JP2005524051A - カラーブラインド蛍光のためのパルスマルチライン励起法 - Google Patents

カラーブラインド蛍光のためのパルスマルチライン励起法 Download PDF

Info

Publication number
JP2005524051A
JP2005524051A JP2003525245A JP2003525245A JP2005524051A JP 2005524051 A JP2005524051 A JP 2005524051A JP 2003525245 A JP2003525245 A JP 2003525245A JP 2003525245 A JP2003525245 A JP 2003525245A JP 2005524051 A JP2005524051 A JP 2005524051A
Authority
JP
Japan
Prior art keywords
excitation
laser
sample
dye
excitation lines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2003525245A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005524051A5 (enExample
Inventor
グラハム ビー． アイ． スコット
カーター キットレル
ロバート エフ． カール
マイケル エル． メッツカー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of JP2005524051A publication Critical patent/JP2005524051A/ja
Publication of JP2005524051A5 publication Critical patent/JP2005524051A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/021—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using plane or convex mirrors, parallel phase plates, or particular reflectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2003525245A 2001-08-28 2002-08-28 カラーブラインド蛍光のためのパルスマルチライン励起法 Withdrawn JP2005524051A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/941,165 US6995841B2 (en) 2001-08-28 2001-08-28 Pulsed-multiline excitation for color-blind fluorescence detection
PCT/US2002/027406 WO2003021212A1 (en) 2001-08-28 2002-08-28 Pulsed-multiline excitation for color-blind fluorescence detection

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2008291646A Division JP2009098151A (ja) 2001-08-28 2008-11-14 カラーブラインド蛍光のためのパルスマルチライン励起法
JP2010227285A Division JP4988023B2 (ja) 2001-08-28 2010-10-07 カラーブラインド蛍光のためのパルスマルチライン励起法

Publications (2)

Publication Number Publication Date
JP2005524051A true JP2005524051A (ja) 2005-08-11
JP2005524051A5 JP2005524051A5 (enExample) 2009-01-08

Family

ID=25476036

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003525245A Withdrawn JP2005524051A (ja) 2001-08-28 2002-08-28 カラーブラインド蛍光のためのパルスマルチライン励起法
JP2008291646A Pending JP2009098151A (ja) 2001-08-28 2008-11-14 カラーブラインド蛍光のためのパルスマルチライン励起法
JP2010227285A Expired - Fee Related JP4988023B2 (ja) 2001-08-28 2010-10-07 カラーブラインド蛍光のためのパルスマルチライン励起法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2008291646A Pending JP2009098151A (ja) 2001-08-28 2008-11-14 カラーブラインド蛍光のためのパルスマルチライン励起法
JP2010227285A Expired - Fee Related JP4988023B2 (ja) 2001-08-28 2010-10-07 カラーブラインド蛍光のためのパルスマルチライン励起法

Country Status (6)

Country Link
US (4) US6995841B2 (enExample)
EP (1) EP1432966A4 (enExample)
JP (3) JP2005524051A (enExample)
AU (1) AU2002323452C1 (enExample)
CA (2) CA2484336C (enExample)
WO (1) WO2003021212A1 (enExample)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007046947A (ja) * 2005-08-08 2007-02-22 Bay Bioscience Kk フローサイトメータおよびフローサイトメトリ方法
WO2007141903A1 (ja) * 2006-06-05 2007-12-13 Nikon Corporation スペクトル観察方法及びスペクトル観察システム
JP2008509400A (ja) * 2004-08-06 2008-03-27 コンピュサイト コーポレイション 染色サンプルにおける光吸収のカラー表示型単色光吸収定量法
JP2008249667A (ja) * 2007-03-30 2008-10-16 Gl Sciences Inc 蛍光検出装置
WO2012032981A1 (ja) * 2010-09-10 2012-03-15 オリンパス株式会社 単一発光粒子の光強度を用いた光分析方法
JP2013507634A (ja) * 2009-10-15 2013-03-04 テクノロジアン・トゥトキムスケスクス・ブイティティー ラマン放射線の測定
US8958066B2 (en) 2010-09-10 2015-02-17 Olympus Corporation Optical analysis method using measurement of light of two or more wavelength bands
US9103718B2 (en) 2010-11-25 2015-08-11 Olympus Corporation Optical analysis device and optical analysis method using a wavelength characteristic of light of a single light-emitting particle
JP2016027340A (ja) * 2011-09-09 2016-02-18 コニカミノルタ株式会社 生体物質検出用の蛍光標識体
JP2016512345A (ja) * 2013-03-12 2016-04-25 ベンタナ メディカル システムズ， インコーポレイテッド 多重化組織用のデジタル的に強化された顕微鏡
JP2018518836A (ja) * 2015-05-20 2018-07-12 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ パルスレーザ及び生物分析システム
JP2018518657A (ja) * 2015-04-08 2018-07-12 モレキュラー デバイシーズ， エルエルシー 蛍光検出のための方法およびシステム
WO2019244358A1 (ja) * 2018-06-22 2019-12-26 株式会社日立ハイテクノロジーズ 電気泳動装置
JP2020114240A (ja) * 2011-05-12 2020-07-30 アンディ・コーポレイションＡＮＤＥ Ｃｏｒｐｏｒａｔｉｏｎ Ｓｔｒ遺伝子座の迅速な多重増幅のための方法および組成物
US10741990B2 (en) 2016-12-16 2020-08-11 Quantum-Si Incorporated Compact mode-locked laser module
JPWO2020235283A1 (enExample) * 2019-05-22 2020-11-26
US11249318B2 (en) 2016-12-16 2022-02-15 Quantum-Si Incorporated Compact beam shaping and steering assembly
JP2022063291A (ja) * 2018-06-22 2022-04-21 株式会社日立ハイテク 電気泳動装置
US11466316B2 (en) 2015-05-20 2022-10-11 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US11567006B2 (en) 2015-05-20 2023-01-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
US11747561B2 (en) 2019-06-14 2023-09-05 Quantum-Si Incorporated Sliced grating coupler with increased beam alignment sensitivity
US11808700B2 (en) 2018-06-15 2023-11-07 Quantum-Si Incorporated Data acquisition control for advanced analytic instruments having pulsed optical sources
US12170433B2 (en) 2020-01-14 2024-12-17 Quantum-Si Incorporated Amplitude-modulated laser

Families Citing this family (206)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780591B2 (en) * 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
DE19829981C2 (de) * 1998-07-04 2002-10-17 Zeiss Carl Jena Gmbh Verfahren und Anordnung zur konfokalen Mikroskopie
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7501245B2 (en) * 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6281471B1 (en) * 1999-12-28 2001-08-28 Gsi Lumonics, Inc. Energy-efficient, laser-based method and system for processing target material
US7838794B2 (en) 1999-12-28 2010-11-23 Gsi Group Corporation Laser-based method and system for removing one or more target link structures
US7723642B2 (en) * 1999-12-28 2010-05-25 Gsi Group Corporation Laser-based system for memory link processing with picosecond lasers
US20040134894A1 (en) * 1999-12-28 2004-07-15 Bo Gu Laser-based system for memory link processing with picosecond lasers
US7671295B2 (en) * 2000-01-10 2010-03-02 Electro Scientific Industries, Inc. Processing a memory link with a set of at least two laser pulses
US20030222324A1 (en) * 2000-01-10 2003-12-04 Yunlong Sun Laser systems for passivation or link processing with a set of laser pulses
US20060141681A1 (en) * 2000-01-10 2006-06-29 Yunlong Sun Processing a memory link with a set of at least two laser pulses
JP2004523243A (ja) 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
DE10112798A1 (de) * 2001-03-16 2002-10-02 Elegene Gmbh Vorrichtung und Verfahren zur automatischen Erzeugung einer Wärmevermeidungsreaktion von Nematoden oder ähnlichen Lebewesen
US6777645B2 (en) * 2001-03-29 2004-08-17 Gsi Lumonics Corporation High-speed, precision, laser-based method and system for processing material of one or more targets within a field
CA2477611A1 (en) * 2002-03-01 2003-09-12 Ravgen, Inc. Rapid analysis of variations in a genome
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20030175821A1 (en) * 2002-03-14 2003-09-18 Hoover Rex A. Apparatus and method for microscopic comet assay
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
EP1506390B1 (en) 2002-05-17 2011-12-14 Life Technologies Corporation Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
US8227256B2 (en) * 2002-09-27 2012-07-24 Saloma Caesar A Two-color (two-photon) excitation with focused excitation beams and a raman shifter
US20040188594A1 (en) * 2003-05-01 2004-09-30 Brown Steven W. Spectrally tunable solid-state light source
US20050170367A1 (en) * 2003-06-10 2005-08-04 Quake Stephen R. Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids
US20050006594A1 (en) * 2003-07-07 2005-01-13 Anthony Calderoni Simple systems for accurately detecting and measuring only fluorescent radiation from a sample in a plastic test tube
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20060172408A1 (en) * 2003-12-01 2006-08-03 Quake Steven R Device for immobilizing chemical and biochemical species and methods of using same
CA2557177A1 (en) 2004-02-19 2005-09-01 Stephen Quake Methods and kits for analyzing polynucleotide sequences
JP4224640B2 (ja) * 2004-03-29 2009-02-18 オリンパス株式会社 蛍光分光分析装置
US20050239085A1 (en) * 2004-04-23 2005-10-27 Buzby Philip R Methods for nucleic acid sequence determination
US20050260609A1 (en) * 2004-05-24 2005-11-24 Lapidus Stanley N Methods and devices for sequencing nucleic acids
US20070117104A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US7476734B2 (en) * 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
WO2006007207A2 (en) * 2004-05-25 2006-01-19 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
US20070117103A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
FR2871358B1 (fr) * 2004-06-14 2007-02-09 Mauna Kea Technologies Soc Par Procede et systeme d'imagerie microscopique de fluorescence fibree multimarquage
JP2006003167A (ja) * 2004-06-16 2006-01-05 Shimadzu Corp 生体試料分析用質量分析装置
CA2575118C (en) * 2004-07-27 2012-01-03 Boris Tartakovsky Multi-wavelength fluorometric system for on-line monitoring of bioprocesses
US20060024678A1 (en) * 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
WO2006036388A2 (en) * 2004-08-23 2006-04-06 U.S. Genomics, Inc. Systems and methods for detecting and analyzing polymers
WO2006055395A2 (en) * 2004-11-15 2006-05-26 Luna Innovations Incorporated Optical device for measuring optical properties of a sample and method relating thereto
US7209223B1 (en) * 2004-11-15 2007-04-24 Luna Innovations Incorporated Optical device for measuring optical properties of a sample and method relating thereto
US20060118754A1 (en) * 2004-12-08 2006-06-08 Lapen Daniel C Stabilizing a polyelectrolyte multilayer
US7286224B2 (en) * 2004-12-21 2007-10-23 Palo Alto Research Center Incorporated Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US20060172328A1 (en) * 2005-01-05 2006-08-03 Buzby Philip R Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
US20060191884A1 (en) * 2005-01-21 2006-08-31 Johnson Shepard D High-speed, precise, laser-based material processing method and system
US7482120B2 (en) * 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US7277169B2 (en) * 2005-02-18 2007-10-02 The Regents Of The University Of Michigan Whole spectrum fluorescence detection with ultrafast white light excitation
US7932081B2 (en) * 2005-03-10 2011-04-26 Gen-Probe Incorporated Signal measuring system for conducting real-time amplification assays
EP1921454B1 (en) * 2005-03-10 2015-08-12 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes
US7499165B2 (en) * 2005-03-15 2009-03-03 Electronic Design To Market, Inc. System of measuring light transmission and/or reflection
EP1886145A2 (en) * 2005-05-03 2008-02-13 Applera Corporation Fluorescent detection system and dye set for use therewith
US20060263790A1 (en) * 2005-05-20 2006-11-23 Timothy Harris Methods for improving fidelity in a nucleic acid synthesis reaction
WO2006130105A1 (en) * 2005-05-30 2006-12-07 Jerker Widengren Apparatus,method and computer program for spectroscopic measurements and analysis
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US7728295B2 (en) * 2005-09-29 2010-06-01 The Trustees Of Princeton University Method and apparatus for detecting surface and subsurface properties of materials
US7560869B2 (en) * 2005-09-29 2009-07-14 The Trustees Of Princeton University Method and apparatus for remotely monitoring properties of gases and plasmas
TWI364889B (en) * 2005-11-11 2012-05-21 Hon Hai Prec Ind Co Ltd Laser device and laser system using the same
DE102005054184B4 (de) 2005-11-14 2020-10-29 Carl Zeiss Microscopy Gmbh Multispektrale Beleuchtungsvorrichtung und Messverfahren
US20070117102A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
JP2009519717A (ja) * 2005-12-16 2009-05-21 アプレラ コーポレイション 位相を固定した配列決定のための方法およびシステム
US7405384B2 (en) * 2005-12-19 2008-07-29 Motorola, Inc. Method and apparatus for intensity control of multiple light sources using source timing
US7449667B2 (en) * 2005-12-19 2008-11-11 Motorola, Inc. Illumination method and apparatus having a plurality of feedback control circuit for controlling intensities of multiple light sources
DE102006009053A1 (de) * 2006-02-27 2007-08-30 Carl Zeiss Jena Gmbh Multispektrale Beleuchtungsvorrichtung
US20080309926A1 (en) * 2006-03-08 2008-12-18 Aaron Weber Systems and methods for reducing detected intensity non uniformity in a laser beam
US7397546B2 (en) * 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US8553221B2 (en) * 2006-10-24 2013-10-08 Pd-Ld, Inc. Compact, low cost Raman monitor for single substances
WO2008070676A2 (en) * 2006-12-04 2008-06-12 Parallel Synthesis Technologies, Inc. Multiplex assay reader system
US7893227B2 (en) * 2006-12-05 2011-02-22 Lasergen, Inc. 3′-OH unblocked nucleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA sequencing
US7897737B2 (en) 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US8999636B2 (en) * 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
WO2008092129A2 (en) * 2007-01-25 2008-07-31 The Trustees Of Princeton University Method and apparatus for detecting surface and subsurface properties of materials
CA2682761C (en) * 2007-04-04 2015-10-13 Network Biosystems, Inc. Methods for rapid multiplexed amplification of target nucleic acids
WO2009009127A2 (en) * 2007-07-12 2009-01-15 U.S. Genomics, Inc. Method and system for transferring and/or concentrating a sample
TWI539001B (zh) * 2007-08-13 2016-06-21 網路生物有限公司 快速多重擴增目標核酸的方法
US8582098B2 (en) * 2007-10-25 2013-11-12 The Research Foundation Of State University Of New York Single photon spectrometer
JP4389991B2 (ja) * 2007-10-26 2009-12-24 ソニー株式会社 微小粒子の光学的測定方法及び光学的測定装置
US8059274B2 (en) * 2007-12-07 2011-11-15 The Spectranetics Corporation Low-loss polarized light diversion
AU2009204461A1 (en) * 2008-01-10 2009-07-16 Pacific Biosciences Of California, Inc. Methods and systems for analysis of fluorescent reactions with modulated excitation
DE102008012635A1 (de) * 2008-03-05 2009-09-10 Carl Zeiss Microlmaging Gmbh Verfahren und Anordnung zur zeitaufgelösten Spektroskopie
EA201100001A3 (ru) 2008-06-11 2013-03-29 Лейзеджен, Инк. Нуклеотиды и нуклеозиды и методы их использования в секвенировании днк
DE112009001880T5 (de) * 2008-08-07 2012-08-30 Agilent Technologies Inc. Lichtquelle für mehrere Wellenlängen
JP5208650B2 (ja) * 2008-09-29 2013-06-12 オリンパス株式会社 顕微鏡システム
US8361716B2 (en) * 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
WO2010045949A2 (en) 2008-10-21 2010-04-29 Chemometec A/S A method and apparatus for analysis of a particle
WO2010091046A2 (en) * 2009-02-03 2010-08-12 President & Fellows Of Harvard College Systems and methods for high throughput, high fidelity, single molecule nucleic acid sequencing using time multiplexed excitation
WO2010119371A1 (en) * 2009-04-15 2010-10-21 Koninklijke Philips Electronics N.V. Device for time controlled fluorescence detection
EP2443254A2 (en) 2009-06-15 2012-04-25 NetBio, Inc. Improved methods for forensic dna quantitation
DE102009029831A1 (de) * 2009-06-17 2011-01-13 W.O.M. World Of Medicine Ag Vorrichtung und Verfahren für die Mehr-Photonen-Fluoreszenzmikroskopie zur Gewinnung von Informationen aus biologischem Gewebe
US8467061B2 (en) * 2010-02-19 2013-06-18 Pacific Biosciences Of California, Inc. Integrated analytical system and method
JP5701618B2 (ja) * 2010-03-04 2015-04-15 ギガフォトン株式会社 極端紫外光生成装置
DE102010015915A1 (de) * 2010-03-11 2011-09-15 Leica Microsystems Cms Gmbh Verfahren für einen beschleunigten Anregungswellenlängen-Scan bei einem Fluoreszenzmikroskop
CA2789384A1 (en) * 2010-03-12 2011-09-15 Societe De Commercialisation Des Produits De La Recherche Appliquee - So Cpra Sciences Sante Et Humaines S.E.C. Method of generating low-energy secondary electrons for applications in biological sciences, radiochemistry, and chemistry of polymers and physics of radiotherapy
US20110312546A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc device for pathogen detection and genetic analysis with chemical lysis, incubation and tandem nucleic acid amplification
US8729502B1 (en) 2010-10-28 2014-05-20 The Research Foundation For The State University Of New York Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection
GB2490857A (en) * 2010-11-05 2012-11-21 Kratos Analytical Ltd Timing device and method
DE102011009075B4 (de) * 2011-01-21 2021-07-22 Kostal Automobil Elektrik Gmbh & Co. Kg Kameraanordnung für ein Kraftfahrzeug
CN103403533B (zh) 2011-02-24 2017-02-15 简.探针公司 用于分辨光信号检测器中不同调制频率的光信号的系统和方法
DE102011005432A1 (de) 2011-03-11 2012-09-13 Hellma Gmbh & Co. Kg Vorrichtung für die Analyse einer kleinen Flüssigkeitsmenge
WO2012151678A1 (en) * 2011-05-12 2012-11-15 Lumen Dynamics Group Inc. Light source, pulse controller and method for programmable pulse generation and synchronization of light emitting devices
JP5323130B2 (ja) * 2011-05-26 2013-10-23 富士フイルム株式会社 蛍光分析装置および蛍光分析方法
DE102011107645A1 (de) * 2011-07-12 2013-01-17 Leica Microsystems Cms Gmbh Vorrichtung und Verfahren zum Detektieren von Licht
EP3670523B1 (en) 2011-09-13 2021-08-11 Agilent Technologies, Inc. 3'-oh unblocked, fast photocleavable terminating nucleotides and their use in methods for nucleic acid sequencing
CN103091211B (zh) * 2011-11-03 2017-05-17 深圳迈瑞生物医疗电子股份有限公司 荧光检测系统和细胞分析仪
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US20140049771A1 (en) * 2012-08-16 2014-02-20 Behrokh B. Sadri High-throughput multi laser wave mixing detection methods and apparatus
US20140049768A1 (en) * 2012-08-16 2014-02-20 Behrokh B. Sadri HIgh-throughput single laser wave mixing detection methods and apparatus
US20140065628A1 (en) * 2012-08-28 2014-03-06 Integenx Inc. Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis
DE102012019471B4 (de) * 2012-09-28 2023-12-21 Carl Zeiss Microscopy Gmbh Vorrichtung und Verfahren zum Ermitteln von Stoffeigenschaften
DE102012110749B4 (de) * 2012-11-09 2023-03-02 Endress+Hauser Conducta Gmbh+Co. Kg Messvorrichtung zur Messung optischer Eigenschaften eines Mediums
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
AU2014332126B2 (en) 2013-10-07 2019-10-31 Agdia Inc. Portable testing device for analyzing biological samples
US9941103B2 (en) * 2013-10-19 2018-04-10 Kla-Tencor Corporation Bias-variant photomultiplier tube
KR102204111B1 (ko) 2014-04-17 2021-01-15 삼성전자주식회사 화합물, 유기 광전 소자 및 이미지 센서
KR102315741B1 (ko) * 2014-06-03 2021-10-21 더 리전츠 오브 더 유니버시티 오브 캘리포니아 나노 입자 분석기
CN104198388B (zh) * 2014-09-15 2017-05-10 中国科学院烟台海岸带研究所 一种基于复合光谱测量的在线水质监测装置
US10184892B2 (en) * 2014-10-29 2019-01-22 Horiba Instruments Incorporated Determination of water treatment parameters based on absorbance and fluorescence
JP6551723B2 (ja) * 2014-11-13 2019-07-31 株式会社リコー 光学センサ、光学検査装置、及び光学特性検出方法
US10746600B2 (en) * 2015-01-09 2020-08-18 California Institute Of Technology Dual wavelength context imaging Raman and fluorescence spectrometer
US11971354B2 (en) 2015-04-08 2024-04-30 Molecular Devices, Llc Methods and systems for fluorescence detection using infrared dyes
AU2016314054A1 (en) * 2015-09-01 2018-03-15 Qiagen Instruments Ag Systems and methods for color detection in high-throughput nucleic acid sequencing systems
US9720243B1 (en) * 2015-12-31 2017-08-01 X Development Llc Wavelength division monolithic optical device
DE102016200271A1 (de) * 2016-01-13 2017-07-13 Institut Dr. Foerster Gmbh & Co. Kg Vorrichtung zur Erzeugung und Messung einer Emission
WO2017139008A1 (en) * 2016-02-11 2017-08-17 Stratio Broadband visible-shortwave infrared spectrometer
US10281327B2 (en) 2016-02-11 2019-05-07 Stratio Spectrometers with self-compensation of rotational misalignment
FI20165148A7 (fi) * 2016-02-25 2017-08-26 Arcdia Int Oy Ltd Kaksoisfotoniviritteistä fluoresenssia hyödyntävä bioaffiniteettimääritysmenetelmä
GB2549298B (en) * 2016-04-12 2022-02-02 Univ I Tromsoe Norges Arktiske Univ Super-resolution imaging
US10527552B2 (en) 2016-04-18 2020-01-07 Hewlett-Packard Development Company, L.P. Simultaneous detection of multiple spectra of scattered radiation
US10338354B2 (en) * 2016-07-18 2019-07-02 Coherent, Inc. Achromatic anastigmatic anamorphic objective
CN106404723B (zh) * 2016-08-22 2022-01-11 深圳大学 一种二次谐波高分辨率成像方法及系统
DE102016123258B4 (de) * 2016-12-01 2018-07-19 Leica Microsystems Cms Gmbh Lumineszenzdetektoranordnung, Fluoreszenzmikroskop und Verfahren zum Detektieren eines Lumineszenzsignals
JP7042457B2 (ja) * 2017-06-06 2022-03-28 パナソニックＩｐマネジメント株式会社 蛍光体および発光装置
US11061019B2 (en) * 2017-06-14 2021-07-13 Jinghong Chen High sensitivity optical detection system
EP3699588A4 (en) * 2017-10-19 2020-11-25 Konica Minolta, Inc. METHOD OF MEASURING THE QUANTITY OF BIOMATERIAL, IMAGE PROCESSING DEVICE, SYSTEM TO SUPPORT PATHOLOGY DIAGNOSIS AND PROGRAM
CN111526777A (zh) 2017-12-27 2020-08-11 爱惜康有限责任公司 缺光环境中的荧光成像
IL277170B2 (en) * 2018-03-23 2025-09-01 Nippon Sheet Glass Co Ltd Reaction processing facility
JP6571303B1 (ja) 2018-03-23 2019-09-04 日本板硝子株式会社 反応処理装置
WO2019222531A1 (en) * 2018-05-17 2019-11-21 Gmj Technologies, Llc Apparatuses for optical and mass spectrometry detection
JP6688342B2 (ja) * 2018-07-06 2020-04-28 日本板硝子株式会社 反応処理装置
DE102018008980B4 (de) * 2018-11-14 2023-08-24 Particle Metrix Gmbh Vorrichtung und Verfahren zur Bestimmung der Fluoreszenz und der Anzahl von Antikörpern auf Exosomen.
NL2023327B1 (en) * 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
CN109873878B (zh) * 2019-04-01 2021-08-24 宁波奥克斯电气股份有限公司 电子终端的通信连接方法与装置及电子终端、存储介质
CN111796475B (zh) * 2019-04-09 2022-03-08 成都理想境界科技有限公司 一种光源合束模组、投影显示装置及投影显示设备
CN110018159A (zh) * 2019-05-08 2019-07-16 衢州超越环保科技有限公司 一种城市雨水ph检测及管理利用系统
EP3980754A1 (en) * 2019-06-07 2022-04-13 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) System and method for real-time multicolor shortwave infrared fluorescence imaging
US11633089B2 (en) 2019-06-20 2023-04-25 Cilag Gmbh International Fluorescence imaging with minimal area monolithic image sensor
US11898909B2 (en) 2019-06-20 2024-02-13 Cilag Gmbh International Noise aware edge enhancement in a pulsed fluorescence imaging system
US11925328B2 (en) 2019-06-20 2024-03-12 Cilag Gmbh International Noise aware edge enhancement in a pulsed hyperspectral imaging system
US11903563B2 (en) 2019-06-20 2024-02-20 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a fluorescence imaging system
US20200397245A1 (en) 2019-06-20 2020-12-24 Ethicon Llc Minimizing image sensor input/output in a pulsed fluorescence imaging system
US11389066B2 (en) 2019-06-20 2022-07-19 Cilag Gmbh International Noise aware edge enhancement in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US10952619B2 (en) 2019-06-20 2021-03-23 Ethicon Llc Hyperspectral and fluorescence imaging and topology laser mapping with minimal area monolithic image sensor
US11671691B2 (en) 2019-06-20 2023-06-06 Cilag Gmbh International Image rotation in an endoscopic laser mapping imaging system
US12357162B2 (en) 2019-06-20 2025-07-15 Cilag Gmbh International Videostroboscopy of vocal cords with a hyperspectral, fluorescence, and laser mapping imaging system
US11412920B2 (en) 2019-06-20 2022-08-16 Cilag Gmbh International Speckle removal in a pulsed fluorescence imaging system
US12440085B2 (en) 2019-06-20 2025-10-14 Cilag Gmbh International Image synchronization without input clock and data transmission clock in a pulsed laser mapping imaging system
US11237270B2 (en) 2019-06-20 2022-02-01 Cilag Gmbh International Hyperspectral, fluorescence, and laser mapping imaging with fixed pattern noise cancellation
US11457154B2 (en) 2019-06-20 2022-09-27 Cilag Gmbh International Speckle removal in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US11937784B2 (en) 2019-06-20 2024-03-26 Cilag Gmbh International Fluorescence imaging in a light deficient environment
US11516387B2 (en) 2019-06-20 2022-11-29 Cilag Gmbh International Image synchronization without input clock and data transmission clock in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US11096565B2 (en) 2019-06-20 2021-08-24 Cilag Gmbh International Driving light emissions according to a jitter specification in a hyperspectral, fluorescence, and laser mapping imaging system
US11432706B2 (en) 2019-06-20 2022-09-06 Cilag Gmbh International Hyperspectral imaging with minimal area monolithic image sensor
US11550057B2 (en) 2019-06-20 2023-01-10 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a fluorescence imaging system
US11471055B2 (en) 2019-06-20 2022-10-18 Cilag Gmbh International Noise aware edge enhancement in a pulsed fluorescence imaging system
US11412152B2 (en) 2019-06-20 2022-08-09 Cilag Gmbh International Speckle removal in a pulsed hyperspectral imaging system
US11540696B2 (en) 2019-06-20 2023-01-03 Cilag Gmbh International Noise aware edge enhancement in a pulsed fluorescence imaging system
US11533417B2 (en) 2019-06-20 2022-12-20 Cilag Gmbh International Laser scanning and tool tracking imaging in a light deficient environment
US11700995B2 (en) 2019-06-20 2023-07-18 Cilag Gmbh International Speckle removal in a pulsed fluorescence imaging system
US20200400499A1 (en) 2019-06-20 2020-12-24 Ethicon Llc Pulsed illumination in a hyperspectral imaging system
US11531112B2 (en) 2019-06-20 2022-12-20 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a hyperspectral, fluorescence, and laser mapping imaging system
US11187658B2 (en) 2019-06-20 2021-11-30 Cilag Gmbh International Fluorescence imaging with fixed pattern noise cancellation
US11674848B2 (en) 2019-06-20 2023-06-13 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for hyperspectral imaging
US11311183B2 (en) 2019-06-20 2022-04-26 Cilag Gmbh International Controlling integral energy of a laser pulse in a fluorescence imaging system
US20200397270A1 (en) 2019-06-20 2020-12-24 Ethicon Llc Optical fiber waveguide in an endoscopic system for fluorescence imaging
US12013496B2 (en) 2019-06-20 2024-06-18 Cilag Gmbh International Noise aware edge enhancement in a pulsed laser mapping imaging system
US10841504B1 (en) 2019-06-20 2020-11-17 Ethicon Llc Fluorescence imaging with minimal area monolithic image sensor
US11624830B2 (en) 2019-06-20 2023-04-11 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for laser mapping imaging
US11134832B2 (en) 2019-06-20 2021-10-05 Cilag Gmbh International Image rotation in an endoscopic hyperspectral, fluorescence, and laser mapping imaging system
US12126887B2 (en) 2019-06-20 2024-10-22 Cilag Gmbh International Hyperspectral and fluorescence imaging with topology laser scanning in a light deficient environment
US11012599B2 (en) 2019-06-20 2021-05-18 Ethicon Llc Hyperspectral imaging in a light deficient environment
US11758256B2 (en) 2019-06-20 2023-09-12 Cilag Gmbh International Fluorescence imaging in a light deficient environment
US11716543B2 (en) 2019-06-20 2023-08-01 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for fluorescence imaging
US11147436B2 (en) 2019-06-20 2021-10-19 Cilag Gmbh International Image rotation in an endoscopic fluorescence imaging system
US11622094B2 (en) 2019-06-20 2023-04-04 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for fluorescence imaging
US11931009B2 (en) 2019-06-20 2024-03-19 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a hyperspectral imaging system
EP4017633A1 (en) * 2019-08-23 2022-06-29 miDiagnostics NV Multi-color system for real time pcr detection
GB201912351D0 (en) * 2019-08-28 2019-10-09 Fluoretiq Ltd Spectrofluoromteric apparatus and methods for the detection of bacteria
DE102020126260A1 (de) * 2019-10-17 2021-04-22 Phoseon Technology, Inc. Verfahren und Systeme für ein Mehrwellenlängen-Beleuchtungssystem
CN110804679B (zh) * 2019-11-08 2021-02-12 宁波胤瑞生物医学仪器有限责任公司 一种核酸扩增仪调节方法
TW202142856A (zh) * 2019-11-17 2021-11-16 美商伯克利之光生命科技公司 用於生物樣本之分析的系統及方法
KR20220110589A (ko) * 2019-12-17 2022-08-08 어플라이드 머티어리얼스, 인코포레이티드 다중 형광 인시튜 하이브리드화 이미지들의 획득 및 프로세싱을 위한 시스템 및 방법
US20210215609A1 (en) * 2020-01-15 2021-07-15 Osram Opto Semiconductors Gmbh Apparatus, a Handheld Electronic Device, and a Method for Carrying Out Raman Spectroscopy
JP7233385B2 (ja) * 2020-01-20 2023-03-06 日本板硝子株式会社 反応処理装置
DE102020207587A1 (de) 2020-06-18 2021-12-23 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren und Steuergerät zum Auswerten eines Lumineszenzsignals in einem Analysegerät zum Analysieren einer Probe biologischen Materials und Analysegerät zum Analysieren einer Probe biologischen Materials
US12313830B2 (en) * 2020-08-05 2025-05-27 Leica Microsystems Cms Gmbh Method for adjusting the illumination in a fluorescence microscope, and corresponding fluorescence microscope
DE112021004082T5 (de) * 2020-12-14 2023-06-01 Suzhou Gendx Biotech Co., Ltd. Tragbare Fluoreszenzdetektionsvorrichtung
US20220195516A1 (en) * 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
DE102021206879A1 (de) * 2021-06-30 2023-01-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Verfahren zur optischen Überwachung und/oder Bestimmung von Eigenschaften an Proben
KR102624004B1 (ko) * 2021-11-16 2024-01-11 한국광기술원 형광영상 및 컬러영상 획득을 위한 다중 형광영상장치 및 그 제어방법
JPWO2023223547A1 (enExample) * 2022-05-20 2023-11-23
US20240326151A1 (en) * 2023-03-30 2024-10-03 Illinois Tool Works Inc. Welding torch consumables cleaning systems
DE102023108783A1 (de) * 2023-04-05 2024-10-10 Ams-Osram International Gmbh Halbleiterlaservorrichtung und verfahren zur herstellung einer halbleiterlaservorrichtung

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0694617A (ja) * 1992-04-14 1994-04-08 Hitachi Ltd 光検出型電気泳動装置
US5485530A (en) * 1991-01-24 1996-01-16 Joseph R. Lakowicz Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
JPH08512137A (ja) * 1993-11-11 1996-12-17 ライカ レーザーテヒニーク ゲーエムベーハー プレパラートの多色照明用装置
US5784157A (en) * 1995-11-21 1998-07-21 The Research Foundation Of State University Of New York Method and apparatus for identifying fluorophores
JPH10267844A (ja) * 1997-03-25 1998-10-09 Jasco Corp 時間分解蛍光検出器およびそれを用いた蛍光分析装置、方法
WO1999009455A1 (en) * 1997-08-13 1999-02-25 Bio-Rad Laboratories Multi parameter scanner
JP2000266666A (ja) * 1999-03-19 2000-09-29 Hitachi Koki Co Ltd エリプソメータ
JP2001124627A (ja) * 1999-10-28 2001-05-11 Horiba Ltd 分光分析装置
JP2001133405A (ja) * 1999-11-04 2001-05-18 Hitachi Kokusai Electric Inc 蛍光読取り装置

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3734631A (en) * 1971-05-28 1973-05-22 Hewlett Packard Co Nondispersive infrared gas analyzer employing solid state emitters and photodetectors
DE3137658C2 (de) * 1981-09-22 1985-06-05 H. Maihak Ag, 2000 Hamburg Vorrichtung zur Messung der Konzentration eines IR-, NIR-, VIS- oder UV-Strahlung absorbierenden Gases in einer Gasmatrix
US4582788A (en) 1982-01-22 1986-04-15 Cetus Corporation HLA typing method and cDNA probes used therein
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
JPS60131428A (ja) 1983-12-21 1985-07-13 Komatsu Ltd カ−ス分光装置
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4744667A (en) * 1986-02-11 1988-05-17 University Of Massachusetts Microspectrofluorimeter
US4855930A (en) * 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
US5510894A (en) * 1988-12-22 1996-04-23 Renishaw Plc Spectroscopic apparatus and methods
US5760900A (en) * 1989-03-18 1998-06-02 Canon Kabushiki Kaisha Method and apparatus for optically measuring specimen
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
WO1992007245A1 (en) * 1990-10-10 1992-04-30 The University Of Maryland Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
US5252834A (en) * 1990-11-13 1993-10-12 Union Oil Company Of California Pulsed and gated multi-mode microspectrophotometry device and method
US5489777A (en) * 1990-12-26 1996-02-06 Denver Seminary Apparatus for remote analysis of vehicle emissions using reflective thermography
US5888819A (en) 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5196709A (en) 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
US5233197A (en) * 1991-07-15 1993-08-03 University Of Massachusetts Medical Center High speed digital imaging microscope
DE69221423T2 (de) * 1991-09-30 1998-03-19 Beckman Instruments Inc Verbesserte Fluoreszenz-Erfassung von Proben in einem Kapillarrohr
US5484571A (en) * 1991-10-08 1996-01-16 Beckman Instruments, Inc. Enhanced fluorescence detection of samples in capillary column
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US6159686A (en) * 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US6153379A (en) 1993-06-22 2000-11-28 Baylor College Of Medicine Parallel primer extension approach to nucleic acid sequence analysis
US5491344A (en) * 1993-12-01 1996-02-13 Tufts University Method and system for examining the composition of a fluid or solid sample using fluorescence and/or absorption spectroscopy
FI95322C (fi) * 1994-03-02 1996-01-10 Instrumentarium Oy Spektroskooppinen mittausanturi väliaineiden analysointiin
US6903347B2 (en) * 1994-07-15 2005-06-07 Stephen C. Baer Superresolution in microlithography and fluorescence microscopy
US5599717A (en) * 1994-09-02 1997-02-04 Martin Marietta Energy Systems, Inc. Advanced synchronous luminescence system
US5556790A (en) * 1994-12-05 1996-09-17 Pettit; John W. Method for Automated DNA sequencing
WO1996023213A1 (en) * 1995-01-23 1996-08-01 Murray Anthony J Analysis of biological molecules
US5675155A (en) * 1995-04-26 1997-10-07 Beckman Instruments, Inc. Multicapillary fluorescent detection system
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JPH09288203A (ja) 1996-02-22 1997-11-04 Nikon Corp 多重焦線レンズ
JPH09329548A (ja) * 1996-06-11 1997-12-22 Bunshi Bio Photonics Kenkyusho:Kk 蛍光寿命測定装置
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
WO1998059233A1 (en) * 1997-06-23 1998-12-30 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
GB9717021D0 (en) * 1997-08-12 1997-10-15 Kalibrant Limited A detector
JPH11119106A (ja) * 1997-10-16 1999-04-30 Olympus Optical Co Ltd レーザ走査型顕微鏡
US6369893B1 (en) * 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
US6038023A (en) 1998-07-31 2000-03-14 The Research Foundation Of State University Of New York Sensors for detection and spectroscopy
US6215598B1 (en) 1998-10-05 2001-04-10 Ruey Jennifer Hwu Apparatus and method for concentrating beams from broad area diode lasers, diode laser bars and/ or diode laser arrays
US6134050A (en) 1998-11-25 2000-10-17 Advanced Laser Technologies, Inc. Laser beam mixer
US6249341B1 (en) 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
JP2001116696A (ja) * 1999-10-21 2001-04-27 Olympus Optical Co Ltd 走査型光学装置
US6630680B2 (en) * 2000-12-25 2003-10-07 Fuji Photo Film Co., Ltd. Scanner having confocal optical system, method for producing focus position data of confocal optical system of scanner having confocal optical system and method for producing digital data of scanner having confocal optical system
DE60220497T2 (de) * 2001-01-26 2008-01-31 Biocal Technology, Inc., Irvine Optische detektion in einem mehrkanaligen bioseparationssystem

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5485530A (en) * 1991-01-24 1996-01-16 Joseph R. Lakowicz Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
JPH0694617A (ja) * 1992-04-14 1994-04-08 Hitachi Ltd 光検出型電気泳動装置
JPH08512137A (ja) * 1993-11-11 1996-12-17 ライカ レーザーテヒニーク ゲーエムベーハー プレパラートの多色照明用装置
US5784157A (en) * 1995-11-21 1998-07-21 The Research Foundation Of State University Of New York Method and apparatus for identifying fluorophores
JPH10267844A (ja) * 1997-03-25 1998-10-09 Jasco Corp 時間分解蛍光検出器およびそれを用いた蛍光分析装置、方法
WO1999009455A1 (en) * 1997-08-13 1999-02-25 Bio-Rad Laboratories Multi parameter scanner
JP2000266666A (ja) * 1999-03-19 2000-09-29 Hitachi Koki Co Ltd エリプソメータ
JP2001124627A (ja) * 1999-10-28 2001-05-11 Horiba Ltd 分光分析装置
JP2001133405A (ja) * 1999-11-04 2001-05-18 Hitachi Kokusai Electric Inc 蛍光読取り装置

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008509400A (ja) * 2004-08-06 2008-03-27 コンピュサイト コーポレイション 染色サンプルにおける光吸収のカラー表示型単色光吸収定量法
JP2007046947A (ja) * 2005-08-08 2007-02-22 Bay Bioscience Kk フローサイトメータおよびフローサイトメトリ方法
US7990525B2 (en) 2005-08-08 2011-08-02 Bay Bioscience Kabushiki Kaisha Flow cytometer and flow cytometry
WO2007141903A1 (ja) * 2006-06-05 2007-12-13 Nikon Corporation スペクトル観察方法及びスペクトル観察システム
US7724365B2 (en) 2006-06-05 2010-05-25 Nikon Corporation Spectral observation method and spectral observation system
JP2008249667A (ja) * 2007-03-30 2008-10-16 Gl Sciences Inc 蛍光検出装置
US8917388B2 (en) 2009-10-15 2014-12-23 Teknologian Tutkimuskeskus Vtt Measurement of raman radiation
JP2013507634A (ja) * 2009-10-15 2013-03-04 テクノロジアン・トゥトキムスケスクス・ブイティティー ラマン放射線の測定
JPWO2012032981A1 (ja) * 2010-09-10 2014-01-20 オリンパス株式会社 単一発光粒子の光強度を用いた光分析方法
US8785886B2 (en) 2010-09-10 2014-07-22 Olympus Corporation Optical analysis method using the light intensity of a single light-emitting particle
US8958066B2 (en) 2010-09-10 2015-02-17 Olympus Corporation Optical analysis method using measurement of light of two or more wavelength bands
WO2012032981A1 (ja) * 2010-09-10 2012-03-15 オリンパス株式会社 単一発光粒子の光強度を用いた光分析方法
US9103718B2 (en) 2010-11-25 2015-08-11 Olympus Corporation Optical analysis device and optical analysis method using a wavelength characteristic of light of a single light-emitting particle
JP2020114240A (ja) * 2011-05-12 2020-07-30 アンディ・コーポレイションＡＮＤＥ Ｃｏｒｐｏｒａｔｉｏｎ Ｓｔｒ遺伝子座の迅速な多重増幅のための方法および組成物
JP2016027340A (ja) * 2011-09-09 2016-02-18 コニカミノルタ株式会社 生体物質検出用の蛍光標識体
JP2018025812A (ja) * 2013-03-12 2018-02-15 ベンタナ メディカル システムズ， インコーポレイテッド 多重化組織用のデジタル的に強化された顕微鏡
JP2016512345A (ja) * 2013-03-12 2016-04-25 ベンタナ メディカル システムズ， インコーポレイテッド 多重化組織用のデジタル的に強化された顕微鏡
US12126880B2 (en) 2013-03-12 2024-10-22 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology
US11070750B2 (en) 2013-03-12 2021-07-20 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology
US10778913B2 (en) 2013-03-12 2020-09-15 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology
JP7038158B2 (ja) 2015-04-08 2022-03-17 モレキュラー デバイシーズ， エルエルシー 蛍光検出のための方法およびシステム
JP2018518657A (ja) * 2015-04-08 2018-07-12 モレキュラー デバイシーズ， エルエルシー 蛍光検出のための方法およびシステム
JP2020106546A (ja) * 2015-04-08 2020-07-09 モレキュラー デバイシーズ， エルエルシー 蛍光検出のための方法およびシステム
JP2018518836A (ja) * 2015-05-20 2018-07-12 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ パルスレーザ及び生物分析システム
US11567006B2 (en) 2015-05-20 2023-01-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
US11466316B2 (en) 2015-05-20 2022-10-11 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US11848531B2 (en) 2016-12-16 2023-12-19 Quantum-Si Incorporated Compact mode-locked laser module
US10741990B2 (en) 2016-12-16 2020-08-11 Quantum-Si Incorporated Compact mode-locked laser module
US12235463B2 (en) 2016-12-16 2025-02-25 Quantum-Si Incorporated Compact beam shaping and steering assembly
US11249318B2 (en) 2016-12-16 2022-02-15 Quantum-Si Incorporated Compact beam shaping and steering assembly
US11322906B2 (en) 2016-12-16 2022-05-03 Quantum-Si Incorporated Compact mode-locked laser module
US11808700B2 (en) 2018-06-15 2023-11-07 Quantum-Si Incorporated Data acquisition control for advanced analytic instruments having pulsed optical sources
JP7228060B2 (ja) 2018-06-22 2023-02-22 株式会社日立ハイテク 電気泳動装置
US11733205B2 (en) 2018-06-22 2023-08-22 Hitachi High-Tech Corporation Electrophoresis apparatus
JP7023358B2 (ja) 2018-06-22 2022-02-21 株式会社日立ハイテク 電気泳動装置
WO2019244358A1 (ja) * 2018-06-22 2019-12-26 株式会社日立ハイテクノロジーズ 電気泳動装置
US12092607B2 (en) 2018-06-22 2024-09-17 Hitachi High-Tech Corporation Electrophoresis apparatus
JP2022063291A (ja) * 2018-06-22 2022-04-21 株式会社日立ハイテク 電気泳動装置
JPWO2019244358A1 (ja) * 2018-06-22 2021-07-01 株式会社日立ハイテク 電気泳動装置
JP7282880B2 (ja) 2019-05-22 2023-05-29 株式会社日立ハイテク 分析装置および分析方法
JP2023101563A (ja) * 2019-05-22 2023-07-21 株式会社日立ハイテク 分析装置および分析方法
GB2597202B (en) * 2019-05-22 2023-12-13 Hitachi High Tech Corp Analysis system and analysis method
WO2020235283A1 (ja) * 2019-05-22 2020-11-26 株式会社日立ハイテク 分析装置および分析方法
CN113840902A (zh) * 2019-05-22 2021-12-24 株式会社日立高新技术 分析装置以及分析方法
JPWO2020235283A1 (enExample) * 2019-05-22 2020-11-26
JP7608515B2 (ja) 2019-05-22 2025-01-06 株式会社日立ハイテク 分析装置および分析方法
GB2597202A (en) * 2019-05-22 2022-01-19 Hitachi High Tech Corp Analysis device and analysis method
US11747561B2 (en) 2019-06-14 2023-09-05 Quantum-Si Incorporated Sliced grating coupler with increased beam alignment sensitivity
US12170433B2 (en) 2020-01-14 2024-12-17 Quantum-Si Incorporated Amplitude-modulated laser

Also Published As

Publication number Publication date
EP1432966A4 (en) 2011-05-04
US8089628B2 (en) 2012-01-03
CA2484336C (en) 2012-06-26
JP2009098151A (ja) 2009-05-07
WO2003021212A1 (en) 2003-03-13
AU2002323452B2 (en) 2008-01-10
US20030058440A1 (en) 2003-03-27
US20090156429A1 (en) 2009-06-18
US6995841B2 (en) 2006-02-07
US7511811B2 (en) 2009-03-31
CA2774152A1 (en) 2003-03-13
AU2002323452C1 (en) 2008-06-26
EP1432966A1 (en) 2004-06-30
US20120219029A1 (en) 2012-08-30
JP4988023B2 (ja) 2012-08-01
CA2484336A1 (en) 2003-03-13
JP2011027748A (ja) 2011-02-10
US20060139634A1 (en) 2006-06-29

Similar Documents

Publication Publication Date Title
JP4988023B2 (ja) カラーブラインド蛍光のためのパルスマルチライン励起法
AU2002323452A1 (en) Pulsed-multiline excitation for color-blind fluorescence detection
JP5096323B2 (ja) 核酸およびタンパク質の解析のための高耐久性装置
JP3287361B2 (ja) 統計的信頼区間の決定を含む多成分分析方法
US9488571B2 (en) Two-dimensional spectral imaging system
US7817273B2 (en) Two-dimensional spectral imaging system
JP2005524051A5 (enExample)
JP2009526997A (ja) 複数のソースからの光学信号をリアルタイムで同時に監視する方法及びシステム
CN102411024B (zh) 一种基于空间校正及光谱校正的毛细管阵列电泳检测方法
US10718012B2 (en) Non-motorized optical multiplexing for the simultaneous detection of DNA target amplicons in a polymerase chain reaction solution
WO2007011549A1 (en) Two-dimensional spectral imaging system
WO2009098624A1 (en) Analysis system and method
KR20070045720A (ko) 다채널 바이오 칩 스캐너
AU2016200902B2 (en) System for finding the detection zone or position of separation channels in an electrophoresis system and method
Stryjewski et al. Multiplexed analysis using time-resolved near-IR fluorescence for the detection of genomic material
Middendorf et al. Nara Narayanan, Abe Oommen, Harry Osterman, Rex Peterson, John Rada

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050829

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050829

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20050829

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080514

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080812

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080819

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080829

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080905

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20081113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081114

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090608

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090904

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090911

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100609

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101007

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20101112

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101210

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101210