound C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 claims 1
- 229910052804 chromium Inorganic materials 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229940027941 immunoglobulin g Drugs 0.000 claims 1
- 239000000543 intermediate Substances 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- MMIPFLVOWGHZQD-UHFFFAOYSA-N manganese(3+) Chemical compound [Mn+3] MMIPFLVOWGHZQD-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 1
- 108010013121 palladium-bacteriopheophorbide Proteins 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 229960003080 taurine Drugs 0.000 claims 1
- 229910052718 tin Inorganic materials 0.000 claims 1
- 239000011135 tin Substances 0.000 claims 1
- UHZLSDKSJFAJNE-UHFFFAOYSA-N tripotassium 3-sulfopropylazanide Chemical compound [K+].[K+].[K+].S(=O)(=O)(O)CCC[NH-].S(=O)(=O)(O)CCC[NH-].S(=O)(=O)(O)CCC[NH-] UHZLSDKSJFAJNE-UHFFFAOYSA-N 0.000 claims 1
- RLOMNZBJVKULKU-UHFFFAOYSA-N tripotassium bis(3-sulfopropyl)azanide Chemical compound C(C[N-]CCCS(=O)(=O)O)CS(=O)(=O)O.C(C[N-]CCCS(=O)(=O)O)CS(=O)(=O)O.C(C[N-]CCCS(=O)(=O)O)CS(=O)(=O)O.[K+].[K+].[K+] RLOMNZBJVKULKU-UHFFFAOYSA-N 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL152900 | 2002-11-17 | ||
| IL15290002A IL152900A0 (en) | 2002-11-17 | 2002-11-17 | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
| PCT/IL2003/000973 WO2004045492A2 (en) | 2002-11-17 | 2003-11-17 | Water-soluble anionic bacteriochlorophyll derivatives and their uses |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011096876A Division JP5555659B2 (ja) | 2002-11-17 | 2011-04-25 | 水溶性陰イオン性バクテリオクロロフィル誘導体及びそれらの使用 |
| JP2011096875A Division JP5566945B2 (ja) | 2002-11-17 | 2011-04-25 | 水溶性陰イオン性バクテリオクロロフィル誘導体及びそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515836A JP2006515836A (ja) | 2006-06-08 |
| JP2006515836A5 true JP2006515836A5 (enExample) | 2006-12-07 |
| JP4922559B2 JP4922559B2 (ja) | 2012-04-25 |
Family
ID=30011928
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004553058A Expired - Lifetime JP4922559B2 (ja) | 2002-11-17 | 2003-11-17 | 水溶性陰イオン性バクテリオクロロフィル誘導体及びそれらの使用 |
| JP2011096876A Expired - Fee Related JP5555659B2 (ja) | 2002-11-17 | 2011-04-25 | 水溶性陰イオン性バクテリオクロロフィル誘導体及びそれらの使用 |
| JP2011096875A Expired - Fee Related JP5566945B2 (ja) | 2002-11-17 | 2011-04-25 | 水溶性陰イオン性バクテリオクロロフィル誘導体及びそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011096876A Expired - Fee Related JP5555659B2 (ja) | 2002-11-17 | 2011-04-25 | 水溶性陰イオン性バクテリオクロロフィル誘導体及びそれらの使用 |
| JP2011096875A Expired - Fee Related JP5566945B2 (ja) | 2002-11-17 | 2011-04-25 | 水溶性陰イオン性バクテリオクロロフィル誘導体及びそれらの使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US7947672B2 (enExample) |
| EP (2) | EP1567147B1 (enExample) |
| JP (3) | JP4922559B2 (enExample) |
| CN (2) | CN102002048B (enExample) |
| AU (1) | AU2003282354C1 (enExample) |
| BE (1) | BE2018C018I2 (enExample) |
| BR (1) | BRPI0316319B8 (enExample) |
| CA (1) | CA2506296C (enExample) |
| CY (2) | CY1115458T1 (enExample) |
| DK (1) | DK1567147T3 (enExample) |
| ES (1) | ES2489516T3 (enExample) |
| FR (1) | FR18C0002I2 (enExample) |
| HU (1) | HUS1800020I1 (enExample) |
| IL (2) | IL152900A0 (enExample) |
| LU (1) | LUC00073I2 (enExample) |
| MX (1) | MXPA05005262A (enExample) |
| NL (1) | NL300934I2 (enExample) |
| NO (2) | NO334978B1 (enExample) |
| NZ (1) | NZ540790A (enExample) |
| PL (1) | PL216661B1 (enExample) |
| PT (1) | PT1567147E (enExample) |
| RU (1) | RU2353624C2 (enExample) |
| WO (1) | WO2004045492A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL152900A0 (en) * | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
| EP2322173B1 (en) * | 2004-06-07 | 2016-08-10 | Yeda Research And Development Co., Ltd. | Cationic bacteriochlorophyll derivatives and uses thereof |
| US9957293B2 (en) * | 2006-08-23 | 2018-05-01 | Yeda Research And Development Company Ltd. | Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses |
| RU2518296C2 (ru) | 2008-02-27 | 2014-06-10 | Йеда Рисерч Энд Дивелопмент Ко. Лтд | Конъюгаты rgd-(бактерио)хлорофилл для фотодинамической терапии и визуализации некротических опухолей |
| EP2425873A1 (fr) * | 2010-09-07 | 2012-03-07 | Steba Maor SA | Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement |
| CN105431199B (zh) | 2011-03-11 | 2018-12-18 | 斯特巴马奥股份有限公司 | 局部光动力疗法 |
| RU2632439C2 (ru) | 2011-08-23 | 2017-10-04 | Йеда Рисерч Энд Дивелопмент Ко., Лтд. | Фотосенсибилизаторы на основе (бактерио)хлорофилла для лечения глазных заболеваний и расстройств |
| CA2905109C (en) | 2013-03-11 | 2021-03-16 | Tookad Ip Sarl | Method for producing bacteriochlorophyll a |
| WO2014145428A2 (en) | 2013-03-15 | 2014-09-18 | Mcfarland Sherri Ann | Metal-based coordination complexes as photodynamic compounds and their use |
| AU2017250732B2 (en) * | 2016-04-10 | 2022-11-10 | Memorial Sloan-Kettering Cancer Center | Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative |
| CN107987081B (zh) * | 2016-10-26 | 2019-12-06 | 刘辉 | 一种二氢卟吩e6衍生物及其药学上可接受的盐、其制备方法和应用 |
| RS65011B1 (sr) * | 2016-12-22 | 2024-01-31 | Daiichi Sankyo Co Ltd | Peptid za lečenje makularne degeneracije povezane sa starenjem |
| US10933134B2 (en) | 2017-03-16 | 2021-03-02 | Memorial Sloan Kettering Cancer Center | Combination therapies for treatment of cancer |
| WO2019116376A1 (en) * | 2017-12-17 | 2019-06-20 | Yeda Research And Development Co. Ltd. | Cop9 signalosome (csn) complex modulators and uses thereof |
| CN111848656B (zh) * | 2020-06-24 | 2023-03-14 | 天津大学 | 离子修饰的原卟啉镓化合物及其制备方法和应用 |
| JP7750527B2 (ja) * | 2020-07-29 | 2025-10-07 | 国立大学法人北陸先端科学技術大学院大学 | がんの治療薬又は診断薬 |
| CN115843960A (zh) * | 2022-11-03 | 2023-03-28 | 中国农业科学院农产品加工研究所 | 一种提高叶绿素稳定性的方法 |
| IL311461A (en) * | 2024-03-13 | 2025-10-01 | Impact Biotech Ltd | Process for preparing bacteriophophorbid derivatives and their alkali metal salts |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4512762A (en) * | 1982-11-23 | 1985-04-23 | The Beth Israel Hospital Association | Method of treatment of atherosclerosis and a balloon catheter for same |
| US4675338A (en) * | 1984-07-18 | 1987-06-23 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| US4693885A (en) * | 1984-07-18 | 1987-09-15 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| US4656186A (en) * | 1985-04-30 | 1987-04-07 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| US4977177A (en) * | 1985-04-30 | 1990-12-11 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents |
| JPS63196586A (ja) * | 1987-02-12 | 1988-08-15 | Toyo Hatsuka Kogyo Kk | バクテリオフエオホ−バイド誘導体 |
| DE3853995T2 (de) * | 1987-04-17 | 1995-11-23 | David H Dolphin | Porphyrine, verfahren zu deren herstellung und verwendungen. |
| US5004811A (en) * | 1987-12-24 | 1991-04-02 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole aminocarboxylic acids |
| US5171741A (en) | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
| DE4121876A1 (de) * | 1991-07-02 | 1993-01-14 | Scheer Hugo | Modifizierte bakteriochlorophylle, verfahren zu ihrer herstellung und ihre verwendung |
| JP3191223B2 (ja) * | 1991-10-04 | 2001-07-23 | 株式会社光ケミカル研究所 | ポルフィリン誘導体とその用途 |
| JPH08506566A (ja) | 1992-06-19 | 1996-07-16 | ザ・ユニバーシティ・オブ・トリド | ポルフィリン系イミンの製造方法及び使用方法 |
| IL102645A (en) * | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| US6147195A (en) * | 1993-07-26 | 2000-11-14 | Yeda Research And Development Co., Ltd. | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| FR2712493B1 (fr) * | 1993-11-16 | 1996-01-19 | Centre Nat Rech Scient | Utilisation de photosensibilisateurs dérivés du noyau phorbine pour la décontamination du sang infecté par des parasites et/ou des virus. |
| JPH09110872A (ja) | 1995-10-23 | 1997-04-28 | Eiken Chem Co Ltd | ヨードポルフィリン誘導体 |
| IL116126A0 (en) * | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
| GB9524553D0 (en) * | 1995-11-30 | 1996-01-31 | Britton Charles J | Plastic lever lid tins |
| US5770730A (en) * | 1996-03-08 | 1998-06-23 | Health Research, Inc. | Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer |
| ES2202640T3 (es) * | 1996-10-01 | 2004-04-01 | Wyeth Lederle Japan Ltd. | Derivados de acido iminoclorina aspartico. |
| IL129929A0 (en) * | 1996-12-17 | 2000-02-29 | Du Pont | Polymerization of ethylene with specific iron or cobalt complexes novel pyridinebis (imines) and novel complexes of pyridinebis(imines) with iron and cobalt |
| RU2144538C1 (ru) * | 1998-01-22 | 2000-01-20 | Закрытое акционерное общество "Вета" | Способ получения водорастворимых хлоринов |
| PL201172B1 (pl) * | 1998-12-09 | 2009-03-31 | Yeda Res & Dev | Pd-Bakteriofeoforbid, sposób jego wytwarzania, kompozycja farmaceutyczna zawierająca go i jego zastosowanie |
| IL133253A0 (en) * | 1999-12-01 | 2001-04-30 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them |
| JP4277159B2 (ja) | 2000-06-02 | 2009-06-10 | 独立行政法人科学技術振興機構 | 新規なテトラピロリル置換ポルフィリン及びその製法 |
| US6624187B1 (en) * | 2000-06-12 | 2003-09-23 | Health Research, Inc. | Long wave length absorbing bacteriochlorin alkyl ether analogs |
| WO2002013820A1 (en) | 2000-08-11 | 2002-02-21 | Ceramoptec Industries, Inc. | Photosensitizing ointment |
| ATE336497T1 (de) * | 2001-06-01 | 2006-09-15 | Ceramoptec Gmbh | Wasserlösliche porphyrinderivate für die photodynamische therapie, deren verwendung und herstellung |
| IL152900A0 (en) * | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
-
2002
- 2002-11-17 IL IL15290002A patent/IL152900A0/xx unknown
-
2003
- 2003-11-17 AU AU2003282354A patent/AU2003282354C1/en not_active Expired
- 2003-11-17 CN CN2010105268579A patent/CN102002048B/zh not_active Expired - Lifetime
- 2003-11-17 US US10/534,692 patent/US7947672B2/en active Active
- 2003-11-17 BR BRPI0316319A patent/BRPI0316319B8/pt active IP Right Grant
- 2003-11-17 CA CA2506296A patent/CA2506296C/en not_active Expired - Lifetime
- 2003-11-17 EP EP03773967.9A patent/EP1567147B1/en not_active Expired - Lifetime
- 2003-11-17 ES ES03773967.9T patent/ES2489516T3/es not_active Expired - Lifetime
- 2003-11-17 PL PL376734A patent/PL216661B1/pl unknown
- 2003-11-17 PT PT37739679T patent/PT1567147E/pt unknown
- 2003-11-17 RU RU2005118771/13A patent/RU2353624C2/ru active
- 2003-11-17 DK DK03773967.9T patent/DK1567147T3/da active
- 2003-11-17 CN CN2003801089065A patent/CN1741801B/zh not_active Expired - Lifetime
- 2003-11-17 JP JP2004553058A patent/JP4922559B2/ja not_active Expired - Lifetime
- 2003-11-17 NZ NZ540790A patent/NZ540790A/en not_active IP Right Cessation
- 2003-11-17 MX MXPA05005262A patent/MXPA05005262A/es active IP Right Grant
- 2003-11-17 EP EP20120161201 patent/EP2522349A1/en not_active Withdrawn
- 2003-11-17 WO PCT/IL2003/000973 patent/WO2004045492A2/en not_active Ceased
-
2005
- 2005-05-09 IL IL168480A patent/IL168480A/en active IP Right Grant
- 2005-06-15 NO NO20052925A patent/NO334978B1/no not_active IP Right Cessation
-
2010
- 2010-11-09 US US12/942,938 patent/US8461142B2/en not_active Expired - Fee Related
-
2011
- 2011-04-25 JP JP2011096876A patent/JP5555659B2/ja not_active Expired - Fee Related
- 2011-04-25 JP JP2011096875A patent/JP5566945B2/ja not_active Expired - Fee Related
-
2013
- 2013-05-08 US US13/890,126 patent/US20130345417A1/en not_active Abandoned
-
2014
- 2014-08-07 CY CY20141100619T patent/CY1115458T1/el unknown
- 2014-10-01 US US14/504,347 patent/US20150238773A1/en not_active Abandoned
-
2017
- 2017-02-06 US US15/425,473 patent/US20170143988A1/en not_active Abandoned
-
2018
- 2018-04-10 NO NO2018012C patent/NO2018012I2/no unknown
- 2018-04-11 LU LU00073C patent/LUC00073I2/fr unknown
- 2018-04-17 FR FR18C0002C patent/FR18C0002I2/fr active Active
- 2018-04-25 HU HUS1800020C patent/HUS1800020I1/hu unknown
- 2018-04-26 NL NL300934C patent/NL300934I2/nl unknown
- 2018-05-02 BE BE2018C018C patent/BE2018C018I2/nl unknown
- 2018-05-04 CY CY2018012C patent/CY2018012I2/el unknown
-
2019
- 2019-04-29 US US16/397,515 patent/US20200094069A1/en not_active Abandoned
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