JP2006503805A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006503805A5 JP2006503805A5 JP2004508112A JP2004508112A JP2006503805A5 JP 2006503805 A5 JP2006503805 A5 JP 2006503805A5 JP 2004508112 A JP2004508112 A JP 2004508112A JP 2004508112 A JP2004508112 A JP 2004508112A JP 2006503805 A5 JP2006503805 A5 JP 2006503805A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- hydrogen
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 51
- 229910052739 hydrogen Inorganic materials 0.000 claims 26
- 239000001257 hydrogen Substances 0.000 claims 26
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 24
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 125000002947 alkylene group Chemical group 0.000 claims 14
- 125000001424 substituent group Chemical group 0.000 claims 14
- 125000001309 chloro group Chemical group Cl* 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000002993 cycloalkylene group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000005549 heteroarylene group Chemical group 0.000 claims 6
- 125000006585 (C6-C10) arylene group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000000732 arylene group Chemical group 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000002421 cell wall Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38327402P | 2002-05-24 | 2002-05-24 | |
| PCT/US2003/016375 WO2003099858A1 (en) | 2002-05-24 | 2003-05-23 | Cross-linked glycopeptide-cephalosporin antibiotics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009144705A Division JP2009256358A (ja) | 2002-05-24 | 2009-06-17 | 架橋グリコペプチド−セファロスポリン抗生物質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503805A JP2006503805A (ja) | 2006-02-02 |
| JP2006503805A5 true JP2006503805A5 (https=) | 2006-05-18 |
| JP4347799B2 JP4347799B2 (ja) | 2009-10-21 |
Family
ID=29584538
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004508112A Expired - Fee Related JP4347799B2 (ja) | 2002-05-24 | 2003-05-23 | 架橋グリコペプチド−セファロスポリン抗生物質 |
| JP2009144705A Withdrawn JP2009256358A (ja) | 2002-05-24 | 2009-06-17 | 架橋グリコペプチド−セファロスポリン抗生物質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009144705A Withdrawn JP2009256358A (ja) | 2002-05-24 | 2009-06-17 | 架橋グリコペプチド−セファロスポリン抗生物質 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US6878686B2 (https=) |
| EP (1) | EP1507796B1 (https=) |
| JP (2) | JP4347799B2 (https=) |
| AT (1) | ATE556088T1 (https=) |
| AU (1) | AU2003231833A1 (https=) |
| ES (1) | ES2384707T3 (https=) |
| TW (1) | TWI325323B (https=) |
| WO (1) | WO2003099858A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1140993E (pt) * | 1998-12-23 | 2003-10-31 | Theravance Inc | Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos |
| TWI335332B (en) * | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
| TWI325323B (en) * | 2002-05-24 | 2010-06-01 | Theravance Inc | Cross-linked glycopeptide-cephalosporin antibiotics |
| JP2007500222A (ja) | 2003-05-23 | 2007-01-11 | セラヴァンス インコーポレーテッド | 架橋グリコペプチド−セファロスポリン抗生物質 |
| DE602004012269T2 (de) * | 2003-07-11 | 2009-04-30 | Theravance, Inc., South San Francisco | Quervernetzte glycopeptid-cephalosporin-antibiotika |
| US20080020961A1 (en) * | 2006-07-21 | 2008-01-24 | Rodrigues Klin A | Low Molecular Weight Graft Copolymers |
| EP2435464B1 (en) * | 2009-05-29 | 2014-07-16 | Covalx AG | Cross-linking reagents for molecular interaction analysis |
| WO2012129493A1 (en) * | 2011-03-24 | 2012-09-27 | Seachaid Pharmaceuticals, Inc. | Vancomycin derivatives |
| MX352760B (es) | 2011-09-09 | 2017-12-07 | Merck Sharp & Dohme Corp Star | Metodos para tratar infecciones intrapulmonares. |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| EP2970164B1 (en) | 2013-03-13 | 2017-05-03 | Theravance Biopharma Antibiotics IP, LLC | Crystalline form of a substituted thiazolylacetic acid triethylamine salt |
| US20140274993A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane-tazobactam pharmaceutical compositions |
| DK2893929T3 (da) | 2013-03-15 | 2025-07-07 | Merck Sharp & Dohme Llc | Antibiotisk ceftolozansammensætninger |
| KR102237887B1 (ko) | 2013-03-15 | 2021-04-07 | 멜린타 서브시디어리 코프. | 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법 |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| EP3043797B1 (en) | 2013-09-09 | 2020-04-08 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| US11878958B2 (en) | 2022-05-25 | 2024-01-23 | Ikena Oncology, Inc. | MEK inhibitors and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693A (en) | 1848-08-01 | Window-catch | ||
| US7A (en) | 1836-08-10 | Thomas Blanchard | Machine for boring holes and cutting lanyard-scores in deadeyes | |
| US947926A (en) * | 1908-09-15 | 1910-02-01 | William C Meyer | Expansion-reamer. |
| GB2033377B (en) | 1978-09-11 | 1983-05-05 | Fujisawa Pharmaceuticalco Ltd | Cephem compounds and processes for preparation thereof |
| US4341775A (en) | 1978-09-11 | 1982-07-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| US4220761A (en) | 1978-09-12 | 1980-09-02 | Fujisawa Pharmaceutical Co., Ltd. | 7-[Substituted oximinoacetamido]-3-[hydroxy alkyltetrazolo]cephalosporin derivatives |
| JPS6041682A (ja) | 1983-08-16 | 1985-03-05 | Meiji Seika Kaisha Ltd | 新規セフアロスポリン化合物及びその製造法 |
| US4921851A (en) | 1986-06-09 | 1990-05-01 | Takeda Chemical Industries, Ltd. | Cephem compounds, their production and use |
| AU1630988A (en) | 1987-05-30 | 1988-12-01 | Kyoto Pharmaceutical Industries, Ltd. | Cephalosporin compound and pharmaceutical composition thereof |
| US5693791A (en) | 1995-04-11 | 1997-12-02 | Truett; William L. | Antibiotics and process for preparation |
| CA2318394A1 (en) | 1998-02-20 | 1999-08-26 | Advanced Medicine, Inc. | Novel antibacterial agents |
| US6437119B1 (en) | 1998-05-07 | 2002-08-20 | William Lawrence Truett | Compounds formed from two or three antibiotics and their processes of preparation |
| US6288234B1 (en) | 1998-06-08 | 2001-09-11 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| US7208572B2 (en) * | 1998-08-21 | 2007-04-24 | Albany Medical College | Leptin-related peptides |
| PT1140993E (pt) | 1998-12-23 | 2003-10-31 | Theravance Inc | Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos |
| AU2001238020A1 (en) * | 2000-02-04 | 2001-08-14 | Advanced Medicine, Inc. | Glycopeptide derivatives having antibiotic activity |
| UA75083C2 (uk) | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Похідні глікопептидфосфонатів |
| US20030008812A1 (en) * | 2001-02-02 | 2003-01-09 | Christensen Burton G. | Glycopeptide derivatives |
| TWI335332B (en) | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
| TWI325323B (en) * | 2002-05-24 | 2010-06-01 | Theravance Inc | Cross-linked glycopeptide-cephalosporin antibiotics |
| JP2007500222A (ja) | 2003-05-23 | 2007-01-11 | セラヴァンス インコーポレーテッド | 架橋グリコペプチド−セファロスポリン抗生物質 |
| US7127856B2 (en) * | 2003-06-06 | 2006-10-31 | Hans T. Hagen, Jr. | Insulated stud panel and method of making such |
| DE602004012269T2 (de) | 2003-07-11 | 2009-04-30 | Theravance, Inc., South San Francisco | Quervernetzte glycopeptid-cephalosporin-antibiotika |
-
2003
- 2003-05-23 TW TW092114010A patent/TWI325323B/zh not_active IP Right Cessation
- 2003-05-23 ES ES03755467T patent/ES2384707T3/es not_active Expired - Lifetime
- 2003-05-23 US US10/444,847 patent/US6878686B2/en not_active Expired - Lifetime
- 2003-05-23 AU AU2003231833A patent/AU2003231833A1/en not_active Abandoned
- 2003-05-23 WO PCT/US2003/016375 patent/WO2003099858A1/en not_active Ceased
- 2003-05-23 EP EP03755467A patent/EP1507796B1/en not_active Expired - Lifetime
- 2003-05-23 JP JP2004508112A patent/JP4347799B2/ja not_active Expired - Fee Related
- 2003-05-23 AT AT03755467T patent/ATE556088T1/de active
-
2004
- 2004-10-18 US US10/967,578 patent/US6995138B2/en not_active Expired - Lifetime
-
2005
- 2005-09-22 US US11/233,220 patent/US7405199B2/en not_active Expired - Lifetime
-
2008
- 2008-06-19 US US12/214,554 patent/US8084417B2/en not_active Expired - Fee Related
-
2009
- 2009-06-17 JP JP2009144705A patent/JP2009256358A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006503805A5 (https=) | ||
| JP2005526107A5 (https=) | ||
| RU2350605C2 (ru) | Аналоги хиназолина в качестве ингибиторов рецепторных тирозинкиназ | |
| JP2021534124A5 (https=) | ||
| JP2006526646A5 (https=) | ||
| ATE311358T1 (de) | Immunoregulierende verbindungen, deren derivate und ihre verwendung | |
| CY1112200T1 (el) | Συνδυασμοι για τη θεραπεια ασθενειων που ενεχουν κυτταρικο πολλαπλασιασμο | |
| EP2251327A3 (en) | Heterocyclic inhibitors of MEK and methods of use thereof | |
| JP2004518723A5 (https=) | ||
| JP2013532652A5 (https=) | ||
| RU2008119842A (ru) | Производные триазола в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы-1 | |
| JP2002543185A5 (https=) | ||
| JP2007520452A5 (https=) | ||
| EP2269610A3 (en) | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors | |
| JP2010530881A5 (https=) | ||
| EP2266569A3 (en) | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors | |
| SE0401971D0 (sv) | Piperidne derivatives | |
| JP2005523922A5 (https=) | ||
| JP2006505543A5 (https=) | ||
| JP2008533191A5 (https=) | ||
| JP2005502621A5 (https=) | ||
| RU2005137032A (ru) | Применение оксазолидинон-хинолиновых гибридных антибиотиков для лечения сибирской язвы и других инфекций | |
| NO20056007L (no) | Dobbel NK1/NK3 antagonister for behandling av schizofreni | |
| JP2009500423A5 (https=) | ||
| JP2004517843A5 (https=) |