NO2018012I2 - Padeliporfin - Google Patents

Padeliporfin

Info

Publication number
NO2018012I2
NO2018012I2 NO2018012C NO2018012C NO2018012I2 NO 2018012 I2 NO2018012 I2 NO 2018012I2 NO 2018012 C NO2018012 C NO 2018012C NO 2018012 C NO2018012 C NO 2018012C NO 2018012 I2 NO2018012 I2 NO 2018012I2
Authority
NO
Norway
Prior art keywords
padeliporfin
Prior art date
Application number
NO2018012C
Other languages
English (en)
Other versions
NO2018012I1 (no
Original Assignee
Yeda Res And Development Company Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30011928&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2018012(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yeda Res And Development Company Ltd filed Critical Yeda Res And Development Company Ltd
Publication of NO2018012I1 publication Critical patent/NO2018012I1/no
Publication of NO2018012I2 publication Critical patent/NO2018012I2/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C07F15/0066—Palladium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/04—Nickel compounds
    • C07F15/045—Nickel compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
NO2018012C 2002-11-17 2018-04-10 Padeliporfin NO2018012I2 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL15290002A IL152900A0 (en) 2002-11-17 2002-11-17 Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
PCT/IL2003/000973 WO2004045492A2 (en) 2002-11-17 2003-11-17 Water-soluble anionic bacteriochlorophyll derivatives and their uses

Publications (2)

Publication Number Publication Date
NO2018012I1 NO2018012I1 (no) 2018-04-10
NO2018012I2 true NO2018012I2 (no) 2018-04-10

Family

ID=30011928

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20052925A NO334978B1 (no) 2002-11-17 2005-06-15 Vannløselig anionisk bakterieklorofyllderivat, fremgangsmåte for fremstilling derav, farmasøytisk sammensetning som inneholder nevnte derivat og anvendelse derav.
NO2018012C NO2018012I2 (no) 2002-11-17 2018-04-10 Padeliporfin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20052925A NO334978B1 (no) 2002-11-17 2005-06-15 Vannløselig anionisk bakterieklorofyllderivat, fremgangsmåte for fremstilling derav, farmasøytisk sammensetning som inneholder nevnte derivat og anvendelse derav.

Country Status (24)

Country Link
US (6) US7947672B2 (no)
EP (2) EP1567147B1 (no)
JP (3) JP4922559B2 (no)
CN (2) CN102002048B (no)
AU (1) AU2003282354C1 (no)
BE (1) BE2018C018I2 (no)
BR (1) BRPI0316319B8 (no)
CA (1) CA2506296C (no)
CY (2) CY1115458T1 (no)
DK (1) DK1567147T3 (no)
ES (1) ES2489516T3 (no)
FR (1) FR18C0002I2 (no)
HK (1) HK1081858A1 (no)
HU (1) HUS1800020I1 (no)
IL (2) IL152900A0 (no)
LU (1) LUC00073I2 (no)
MX (1) MXPA05005262A (no)
NL (1) NL300934I2 (no)
NO (2) NO334978B1 (no)
NZ (1) NZ540790A (no)
PL (1) PL216661B1 (no)
PT (1) PT1567147E (no)
RU (1) RU2353624C2 (no)
WO (1) WO2004045492A2 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
BRPI0511909A (pt) * 2004-06-07 2008-01-15 Yeda Res & Dev derivado catiÈnico de bacterioclorofilas e respectiva composição farmacêutica
US9957293B2 (en) * 2006-08-23 2018-05-01 Yeda Research And Development Company Ltd. Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses
JP5620279B2 (ja) 2008-02-27 2014-11-05 イエダ リサーチ アンド デベロップメント カンパニー リミテッド 壊死性腫瘍の光線力学的治療及び画像化のためのｒｇｄ−（バクテリオ）クロロフィルコンジュゲート
EP2425873A1 (fr) 2010-09-07 2012-03-07 Steba Maor SA Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement
ES2607613T3 (es) 2011-03-11 2017-04-03 Steba Maor Sa Métodos de planificación de terapia fotodinámica focal
ES2856698T3 (es) 2011-08-23 2021-09-28 Yeda Res & Dev Fotosensibilizadores de (bacterio)clorofila para el tratamiento de enfermedades y trastornos oculares
PL2971026T3 (pl) 2013-03-11 2021-06-14 Tookad Ip Sarl Sposób wytwarzania bakteriochlorofilu a
CN105377862B (zh) 2013-03-15 2019-09-13 希瑞·安·麦克法兰 用作光动力化合物的金属基配合物及其用途
WO2017179053A1 (en) * 2016-04-10 2017-10-19 Yeda Research And Development Co. Ltd. Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative
CN107987081B (zh) * 2016-10-26 2019-12-06 刘辉 一种二氢卟吩e6衍生物及其药学上可接受的盐、其制备方法和应用
DK3561056T5 (da) * 2016-12-22 2024-09-02 Daiichi Sankyo Co Ltd Peptid til behandling af aldersrelateret makuladegeneration
US10933134B2 (en) 2017-03-16 2021-03-02 Memorial Sloan Kettering Cancer Center Combination therapies for treatment of cancer
WO2019116376A1 (en) * 2017-12-17 2019-06-20 Yeda Research And Development Co. Ltd. Cop9 signalosome (csn) complex modulators and uses thereof
CN111848656B (zh) * 2020-06-24 2023-03-14 天津大学 离子修饰的原卟啉镓化合物及其制备方法和应用
JPWO2022025043A1 (no) * 2020-07-29 2022-02-03
CN115843960A (zh) * 2022-11-03 2023-03-28 中国农业科学院农产品加工研究所 一种提高叶绿素稳定性的方法

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US4675338A (en) * 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4693885A (en) * 1984-07-18 1987-09-15 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4656186A (en) * 1985-04-30 1987-04-07 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
JPS63196586A (ja) * 1987-02-12 1988-08-15 Toyo Hatsuka Kogyo Kk バクテリオフエオホ−バイド誘導体
DE3853995T2 (de) 1987-04-17 1995-11-23 David H Dolphin Porphyrine, verfahren zu deren herstellung und verwendungen.
US5004811A (en) * 1987-12-24 1991-04-02 Nippon Petrochemicals Company, Ltd. Tetrapyrrole aminocarboxylic acids
US5171741A (en) 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
DE4121876A1 (de) * 1991-07-02 1993-01-14 Scheer Hugo Modifizierte bakteriochlorophylle, verfahren zu ihrer herstellung und ihre verwendung
JP3191223B2 (ja) * 1991-10-04 2001-07-23 株式会社光ケミカル研究所 ポルフィリン誘導体とその用途
EP0644759A4 (en) * 1992-06-19 1998-04-01 Univ Toledo PRODUCTION AND USE OF PORPHYRIN IMINES.
IL102645A (en) 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
US6147195A (en) * 1993-07-26 2000-11-14 Yeda Research And Development Co., Ltd. Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
FR2712493B1 (fr) * 1993-11-16 1996-01-19 Centre Nat Rech Scient Utilisation de photosensibilisateurs dérivés du noyau phorbine pour la décontamination du sang infecté par des parasites et/ou des virus.
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IL116126A0 (en) 1995-11-24 1996-01-31 Yeda Res & Dev Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them
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IL133253A0 (en) 1999-12-01 2001-04-30 Yeda Res & Dev Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
JP4277159B2 (ja) * 2000-06-02 2009-06-10 独立行政法人科学技術振興機構 新規なテトラピロリル置換ポルフィリン及びその製法
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AU2002312154B2 (en) * 2001-06-01 2008-05-15 Biolitec Pharma Marketing Ltd Water-soluble porphyrin derivatives for photodynamic therapy, their use and manufacture
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses

Also Published As

Publication number Publication date
NO20052925D0 (no) 2005-06-15
CN102002048A (zh) 2011-04-06
JP2006515836A (ja) 2006-06-08
US20150238773A1 (en) 2015-08-27
US20060142260A1 (en) 2006-06-29
PL216661B1 (pl) 2014-04-30
WO2004045492A3 (en) 2004-07-08
NO2018012I1 (no) 2018-04-10
CA2506296C (en) 2012-09-11
BE2018C018I2 (no) 2023-03-07
NL300934I2 (nl) 2018-05-22
MXPA05005262A (es) 2005-07-25
NZ540790A (en) 2009-12-24
RU2353624C2 (ru) 2009-04-27
EP1567147A4 (en) 2008-07-09
EP1567147B1 (en) 2014-05-07
JP2011148822A (ja) 2011-08-04
BRPI0316319B1 (pt) 2017-06-27
EP2522349A1 (en) 2012-11-14
JP2011162551A (ja) 2011-08-25
PL376734A1 (pl) 2006-01-09
AU2003282354C1 (en) 2009-10-29
HK1081858A1 (en) 2006-05-26
FR18C0002I1 (no) 2018-06-15
ES2489516T3 (es) 2014-09-02
PT1567147E (pt) 2014-08-25
BRPI0316319B8 (pt) 2021-05-25
RU2005118771A (ru) 2006-01-20
DK1567147T3 (da) 2014-08-11
NO20052925L (no) 2005-06-15
BR0316319A (pt) 2005-09-27
WO2004045492A2 (en) 2004-06-03
CN102002048B (zh) 2012-11-28
US20110117029A1 (en) 2011-05-19
US8461142B2 (en) 2013-06-11
HUS1800020I1 (hu) 2018-05-28
US7947672B2 (en) 2011-05-24
NO334978B1 (no) 2014-08-11
US20200094069A1 (en) 2020-03-26
CN1741801B (zh) 2010-12-22
IL168480A (en) 2015-01-29
EP1567147A2 (en) 2005-08-31
CY1115458T1 (el) 2017-01-04
LUC00073I2 (en) 2018-06-20
IL152900A0 (en) 2003-06-24
CY2018012I2 (el) 2018-09-05
AU2003282354A1 (en) 2004-06-15
AU2003282354B2 (en) 2009-04-23
JP5555659B2 (ja) 2014-07-23
AU2003282354B8 (en) 2009-05-14
JP4922559B2 (ja) 2012-04-25
JP5566945B2 (ja) 2014-08-06
CN1741801A (zh) 2006-03-01
CA2506296A1 (en) 2004-06-03
FR18C0002I2 (fr) 2020-03-13
US20170143988A1 (en) 2017-05-25
US20130345417A1 (en) 2013-12-26
CY2018012I1 (el) 2018-09-05

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