JP2010511663A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010511663A5 JP2010511663A5 JP2009539724A JP2009539724A JP2010511663A5 JP 2010511663 A5 JP2010511663 A5 JP 2010511663A5 JP 2009539724 A JP2009539724 A JP 2009539724A JP 2009539724 A JP2009539724 A JP 2009539724A JP 2010511663 A5 JP2010511663 A5 JP 2010511663A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- mixture obtained
- compound according
- wetting agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000000314 lubricant Substances 0.000 claims 7
- 239000000080 wetting agent Substances 0.000 claims 7
- 239000004480 active ingredient Substances 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 206010062207 Mycobacterial infection Diseases 0.000 claims 5
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 3
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 238000007580 dry-mixing Methods 0.000 claims 2
- 238000005469 granulation Methods 0.000 claims 2
- 230000003179 granulation Effects 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 238000005507 spraying Methods 0.000 claims 2
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 1
- 229920002261 Corn starch Polymers 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229960001021 lactose monohydrate Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- -1 sorbitan fatty acid ester Chemical class 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125443 | 2006-12-05 | ||
| PCT/EP2007/063186 WO2008068231A1 (en) | 2006-12-05 | 2007-12-03 | Fumarate salt of (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014191134A Division JP5894239B2 (ja) | 2006-12-05 | 2014-09-19 | （アルファｓ，ベータｒ）−６−ブロモ−アルファ−［２−（ジメチルアミノ）エチル］−２−メトキシ−アルファ−１−ナフタレニル−ベータ−フェニル−３−キノリンエタノールのフマル酸塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010511663A JP2010511663A (ja) | 2010-04-15 |
| JP2010511663A5 true JP2010511663A5 (enExample) | 2010-10-21 |
Family
ID=37983588
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539724A Pending JP2010511663A (ja) | 2006-12-05 | 2007-12-03 | （アルファｓ，ベータｒ）−６−ブロモ−アルファ−［２−（ジメチルアミノ）エチル］−２−メトキシ−アルファ−１−ナフタレニル−ベータ−フェニル−３−キノリンエタノールのフマル酸塩 |
| JP2014191134A Active JP5894239B2 (ja) | 2006-12-05 | 2014-09-19 | （アルファｓ，ベータｒ）−６−ブロモ−アルファ−［２−（ジメチルアミノ）エチル］−２−メトキシ−アルファ−１−ナフタレニル−ベータ−フェニル−３−キノリンエタノールのフマル酸塩 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014191134A Active JP5894239B2 (ja) | 2006-12-05 | 2014-09-19 | （アルファｓ，ベータｒ）−６−ブロモ−アルファ−［２−（ジメチルアミノ）エチル］−２−メトキシ−アルファ−１−ナフタレニル−ベータ−フェニル−３−キノリンエタノールのフマル酸塩 |
Country Status (34)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120010216A1 (en) * | 2010-07-06 | 2012-01-12 | Brown Arthur M | Pharmaceutical compositions containing vanoxerine |
| CZ2014708A3 (cs) | 2014-10-16 | 2016-04-27 | Zentiva, K.S. | Soli Bedaquilinu |
| WO2016120258A1 (en) * | 2015-01-27 | 2016-08-04 | Janssen Pharmaceutica Nv | Dispersible compositions |
| CN106279017A (zh) * | 2015-05-21 | 2017-01-04 | 重庆圣华曦药业股份有限公司 | 贝达喹啉晶型、组合物及其制备方法 |
| CZ2015391A3 (cs) | 2015-06-09 | 2016-12-21 | Zentiva, K.S. | Sůl bedaquilinu s kyselinou citronovou |
| US10196360B2 (en) * | 2015-10-20 | 2019-02-05 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Crystal forms of bedaquiline fumarate and preparation methods therefor |
| HRP20241015T1 (hr) * | 2016-07-20 | 2024-11-08 | Novartis Ag | Derivati aminopiridina i njihova uporaba kao selektivnih alk-2 inhibitora |
| CN106316943A (zh) * | 2016-07-27 | 2017-01-11 | 重庆华邦制药有限公司 | 富马酸贝达喹啉晶型化合物的精制方法 |
| EP4356968A3 (en) | 2017-07-14 | 2024-07-10 | JANSSEN Pharmaceutica NV | Long-acting formulations |
| US20220023282A1 (en) * | 2018-12-13 | 2022-01-27 | Mannkind Corporation | Compositions of Bedaquiline, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them |
| JP2022516671A (ja) | 2019-01-09 | 2022-03-01 | ヤンセン ファーマシューティカ エヌ．ベー． | 非結核性抗酸菌症の処置における組合せ |
| WO2020161743A1 (en) * | 2019-02-08 | 2020-08-13 | Mylan Laboratories Limited | Process for the preparation of bedaquiline fumarate |
| KR102303635B1 (ko) * | 2020-07-01 | 2021-09-17 | 동아에스티 주식회사 | (1r,2s)-1-(6-브로모-2-메톡시퀴놀린-3-일)-4-디메틸아미노-2-(1-나프틸)-1-페닐-부탄-2-올 및 이의 약제학적으로 허용 가능한 염의 제조방법 |
| CN111888477B (zh) * | 2020-09-15 | 2023-03-07 | 北京福元医药股份有限公司 | 一种贝达喹啉药物制剂 |
| TW202233168A (zh) | 2020-11-12 | 2022-09-01 | 比利時商健生藥品公司 | 治療非結核分枝桿菌疾病的藥物組分之組合 |
| US11793808B2 (en) | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
| WO2023150747A1 (en) | 2022-02-07 | 2023-08-10 | Insmed Incorporated | Dry powder compositions of bedaquiline and salts and methods of use thereof |
| WO2023232838A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Pharmaceutica Nv | Bedaquiline for use in the treatment of leprosy |
| CN117399070B (zh) * | 2022-07-07 | 2025-06-24 | 上海交通大学 | 含有螯合配体的双手性金属协同催化体系及其不对称合成贝达喹啉的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3237575A1 (de) * | 1982-10-09 | 1984-04-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue orale mopidamolformen |
| GB8824392D0 (en) * | 1988-10-18 | 1988-11-23 | Ciba Geigy Ag | Dispersible formulation |
| TW355683B (en) * | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
| US5965572A (en) | 1996-10-28 | 1999-10-12 | The United States Of America As Respresented By The Secretary Of The Army | Methods for treating antibiotic-resistant infections |
| CZ300261B6 (cs) * | 1996-10-30 | 2009-04-01 | Eli Lilly And Company | Použití hydrochloridové soli raloxifenu pro prípravu léciva pro prevenci rakoviny prsu |
| US6819464B2 (en) * | 2002-06-19 | 2004-11-16 | Seiko Epson Corporation | Optical modulator, optical device and projector |
| ATE463482T1 (de) * | 2002-07-25 | 2010-04-15 | Janssen Pharmaceutica Nv | Chinolinderivate und deren verwendung als mycobakterielle inhibitoren |
| AU2002350719A1 (en) * | 2002-11-29 | 2004-06-23 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
| AP2037A (en) * | 2004-05-28 | 2009-10-09 | Janssen Pharmaceutica Nv | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases |
| WO2006024667A1 (en) * | 2004-09-02 | 2006-03-09 | Janssen Pharmaceutica N.V. | Furamate of 4-( (4-( (4- (2-cyanoethenyl) -2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile |
| JP2006182755A (ja) * | 2004-12-24 | 2006-07-13 | Janssen Pharmaceut Nv | 潜伏性結核の処置 |
-
2007
- 2007-03-12 UA UAA200904218A patent/UA97813C2/uk unknown
- 2007-12-02 JO JO2007511A patent/JO2973B1/en active
- 2007-12-03 RS RS20120336A patent/RS52408B/sr unknown
- 2007-12-03 AU AU2007328945A patent/AU2007328945B2/en active Active
- 2007-12-03 AP AP2009004870A patent/AP2498A/xx active
- 2007-12-03 CN CN201510368829.1A patent/CN105012303A/zh active Pending
- 2007-12-03 KR KR1020097011043A patent/KR101514700B1/ko active Active
- 2007-12-03 WO PCT/EP2007/063186 patent/WO2008068231A1/en not_active Ceased
- 2007-12-03 DK DK07847697.5T patent/DK2086940T3/da active
- 2007-12-03 SI SI200730984T patent/SI2086940T1/sl unknown
- 2007-12-03 EA EA200970532A patent/EA017091B9/ru active Protection Beyond IP Right Term
- 2007-12-03 MX MX2009005909A patent/MX2009005909A/es active IP Right Grant
- 2007-12-03 HR HRP20120639TT patent/HRP20120639T1/hr unknown
- 2007-12-03 CN CNA2007800448088A patent/CN101547904A/zh active Pending
- 2007-12-03 NZ NZ576485A patent/NZ576485A/en unknown
- 2007-12-03 PT PT07847697T patent/PT2086940E/pt unknown
- 2007-12-03 CL CL200703472A patent/CL2007003472A1/es unknown
- 2007-12-03 MY MYPI20092284A patent/MY148844A/en unknown
- 2007-12-03 ME MEP-2012-95A patent/ME01456B/me unknown
- 2007-12-03 BR BRPI0719693-8A2A patent/BRPI0719693A2/pt not_active Application Discontinuation
- 2007-12-03 JP JP2009539724A patent/JP2010511663A/ja active Pending
- 2007-12-03 CA CA2668512A patent/CA2668512C/en active Active
- 2007-12-03 US US12/515,986 patent/US8546428B2/en active Active
- 2007-12-03 ES ES07847697T patent/ES2387923T3/es active Active
- 2007-12-03 EP EP07847697A patent/EP2086940B1/en active Active
- 2007-12-03 PL PL07847697T patent/PL2086940T3/pl unknown
- 2007-12-04 TW TW096146000A patent/TWI417098B/zh active
- 2007-12-05 UY UY30762A patent/UY30762A1/es active IP Right Grant
- 2007-12-05 PE PE2007001719A patent/PE20081350A1/es active IP Right Grant
- 2007-12-05 AR ARP070105442A patent/AR064149A1/es not_active Application Discontinuation
-
2009
- 2009-06-02 IL IL199077A patent/IL199077A/en active IP Right Grant
- 2009-06-04 ZA ZA2009/03907A patent/ZA200903907B/en unknown
- 2009-07-06 NO NO20092535A patent/NO342773B1/no unknown
-
2012
- 2012-08-13 CY CY20121100734T patent/CY1113594T1/el unknown
-
2014
- 2014-09-19 JP JP2014191134A patent/JP5894239B2/ja active Active
-
2016
- 2016-03-04 HK HK16102481.4A patent/HK1214513A1/zh unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010511663A5 (enExample) | ||
| AU2005249467B2 (en) | Coated tablet formulation and method | |
| CN102548544B (zh) | 同时具有速效特性和长效特性的药物组合物 | |
| JP5421775B2 (ja) | オキシコドンを含む顆粒及び口腔内崩壊錠剤 | |
| HRP20120639T1 (hr) | Fumaratna sol (alfa s, beta r)-6-bromo-alfa-[2-(dimetilamino)etil]-2-metoksi-alfa-1-naftalenil-beta-fenil-3-kinolinetanola | |
| JP2009545560A5 (enExample) | ||
| CN105998017A (zh) | 具有提高的稳定性的包含氨氯地平和氯沙坦的固体药物组合物 | |
| HU202102B (en) | Process for producing oral pharmaceutical compositions with controlled release of the active components | |
| JP2013530196A (ja) | ４−アミノ−５−フルオロ−３−［６−（４−メチルピペラジン−１−イル）−１ｈ−ベンズイミダゾール−２−イル］−１ｈ−キノリン−２−オンラクテート一水和物を含む医薬組成物 | |
| WO2013020416A1 (zh) | 伊伐布雷定或其可药用盐的缓释制剂 | |
| JP2011502140A (ja) | トルテロジンの制御放出型医薬組成物 | |
| US8563035B2 (en) | Oral tablet compositions of dexlansoprazole | |
| JP5211040B2 (ja) | ピリジルメチルスルフィニルベンズイミダゾールのための経口速放医薬製剤 | |
| TW201035089A (en) | Pharmaceutical composition | |
| WO2014207691A1 (en) | Disintegrant free composition of cinacalcet | |
| WO2014006636A2 (en) | Stable compositions of fesoterodine | |
| WO2012123922A1 (en) | Controlled release pharmaceutical compositions of selective serotonin reuptake inhibitor | |
| US20150250734A1 (en) | Stable pharmaceutical compositions of saxagliptin or salts thereof | |
| WO2011161689A1 (en) | Imatinib mesilate pharmaceutical tablet | |
| JP2015503555A (ja) | ボセンタン制御放出性経口製剤 | |
| WO2011000518A1 (en) | Pharmaceutical composition comprising desloratadine | |
| US9694007B2 (en) | Oral complex composition comprising pseudoephedrine and levocetirizine | |
| WO2014096983A1 (en) | Stable pharmaceutical compositions of saxagliptin or salts thereof | |
| JP2010516712A5 (enExample) | ||
| EP2803353B1 (en) | Compositions of Imatinib |