PA8568101A1 - Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso - Google Patents
Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su usoInfo
- Publication number
- PA8568101A1 PA8568101A1 PA20038568101A PA8568101A PA8568101A1 PA 8568101 A1 PA8568101 A1 PA 8568101A1 PA 20038568101 A PA20038568101 A PA 20038568101A PA 8568101 A PA8568101 A PA 8568101A PA 8568101 A1 PA8568101 A1 PA 8568101A1
- Authority
- PA
- Panama
- Prior art keywords
- procedures
- tienopiridins
- antiangiogen
- indolil
- agents
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000004202 carbamide Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36095202P | 2002-03-01 | 2002-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8568101A1 true PA8568101A1 (es) | 2003-11-12 |
Family
ID=27789048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20038568101A PA8568101A1 (es) | 2002-03-01 | 2003-02-27 | Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6833456B2 (https=) |
| EP (1) | EP1483268A2 (https=) |
| JP (1) | JP2005527511A (https=) |
| AR (1) | AR040398A1 (https=) |
| AU (1) | AU2003206068A1 (https=) |
| BR (1) | BR0308162A (https=) |
| CA (1) | CA2478050A1 (https=) |
| GT (1) | GT200300046A (https=) |
| HN (1) | HN2003000080A (https=) |
| MX (1) | MXPA04008403A (https=) |
| PA (1) | PA8568101A1 (https=) |
| PE (1) | PE20030944A1 (https=) |
| TW (1) | TW200306193A (https=) |
| UY (1) | UY27685A1 (https=) |
| WO (1) | WO2003074529A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA77303C2 (en) | 2002-06-14 | 2006-11-15 | Pfizer | Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use |
| TW200503994A (en) * | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| AU2004309166B2 (en) * | 2003-12-23 | 2008-02-21 | Pfizer Inc. | Novel quinoline derivatives |
| AU2008202205B2 (en) * | 2003-12-23 | 2009-09-10 | Pfizer Inc. | Novel quinoline derivatives |
| EP1698621A4 (en) * | 2003-12-26 | 2008-11-19 | Daiichi Seiyaku Co | PROCESS FOR PREPARING A PYRROLIDINE DERIVATIVE |
| GB0412467D0 (en) * | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
| ES2438017T3 (es) | 2004-07-30 | 2014-01-15 | Methylgene Inc. | Inhibidores de la señalización del receptor del VEGF y del receptor del HGF |
| KR101378716B1 (ko) | 2005-05-20 | 2014-04-10 | 메틸진 인코포레이티드 | Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제 |
| AU2006313456B2 (en) | 2005-05-20 | 2011-06-23 | Methylgene Inc. | Inhibitors of VEGF receptor and HGF receptor signaling |
| AU2006277742B2 (en) | 2005-08-08 | 2010-08-26 | Pfizer Inc. | Salts and polymorphs of a VEGF-R inhibitor |
| JP2009526761A (ja) * | 2006-01-30 | 2009-07-23 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環式チオフェン化合物および使用の方法 |
| AR060061A1 (es) * | 2006-03-22 | 2008-05-21 | Methylgene Inc | Inhibidores de la actividad de la proteina tirosina quinasa |
| JP2009539878A (ja) * | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
| NZ588355A (en) | 2008-03-05 | 2012-03-30 | Methylgene Inc | Inhibitors of protein tyrosine kinase activity |
| KR101126736B1 (ko) * | 2008-11-27 | 2012-04-12 | 주식회사 레고켐 바이오사이언스 | 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물 |
| BR112013001721A2 (pt) | 2010-07-29 | 2016-05-31 | Bial Portela & Ca Sa | processo de síntese de compostos de ureia substituída |
| AR088218A1 (es) | 2011-07-19 | 2014-05-21 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos utiles como inhibidores de pi3k |
| CA2929742C (en) | 2013-12-04 | 2022-09-20 | Evotec International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| WO2015162515A1 (en) | 2014-04-25 | 2015-10-29 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| CN115746017B (zh) * | 2022-11-30 | 2024-06-07 | 英维沃化工科技(广州)有限公司 | 一种噻吩并嘧啶类化合物及其制备方法和应用 |
| CN116082214A (zh) * | 2023-02-24 | 2023-05-09 | 常州大学 | 一种2-芳基-3-叔丁基吲哚类化合物、制备方法及其应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| RU2137762C1 (ru) | 1994-02-23 | 1999-09-20 | Пфайзер Инк. | 4-гетероциклил-замещенные производные хиназолина, фармацевтическая композиция |
| US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| DE69536015D1 (de) | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
| ES2153031T4 (es) | 1995-04-20 | 2001-05-16 | Pfizer | Derivados del acido arilsulfonil hidroxamico como inhibidores de mmp y tnf. |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| JP3290666B2 (ja) | 1995-06-07 | 2002-06-10 | ファイザー・インコーポレーテッド | 複素環式の縮合環ピリミジン誘導体 |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| NZ331191A (en) | 1996-03-05 | 2000-03-27 | Zeneca Ltd | 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof |
| CA2258548C (en) | 1996-06-24 | 2005-07-26 | Pfizer Inc. | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases |
| WO1997049700A1 (en) * | 1996-06-27 | 1997-12-31 | Pfizer Inc. | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors |
| EA199900021A1 (ru) | 1996-07-13 | 1999-08-26 | Глаксо, Груп Лимитед | Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| KR20000067904A (ko) | 1996-07-18 | 2000-11-25 | 디. 제이. 우드, 스피겔 알렌 제이 | 매트릭스 메탈로프로테아제의 포스피네이트계 억제제 |
| KR20000068248A (ko) | 1996-08-23 | 2000-11-25 | 디. 제이. 우드, 스피겔 알렌 제이 | 아릴설포닐아미노 하이드록삼산 유도체 |
| WO1998023613A1 (en) | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Fused bicyclic pyrimidine derivatives |
| JP3338064B2 (ja) | 1997-01-06 | 2002-10-28 | ファイザー・インク | 環状スルホン誘導体 |
| NZ336840A (en) | 1997-02-03 | 2001-01-26 | Pfizer Prod Inc | Arylsulfonylamino hydroxamic acid derivatives useful in the treatment of tumor necrosis factor and matrix metalloproteinase mediated diseases |
| JP2000507975A (ja) | 1997-02-07 | 2000-06-27 | ファイザー・インク | Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用 |
| EP0960098A1 (en) | 1997-02-11 | 1999-12-01 | Pfizer Inc. | Arylsulfonyl hydroxamic acid derivatives |
| JP2002501532A (ja) | 1997-05-30 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 新規血管形成阻害薬 |
| ES2289791T3 (es) | 1997-08-22 | 2008-02-01 | Astrazeneca Ab | Derivados de oxindolilquinazolina como inhibidores de la angiogenesis. |
| AU744939B2 (en) | 1997-09-26 | 2002-03-07 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
| SK287132B6 (sk) | 1998-05-29 | 2009-12-07 | Sugen, Inc. | Farmaceutická kompozícia obsahujúca pyrolom substituovaný 2-indolinón, súprava obsahujúca uvedenú kompozíciu a použitie pyrolom substituovaného 2-indolinónu |
| AU2592600A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| BR0111377A (pt) * | 2000-06-06 | 2003-06-03 | Pfizer Prod Inc | Derivados de tiofeno úteis como agentes anticancerìgenos |
| WO2003000194A2 (en) * | 2001-06-21 | 2003-01-03 | Pfizer Inc. | Thienopyridine and thienopyrimidine anticancer agents |
-
2003
- 2003-02-17 AU AU2003206068A patent/AU2003206068A1/en not_active Abandoned
- 2003-02-17 CA CA002478050A patent/CA2478050A1/en not_active Abandoned
- 2003-02-17 MX MXPA04008403A patent/MXPA04008403A/es active IP Right Grant
- 2003-02-17 WO PCT/IB2003/000740 patent/WO2003074529A2/en not_active Ceased
- 2003-02-17 BR BR0308162-1A patent/BR0308162A/pt not_active IP Right Cessation
- 2003-02-17 EP EP03702952A patent/EP1483268A2/en not_active Withdrawn
- 2003-02-17 JP JP2003572997A patent/JP2005527511A/ja not_active Abandoned
- 2003-02-21 US US10/371,337 patent/US6833456B2/en not_active Expired - Fee Related
- 2003-02-24 TW TW092103808A patent/TW200306193A/zh unknown
- 2003-02-26 PE PE2003000186A patent/PE20030944A1/es not_active Application Discontinuation
- 2003-02-27 GT GT200300046A patent/GT200300046A/es unknown
- 2003-02-27 UY UY27685A patent/UY27685A1/es not_active Application Discontinuation
- 2003-02-27 HN HN2003000080A patent/HN2003000080A/es unknown
- 2003-02-27 PA PA20038568101A patent/PA8568101A1/es unknown
- 2003-02-28 AR AR20030100668A patent/AR040398A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20030944A1 (es) | 2003-11-08 |
| MXPA04008403A (es) | 2004-11-26 |
| HN2003000080A (es) | 2004-05-05 |
| BR0308162A (pt) | 2004-12-07 |
| AR040398A1 (es) | 2005-04-06 |
| TW200306193A (en) | 2003-11-16 |
| UY27685A1 (es) | 2003-10-31 |
| AU2003206068A1 (en) | 2003-09-16 |
| US6833456B2 (en) | 2004-12-21 |
| WO2003074529A3 (en) | 2003-12-24 |
| AU2003206068A8 (en) | 2003-09-16 |
| EP1483268A2 (en) | 2004-12-08 |
| GT200300046A (es) | 2003-10-10 |
| JP2005527511A (ja) | 2005-09-15 |
| US20040019065A1 (en) | 2004-01-29 |
| WO2003074529A2 (en) | 2003-09-12 |
| CA2478050A1 (en) | 2003-09-12 |
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