JP2005527511A5 - - Google Patents
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- Publication number
- JP2005527511A5 JP2005527511A5 JP2003572997A JP2003572997A JP2005527511A5 JP 2005527511 A5 JP2005527511 A5 JP 2005527511A5 JP 2003572997 A JP2003572997 A JP 2003572997A JP 2003572997 A JP2003572997 A JP 2003572997A JP 2005527511 A5 JP2005527511 A5 JP 2005527511A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- integer
- substituted
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000003118 aryl group Chemical group 0.000 claims 49
- 125000000623 heterocyclic group Chemical group 0.000 claims 41
- 125000000753 cycloalkyl group Chemical group 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 229910052799 carbon Inorganic materials 0.000 claims 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000001424 substituent group Chemical group 0.000 claims 16
- 125000001475 halogen functional group Chemical group 0.000 claims 14
- 229940002612 prodrug Drugs 0.000 claims 12
- 239000000651 prodrug Substances 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 150000001540 azides Chemical class 0.000 claims 5
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 4
- 125000004069 aziridinyl group Chemical group 0.000 claims 4
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 4
- 125000002757 morpholinyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 125000004193 piperazinyl group Chemical group 0.000 claims 4
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 3
- -1 Azechijini Chemical group 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 125000002393 azetidinyl group Chemical group 0.000 claims 3
- 125000005045 dihydroisoquinolinyl group Chemical group C1(NC=CC2=CC=CC=C12)* 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000005936 piperidyl group Chemical group 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 0 *c1cc(nccc2*)c2[s]1 Chemical compound *c1cc(nccc2*)c2[s]1 0.000 description 1
- XHKZQTQAARPTGG-LNYMIDHXSA-N Cc([n](C(NCC#C)=O)c(cc1)c2c(F)c1Oc1ccnc3c1[s]c(C(N(CC1)C[C@H]1O)O)c3)c2Cl Chemical compound Cc([n](C(NCC#C)=O)c(cc1)c2c(F)c1Oc1ccnc3c1[s]c(C(N(CC1)C[C@H]1O)O)c3)c2Cl XHKZQTQAARPTGG-LNYMIDHXSA-N 0.000 description 1
- WLDGJTCVRIQBLV-SFHVURJKSA-N Cc1cc2cc(Nc3c4[s]c(C(N5[C@H](COC)CCC5)=O)cc4ncc3)ccc2[n]1C(NC)=O Chemical compound Cc1cc2cc(Nc3c4[s]c(C(N5[C@H](COC)CCC5)=O)cc4ncc3)ccc2[n]1C(NC)=O WLDGJTCVRIQBLV-SFHVURJKSA-N 0.000 description 1
- WLDGJTCVRIQBLV-GOSISDBHSA-N Cc1cc2cc(Nc3ccnc4c3[s]c(C(N3[C@@H](COC)CCC3)=O)c4)ccc2[n]1C(NC)=O Chemical compound Cc1cc2cc(Nc3ccnc4c3[s]c(C(N3[C@@H](COC)CCC3)=O)c4)ccc2[n]1C(NC)=O WLDGJTCVRIQBLV-GOSISDBHSA-N 0.000 description 1
- PJWVMDHNOWVNTA-UHFFFAOYSA-N Cc1cc2cc(Oc3ccnc4c3[s]c(C(N(CC3)CC3OC)=O)c4)ccc2[n]1C(NCC#C)=O Chemical compound Cc1cc2cc(Oc3ccnc4c3[s]c(C(N(CC3)CC3OC)=O)c4)ccc2[n]1C(NCC#C)=O PJWVMDHNOWVNTA-UHFFFAOYSA-N 0.000 description 1
- NNRZUJRBORPOJH-QGZVFWFLSA-N Cc1cc2cc(Oc3ccnc4c3[s]c(C(N(CC3)C[C@@H]3O)=O)c4)ccc2[n]1C(NCC#C)=O Chemical compound Cc1cc2cc(Oc3ccnc4c3[s]c(C(N(CC3)C[C@@H]3O)=O)c4)ccc2[n]1C(NCC#C)=O NNRZUJRBORPOJH-QGZVFWFLSA-N 0.000 description 1
- PJWVMDHNOWVNTA-IBGZPJMESA-N Cc1cc2cc(Oc3ccnc4c3[s]c(C(N(CC3)C[C@H]3OC)=O)c4)ccc2[n]1C(NCC#C)=O Chemical compound Cc1cc2cc(Oc3ccnc4c3[s]c(C(N(CC3)C[C@H]3OC)=O)c4)ccc2[n]1C(NCC#C)=O PJWVMDHNOWVNTA-IBGZPJMESA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36095202P | 2002-03-01 | 2002-03-01 | |
| PCT/IB2003/000740 WO2003074529A2 (en) | 2002-03-01 | 2003-02-17 | iNDOLYL-UREA DERIVATIVES OF THIENOPYRIDINES USEFUL AS ANTI-ANGIOGENIC AGENTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005527511A JP2005527511A (ja) | 2005-09-15 |
| JP2005527511A5 true JP2005527511A5 (https=) | 2006-03-30 |
Family
ID=27789048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003572997A Abandoned JP2005527511A (ja) | 2002-03-01 | 2003-02-17 | 抗血管形成剤として有用なチエノピリジンのインドリル−尿素誘導体およびその使用法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6833456B2 (https=) |
| EP (1) | EP1483268A2 (https=) |
| JP (1) | JP2005527511A (https=) |
| AR (1) | AR040398A1 (https=) |
| AU (1) | AU2003206068A1 (https=) |
| BR (1) | BR0308162A (https=) |
| CA (1) | CA2478050A1 (https=) |
| GT (1) | GT200300046A (https=) |
| HN (1) | HN2003000080A (https=) |
| MX (1) | MXPA04008403A (https=) |
| PA (1) | PA8568101A1 (https=) |
| PE (1) | PE20030944A1 (https=) |
| TW (1) | TW200306193A (https=) |
| UY (1) | UY27685A1 (https=) |
| WO (1) | WO2003074529A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA77303C2 (en) | 2002-06-14 | 2006-11-15 | Pfizer | Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use |
| TW200503994A (en) * | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| EA009994B1 (ru) * | 2003-12-23 | 2008-06-30 | Пфайзер Инк. | Новые хинолиновые производные |
| AU2008202205B2 (en) * | 2003-12-23 | 2009-09-10 | Pfizer Inc. | Novel quinoline derivatives |
| WO2005066124A1 (ja) * | 2003-12-26 | 2005-07-21 | Daiichi Pharmaceutical Co., Ltd. | ピロリジン誘導体の製造法 |
| GB0412467D0 (en) * | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
| KR101257343B1 (ko) | 2004-07-30 | 2013-04-23 | 메틸진 인코포레이티드 | Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달 억제제 |
| AU2006313456B2 (en) * | 2005-05-20 | 2011-06-23 | Methylgene Inc. | Inhibitors of VEGF receptor and HGF receptor signaling |
| CN101796055B (zh) | 2005-05-20 | 2013-09-04 | 梅特希尔基因公司 | Vegf受体和hgf受体信号的抑制剂 |
| MX2008001838A (es) | 2005-08-08 | 2008-04-09 | Pfizer | Sales y polimorfos de un inhibidor de vegf-r. |
| JP2009526761A (ja) * | 2006-01-30 | 2009-07-23 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環式チオフェン化合物および使用の方法 |
| WO2007107005A1 (en) * | 2006-03-22 | 2007-09-27 | Methylgene, Inc. | Inhibitors of protein tyrosine kinase activity |
| JP2009539878A (ja) * | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
| BRPI0908573A2 (pt) | 2008-03-05 | 2012-12-25 | Methylgene Inc | inibidores da atividade de proteÍna tirosina quinase |
| KR101126736B1 (ko) * | 2008-11-27 | 2012-04-12 | 주식회사 레고켐 바이오사이언스 | 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물 |
| CA2806701A1 (en) | 2010-07-29 | 2012-02-02 | Bial - Portela & Ca, S.A. | Process for the synthesis of substituted urea compounds |
| MX2014000648A (es) | 2011-07-19 | 2014-09-25 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y sus usos. |
| CA2929742C (en) | 2013-12-04 | 2022-09-20 | Evotec International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| EA201691831A1 (ru) | 2014-04-25 | 2017-02-28 | Пфайзер Инк. | Гетероароматические соединения и их применение в качестве допаминовых d1 лигандов |
| CN115746017B (zh) * | 2022-11-30 | 2024-06-07 | 英维沃化工科技(广州)有限公司 | 一种噻吩并嘧啶类化合物及其制备方法和应用 |
| CN116082214A (zh) * | 2023-02-24 | 2023-05-09 | 常州大学 | 一种2-芳基-3-叔丁基吲哚类化合物、制备方法及其应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| BR9506936A (pt) | 1994-02-23 | 1997-09-09 | Pfizer | Derivados de quinazolina substituídos com 4-heterociclila processos para sua preparaçao e seu uso como agentes anticancerosos |
| US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| MX9707453A (es) | 1995-03-30 | 1997-12-31 | Pfizer | Derivados de quinazolina. |
| DK0821671T3 (da) * | 1995-04-20 | 2001-04-23 | Pfizer | Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| ATE247469T1 (de) | 1995-06-07 | 2003-09-15 | Pfizer | Heterocyclische kondensierte pyrimidin-derivate |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| EP0907642B1 (en) | 1996-06-24 | 2005-11-02 | Pfizer Inc. | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases |
| US6071935A (en) * | 1996-06-27 | 2000-06-06 | Pfizer Inc. | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors |
| ES2191187T3 (es) | 1996-07-13 | 2003-09-01 | Glaxo Group Ltd | Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa. |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| EP0923585B1 (en) | 1996-07-18 | 2002-05-08 | Pfizer Inc. | Phosphinate based inhibitors of matrix metalloproteases |
| WO1998007697A1 (en) | 1996-08-23 | 1998-02-26 | Pfizer Inc. | Arylsulfonylamino hydroxamic acid derivatives |
| US6413971B1 (en) | 1996-11-27 | 2002-07-02 | Pfizer Inc | Fused bicyclic pyrimidine derivatives |
| WO1998030566A1 (en) | 1997-01-06 | 1998-07-16 | Pfizer Inc. | Cyclic sulfone derivatives |
| EP0977733B1 (en) | 1997-02-03 | 2003-09-03 | Pfizer Products Inc. | Arylsulfonylamino hydroxamic acid derivatives |
| JP2000507975A (ja) | 1997-02-07 | 2000-06-27 | ファイザー・インク | Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用 |
| EA002546B1 (ru) | 1997-02-11 | 2002-06-27 | Пфайзер Инк. | Производные арилсульфонилгидроксамовой кислоты |
| CA2291709A1 (en) | 1997-05-30 | 1998-12-03 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| WO1999010349A1 (en) | 1997-08-22 | 1999-03-04 | Zeneca Limited | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
| WO1999016755A1 (en) | 1997-09-26 | 1999-04-08 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
| EA005032B1 (ru) | 1998-05-29 | 2004-10-28 | Сьюджен, Инк. | Пирролзамещенные 2-индолиноны (варианты), фармацевтическая композиция (варианты), способ модулирования каталитической активности протеинкиназы, способ лечения или профилактики нарушения в организме, связанного с протеинкиназой |
| BR9916536A (pt) | 1998-12-23 | 2002-01-02 | Searle & Co | Método para o tratamento ou prevenção de um distúrbio de neoplasia em um mamìfero em necessidade deste tratamento ou prevenção, e, combinação |
| JP2003535867A (ja) * | 2000-06-06 | 2003-12-02 | ファイザー プロダクツ インコーポレイテッド | 抗癌剤として有用なチオフェン誘導体 |
| AU2002345792A1 (en) * | 2001-06-21 | 2003-01-08 | Pfizer Inc. | Thienopyridine and thienopyrimidine anticancer agents |
-
2003
- 2003-02-17 BR BR0308162-1A patent/BR0308162A/pt not_active IP Right Cessation
- 2003-02-17 MX MXPA04008403A patent/MXPA04008403A/es active IP Right Grant
- 2003-02-17 WO PCT/IB2003/000740 patent/WO2003074529A2/en not_active Ceased
- 2003-02-17 JP JP2003572997A patent/JP2005527511A/ja not_active Abandoned
- 2003-02-17 EP EP03702952A patent/EP1483268A2/en not_active Withdrawn
- 2003-02-17 AU AU2003206068A patent/AU2003206068A1/en not_active Abandoned
- 2003-02-17 CA CA002478050A patent/CA2478050A1/en not_active Abandoned
- 2003-02-21 US US10/371,337 patent/US6833456B2/en not_active Expired - Fee Related
- 2003-02-24 TW TW092103808A patent/TW200306193A/zh unknown
- 2003-02-26 PE PE2003000186A patent/PE20030944A1/es not_active Application Discontinuation
- 2003-02-27 GT GT200300046A patent/GT200300046A/es unknown
- 2003-02-27 HN HN2003000080A patent/HN2003000080A/es unknown
- 2003-02-27 UY UY27685A patent/UY27685A1/es not_active Application Discontinuation
- 2003-02-27 PA PA20038568101A patent/PA8568101A1/es unknown
- 2003-02-28 AR AR20030100668A patent/AR040398A1/es not_active Application Discontinuation
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