PE20030944A1 - Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su uso - Google Patents
Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su usoInfo
- Publication number
- PE20030944A1 PE20030944A1 PE2003000186A PE2003000186A PE20030944A1 PE 20030944 A1 PE20030944 A1 PE 20030944A1 PE 2003000186 A PE2003000186 A PE 2003000186A PE 2003000186 A PE2003000186 A PE 2003000186A PE 20030944 A1 PE20030944 A1 PE 20030944A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- thenopyridines
- indolyl
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A INDOLIL-UREA DERIVADOS DE TIENOPIRIDINAS DE FORMULA I DONDE X ES -CH-, -N-; Y ES -NH-, -O-, -S-, -CH2-; R1 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C10, C(O)(ALQUILO C1-C6), ARILO C6-C10, HETEROCICLILO DE 5 A 13 MIEMBROS; R5 ES HALO, CIANO, NITRO, TRIFLUOROMETOXI, TRIFLUOROMETILO, AZIDO, NR6R7, ENTRE OTROS; R6 Y R7 SON H, OH, ALQUILO C1-C6, CICLOALQUILO C3-C10, -(CH2)tCN(CH2)tR9, ENTRE OTROS DONDE t ES 0-6; q ES 2-6; R8 ES H, ALQUILO C1-C10, CICLOALQUILO C3-C10, ENTRE OTROS; R9 ES H, OR6, ALQUILO C1-C6, CICLOALQUILO C3-C10, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. SON COMPUESTOS PREFERIDOS METILAMIDA DEL ACIDO 5-[2-(2R-HIDROXIMETIL-PIRROLIDIN-1-CARBONIL)-TIENO[3,2-b]PIRIDIN-7-ILAMINO]-METIL-INDOL-1-CARBOXILICO, METILAMIDA DEL ACIDO 5-[2-(2R-METOXIMETIL-PIRROLIDINA-1-CARBONIL)-TIENO[3,2-b]PIRIDIN-7-ILAMINO]-2-METIL-INDOL-1-CARBOXILICO, CICLOPROPILAMIDA DEL ACIDO 5-[2-(2R-HIDROXIMETIL-PIRROLIDINA-1-CARBONIL)-TIENO[3,2-b]PIRIDIN-7-ILAMINO]-2-METIL-INDOL-1-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA UTIL PARA EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36095202P | 2002-03-01 | 2002-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030944A1 true PE20030944A1 (es) | 2003-11-08 |
Family
ID=27789048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000186A PE20030944A1 (es) | 2002-03-01 | 2003-02-26 | Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su uso |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6833456B2 (es) |
| EP (1) | EP1483268A2 (es) |
| JP (1) | JP2005527511A (es) |
| AR (1) | AR040398A1 (es) |
| AU (1) | AU2003206068A1 (es) |
| BR (1) | BR0308162A (es) |
| CA (1) | CA2478050A1 (es) |
| GT (1) | GT200300046A (es) |
| HN (1) | HN2003000080A (es) |
| MX (1) | MXPA04008403A (es) |
| PA (1) | PA8568101A1 (es) |
| PE (1) | PE20030944A1 (es) |
| TW (1) | TW200306193A (es) |
| UY (1) | UY27685A1 (es) |
| WO (1) | WO2003074529A2 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA77303C2 (en) | 2002-06-14 | 2006-11-15 | Pfizer | Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use |
| TW200503994A (en) * | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| AU2008202205B2 (en) * | 2003-12-23 | 2009-09-10 | Pfizer Inc. | Novel quinoline derivatives |
| SG141459A1 (en) * | 2003-12-23 | 2008-04-28 | Pfizer | Novel quinoline derivatives |
| JPWO2005066124A1 (ja) * | 2003-12-26 | 2007-12-20 | 第一三共株式会社 | ピロリジン誘導体の製造法 |
| GB0412467D0 (en) * | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
| US7772247B2 (en) | 2004-07-30 | 2010-08-10 | Methylgene Inc. | Substituted thieno[3,2-d]pyridines as inhibitors of the VEGF receptor and HGF receptor |
| MX2007014616A (es) | 2005-05-20 | 2009-08-12 | Methylgene Inc | Inhibidores de señalizacion del receptor del factor a de crecimiento endotelial vascular y del receptor del factor de crecimiento de hepatocitos. |
| MX2007014617A (es) * | 2005-05-20 | 2008-02-11 | Methylgene Inc | Inhibidores de senalizacion de receptor de factor de crecimiento endotelial bascular y receptor de factor de crecimiento de hepatocitos. |
| MX2008001838A (es) | 2005-08-08 | 2008-04-09 | Pfizer | Sales y polimorfos de un inhibidor de vegf-r. |
| JP2009526761A (ja) * | 2006-01-30 | 2009-07-23 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環式チオフェン化合物および使用の方法 |
| US20080064718A1 (en) * | 2006-03-22 | 2008-03-13 | Saavedra Oscar M | Inhibitors of protein tyrosine kinase activity |
| US20110053931A1 (en) * | 2006-06-08 | 2011-03-03 | John Gaudino | Quinoline compounds and methods of use |
| RU2498988C2 (ru) | 2008-03-05 | 2013-11-20 | Метилджин, Инк. | Ингибиторы активности протеинтирозинкиназы |
| KR101126736B1 (ko) * | 2008-11-27 | 2012-04-12 | 주식회사 레고켐 바이오사이언스 | 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물 |
| WO2012015324A1 (en) * | 2010-07-29 | 2012-02-02 | Bial - Portela & Ca, S.A. | Process for the synthesis of substituted urea compounds |
| CN103946226A (zh) | 2011-07-19 | 2014-07-23 | 无限药品股份有限公司 | 杂环化合物及其应用 |
| AU2014359456B2 (en) | 2013-12-04 | 2019-01-24 | Evotec International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| WO2015162515A1 (en) | 2014-04-25 | 2015-10-29 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| CN115746017B (zh) * | 2022-11-30 | 2024-06-07 | 英维沃化工科技(广州)有限公司 | 一种噻吩并嘧啶类化合物及其制备方法和应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| CA2183655C (en) | 1994-02-23 | 2001-03-06 | Lee D. Arnold | 4-polycyclic amino-substituted quinazoline derivatives |
| US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| CA2216796C (en) | 1995-03-30 | 2003-09-02 | Pfizer Inc. | Quinazoline derivatives |
| JP3053222B2 (ja) | 1995-04-20 | 2000-06-19 | ファイザー・インコーポレーテッド | Ｍｍｐおよびｔｎｆ抑制剤としてのアリールスルホニルヒドロキサム酸誘導体 |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| PT831829E (pt) | 1995-06-07 | 2003-12-31 | Pfizer | Derivados de pirimidina heterociclicos de aneis fundidos |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| ATE211134T1 (de) | 1996-03-05 | 2002-01-15 | 4-anilinochinazolin derivate | |
| CA2258548C (en) | 1996-06-24 | 2005-07-26 | Pfizer Inc. | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases |
| BR9709974A (pt) | 1996-06-27 | 1999-08-10 | Pfizer | Derivados de 2-(2-oxo-etidileno)-imidazolidin-4-ona e seu uso como inibidores da transferase da proteina de farnesila |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| EA199900021A1 (ru) | 1996-07-13 | 1999-08-26 | Глаксо, Груп Лимитед | Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы |
| TR199900066T2 (xx) | 1996-07-18 | 1999-04-21 | Pfizer Inc. | Matriks metalloproteazlar�n fosfinat bazl� inhibit�rleri |
| SK21499A3 (en) | 1996-08-23 | 2000-05-16 | Pfizer | Arylsulfonylamino hydroxamic acid derivatives |
| KR20000057228A (ko) | 1996-11-27 | 2000-09-15 | 디. 제이. 우드, 스피겔 알렌 제이 | 축합된 비사이클릭 피리미딘 유도체 |
| US6077864A (en) | 1997-01-06 | 2000-06-20 | Pfizer Inc. | Cyclic sulfone derivatives |
| DE69817801T2 (de) | 1997-02-03 | 2004-03-11 | Pfizer Products Inc., Groton | Arylsulfonylhydroxamsäurederivate |
| BR9807824A (pt) | 1997-02-07 | 2000-03-08 | Pfizer | Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz |
| EP0960098A1 (en) | 1997-02-11 | 1999-12-01 | Pfizer Inc. | Arylsulfonyl hydroxamic acid derivatives |
| CA2291709A1 (en) | 1997-05-30 | 1998-12-03 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| DE69838172T2 (de) | 1997-08-22 | 2008-04-10 | Astrazeneca Ab | Oxindolylchinazolinderivate als angiogenesehemmer |
| AU744939B2 (en) | 1997-09-26 | 2002-03-07 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
| CO5031249A1 (es) | 1998-05-29 | 2001-04-27 | Sugen Inc | Pirrol substituido-2-indolinonas inhibidoras de proteinci-nasas |
| WO2000038730A2 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Use of a cyclooxygenase-2 inhibitor and one or more antineoplastic agents for combination therapy in neoplasia |
| ATE277933T1 (de) * | 2000-06-06 | 2004-10-15 | Pfizer Prod Inc | Thiophenverbindungen zur verwendung als antikrebsmittel |
| US6995171B2 (en) * | 2001-06-21 | 2006-02-07 | Agouron Pharmaceuticals, Inc. | Bicyclic pyrimidine and pyrimidine derivatives useful as anticancer agents |
-
2003
- 2003-02-17 JP JP2003572997A patent/JP2005527511A/ja not_active Abandoned
- 2003-02-17 BR BR0308162-1A patent/BR0308162A/pt not_active IP Right Cessation
- 2003-02-17 CA CA002478050A patent/CA2478050A1/en not_active Abandoned
- 2003-02-17 AU AU2003206068A patent/AU2003206068A1/en not_active Abandoned
- 2003-02-17 WO PCT/IB2003/000740 patent/WO2003074529A2/en not_active Application Discontinuation
- 2003-02-17 EP EP03702952A patent/EP1483268A2/en not_active Withdrawn
- 2003-02-17 MX MXPA04008403A patent/MXPA04008403A/es active IP Right Grant
- 2003-02-21 US US10/371,337 patent/US6833456B2/en not_active Expired - Fee Related
- 2003-02-24 TW TW092103808A patent/TW200306193A/zh unknown
- 2003-02-26 PE PE2003000186A patent/PE20030944A1/es not_active Application Discontinuation
- 2003-02-27 HN HN2003000080A patent/HN2003000080A/es unknown
- 2003-02-27 GT GT200300046A patent/GT200300046A/es unknown
- 2003-02-27 UY UY27685A patent/UY27685A1/es not_active Application Discontinuation
- 2003-02-27 PA PA20038568101A patent/PA8568101A1/es unknown
- 2003-02-28 AR AR20030100668A patent/AR040398A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04008403A (es) | 2004-11-26 |
| AR040398A1 (es) | 2005-04-06 |
| WO2003074529A2 (en) | 2003-09-12 |
| HN2003000080A (es) | 2004-05-05 |
| EP1483268A2 (en) | 2004-12-08 |
| AU2003206068A8 (en) | 2003-09-16 |
| UY27685A1 (es) | 2003-10-31 |
| WO2003074529A3 (en) | 2003-12-24 |
| TW200306193A (en) | 2003-11-16 |
| JP2005527511A (ja) | 2005-09-15 |
| US6833456B2 (en) | 2004-12-21 |
| CA2478050A1 (en) | 2003-09-12 |
| AU2003206068A1 (en) | 2003-09-16 |
| US20040019065A1 (en) | 2004-01-29 |
| GT200300046A (es) | 2003-10-10 |
| BR0308162A (pt) | 2004-12-07 |
| PA8568101A1 (es) | 2003-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |