CY1111316T1 - Νεα παραγωγα 5-υποκατεστημενο 7-αμινο-[1,3]θειαζολο[4,5-d] πυριμιδινης - Google Patents

Νεα παραγωγα 5-υποκατεστημενο 7-αμινο-[1,3]θειαζολο[4,5-d] πυριμιδινης

Info

Publication number
CY1111316T1
CY1111316T1 CY20111100040T CY111100040T CY1111316T1 CY 1111316 T1 CY1111316 T1 CY 1111316T1 CY 20111100040 T CY20111100040 T CY 20111100040T CY 111100040 T CY111100040 T CY 111100040T CY 1111316 T1 CY1111316 T1 CY 1111316T1
Authority
CY
Cyprus
Prior art keywords
rheumatoid arthritis
thiazolo
amino
substituted
pyrimidine
Prior art date
Application number
CY20111100040T
Other languages
English (en)
Inventor
Gunnar Nordvall
Colin Ray
Tobias Rein
Daniel D Sohn
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CY1111316T1 publication Critical patent/CY1111316T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Αποκαλύπτονται νέα παράγωγα 5-υποκατεστημένο 7-αμινο-[1,3]θειάζολο[4,5-d] πυριμιδίνης του τύπου (I) όπου το R1, το R2, το R3, το R4 και το R5 είναι όπως ορίζονται στην περιγραφή, και φαρμακευτικώς αποδεκτά άλατα αυτών, μαζί με τις διαδικασίες για την παρασκευή τους, φαρμακευτικές συνθέσεις που τα περιλαμβάνουν και χρήση τους στη θεραπεία. Οι ενώσεις του τύπου (I) είναι ανταγωνιστές υποδοχέα CX3CR1 και είναι έτσι ιδιαίτερα χρήσιμες στη θεραπεία ή την προφύλαξη από νευροεκφυλιστικές διαταραχές, απομυελίνωση, καρδιαγγειακές και εγκεφαλοαγγειακές αθηροσκληρωτικές διαταραχές, περιφερική αρτηριακή νόσο, ρευματοειδή αρθρίτιδα, πνευμονικές παθήσεις, όπως η χρόνια αποφρακτική πνευμονοπάθεια (ΧΑΠ), άσθμα ή πόνο.
CY20111100040T 2005-04-06 2011-01-13 Νεα παραγωγα 5-υποκατεστημενο 7-αμινο-[1,3]θειαζολο[4,5-d] πυριμιδινης CY1111316T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0500767 2005-04-06
EP06717078A EP1869056B1 (en) 2005-04-06 2006-04-03 Novel 5-substituted 7-amino-ý1,3¨thiazoloý4,5-d¨pyrimidine derivatives

Publications (1)

Publication Number Publication Date
CY1111316T1 true CY1111316T1 (el) 2015-08-05

Family

ID=37073739

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100040T CY1111316T1 (el) 2005-04-06 2011-01-13 Νεα παραγωγα 5-υποκατεστημενο 7-αμινο-[1,3]θειαζολο[4,5-d] πυριμιδινης

Country Status (31)

Country Link
US (2) US7947693B2 (el)
EP (1) EP1869056B1 (el)
JP (1) JP5165553B2 (el)
KR (1) KR101335055B1 (el)
CN (1) CN101193897B (el)
AR (1) AR055890A1 (el)
AT (1) ATE487727T1 (el)
AU (1) AU2006231836B2 (el)
BR (1) BRPI0609738A2 (el)
CA (1) CA2604017C (el)
CY (1) CY1111316T1 (el)
DE (1) DE602006018124D1 (el)
DK (1) DK1869056T3 (el)
ES (1) ES2354450T3 (el)
HK (1) HK1118556A1 (el)
HR (1) HRP20110047T1 (el)
IL (1) IL185912A0 (el)
MX (1) MX2007012060A (el)
NO (1) NO20075603L (el)
NZ (1) NZ561460A (el)
PL (1) PL1869056T3 (el)
PT (1) PT1869056E (el)
RS (1) RS51581B (el)
RU (1) RU2419623C2 (el)
SA (1) SA06270072B1 (el)
SI (1) SI1869056T1 (el)
TW (1) TW200714605A (el)
UA (1) UA90707C2 (el)
UY (1) UY29454A1 (el)
WO (1) WO2006107258A1 (el)
ZA (1) ZA200708187B (el)

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EP1806145B1 (en) 2004-10-29 2017-08-16 Eisai R&D Management Co., Ltd. Remedy for inflammatory diseases
AR053347A1 (es) 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
NZ576519A (en) * 2006-09-29 2011-11-25 Astrazeneca Ab Novel 5,7-disubstituted [1, 3] thiazolo [4, 5-d] pyrimidin-2 (3h)-amine derivatives and their use in therapy
TW200820973A (en) 2006-09-29 2008-05-16 Astrazeneca Ab Novel compounds 480
BRPI0907974A2 (pt) 2008-03-07 2015-08-04 Acraf Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças
EP2262777B8 (en) 2008-03-07 2016-05-04 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1 and cx3cr1
US7919518B2 (en) 2008-03-07 2011-04-05 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
CA2762680C (en) 2009-05-21 2018-04-17 Chlorion Pharma, Inc. Methyl sulfanyl pyrmidmes useful as antiinflammatories, analgesics, and antiepileptics
JO3437B1 (ar) 2009-10-30 2019-10-20 Esai R & D Man Co Ltd أجسام مضادة محسنة مضادة للفراكتالكين البشري واستخداماتها
WO2012078633A2 (en) 2010-12-07 2012-06-14 Philadelphia Health And Education Corporation, D/B/A Drexel University College Of Medicene Methods of inhibiting metastasis from cancer
JO3082B1 (ar) 2011-09-13 2017-03-15 Eisai R&D Man Co Ltd مشتق بيروليدين-3- يل حمض خليك
US8476301B2 (en) 2011-09-13 2013-07-02 Eisai R&D Management Co., Ltd. Pyrrolidin-3-ylacetic acid derivative
EP2975035B1 (en) 2013-03-12 2017-08-02 Eisai R&D Management Co., Ltd. Salt of pyrrolidin-3-yl acetic acid derivative and crystals thereof
RU2016110852A (ru) 2013-09-27 2017-10-30 Нимбус Айрис, Инк. Ингибиторы irak и их применения
WO2016200939A1 (en) * 2015-06-08 2016-12-15 The Johns Hopkins University Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines for imaging fractalkine receptor (cx3cr1)
WO2018204370A1 (en) 2017-05-02 2018-11-08 Drexel University Cx3cr1 small molecule antagonists, and methods using same
GB201807898D0 (en) * 2018-05-15 2018-06-27 Kancera Ab New processes and products with increased chiral purity
GB201811169D0 (en) 2018-07-06 2018-08-29 Kancera Ab New compounds
GB202006849D0 (en) 2020-05-08 2020-06-24 Kancera Ab New use
WO2024083933A1 (en) 2022-10-19 2024-04-25 Astrazeneca Ab 2,4,6-trisubstituted 1,3,5-triazines as modulators of cx 3cr1

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Also Published As

Publication number Publication date
US7947693B2 (en) 2011-05-24
US20110092519A1 (en) 2011-04-21
RU2007140551A (ru) 2009-05-20
RS51581B (en) 2011-08-31
CA2604017C (en) 2012-03-06
PL1869056T3 (pl) 2011-04-29
KR101335055B1 (ko) 2013-12-02
CN101193897B (zh) 2010-12-01
ATE487727T1 (de) 2010-11-15
RU2419623C2 (ru) 2011-05-27
WO2006107258A1 (en) 2006-10-12
US20080214578A1 (en) 2008-09-04
NO20075603L (no) 2008-01-04
JP5165553B2 (ja) 2013-03-21
CN101193897A (zh) 2008-06-04
PT1869056E (pt) 2011-01-13
AR055890A1 (es) 2007-09-12
KR20080004483A (ko) 2008-01-09
US9440992B2 (en) 2016-09-13
EP1869056B1 (en) 2010-11-10
AU2006231836A1 (en) 2006-10-12
UA90707C2 (en) 2010-05-25
UY29454A1 (es) 2006-11-30
SA06270072B1 (ar) 2009-02-07
EP1869056A4 (en) 2010-02-17
DK1869056T3 (da) 2011-02-07
BRPI0609738A2 (pt) 2011-10-18
EP1869056A1 (en) 2007-12-26
JP2008535835A (ja) 2008-09-04
MX2007012060A (es) 2007-12-13
DE602006018124D1 (de) 2010-12-23
ES2354450T3 (es) 2011-03-15
ZA200708187B (en) 2008-11-26
CA2604017A1 (en) 2006-10-12
NZ561460A (en) 2010-12-24
IL185912A0 (en) 2008-01-06
HK1118556A1 (en) 2009-02-13
HRP20110047T1 (hr) 2011-03-31
TW200714605A (en) 2007-04-16
SI1869056T1 (sl) 2011-02-28
AU2006231836B2 (en) 2010-07-15

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