UY29454A1 - Derivados novedosos de 7-amino-(1,3) tiazol(4,5-d) pirimidina 5-sustituidos - Google Patents

Derivados novedosos de 7-amino-(1,3) tiazol(4,5-d) pirimidina 5-sustituidos

Info

Publication number
UY29454A1
UY29454A1 UY29454A UY29454A UY29454A1 UY 29454 A1 UY29454 A1 UY 29454A1 UY 29454 A UY29454 A UY 29454A UY 29454 A UY29454 A UY 29454A UY 29454 A1 UY29454 A1 UY 29454A1
Authority
UY
Uruguay
Prior art keywords
amino
pyrimidine
disease
derivatives
tiazol
Prior art date
Application number
UY29454A
Other languages
English (en)
Inventor
Nordvall Gunnar
Ray Colin
Rein Tobias
Sohn Daniel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY29454A1 publication Critical patent/UY29454A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Nuevos derivados 5-sustituidos de 7-amino-(1,3) tiazol (4,5-d) pirimidina de fórmula (I)en los que R1, R2, R3, R4 u R5 son como se define en la memoria descriptiva, y sales farmacéuticamente aceptables de los mismos, procesos para su preparación, composiciones farmacéuticas que los comprenden y aplicaciones. Los compuestos de fórmula (I) son antagonistas de receptor CX3CR1 y son así particularmente útiles para tratamiento o profilaxis de trastornos neurodegenerativos, enfermedad desmielizante, trastornos ateroscleróticos cardio y cerebrovasculares, enfermedad arterial periferal, arthritis reumatoide, enfermedades pulmonares como COPD/enfermedad pulmonaria obstructiva crónica/, asma o dolor.
UY29454A 2005-04-06 2006-04-04 Derivados novedosos de 7-amino-(1,3) tiazol(4,5-d) pirimidina 5-sustituidos UY29454A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0500767 2005-04-06

Publications (1)

Publication Number Publication Date
UY29454A1 true UY29454A1 (es) 2006-11-30

Family

ID=37073739

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29454A UY29454A1 (es) 2005-04-06 2006-04-04 Derivados novedosos de 7-amino-(1,3) tiazol(4,5-d) pirimidina 5-sustituidos

Country Status (31)

Country Link
US (2) US7947693B2 (es)
EP (1) EP1869056B1 (es)
JP (1) JP5165553B2 (es)
KR (1) KR101335055B1 (es)
CN (1) CN101193897B (es)
AR (1) AR055890A1 (es)
AT (1) ATE487727T1 (es)
AU (1) AU2006231836B2 (es)
BR (1) BRPI0609738A2 (es)
CA (1) CA2604017C (es)
CY (1) CY1111316T1 (es)
DE (1) DE602006018124D1 (es)
DK (1) DK1869056T3 (es)
ES (1) ES2354450T3 (es)
HK (1) HK1118556A1 (es)
HR (1) HRP20110047T1 (es)
IL (1) IL185912A0 (es)
MX (1) MX2007012060A (es)
NO (1) NO20075603L (es)
NZ (1) NZ561460A (es)
PL (1) PL1869056T3 (es)
PT (1) PT1869056E (es)
RS (1) RS51581B (es)
RU (1) RU2419623C2 (es)
SA (1) SA06270072B1 (es)
SI (1) SI1869056T1 (es)
TW (1) TW200714605A (es)
UA (1) UA90707C2 (es)
UY (1) UY29454A1 (es)
WO (1) WO2006107258A1 (es)
ZA (1) ZA200708187B (es)

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WO2006046739A1 (ja) 2004-10-29 2006-05-04 Eisai R & D Management Co., Ltd. 炎症性疾患治療剤
AR053347A1 (es) 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
TW200820973A (en) 2006-09-29 2008-05-16 Astrazeneca Ab Novel compounds 480
MX2009003003A (es) * 2006-09-29 2009-04-01 Astrazeneca Ab Nuevos derivados de [1,3]tiazolo [4,5-d]pirimidin-2-(3h)-amina 5,7-disustituidos y su uso en terapia.
AU2009221089B2 (en) 2008-03-07 2013-12-05 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
LT2262778T (lt) 2008-03-07 2019-11-11 Acraf 1-benzil-3-hidroksimetilindazolo dariniai ir jų panaudojimas gydant ligas, pagrįstas mcp-1, cxcr1 ir p40 raiška
KR101581829B1 (ko) 2008-03-07 2015-12-31 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 1-벤질-3-하이드록시메틸인다졸 유도체들 및 ｍｃｐ-1 및 ｃｘ3ｃｒ1의 발현을 기초로 한 질환들의 치료에서 이의 용도
AR076601A1 (es) 2009-05-21 2011-06-22 Chlorion Pharma Inc Pirimidinas como agentes terapeuticos
JO3437B1 (ar) 2009-10-30 2019-10-20 Esai R & D Man Co Ltd أجسام مضادة محسنة مضادة للفراكتالكين البشري واستخداماتها
US8435993B2 (en) 2010-12-07 2013-05-07 Philadelphia Health And Education Corporation Methods of inhibiting metastasis from cancer
US8476301B2 (en) 2011-09-13 2013-07-02 Eisai R&D Management Co., Ltd. Pyrrolidin-3-ylacetic acid derivative
JO3082B1 (ar) 2011-09-13 2017-03-15 Eisai R&D Man Co Ltd مشتق بيروليدين-3- يل حمض خليك
US9550732B2 (en) 2013-03-12 2017-01-24 Eisai R&D Management Co., Ltd. Salt of pyrrolidin-3-yl acetic acid derivative and crystals thereof
CA2925211A1 (en) * 2013-09-27 2015-04-02 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US20180222922A1 (en) * 2015-06-08 2018-08-09 The Johns Hopkins University Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines for imaging fractalkine receptor (cx3cr1)
US11267817B2 (en) 2017-05-02 2022-03-08 Drexel University Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
GB201807898D0 (en) * 2018-05-15 2018-06-27 Kancera Ab New processes and products with increased chiral purity
GB201811169D0 (en) 2018-07-06 2018-08-29 Kancera Ab New compounds
GB202006849D0 (en) 2020-05-08 2020-06-24 Kancera Ab New use
US20240199558A1 (en) 2022-10-19 2024-06-20 Astrazeneca Ab 2,4,6-trisubstituted 1,3,5-triazines as modulators of cx3cr1

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US4639433A (en) 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
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JP2007507494A (ja) * 2003-10-07 2007-03-29 アストラゼネカ・アクチエボラーグ ケモカイン受容体アンタゴニストとりわけＣＸ３ＣＲ１として有用な新規な２−置換４−アミノ−チアゾロ［４，５−ｄ］ピリミジン
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Also Published As

Publication number Publication date
TW200714605A (en) 2007-04-16
US20080214578A1 (en) 2008-09-04
PT1869056E (pt) 2011-01-13
SI1869056T1 (sl) 2011-02-28
CN101193897B (zh) 2010-12-01
AU2006231836B2 (en) 2010-07-15
HK1118556A1 (en) 2009-02-13
CA2604017C (en) 2012-03-06
AU2006231836A1 (en) 2006-10-12
US7947693B2 (en) 2011-05-24
WO2006107258A1 (en) 2006-10-12
RS51581B (en) 2011-08-31
DK1869056T3 (da) 2011-02-07
UA90707C2 (en) 2010-05-25
SA06270072B1 (ar) 2009-02-07
JP5165553B2 (ja) 2013-03-21
KR20080004483A (ko) 2008-01-09
PL1869056T3 (pl) 2011-04-29
NZ561460A (en) 2010-12-24
HRP20110047T1 (hr) 2011-03-31
RU2419623C2 (ru) 2011-05-27
MX2007012060A (es) 2007-12-13
CA2604017A1 (en) 2006-10-12
EP1869056A4 (en) 2010-02-17
CY1111316T1 (el) 2015-08-05
IL185912A0 (en) 2008-01-06
US20110092519A1 (en) 2011-04-21
CN101193897A (zh) 2008-06-04
ATE487727T1 (de) 2010-11-15
DE602006018124D1 (de) 2010-12-23
NO20075603L (no) 2008-01-04
ES2354450T3 (es) 2011-03-15
KR101335055B1 (ko) 2013-12-02
RU2007140551A (ru) 2009-05-20
BRPI0609738A2 (pt) 2011-10-18
AR055890A1 (es) 2007-09-12
ZA200708187B (en) 2008-11-26
JP2008535835A (ja) 2008-09-04
EP1869056A1 (en) 2007-12-26
EP1869056B1 (en) 2010-11-10
US9440992B2 (en) 2016-09-13

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