MXPA04008403A

MXPA04008403A - Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso.

Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso.

Info

Publication number: MXPA04008403A
Authority: MX; Mexico
Prior art keywords: alkyl; aryl; integer; cycloalkyl; substituted
Prior art date: 2002-03-01

Application number

MXPA04008403A

Other languages

English (en)

Spanish (es)

Inventor

Ru Zhou

Original Assignee

Pfizer

Priority date

2002-03-01

Filing date

2003-02-17

Publication date

2004-11-26

2003-02-17 Application filed by Pfizer filed Critical Pfizer

2004-11-26 Publication of MXPA04008403A publication Critical patent/MXPA04008403A/es

Links

239000004037 angiogenesis inhibitor Substances 0.000 title description 2
229940125670 thienopyridine Drugs 0.000 title description 2
239000002175 thienopyridine Substances 0.000 title description 2
ZGMSLRPPUJSIGP-UHFFFAOYSA-N 1h-indol-2-ylurea Chemical class C1=CC=C2NC(NC(=O)N)=CC2=C1 ZGMSLRPPUJSIGP-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 230
239000000651 prodrug Substances 0.000 claims abstract description 79
229940002612 prodrug Drugs 0.000 claims abstract description 79
150000003839 salts Chemical class 0.000 claims abstract description 69
239000012453 solvate Substances 0.000 claims abstract description 34
241000124008 Mammalia Species 0.000 claims abstract description 32
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 28
230000003463 hyperproliferative effect Effects 0.000 claims abstract description 13
229910052739 hydrogen Inorganic materials 0.000 claims description 807
-1 morphoin Chemical group 0.000 claims description 106
229910052757 nitrogen Inorganic materials 0.000 claims description 106
125000000623 heterocyclic group Chemical group 0.000 claims description 97
125000003118 aryl group Chemical group 0.000 claims description 62
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 55
125000001424 substituent group Chemical group 0.000 claims description 55
125000000753 cycloalkyl group Chemical group 0.000 claims description 53
125000000217 alkyl group Chemical group 0.000 claims description 52
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 32
238000011282 treatment Methods 0.000 claims description 30
125000000041 C6-C10 aryl group Chemical group 0.000 claims description 24
125000000719 pyrrolidinyl group Chemical group 0.000 claims description 23
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 20
201000010099 disease Diseases 0.000 claims description 19
125000004193 piperazinyl group Chemical group 0.000 claims description 18
125000002757 morpholinyl group Chemical group 0.000 claims description 17
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 17
229910052760 oxygen Inorganic materials 0.000 claims description 17
125000004093 cyano group Chemical group *C#N 0.000 claims description 16
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 16
125000004568 thiomorpholinyl group Chemical group 0.000 claims description 16
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 15
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 15
239000001301 oxygen Substances 0.000 claims description 15
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 14
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 14
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125000001072 heteroaryl group Chemical group 0.000 claims description 13
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125000001475 halogen functional group Chemical group 0.000 claims 14
125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
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238000000034 method Methods 0.000 abstract description 56
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238000006243 chemical reaction Methods 0.000 description 26
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238000003556 assay Methods 0.000 description 21
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