CY1118203T1 - Κατιονika παραγωγα βακτηριοχλωροφυλλης και χρησεις αυτων - Google Patents
Κατιονika παραγωγα βακτηριοχλωροφυλλης και χρησεις αυτωνInfo
- Publication number
- CY1118203T1 CY1118203T1 CY20161101097T CY161101097T CY1118203T1 CY 1118203 T1 CY1118203 T1 CY 1118203T1 CY 20161101097 T CY20161101097 T CY 20161101097T CY 161101097 T CY161101097 T CY 161101097T CY 1118203 T1 CY1118203 T1 CY 1118203T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- groups
- bchls
- converted
- positively charged
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229910052785 arsenic Inorganic materials 0.000 abstract 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 abstract 1
- YRPWLKVCRKAUAO-UHFFFAOYSA-N bismuthonium Chemical compound [BiH4+] YRPWLKVCRKAUAO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 abstract 1
- 125000003010 ionic group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-O oxonium Chemical compound [OH3+] XLYOFNOQVPJJNP-UHFFFAOYSA-O 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 abstract 1
- 238000002428 photodynamic therapy Methods 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
- 229910052711 selenium Inorganic materials 0.000 abstract 1
- 239000011669 selenium Substances 0.000 abstract 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D229/00—Heterocyclic compounds containing rings of less than five members having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Η εφεύρεση παρέχει κατιονικά τετρακυκλικά και πεντακυκλικά παράγωγα βακτηριοχλωροφύλλης (Bchls) που περιέχουν τουλάχιστον μία θετικώς φορτισμένη ομάδα ή/και τουλάχιστον μια βασική ομάδα, η οποία μετατρέπεται προς θετικώς φορτισμένη ομάδα υπό φυσιολογικές συνθήκες, κατά προτίμηση Bchls που έχουν ομάδες ωνίου προερχόμενες από αλειφατική ή ετεροκυκλική ρίζα που περιέχει Ν όπως αμμώνιο, γουανιδίνιο, ιμιδαζόλιο, πυριδίνιο, και τα παρόμοια τους ή ομάδα φωσφονίου, αρσονίου, οξονίου, σουλφονίου, σεληνονίου, τελλουρονίου, στιβονίου, ή βισμουθονίου ή βασική ομάδα η οποία μετατρέπεται προς τέτοιες ομάδες ωνίου υπό φυσιολογικές συνθήκες, οι εν λόγω δε ομάδες είναι δεσμευμένες προς μία ή περισσότερες από τις θέσεις 173, 133 και 32 του Bchl μορίου μέσω εστέρα ή δεσμού αμιδίου. Τα Bchls είναι χρήσιμα για φωτοδυναμική θεραπεία και διάγνωση.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57719604P | 2004-06-07 | 2004-06-07 | |
| EP05749886.7A EP1753457B8 (en) | 2004-06-07 | 2005-06-07 | Cationic bacteriochlorophyll derivatives and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118203T1 true CY1118203T1 (el) | 2017-06-28 |
Family
ID=35044538
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161101099T CY1118194T1 (el) | 2004-06-07 | 2016-10-27 | Κατιονikα παραγωγα βακτηριοχλωροφυλλης και χρησεις αυτων |
| CY20161101097T CY1118203T1 (el) | 2004-06-07 | 2016-10-27 | Κατιονika παραγωγα βακτηριοχλωροφυλλης και χρησεις αυτων |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161101099T CY1118194T1 (el) | 2004-06-07 | 2016-10-27 | Κατιονikα παραγωγα βακτηριοχλωροφυλλης και χρησεις αυτων |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8207154B2 (el) |
| EP (2) | EP1753457B8 (el) |
| JP (1) | JP5372371B2 (el) |
| KR (1) | KR101191700B1 (el) |
| CN (1) | CN1980661B (el) |
| AU (1) | AU2005251556B2 (el) |
| BR (1) | BRPI0511909A (el) |
| CA (1) | CA2569675C (el) |
| CY (2) | CY1118194T1 (el) |
| DK (2) | DK2322173T3 (el) |
| ES (2) | ES2602204T3 (el) |
| HU (2) | HUE031075T2 (el) |
| MX (1) | MXPA06014326A (el) |
| NO (2) | NO339304B1 (el) |
| NZ (1) | NZ551845A (el) |
| PT (2) | PT1753457T (el) |
| RU (1) | RU2397172C2 (el) |
| WO (1) | WO2005120573A2 (el) |
| ZA (1) | ZA200700169B (el) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2008665A1 (fr) * | 2007-06-25 | 2008-12-31 | Steba Biotech N.V. | Formulation injectable pour thérapie photodynamique |
| WO2009107139A1 (en) | 2008-02-27 | 2009-09-03 | Yeda Research And Development Co. Ltd | Rgd-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors |
| CA2846011C (en) | 2011-08-23 | 2019-10-15 | Yeda Research And Development Co.Ltd. | (bacterio)chlorophyll photosensitizers for treatment of eye diseases and disorders |
| PL2971026T3 (pl) | 2013-03-11 | 2021-06-14 | Tookad Ip Sarl | Sposób wytwarzania bakteriochlorofilu a |
| RU2548675C9 (ru) * | 2013-05-29 | 2015-11-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В. Ломоносова) | Аминоамиды в ряду бактериохлорофилла a, обладающие фотодинамической активностью, и способ их получения |
| JP6218073B2 (ja) * | 2013-11-26 | 2017-10-25 | 国立大学法人群馬大学 | 細胞・組織内酸素濃度測定のための高感度近赤外りん光イリジウム錯体 |
| RU2549953C2 (ru) * | 2013-12-25 | 2015-05-10 | Федеральное государственное унитарное предприятие Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Фотосенсибилизатор для фотодинамической терапии |
| RU2610566C1 (ru) * | 2015-09-17 | 2017-02-13 | Сергей Сергеевич Брусов | Способ фотодинамической терапии локальных очагов инфекции |
| CN105424857A (zh) * | 2015-12-01 | 2016-03-23 | 浙江汇能生物股份有限公司 | 一种二甲基半胱胺盐酸盐的高效液相色谱分析方法 |
| US10836774B2 (en) | 2016-11-30 | 2020-11-17 | North Carolina State University | Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds |
| WO2022115443A1 (en) * | 2020-11-24 | 2022-06-02 | The Regents Of The University Of California | Mitochondria targeting quinolinium-drug conjugates and their self-assembling nanoformulations for cancer therapy |
| CN115093422B (zh) * | 2022-06-15 | 2023-06-20 | 西北工业大学 | 一种基于代谢标记策略的新型光敏剂及其制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3050296A (en) * | 1960-12-19 | 1962-08-21 | Trimborn Hans | Transport roller for industrial furnaces |
| US3203888A (en) * | 1961-04-24 | 1965-08-31 | Exxon Research Engineering Co | Treating athabaska sands utilizing a flotation gas |
| DE2018970A1 (de) | 1970-04-21 | 1971-11-11 | Badische Anilin- & Soda Fabrik AG, 6700 Ludwigshafen | Verfahren zur Herstellung von beta-Aminoäthylsulfoniumverbindungen |
| US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
| US5744598A (en) * | 1992-06-19 | 1998-04-28 | University Of Toledo | Imines of porphyrins, of porphyrin derivatives, and of related compounds, and pharmaceutical compositions containing such imines |
| IL102645A (en) | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| US6147195A (en) | 1993-07-26 | 2000-11-14 | Yeda Research And Development Co., Ltd. | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| IL116126A0 (en) | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
| US5770730A (en) | 1996-03-08 | 1998-06-23 | Health Research, Inc. | Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer |
| HU228208B1 (en) | 1998-12-09 | 2013-01-28 | Yeda Res & Dev | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
| IL133253A0 (en) * | 1999-12-01 | 2001-04-30 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them |
| US6573258B2 (en) | 2000-09-27 | 2003-06-03 | Frontier Scientific, Inc. | Photodynamic porphyrin antimicrobial agents |
| AU2002312154B2 (en) * | 2001-06-01 | 2008-05-15 | Biolitec Pharma Marketing Ltd | Water-soluble porphyrin derivatives for photodynamic therapy, their use and manufacture |
| US20030203888A1 (en) * | 2001-06-06 | 2003-10-30 | Boyle Ross William | Chromophores |
| AU2002336637A1 (en) | 2001-10-03 | 2003-04-14 | Miravant Pharmaceuticals, Inc. | Chlorin photosensitizing agents for use in photodynamic therapy |
| CA2462508A1 (en) | 2001-10-03 | 2003-04-10 | Miravant Pharmaceuticals, Inc. | Photosensitizing carbamate derivatives |
| DE10154436A1 (de) | 2001-11-07 | 2003-05-15 | Rodotech Gmbh | pyro-Bakteriopheophorbidderivate |
| GB0130778D0 (en) * | 2001-12-21 | 2002-02-06 | Catalyst Biomedica Ltd | Novel compounds |
| BR0304716A (pt) | 2002-05-08 | 2004-07-13 | Yeda Res & Dev | Método para formação de imagens de mri-bold on line, sensibilizada |
| WO2004002476A2 (en) * | 2002-06-27 | 2004-01-08 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
| IL152900A0 (en) | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
-
2005
- 2005-06-07 PT PT57498867T patent/PT1753457T/pt unknown
- 2005-06-07 BR BRPI0511909-0A patent/BRPI0511909A/pt not_active IP Right Cessation
- 2005-06-07 AU AU2005251556A patent/AU2005251556B2/en not_active Ceased
- 2005-06-07 NZ NZ551845A patent/NZ551845A/en not_active IP Right Cessation
- 2005-06-07 CA CA2569675A patent/CA2569675C/en not_active Expired - Fee Related
- 2005-06-07 KR KR1020067025726A patent/KR101191700B1/ko active IP Right Grant
- 2005-06-07 MX MXPA06014326A patent/MXPA06014326A/es active IP Right Grant
- 2005-06-07 PT PT100129279T patent/PT2322173T/pt unknown
- 2005-06-07 EP EP05749886.7A patent/EP1753457B8/en active Active
- 2005-06-07 HU HUE10012927A patent/HUE031075T2/en unknown
- 2005-06-07 US US11/628,719 patent/US8207154B2/en active Active
- 2005-06-07 ES ES05749886.7T patent/ES2602204T3/es active Active
- 2005-06-07 CN CN2005800185365A patent/CN1980661B/zh active Active
- 2005-06-07 DK DK10012927.9T patent/DK2322173T3/en active
- 2005-06-07 ES ES10012927.9T patent/ES2602460T3/es active Active
- 2005-06-07 JP JP2007526692A patent/JP5372371B2/ja active Active
- 2005-06-07 RU RU2006146677/04A patent/RU2397172C2/ru not_active IP Right Cessation
- 2005-06-07 WO PCT/IL2005/000602 patent/WO2005120573A2/en active Application Filing
- 2005-06-07 DK DK05749886.7T patent/DK1753457T3/en active
- 2005-06-07 EP EP10012927.9A patent/EP2322173B1/en active Active
- 2005-06-07 ZA ZA200700169A patent/ZA200700169B/en unknown
- 2005-06-07 HU HUE05749886A patent/HUE030586T2/en unknown
-
2007
- 2007-01-05 NO NO20070083A patent/NO339304B1/no not_active IP Right Cessation
-
2016
- 2016-09-19 NO NO20161485A patent/NO20161485A1/no not_active Application Discontinuation
- 2016-10-27 CY CY20161101099T patent/CY1118194T1/el unknown
- 2016-10-27 CY CY20161101097T patent/CY1118203T1/el unknown
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