CA2478050A1 - Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents - Google Patents

Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents Download PDF

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Publication number
CA2478050A1
CA2478050A1 CA002478050A CA2478050A CA2478050A1 CA 2478050 A1 CA2478050 A1 CA 2478050A1 CA 002478050 A CA002478050 A CA 002478050A CA 2478050 A CA2478050 A CA 2478050A CA 2478050 A1 CA2478050 A1 CA 2478050A1
Authority
CA
Canada
Prior art keywords
alkyl
aryl
integer
membered heterocyclic
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002478050A
Other languages
English (en)
French (fr)
Inventor
Robert Steven Kania
William Henry Romines Iii
Stephan James Cripps
Mingying He
Jihong Lou
Ru Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2478050A1 publication Critical patent/CA2478050A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA002478050A 2002-03-01 2003-02-17 Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents Abandoned CA2478050A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36095202P 2002-03-01 2002-03-01
US60/360,952 2002-03-01
PCT/IB2003/000740 WO2003074529A2 (en) 2002-03-01 2003-02-17 iNDOLYL-UREA DERIVATIVES OF THIENOPYRIDINES USEFUL AS ANTI-ANGIOGENIC AGENTS

Publications (1)

Publication Number Publication Date
CA2478050A1 true CA2478050A1 (en) 2003-09-12

Family

ID=27789048

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002478050A Abandoned CA2478050A1 (en) 2002-03-01 2003-02-17 Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents

Country Status (15)

Country Link
US (1) US6833456B2 (https=)
EP (1) EP1483268A2 (https=)
JP (1) JP2005527511A (https=)
AR (1) AR040398A1 (https=)
AU (1) AU2003206068A1 (https=)
BR (1) BR0308162A (https=)
CA (1) CA2478050A1 (https=)
GT (1) GT200300046A (https=)
HN (1) HN2003000080A (https=)
MX (1) MXPA04008403A (https=)
PA (1) PA8568101A1 (https=)
PE (1) PE20030944A1 (https=)
TW (1) TW200306193A (https=)
UY (1) UY27685A1 (https=)
WO (1) WO2003074529A2 (https=)

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AU2006313456B2 (en) 2005-05-20 2011-06-23 Methylgene Inc. Inhibitors of VEGF receptor and HGF receptor signaling
AU2006277742B2 (en) 2005-08-08 2010-08-26 Pfizer Inc. Salts and polymorphs of a VEGF-R inhibitor
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JP2009539878A (ja) * 2006-06-08 2009-11-19 アレイ バイオファーマ、インコーポレイテッド キノリン化合物および使用方法
NZ588355A (en) 2008-03-05 2012-03-30 Methylgene Inc Inhibitors of protein tyrosine kinase activity
KR101126736B1 (ko) * 2008-11-27 2012-04-12 주식회사 레고켐 바이오사이언스 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물
BR112013001721A2 (pt) 2010-07-29 2016-05-31 Bial Portela & Ca Sa processo de síntese de compostos de ureia substituída
AR088218A1 (es) 2011-07-19 2014-05-21 Infinity Pharmaceuticals Inc Compuestos heterociclicos utiles como inhibidores de pi3k
CA2929742C (en) 2013-12-04 2022-09-20 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
WO2015162515A1 (en) 2014-04-25 2015-10-29 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
CN115746017B (zh) * 2022-11-30 2024-06-07 英维沃化工科技(广州)有限公司 一种噻吩并嘧啶类化合物及其制备方法和应用
CN116082214A (zh) * 2023-02-24 2023-05-09 常州大学 一种2-芳基-3-叔丁基吲哚类化合物、制备方法及其应用

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US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
RU2137762C1 (ru) 1994-02-23 1999-09-20 Пфайзер Инк. 4-гетероциклил-замещенные производные хиназолина, фармацевтическая композиция
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
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ES2153031T4 (es) 1995-04-20 2001-05-16 Pfizer Derivados del acido arilsulfonil hidroxamico como inhibidores de mmp y tnf.
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KR20000068248A (ko) 1996-08-23 2000-11-25 디. 제이. 우드, 스피겔 알렌 제이 아릴설포닐아미노 하이드록삼산 유도체
WO1998023613A1 (en) 1996-11-27 1998-06-04 Pfizer Inc. Fused bicyclic pyrimidine derivatives
JP3338064B2 (ja) 1997-01-06 2002-10-28 ファイザー・インク 環状スルホン誘導体
NZ336840A (en) 1997-02-03 2001-01-26 Pfizer Prod Inc Arylsulfonylamino hydroxamic acid derivatives useful in the treatment of tumor necrosis factor and matrix metalloproteinase mediated diseases
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AU2592600A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
BR0111377A (pt) * 2000-06-06 2003-06-03 Pfizer Prod Inc Derivados de tiofeno úteis como agentes anticancerìgenos
WO2003000194A2 (en) * 2001-06-21 2003-01-03 Pfizer Inc. Thienopyridine and thienopyrimidine anticancer agents

Also Published As

Publication number Publication date
PA8568101A1 (es) 2003-11-12
PE20030944A1 (es) 2003-11-08
MXPA04008403A (es) 2004-11-26
HN2003000080A (es) 2004-05-05
BR0308162A (pt) 2004-12-07
AR040398A1 (es) 2005-04-06
TW200306193A (en) 2003-11-16
UY27685A1 (es) 2003-10-31
AU2003206068A1 (en) 2003-09-16
US6833456B2 (en) 2004-12-21
WO2003074529A3 (en) 2003-12-24
AU2003206068A8 (en) 2003-09-16
EP1483268A2 (en) 2004-12-08
GT200300046A (es) 2003-10-10
JP2005527511A (ja) 2005-09-15
US20040019065A1 (en) 2004-01-29
WO2003074529A2 (en) 2003-09-12

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