JP2010516712A5 - - Google Patents
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- Publication number
- JP2010516712A5 JP2010516712A5 JP2009546620A JP2009546620A JP2010516712A5 JP 2010516712 A5 JP2010516712 A5 JP 2010516712A5 JP 2009546620 A JP2009546620 A JP 2009546620A JP 2009546620 A JP2009546620 A JP 2009546620A JP 2010516712 A5 JP2010516712 A5 JP 2010516712A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- pharmaceutical composition
- composition according
- nebivolol
- polysorbate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- 239000000080 wetting agent Substances 0.000 claims 5
- KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 4
- 229940068968 polysorbate 80 Drugs 0.000 claims 4
- 229920000053 polysorbate 80 Polymers 0.000 claims 4
- JWEXHQAEWHKGCW-VCVZPGOSSA-N (S,R,R,R)-nebivolol hydrochloride Chemical compound [Cl-].C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)C[NH2+]C[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 JWEXHQAEWHKGCW-VCVZPGOSSA-N 0.000 claims 3
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 3
- 229920002261 Corn starch Polymers 0.000 claims 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 239000008120 corn starch Substances 0.000 claims 3
- 229960001681 croscarmellose sodium Drugs 0.000 claims 3
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 3
- 239000011363 dried mixture Substances 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 229960001375 lactose Drugs 0.000 claims 3
- 239000008101 lactose Substances 0.000 claims 3
- 229960001021 lactose monohydrate Drugs 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229960000619 nebivolol Drugs 0.000 claims 3
- 229940068174 nebivolol hydrochloride Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010020772 Hypertension Diseases 0.000 claims 2
- 239000004067 bulking agent Substances 0.000 claims 2
- 229920000136 polysorbate Polymers 0.000 claims 2
- 229950008882 polysorbate Drugs 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 206010059245 Angiopathy Diseases 0.000 claims 1
- 208000007530 Essential hypertension Diseases 0.000 claims 1
- 239000004606 Fillers/Extenders Substances 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008240 homogeneous mixture Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000005550 wet granulation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2575527 | 2007-01-22 | ||
| CA2,575,527 | 2007-01-22 | ||
| PCT/CA2008/000119 WO2008089549A1 (en) | 2007-01-22 | 2008-01-22 | Pharmaceutical compositions comprising nebivolol or a nebivolol analogue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516712A JP2010516712A (ja) | 2010-05-20 |
| JP2010516712A5 true JP2010516712A5 (enExample) | 2010-12-16 |
| JP5448844B2 JP5448844B2 (ja) | 2014-03-19 |
Family
ID=39644046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546620A Expired - Fee Related JP5448844B2 (ja) | 2007-01-22 | 2008-01-22 | ネビボロールを含む固体の医薬組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20100137424A1 (enExample) |
| EP (1) | EP2124931A4 (enExample) |
| JP (1) | JP5448844B2 (enExample) |
| AU (1) | AU2008209264B2 (enExample) |
| CA (1) | CA2675538C (enExample) |
| WO (1) | WO2008089549A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3768378B1 (en) | 2018-03-22 | 2025-08-06 | InCarda Therapeutics, Inc. | A novel method to slow ventricular rate |
| US20220016025A1 (en) * | 2020-07-08 | 2022-01-20 | Vinayak Dinesh DENDUKURI | Formulations of nebivolol |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337429C (en) | 1983-12-05 | 1995-10-24 | Guy Rosalia Eugene Van Lommen | Derivatives of 2,2'-iminobisethanol |
| CA1337432C (en) | 1988-03-23 | 1995-10-24 | Raymond M. Xhonneux | Method of lowering the blood pressure |
| US5338732A (en) * | 1991-06-18 | 1994-08-16 | Bristol-Myers Squibb Company | Megestrol acetate formulation |
| TW355683B (en) | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
| JPH098913A (ja) | 1995-06-22 | 1997-01-10 | Hitachi Maxell Ltd | 情報通信システム |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| FR2809731B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique |
| WO2005099699A1 (en) * | 2004-04-07 | 2005-10-27 | Sepracor Inc. | Combination of (s)-amlodipine and a beta-blocker, and methods for reducing hypertension |
| WO2005117899A1 (en) * | 2004-06-02 | 2005-12-15 | Cipla Limited | Pharmaceutical composition comprising tibolone and process for procuding the same |
| WO2006025070A2 (en) * | 2004-07-30 | 2006-03-09 | Torrent Pharmaceuticals Limited | Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol |
| EP1850842A1 (de) | 2005-02-11 | 2007-11-07 | Stada Arzneimittel Ag | Pharmazeutische zusammensetzungen nebivolo und ein hydrophiles polymer |
| NZ563759A (en) * | 2005-05-31 | 2010-06-25 | Mylan Lab Inc | Compositions comprising nebivolol, a hydralazine compound and an isosorbide nitrate |
| EP1839658A1 (en) * | 2006-03-30 | 2007-10-03 | Hexal A/S | Pharmaceutical composition comprising micronized nebivolol |
-
2008
- 2008-01-22 AU AU2008209264A patent/AU2008209264B2/en not_active Ceased
- 2008-01-22 WO PCT/CA2008/000119 patent/WO2008089549A1/en not_active Ceased
- 2008-01-22 JP JP2009546620A patent/JP5448844B2/ja not_active Expired - Fee Related
- 2008-01-22 EP EP08706266.7A patent/EP2124931A4/en not_active Withdrawn
- 2008-01-22 US US12/523,686 patent/US20100137424A1/en not_active Abandoned
- 2008-01-22 CA CA2675538A patent/CA2675538C/en active Active
-
2015
- 2015-05-05 US US14/704,375 patent/US10117939B2/en not_active Expired - Fee Related
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