CY1115458T1 - Υδατοδιαλυτα ανιοντικα παραγωγα βακτηριοχλωροφυλλης και η χρηση αυτων - Google Patents
Υδατοδιαλυτα ανιοντικα παραγωγα βακτηριοχλωροφυλλης και η χρηση αυτωνInfo
- Publication number
- CY1115458T1 CY1115458T1 CY20141100619T CY141100619T CY1115458T1 CY 1115458 T1 CY1115458 T1 CY 1115458T1 CY 20141100619 T CY20141100619 T CY 20141100619T CY 141100619 T CY141100619 T CY 141100619T CY 1115458 T1 CY1115458 T1 CY 1115458T1
- Authority
- CY
- Cyprus
- Prior art keywords
- chlophyline
- bacteriol
- water
- soluble anionic
- anionic derivatives
- Prior art date
Links
- 125000000129 anionic group Chemical group 0.000 title abstract 2
- -1 COSH Chemical group 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0036—Porphyrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/006—Palladium compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/006—Palladium compounds
- C07F15/0066—Palladium compounds without a metal-carbon linkage
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/04—Nickel compounds
- C07F15/045—Nickel compounds without a metal-carbon linkage
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/06—Zinc compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Η εφεύρεση παρέχει ανιοντικά υδατοδιαλυτά παράγωγα τετρακυκλικής και πεντακυκλικής βακτηριοχλωροφύλλης (Bchls), τα οποία περιέχουν τουλάχιστον μία, κατά προτίμηση δύο ή τρεις αρνητικά φορτισμένες ομάδες και/ή όξινες ομάδες, οι οποίες έχουν μετατραπεί προς αρνητικά φορτισμένες ομάδες σε φυσιολογική τιμή pΗ, κατά προτίμηση Bchls, τα οποία έχουν μία ομάδα COO-, COS-, SO3-, ΡO32-, COOH, COSH, SO3H και/ή ΡO3Η2 δεσμευμένη μέσω ενός εστερικού ή αμιδικού δεσμού προς μία ή περισσότερες από τις θέσεις 173, 133 και 32 του τετρακυκλικού ή πεντακυκλικού μορίου Bchl, για φωτοδυναμική θεραπεία και διάγνωση.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL15290002A IL152900A0 (en) | 2002-11-17 | 2002-11-17 | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
EP03773967.9A EP1567147B1 (en) | 2002-11-17 | 2003-11-17 | Water-soluble anionic bacteriochlorophyll derivatives and their uses |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115458T1 true CY1115458T1 (el) | 2017-01-04 |
Family
ID=30011928
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100619T CY1115458T1 (el) | 2002-11-17 | 2014-08-07 | Υδατοδιαλυτα ανιοντικα παραγωγα βακτηριοχλωροφυλλης και η χρηση αυτων |
CY2018012C CY2018012I1 (el) | 2002-11-17 | 2018-05-04 | Υδατοδιαλυτα ανιοντικα παραγωγα βακτηριοχλωροφυλλης και η χρηση αυτων |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY2018012C CY2018012I1 (el) | 2002-11-17 | 2018-05-04 | Υδατοδιαλυτα ανιοντικα παραγωγα βακτηριοχλωροφυλλης και η χρηση αυτων |
Country Status (24)
Country | Link |
---|---|
US (6) | US7947672B2 (el) |
EP (2) | EP1567147B1 (el) |
JP (3) | JP4922559B2 (el) |
CN (2) | CN102002048B (el) |
AU (1) | AU2003282354C1 (el) |
BE (1) | BE2018C018I2 (el) |
BR (1) | BRPI0316319B8 (el) |
CA (1) | CA2506296C (el) |
CY (2) | CY1115458T1 (el) |
DK (1) | DK1567147T3 (el) |
ES (1) | ES2489516T3 (el) |
FR (1) | FR18C0002I2 (el) |
HK (1) | HK1081858A1 (el) |
HU (1) | HUS1800020I1 (el) |
IL (2) | IL152900A0 (el) |
LU (1) | LUC00073I2 (el) |
MX (1) | MXPA05005262A (el) |
NL (1) | NL300934I2 (el) |
NO (2) | NO334978B1 (el) |
NZ (1) | NZ540790A (el) |
PL (1) | PL216661B1 (el) |
PT (1) | PT1567147E (el) |
RU (1) | RU2353624C2 (el) |
WO (1) | WO2004045492A2 (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL152900A0 (en) * | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
CA2569675C (en) | 2004-06-07 | 2015-03-17 | Yeda Research And Development Co. Ltd | Cationic bacteriochlorophyll derivatives and uses thereof |
US9957293B2 (en) * | 2006-08-23 | 2018-05-01 | Yeda Research And Development Company Ltd. | Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses |
MX2010009530A (es) | 2008-02-27 | 2010-11-30 | Yeda Res & Dev | Conjugados de rgd-(bacterio) clorofila para terapia fotodinámica y formación de imágenes de tumores necróticos. |
EP2425873A1 (fr) | 2010-09-07 | 2012-03-07 | Steba Maor SA | Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement |
DK2683441T3 (en) | 2011-03-11 | 2017-01-09 | Steba Maor Sa | PROCESSES FOR PLANNING focal PHOTO DYNAMIC THERAPY |
JP6215203B2 (ja) | 2011-08-23 | 2017-10-18 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッドYeda Research And Development Co. Ltd | 眼疾患および障害の治療用の(バクテリオ)クロロフィル光増感剤 |
MX360151B (es) | 2013-03-11 | 2018-10-24 | Tookad Ip Sarl | Metodo para producir bacterioclorofila a. |
US10766915B2 (en) | 2013-03-15 | 2020-09-08 | Sherri Ann McFARLAND | Metal-based coordination complexes as photodynamic compounds and their use |
JP2019510807A (ja) * | 2016-04-10 | 2019-04-18 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | バクテリオクロロフィル誘導体を含む、がんの治療のための併用療法 |
CN107987081B (zh) * | 2016-10-26 | 2019-12-06 | 刘辉 | 一种二氢卟吩e6衍生物及其药学上可接受的盐、其制备方法和应用 |
CA3047893C (en) * | 2016-12-22 | 2022-11-15 | Daiichi Sankyo Company, Limited | Spink2 peptide for preventing and/or treating age-related macular degeneration |
US10933134B2 (en) | 2017-03-16 | 2021-03-02 | Memorial Sloan Kettering Cancer Center | Combination therapies for treatment of cancer |
EP3723785A1 (en) * | 2017-12-17 | 2020-10-21 | Yeda Research and Development Co. Ltd | Cop9 signalosome (csn) complex modulators and uses thereof |
CN111848656B (zh) * | 2020-06-24 | 2023-03-14 | 天津大学 | 离子修饰的原卟啉镓化合物及其制备方法和应用 |
JPWO2022025043A1 (el) * | 2020-07-29 | 2022-02-03 | ||
CN115843960A (zh) * | 2022-11-03 | 2023-03-28 | 中国农业科学院农产品加工研究所 | 一种提高叶绿素稳定性的方法 |
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US4693885A (en) * | 1984-07-18 | 1987-09-15 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
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JPS63196586A (ja) * | 1987-02-12 | 1988-08-15 | Toyo Hatsuka Kogyo Kk | バクテリオフエオホ−バイド誘導体 |
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US5004811A (en) | 1987-12-24 | 1991-04-02 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole aminocarboxylic acids |
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EP0644759A4 (en) * | 1992-06-19 | 1998-04-01 | Univ Toledo | PRODUCTION AND USE OF PORPHYRIN IMINES. |
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IL116126A0 (en) * | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
GB9524553D0 (en) * | 1995-11-30 | 1996-01-31 | Britton Charles J | Plastic lever lid tins |
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IL129929A0 (en) * | 1996-12-17 | 2000-02-29 | Du Pont | Polymerization of ethylene with specific iron or cobalt complexes novel pyridinebis (imines) and novel complexes of pyridinebis(imines) with iron and cobalt |
PT1137411E (pt) * | 1998-12-09 | 2007-02-28 | Yeda Res & Dev | Processo para inibir respostas ao etileno em plantas |
IL133253A0 (en) * | 1999-12-01 | 2001-04-30 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them |
JP4277159B2 (ja) | 2000-06-02 | 2009-06-10 | 独立行政法人科学技術振興機構 | 新規なテトラピロリル置換ポルフィリン及びその製法 |
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CN100488965C (zh) | 2001-06-01 | 2009-05-20 | 塞拉莫普泰克工业公司 | 用于光动力学治疗的水溶性卟啉衍生物、其用途和制备 |
IL152900A0 (en) * | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
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2002
- 2002-11-17 IL IL15290002A patent/IL152900A0/xx unknown
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2003
- 2003-11-17 PL PL376734A patent/PL216661B1/pl unknown
- 2003-11-17 MX MXPA05005262A patent/MXPA05005262A/es active IP Right Grant
- 2003-11-17 EP EP03773967.9A patent/EP1567147B1/en not_active Expired - Lifetime
- 2003-11-17 PT PT37739679T patent/PT1567147E/pt unknown
- 2003-11-17 CA CA2506296A patent/CA2506296C/en not_active Expired - Lifetime
- 2003-11-17 ES ES03773967.9T patent/ES2489516T3/es not_active Expired - Lifetime
- 2003-11-17 JP JP2004553058A patent/JP4922559B2/ja not_active Expired - Lifetime
- 2003-11-17 EP EP20120161201 patent/EP2522349A1/en not_active Withdrawn
- 2003-11-17 DK DK03773967.9T patent/DK1567147T3/da active
- 2003-11-17 CN CN2010105268579A patent/CN102002048B/zh not_active Expired - Lifetime
- 2003-11-17 CN CN2003801089065A patent/CN1741801B/zh not_active Expired - Lifetime
- 2003-11-17 WO PCT/IL2003/000973 patent/WO2004045492A2/en active Search and Examination
- 2003-11-17 BR BRPI0316319A patent/BRPI0316319B8/pt active IP Right Grant
- 2003-11-17 NZ NZ540790A patent/NZ540790A/en not_active IP Right Cessation
- 2003-11-17 US US10/534,692 patent/US7947672B2/en active Active
- 2003-11-17 RU RU2005118771/13A patent/RU2353624C2/ru active
- 2003-11-17 AU AU2003282354A patent/AU2003282354C1/en not_active Expired
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2005
- 2005-05-09 IL IL168480A patent/IL168480A/en active IP Right Grant
- 2005-06-15 NO NO20052925A patent/NO334978B1/no not_active IP Right Cessation
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2006
- 2006-02-17 HK HK06102165.9A patent/HK1081858A1/xx not_active IP Right Cessation
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2010
- 2010-11-09 US US12/942,938 patent/US8461142B2/en not_active Expired - Lifetime
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2011
- 2011-04-25 JP JP2011096876A patent/JP5555659B2/ja not_active Expired - Fee Related
- 2011-04-25 JP JP2011096875A patent/JP5566945B2/ja not_active Expired - Fee Related
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2013
- 2013-05-08 US US13/890,126 patent/US20130345417A1/en not_active Abandoned
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2014
- 2014-08-07 CY CY20141100619T patent/CY1115458T1/el unknown
- 2014-10-01 US US14/504,347 patent/US20150238773A1/en not_active Abandoned
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2017
- 2017-02-06 US US15/425,473 patent/US20170143988A1/en not_active Abandoned
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2018
- 2018-04-10 NO NO2018012C patent/NO2018012I1/no unknown
- 2018-04-11 LU LU00073C patent/LUC00073I2/fr unknown
- 2018-04-17 FR FR18C0002C patent/FR18C0002I2/fr active Active
- 2018-04-25 HU HUS1800020C patent/HUS1800020I1/hu unknown
- 2018-04-26 NL NL300934C patent/NL300934I2/nl unknown
- 2018-05-02 BE BE2018C018C patent/BE2018C018I2/nl unknown
- 2018-05-04 CY CY2018012C patent/CY2018012I1/el unknown
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2019
- 2019-04-29 US US16/397,515 patent/US20200094069A1/en not_active Abandoned
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