HUP0300694A2 - Indolszármazékok mint MCP-1 receptor antagonisták, alkalmazásuk, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Indolszármazékok mint MCP-1 receptor antagonisták, alkalmazásuk, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0300694A2 HUP0300694A2 HU0300694A HUP0300694A HUP0300694A2 HU P0300694 A2 HUP0300694 A2 HU P0300694A2 HU 0300694 A HU0300694 A HU 0300694A HU P0300694 A HUP0300694 A HU P0300694A HU P0300694 A2 HUP0300694 A2 HU P0300694A2
- Authority
- HU
- Hungary
- Prior art keywords
- halogen
- hydrogen
- mcp
- compounds
- preparation
- Prior art date
Links
- 102000004497 CCR2 Receptors Human genes 0.000 title 1
- 108010017312 CCR2 Receptors Proteins 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052731 fluorine Chemical group 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 102100021943 C-C motif chemokine 2 Human genes 0.000 abstract 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
A találmány tárgyát az általános képletű vegyületek - ahol R1hidrogén-, halogénatom vagy metoxicsoport; R2 hidrogén-, halogénatom,metil-, etil- vagy metoxicsoport; R3 halogénatom vagy trifluor-metil-csoport; R4 halogénatom vagy trifluor-metil-csoport; R5 hidrogén- vagyhalogénatom; R6 hidrogén- vagy halogénatom; azzal a fenntartással,hogy ha mind R5, mind R6 hidrogénatom, és R3 és R4 közül az egyikklór- vagy fluoratom, akkor a másik klór- vagy fluoratomtól eltérő -és gyógyszerészetileg elfogadható sóik vagy prodrugjaik képezik. Ezeka vegyületek hasznos aktivitással rendelkeznek a gyulladásosbetegségek kezelésére, különösen egy MCP-1 által közvetített hatásantagonizálására melegvérű állatban, így emberben is. A találmánykiterjed a vegyületek előállítására és ezeket tartalmazógyógyszerkészítményekre is. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0000626.2A GB0000626D0 (en) | 2000-01-13 | 2000-01-13 | Chemical compounds |
| PCT/GB2001/000069 WO2001051466A1 (en) | 2000-01-13 | 2001-01-11 | Indole derivatives as mcp-1 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0300694A2 true HUP0300694A2 (hu) | 2003-07-28 |
| HUP0300694A3 HUP0300694A3 (en) | 2005-08-29 |
Family
ID=9883551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300694A HUP0300694A3 (en) | 2000-01-13 | 2001-01-11 | Indole derivatives as mcp-1 receptor antagonists, their use, process for their preparation and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20030144339A1 (hu) |
| EP (1) | EP1252142A1 (hu) |
| JP (1) | JP2003519683A (hu) |
| KR (1) | KR20020064375A (hu) |
| CN (1) | CN1395565A (hu) |
| AR (1) | AR026839A1 (hu) |
| AU (1) | AU780992B2 (hu) |
| BG (1) | BG106894A (hu) |
| BR (1) | BR0107404A (hu) |
| CA (1) | CA2393592A1 (hu) |
| CO (1) | CO5271703A1 (hu) |
| EE (1) | EE200200394A (hu) |
| GB (1) | GB0000626D0 (hu) |
| HK (1) | HK1049486A1 (hu) |
| HU (1) | HUP0300694A3 (hu) |
| IL (1) | IL150272A0 (hu) |
| IS (1) | IS6429A (hu) |
| MX (1) | MXPA02006611A (hu) |
| NO (1) | NO20023380L (hu) |
| NZ (1) | NZ519312A (hu) |
| PL (1) | PL356031A1 (hu) |
| RU (1) | RU2002121636A (hu) |
| SK (1) | SK10072002A3 (hu) |
| WO (1) | WO2001051466A1 (hu) |
| ZA (1) | ZA200204354B (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| WO2004069809A1 (en) | 2003-02-03 | 2004-08-19 | Janssen Pharmaceutica N.V. | Mercaptoimidazoles as ccr2 receptor antagonists |
| WO2006030946A1 (ja) * | 2004-09-13 | 2006-03-23 | Kureha Corporation | 熱発泡性マイクロスフェアー、その製造方法、その使用、それを含む組成物、及び物品 |
| EP1960401B1 (en) | 2005-12-09 | 2009-11-11 | F.Hoffmann-La Roche Ag | Tricyclic amide derivatives useful for treating obesity |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| US7507736B2 (en) | 2007-02-07 | 2009-03-24 | Hoffmann-La Roche Inc. | Indol-2-yl-piperazin-1-yl-methanone derivatives |
| DK2134685T3 (en) * | 2007-04-16 | 2015-12-07 | Abbvie Inc | 7-unsubstituted indole derivatives as MCL-1 inhibitors |
| WO2023224981A1 (en) * | 2022-05-17 | 2023-11-23 | Inipharm, Inc. | Hsd17b13 inhibitors and uses thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529724A (en) * | 1983-10-11 | 1985-07-16 | Mcneilab, Inc. | 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives |
| DE3907388A1 (de) * | 1989-03-08 | 1990-09-13 | Kali Chemie Pharma Gmbh | Verfahren zur herstellung von indolcarbonsaeurederivaten |
| US5272145A (en) * | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5081145A (en) * | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5389650A (en) * | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5273980A (en) * | 1991-09-30 | 1993-12-28 | Merck Frosst Canada Inc. | Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5288743A (en) * | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
| US5852046A (en) * | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
| US5686481A (en) * | 1993-12-21 | 1997-11-11 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| US5482960A (en) * | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
| US5684032A (en) * | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| EP1021181A4 (en) * | 1996-03-28 | 2002-06-26 | Smithkline Beecham Corp | INDOLCARBOXYLIC ACIDS AS CHEMOKIN INHIBITORS |
| AU4054197A (en) * | 1996-08-14 | 1998-03-06 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
| GB9716656D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9803228D0 (en) * | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| GB9803226D0 (en) * | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
-
2000
- 2000-01-13 GB GBGB0000626.2A patent/GB0000626D0/en not_active Ceased
-
2001
- 2001-01-11 EE EEP200200394A patent/EE200200394A/xx unknown
- 2001-01-11 KR KR1020027009021A patent/KR20020064375A/ko not_active Application Discontinuation
- 2001-01-11 PL PL01356031A patent/PL356031A1/xx not_active Application Discontinuation
- 2001-01-11 EP EP01900494A patent/EP1252142A1/en not_active Withdrawn
- 2001-01-11 WO PCT/GB2001/000069 patent/WO2001051466A1/en not_active Application Discontinuation
- 2001-01-11 AU AU25324/01A patent/AU780992B2/en not_active Ceased
- 2001-01-11 MX MXPA02006611A patent/MXPA02006611A/es unknown
- 2001-01-11 SK SK1007-2002A patent/SK10072002A3/sk unknown
- 2001-01-11 US US10/169,717 patent/US20030144339A1/en not_active Abandoned
- 2001-01-11 RU RU2002121636/04A patent/RU2002121636A/ru not_active Application Discontinuation
- 2001-01-11 JP JP2001551848A patent/JP2003519683A/ja active Pending
- 2001-01-11 BR BR0107404-0A patent/BR0107404A/pt not_active IP Right Cessation
- 2001-01-11 NZ NZ519312A patent/NZ519312A/en unknown
- 2001-01-11 HU HU0300694A patent/HUP0300694A3/hu unknown
- 2001-01-11 CN CN01803645A patent/CN1395565A/zh active Pending
- 2001-01-11 CA CA002393592A patent/CA2393592A1/en not_active Abandoned
- 2001-01-11 IL IL15027201A patent/IL150272A0/xx unknown
- 2001-01-12 AR ARP010100144A patent/AR026839A1/es not_active Application Discontinuation
- 2001-01-15 CO CO01002379A patent/CO5271703A1/es not_active Application Discontinuation
-
2002
- 2002-05-30 ZA ZA200204354A patent/ZA200204354B/en unknown
- 2002-06-19 IS IS6429A patent/IS6429A/is unknown
- 2002-07-02 BG BG106894A patent/BG106894A/bg unknown
- 2002-07-12 NO NO20023380A patent/NO20023380L/no not_active Application Discontinuation
-
2003
- 2003-03-06 HK HK03101662.2A patent/HK1049486A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2393592A1 (en) | 2001-07-19 |
| RU2002121636A (ru) | 2004-01-10 |
| EP1252142A1 (en) | 2002-10-30 |
| CN1395565A (zh) | 2003-02-05 |
| HK1049486A1 (zh) | 2003-05-16 |
| WO2001051466A1 (en) | 2001-07-19 |
| PL356031A1 (en) | 2004-06-14 |
| AU2532401A (en) | 2001-07-24 |
| EE200200394A (et) | 2003-12-15 |
| KR20020064375A (ko) | 2002-08-07 |
| ZA200204354B (en) | 2003-09-01 |
| GB0000626D0 (en) | 2000-03-01 |
| IL150272A0 (en) | 2002-12-01 |
| NO20023380L (no) | 2002-09-03 |
| IS6429A (is) | 2002-06-19 |
| CO5271703A1 (es) | 2003-04-30 |
| JP2003519683A (ja) | 2003-06-24 |
| BR0107404A (pt) | 2002-10-08 |
| US20030144339A1 (en) | 2003-07-31 |
| SK10072002A3 (sk) | 2003-06-03 |
| HUP0300694A3 (en) | 2005-08-29 |
| NO20023380D0 (no) | 2002-07-12 |
| MXPA02006611A (es) | 2002-09-30 |
| NZ519312A (en) | 2004-04-30 |
| BG106894A (bg) | 2003-04-30 |
| AU780992B2 (en) | 2005-04-28 |
| AR026839A1 (es) | 2003-02-26 |
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