NO20075603L - Nye 5-substituerte 7-amino[1,3]tiazol[4,5-d]pyrimidinderivater - Google Patents

Nye 5-substituerte 7-amino[1,3]tiazol[4,5-d]pyrimidinderivater

Info

Publication number
NO20075603L
NO20075603L NO20075603A NO20075603A NO20075603L NO 20075603 L NO20075603 L NO 20075603L NO 20075603 A NO20075603 A NO 20075603A NO 20075603 A NO20075603 A NO 20075603A NO 20075603 L NO20075603 L NO 20075603L
Authority
NO
Norway
Prior art keywords
thiazole
amino
substituted
disease
pyrimidine derivatives
Prior art date
Application number
NO20075603A
Other languages
English (en)
Inventor
Gunnar Nordvall
Tobias Rein
Colin Ray
Daniel Sohn
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20075603L publication Critical patent/NO20075603L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Det er beskrevet nye 5-substituerte 7-amino-[1,3]tiazol[4,5-d]pyrimidinderivativer med formel (I) hvori R1, R2 , R3 , R4 og R5 er som definert i beskrivelsen, og farmasøytisk akseptable salter derav, sammen med fremgangsmåter for deres fremstilling, farmasøytiske sammensetninger som innbefatter dem og deres anvendelse ved behandling. Forbindelsene med formel (I) er CX3CR1 reseptorantagonister og er derved særlig anvendelige ved behandling eller profylakse av neurodegenerative forstyrrelser, demyelinerende sykdom, kardio- og cerebrovaskulære aterosklerotiske forstyrrelser, periferal arteriesykdom, reumatoid artritt, lungesykdommer slike som COPD, astma og smerte.
NO20075603A 2005-04-06 2007-11-05 Nye 5-substituerte 7-amino[1,3]tiazol[4,5-d]pyrimidinderivater NO20075603L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0500767 2005-04-06
PCT/SE2006/000399 WO2006107258A1 (en) 2005-04-06 2006-04-03 Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives

Publications (1)

Publication Number Publication Date
NO20075603L true NO20075603L (no) 2008-01-04

Family

ID=37073739

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075603A NO20075603L (no) 2005-04-06 2007-11-05 Nye 5-substituerte 7-amino[1,3]tiazol[4,5-d]pyrimidinderivater

Country Status (31)

Country Link
US (2) US7947693B2 (no)
EP (1) EP1869056B1 (no)
JP (1) JP5165553B2 (no)
KR (1) KR101335055B1 (no)
CN (1) CN101193897B (no)
AR (1) AR055890A1 (no)
AT (1) ATE487727T1 (no)
AU (1) AU2006231836B2 (no)
BR (1) BRPI0609738A2 (no)
CA (1) CA2604017C (no)
CY (1) CY1111316T1 (no)
DE (1) DE602006018124D1 (no)
DK (1) DK1869056T3 (no)
ES (1) ES2354450T3 (no)
HK (1) HK1118556A1 (no)
HR (1) HRP20110047T1 (no)
IL (1) IL185912A0 (no)
MX (1) MX2007012060A (no)
NO (1) NO20075603L (no)
NZ (1) NZ561460A (no)
PL (1) PL1869056T3 (no)
PT (1) PT1869056E (no)
RS (1) RS51581B (no)
RU (1) RU2419623C2 (no)
SA (1) SA06270072B1 (no)
SI (1) SI1869056T1 (no)
TW (1) TW200714605A (no)
UA (1) UA90707C2 (no)
UY (1) UY29454A1 (no)
WO (1) WO2006107258A1 (no)
ZA (1) ZA200708187B (no)

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ES2641815T3 (es) 2004-10-29 2017-11-14 Eisai R&D Management Co., Ltd. Tratamiento para enfermedades inflamatorias
AR053347A1 (es) 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
MX2009003003A (es) 2006-09-29 2009-04-01 Astrazeneca Ab Nuevos derivados de [1,3]tiazolo [4,5-d]pirimidin-2-(3h)-amina 5,7-disustituidos y su uso en terapia.
TW200820973A (en) 2006-09-29 2008-05-16 Astrazeneca Ab Novel compounds 480
MX2010009624A (es) 2008-03-07 2010-09-28 Acraf Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1 y cx3cr1.
AU2009221087B2 (en) 2008-03-07 2013-12-05 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
PT2254869T (pt) 2008-03-07 2017-07-18 Acraf Novos derivados de 1-benzil-3-hidroximetilindazole e suas utilizações no tratamento de doenças com base na expressão de cx3cr1 e p40
US9040538B2 (en) 2009-05-21 2015-05-26 Universite Laval Pyrimidines as novel therapeutic agents
JO3437B1 (ar) 2009-10-30 2019-10-20 Esai R & D Man Co Ltd أجسام مضادة محسنة مضادة للفراكتالكين البشري واستخداماتها
EP2648754A4 (en) 2010-12-07 2016-02-24 Philadelphia Health & Educatio METHODS OF INHIBITING THE METASTASIS OF CANCER
TWI543975B (zh) 2011-09-13 2016-08-01 Eisai R&D Man Co Ltd Pyrrolidin-3-yl acetic acid derivatives
US8476301B2 (en) 2011-09-13 2013-07-02 Eisai R&D Management Co., Ltd. Pyrrolidin-3-ylacetic acid derivative
RU2640047C2 (ru) 2013-03-12 2017-12-26 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Соль производного пирролидин-3-ил-уксусной кислоты и ее кристаллы
BR112016006319A2 (pt) 2013-09-27 2017-08-01 Nimbus Iris Inc inibidores de irak e usos dos mesmos
US20180222922A1 (en) * 2015-06-08 2018-08-09 The Johns Hopkins University Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines for imaging fractalkine receptor (cx3cr1)
US11267817B2 (en) 2017-05-02 2022-03-08 Drexel University Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
GB201807898D0 (en) 2018-05-15 2018-06-27 Kancera Ab New processes and products with increased chiral purity
GB201811169D0 (en) * 2018-07-06 2018-08-29 Kancera Ab New compounds
GB202006849D0 (en) 2020-05-08 2020-06-24 Kancera Ab New use
WO2024083933A1 (en) 2022-10-19 2024-04-25 Astrazeneca Ab 2,4,6-trisubstituted 1,3,5-triazines as modulators of cx 3cr1

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Also Published As

Publication number Publication date
EP1869056B1 (en) 2010-11-10
TW200714605A (en) 2007-04-16
ATE487727T1 (de) 2010-11-15
BRPI0609738A2 (pt) 2011-10-18
ES2354450T3 (es) 2011-03-15
SA06270072B1 (ar) 2009-02-07
CN101193897A (zh) 2008-06-04
PT1869056E (pt) 2011-01-13
AU2006231836A1 (en) 2006-10-12
EP1869056A1 (en) 2007-12-26
AR055890A1 (es) 2007-09-12
SI1869056T1 (sl) 2011-02-28
US20080214578A1 (en) 2008-09-04
UY29454A1 (es) 2006-11-30
JP2008535835A (ja) 2008-09-04
RS51581B (en) 2011-08-31
ZA200708187B (en) 2008-11-26
CY1111316T1 (el) 2015-08-05
JP5165553B2 (ja) 2013-03-21
HK1118556A1 (en) 2009-02-13
PL1869056T3 (pl) 2011-04-29
KR20080004483A (ko) 2008-01-09
CA2604017A1 (en) 2006-10-12
DK1869056T3 (da) 2011-02-07
US20110092519A1 (en) 2011-04-21
IL185912A0 (en) 2008-01-06
CA2604017C (en) 2012-03-06
CN101193897B (zh) 2010-12-01
US7947693B2 (en) 2011-05-24
NZ561460A (en) 2010-12-24
WO2006107258A1 (en) 2006-10-12
KR101335055B1 (ko) 2013-12-02
MX2007012060A (es) 2007-12-13
DE602006018124D1 (de) 2010-12-23
RU2419623C2 (ru) 2011-05-27
AU2006231836B2 (en) 2010-07-15
RU2007140551A (ru) 2009-05-20
EP1869056A4 (en) 2010-02-17
UA90707C2 (en) 2010-05-25
US9440992B2 (en) 2016-09-13
HRP20110047T1 (hr) 2011-03-31

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