JP2005534669A5 - - Google Patents
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- JP2005534669A5 JP2005534669A5 JP2004513293A JP2004513293A JP2005534669A5 JP 2005534669 A5 JP2005534669 A5 JP 2005534669A5 JP 2004513293 A JP2004513293 A JP 2004513293A JP 2004513293 A JP2004513293 A JP 2004513293A JP 2005534669 A5 JP2005534669 A5 JP 2005534669A5
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- JP
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- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- substituted
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 7
- 125000003118 aryl group Chemical group 0.000 claims 27
- 125000000623 heterocyclic group Chemical group 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- 125000001475 halogen functional group Chemical group 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000001540 azides Chemical class 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 5
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 4
- 230000033115 angiogenesis Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- -1 methylureido group Chemical group 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000004069 aziridinyl group Chemical group 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000005045 dihydroisoquinolinyl group Chemical group C1(NC=CC2=CC=CC=C12)* 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 210000002615 epidermis Anatomy 0.000 claims 2
- 201000011066 hemangioma Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 201000001514 prostate carcinoma Diseases 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 230000005747 tumor angiogenesis Effects 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims 1
- 229940030600 antihypertensive agent Drugs 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000005936 piperidyl group Chemical group 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 150000003254 radicals Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 description 3
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38911002P | 2002-06-14 | 2002-06-14 | |
| PCT/IB2003/002393 WO2003106462A1 (en) | 2002-06-14 | 2003-06-04 | Benzofused heteroaryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005534669A JP2005534669A (ja) | 2005-11-17 |
| JP2005534669A5 true JP2005534669A5 (https=) | 2006-06-15 |
Family
ID=29736588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513293A Withdrawn JP2005534669A (ja) | 2002-06-14 | 2003-06-04 | 治療剤として有用なチエノピリジンのベンゾ縮合ヘテロアリールアミド誘導体、それが含まれる医薬組成物、並びにその使用の方法 |
Country Status (36)
Families Citing this family (53)
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| DE60137273D1 (de) * | 2000-10-20 | 2009-02-12 | Eisai R&D Man Co Ltd | Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten |
| RU2309956C2 (ru) | 2002-10-03 | 2007-11-10 | Ф.Хоффманн-Ля Рош Аг | Производные индол-3-карбоксамида в качестве активаторов глюкокиназы |
| ATE508747T1 (de) * | 2003-03-10 | 2011-05-15 | Eisai R&D Man Co Ltd | C-kit kinase-hemmer |
| US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
| US7683172B2 (en) * | 2003-11-11 | 2010-03-23 | Eisai R&D Management Co., Ltd. | Urea derivative and process for preparing the same |
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| AU2016224583B2 (en) | 2015-02-25 | 2021-06-03 | Eisai R&D Management Co., Ltd. | Method for suppressing bitterness of quinoline derivative |
| KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| BR112017027227B1 (pt) | 2015-06-16 | 2023-12-12 | Eisai R&D Management Co., Ltd | Agente anti-câncer |
| JP6553726B2 (ja) | 2015-08-20 | 2019-07-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療剤 |
| JP6581320B2 (ja) | 2017-02-08 | 2019-09-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療用医薬組成物 |
| EP3624800A4 (en) | 2017-05-16 | 2021-02-17 | Eisai R&D Management Co., Ltd. | TREATMENT OF HEPATOCELLULAR CARCINOMA |
| CN109053524A (zh) * | 2018-09-11 | 2018-12-21 | 山东谛爱生物技术有限公司 | 一种N-Boc-3-羟基氮杂环丁烷的制备方法 |
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| PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
| US6269027B1 (en) * | 1998-04-14 | 2001-07-31 | Honeywell, Inc. | Non-volatile storage latch |
| EA005032B1 (ru) | 1998-05-29 | 2004-10-28 | Сьюджен, Инк. | Пирролзамещенные 2-индолиноны (варианты), фармацевтическая композиция (варианты), способ модулирования каталитической активности протеинкиназы, способ лечения или профилактики нарушения в организме, связанного с протеинкиназой |
| BR9916536A (pt) | 1998-12-23 | 2002-01-02 | Searle & Co | Método para o tratamento ou prevenção de um distúrbio de neoplasia em um mamìfero em necessidade deste tratamento ou prevenção, e, combinação |
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2003
- 2003-04-06 UA UA20041210250A patent/UA77303C2/uk unknown
- 2003-06-04 EP EP03727888A patent/EP1515975B1/en not_active Expired - Lifetime
- 2003-06-04 GE GEAP8535A patent/GEP20074033B/en unknown
- 2003-06-04 AP AP2004003184A patent/AP2004003184A0/xx unknown
- 2003-06-04 NZ NZ537140A patent/NZ537140A/en unknown
- 2003-06-04 EA EA200500018A patent/EA008255B1/ru unknown
- 2003-06-04 HR HR20041173A patent/HRP20041173A2/hr not_active Application Discontinuation
- 2003-06-04 CA CA002489466A patent/CA2489466A1/en not_active Abandoned
- 2003-06-04 MX MXPA04011637A patent/MXPA04011637A/es unknown
- 2003-06-04 BR BR0311806-1A patent/BR0311806A/pt not_active IP Right Cessation
- 2003-06-04 KR KR1020047020286A patent/KR100671632B1/ko not_active Expired - Fee Related
- 2003-06-04 KR KR1020067019988A patent/KR100714545B1/ko not_active Expired - Fee Related
- 2003-06-04 PL PL03374542A patent/PL374542A1/xx not_active Application Discontinuation
- 2003-06-04 ES ES03727888T patent/ES2290460T3/es not_active Expired - Lifetime
- 2003-06-04 WO PCT/IB2003/002393 patent/WO2003106462A1/en not_active Ceased
- 2003-06-04 DE DE60316440T patent/DE60316440T2/de not_active Expired - Fee Related
- 2003-06-04 JP JP2004513293A patent/JP2005534669A/ja not_active Withdrawn
- 2003-06-04 CN CNA038181096A patent/CN1671714A/zh active Pending
- 2003-06-04 RS YU107504A patent/RS107504A/sr unknown
- 2003-06-04 AU AU2003233134A patent/AU2003233134A1/en not_active Abandoned
- 2003-06-04 OA OA1200400325A patent/OA12865A/en unknown
- 2003-06-04 AT AT03727888T patent/ATE373665T1/de not_active IP Right Cessation
- 2003-06-11 US US10/460,010 patent/US6869962B2/en not_active Expired - Fee Related
- 2003-06-11 PE PE2003000579A patent/PE20050123A1/es not_active Application Discontinuation
- 2003-06-12 PA PA20038575401A patent/PA8575401A1/es unknown
- 2003-06-12 GT GT200300129A patent/GT200300129A/es unknown
- 2003-06-13 TW TW092116098A patent/TW200404070A/zh unknown
- 2003-06-13 AR ARP030102121A patent/AR039673A1/es not_active Application Discontinuation
- 2003-06-13 HN HN2003000182A patent/HN2003000182A/es unknown
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2004
- 2004-03-09 US US10/796,226 patent/US7045528B2/en not_active Expired - Fee Related
- 2004-11-24 NO NO20045103A patent/NO20045103L/no not_active Application Discontinuation
- 2004-11-25 IS IS7552A patent/IS7552A/is unknown
- 2004-12-06 ZA ZA200409862A patent/ZA200409862B/xx unknown
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- 2004-12-08 MA MA27986A patent/MA27596A1/fr unknown
- 2004-12-09 CO CO04123221A patent/CO5631447A2/es not_active Application Discontinuation
- 2004-12-09 EC EC2004005483A patent/ECSP045483A/es unknown
- 2004-12-13 TN TNP2004000246A patent/TNSN04246A1/fr unknown
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2005
- 2005-10-21 US US11/256,477 patent/US20060079548A1/en not_active Abandoned
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