JP2005097323A5 - - Google Patents
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- JP2005097323A5 JP2005097323A5 JP2004368948A JP2004368948A JP2005097323A5 JP 2005097323 A5 JP2005097323 A5 JP 2005097323A5 JP 2004368948 A JP2004368948 A JP 2004368948A JP 2004368948 A JP2004368948 A JP 2004368948A JP 2005097323 A5 JP2005097323 A5 JP 2005097323A5
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- active ingredient
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- -1 3-butyl Chemical group 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000008188 pellet Substances 0.000 claims 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 claims 1
- 229960004419 dimethyl fumarate Drugs 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000023328 Basedow disease Diseases 0.000 description 1
- 208000015023 Graves' disease Diseases 0.000 description 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
- 208000031845 Pernicious anaemia Diseases 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853487A DE19853487A1 (de) | 1998-11-19 | 1998-11-19 | Verwendung von Dialkylfumaraten |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000583505A Division JP2002530324A (ja) | 1998-11-19 | 1999-10-29 | ジアルキルフマレートの使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009185402A Division JP5828614B2 (ja) | 1998-11-19 | 2009-08-10 | ジアルキルフマレート含有薬剤調合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005097323A JP2005097323A (ja) | 2005-04-14 |
| JP2005097323A5 true JP2005097323A5 (enExample) | 2009-01-08 |
Family
ID=7888396
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000583505A Withdrawn JP2002530324A (ja) | 1998-11-19 | 1999-10-29 | ジアルキルフマレートの使用 |
| JP2004368948A Pending JP2005097323A (ja) | 1998-11-19 | 2004-12-21 | ジアルキルフマレート含有薬剤調合物 |
| JP2009185402A Expired - Lifetime JP5828614B2 (ja) | 1998-11-19 | 2009-08-10 | ジアルキルフマレート含有薬剤調合物 |
| JP2012185136A Withdrawn JP2012255020A (ja) | 1998-11-19 | 2012-08-24 | ジアルキルフマレート含有薬剤調合物 |
| JP2015207653A Withdrawn JP2016047830A (ja) | 1998-11-19 | 2015-10-22 | ジアルキルフマレート含有薬剤調合物 |
| JP2017150481A Withdrawn JP2017226681A (ja) | 1998-11-19 | 2017-08-03 | ジアルキルフマレート含有薬剤調合物 |
| JP2019066965A Pending JP2019123738A (ja) | 1998-11-19 | 2019-03-29 | ジアルキルフマレート含有薬剤調合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000583505A Withdrawn JP2002530324A (ja) | 1998-11-19 | 1999-10-29 | ジアルキルフマレートの使用 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009185402A Expired - Lifetime JP5828614B2 (ja) | 1998-11-19 | 2009-08-10 | ジアルキルフマレート含有薬剤調合物 |
| JP2012185136A Withdrawn JP2012255020A (ja) | 1998-11-19 | 2012-08-24 | ジアルキルフマレート含有薬剤調合物 |
| JP2015207653A Withdrawn JP2016047830A (ja) | 1998-11-19 | 2015-10-22 | ジアルキルフマレート含有薬剤調合物 |
| JP2017150481A Withdrawn JP2017226681A (ja) | 1998-11-19 | 2017-08-03 | ジアルキルフマレート含有薬剤調合物 |
| JP2019066965A Pending JP2019123738A (ja) | 1998-11-19 | 2019-03-29 | ジアルキルフマレート含有薬剤調合物 |
Country Status (34)
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19853487A1 (de) * | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| DE10000577A1 (de) | 2000-01-10 | 2001-07-26 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten |
| US6912052B2 (en) * | 2000-11-17 | 2005-06-28 | Cymer, Inc. | Gas discharge MOPA laser spectral analysis module |
| DE10101307A1 (de) * | 2001-01-12 | 2002-08-01 | Fumapharm Ag Muri | Fumarsäurederivate als NF-kappaB-Inhibitor |
| EE05472B1 (et) * | 2001-01-12 | 2011-10-17 | Fumapharm Ag | Fumaarhappeamiidide kasutamine ravimina |
| US20050259709A1 (en) * | 2002-05-07 | 2005-11-24 | Cymer, Inc. | Systems and methods for implementing an interaction between a laser shaped as a line beam and a film deposited on a substrate |
| DE10217314A1 (de) | 2002-04-18 | 2003-11-13 | Fumapharm Ag Muri | Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere |
| AU2003236156A1 (en) * | 2003-04-24 | 2005-01-04 | Shin-Jen Shiao | Pharmaceutical compositions used for immune disease treatment and improvement |
| US7277188B2 (en) * | 2003-04-29 | 2007-10-02 | Cymer, Inc. | Systems and methods for implementing an interaction between a laser shaped as a line beam and a film deposited on a substrate |
| WO2005023241A1 (en) | 2003-09-09 | 2005-03-17 | Fumapharm Ag | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
| DE10360869A1 (de) * | 2003-09-09 | 2005-04-07 | Fumapharm Ag | Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma |
| DE10342423A1 (de) * | 2003-09-13 | 2005-04-14 | Heidland, August, Prof. Dr.med. Dr.h.c. | Verwendung von Fumarsäurederivaten zur Prophylaxe und zur Behandlung von Genomschäden |
| US6894785B2 (en) * | 2003-09-30 | 2005-05-17 | Cymer, Inc. | Gas discharge MOPA laser spectral analysis module |
| US6873418B1 (en) | 2003-09-30 | 2005-03-29 | Cymer, Inc. | Optical mountings for gas discharge MOPA laser spectral analysis module |
| CA2478458A1 (en) * | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
| DK1799196T3 (en) * | 2004-10-08 | 2016-08-15 | Forward Pharma As | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
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| US7653095B2 (en) * | 2005-06-30 | 2010-01-26 | Cymer, Inc. | Active bandwidth control for a laser |
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| DE102008030023A1 (de) | 2008-06-16 | 2009-12-17 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Behandlung einer durch Parasiten verursachten Krankheit |
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