JP2007091758A5 - - Google Patents
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- Publication number
- JP2007091758A5 JP2007091758A5 JP2007003546A JP2007003546A JP2007091758A5 JP 2007091758 A5 JP2007091758 A5 JP 2007091758A5 JP 2007003546 A JP2007003546 A JP 2007003546A JP 2007003546 A JP2007003546 A JP 2007003546A JP 2007091758 A5 JP2007091758 A5 JP 2007091758A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- weight
- active agent
- disintegrant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000203 mixture Substances 0.000 claims 21
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 9
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 7
- 239000013543 active substance Substances 0.000 claims 6
- 239000007884 disintegrant Substances 0.000 claims 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- 229960000913 crospovidone Drugs 0.000 claims 5
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 5
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 5
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 4
- 229960004699 valsartan Drugs 0.000 claims 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 239000000945 filler Substances 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 229910002016 Aerosil® 200 Inorganic materials 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims 2
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 2
- 239000008358 core component Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 229920003084 Avicel® PH-102 Polymers 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 claims 1
- 208000021908 Myocardial disease Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 239000008119 colloidal silica Substances 0.000 claims 1
- 239000000306 component Substances 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59968700A | 2000-06-22 | 2000-06-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002503289A Division JP2003535895A (ja) | 2000-06-22 | 2001-06-20 | 固体バルサルタン医薬組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012172246A Division JP2012211200A (ja) | 2000-06-22 | 2012-08-02 | 固体バルサルタン医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007091758A JP2007091758A (ja) | 2007-04-12 |
| JP2007091758A5 true JP2007091758A5 (enExample) | 2007-09-13 |
Family
ID=24400655
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002503289A Withdrawn JP2003535895A (ja) | 2000-06-22 | 2001-06-20 | 固体バルサルタン医薬組成物 |
| JP2007003546A Withdrawn JP2007091758A (ja) | 2000-06-22 | 2007-01-11 | 固体バルサルタン医薬組成物 |
| JP2012172246A Pending JP2012211200A (ja) | 2000-06-22 | 2012-08-02 | 固体バルサルタン医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002503289A Withdrawn JP2003535895A (ja) | 2000-06-22 | 2001-06-20 | 固体バルサルタン医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012172246A Pending JP2012211200A (ja) | 2000-06-22 | 2012-08-02 | 固体バルサルタン医薬組成物 |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP2072049A3 (enExample) |
| JP (3) | JP2003535895A (enExample) |
| KR (2) | KR100659644B1 (enExample) |
| CN (2) | CN1221256C (enExample) |
| AU (2) | AU8576801A (enExample) |
| BR (1) | BR0111868A (enExample) |
| CA (1) | CA2411882C (enExample) |
| CZ (1) | CZ20024180A3 (enExample) |
| EC (1) | ECSP024389A (enExample) |
| HK (1) | HK1052868A1 (enExample) |
| HU (1) | HUP0301390A3 (enExample) |
| IL (2) | IL153428A0 (enExample) |
| MX (1) | MXPA02012683A (enExample) |
| NO (1) | NO20026123L (enExample) |
| NZ (2) | NZ540748A (enExample) |
| PL (1) | PL358290A1 (enExample) |
| RU (1) | RU2333757C2 (enExample) |
| SG (1) | SG162605A1 (enExample) |
| SK (1) | SK18062002A3 (enExample) |
| WO (1) | WO2001097805A2 (enExample) |
| ZA (1) | ZA200210359B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ297795B6 (cs) * | 1998-12-23 | 2007-03-28 | Novartis Ag | Tablety obsahující valsartan |
| US7468390B2 (en) | 2002-01-17 | 2008-12-23 | Novartis Ag | Methods of treatment and pharmaceutical composition |
| KR20100057704A (ko) * | 2002-01-17 | 2010-05-31 | 노파르티스 아게 | 발사르탄 및 ｎｅｐ 저해제를 포함하는 제약학적 조성물 |
| GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| TWI299663B (en) * | 2002-05-14 | 2008-08-11 | Novartis Ag | Methods of treatment |
| JP4505859B2 (ja) * | 2003-08-08 | 2010-07-21 | 味の素株式会社 | ナテグリニド含有製剤 |
| WO2006021443A2 (en) * | 2004-08-26 | 2006-03-02 | Novartis Ag | Composition comprising an at1 receptor blocker and a macrolide t-cell immunomodulator |
| WO2006066961A1 (en) | 2004-12-24 | 2006-06-29 | Krka, D.D., Novo Mesto | Solid pharmaceutical composition comprising valsartan |
| JP2009001520A (ja) * | 2007-06-21 | 2009-01-08 | Kowa Co | ジフェンヒドラミン含有固形製剤 |
| CA2701695A1 (en) | 2007-10-09 | 2009-04-16 | Novartis Ag | Pharmaceutical formulation of valsartan |
| WO2009059605A1 (en) * | 2007-11-08 | 2009-05-14 | University Of Copenhagen | Small scale solid state screening |
| EP2067470A1 (en) * | 2007-12-03 | 2009-06-10 | Laboratorios Lesvi, S.L. | Pharmaceutical compositions containing valsartan and process for its preparation |
| EP2536396B1 (en) | 2010-02-16 | 2016-08-10 | KRKA, D.D., Novo Mesto | Process for the preparation of oral solid dosage forms comprising valsartan |
| CN102362865B (zh) * | 2011-10-28 | 2013-06-26 | 山东司邦得制药有限公司 | 一种含有盐酸贝尼地平和缬沙坦的复方制剂及其应用 |
| WO2013098576A1 (en) | 2011-12-31 | 2013-07-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Immediate release pharmaceutical composition of valsartan |
| WO2013098578A1 (en) | 2011-12-31 | 2013-07-04 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Immediate release pharmaceutical composition of valsartan hydrochlorothiazide |
| CN103599084B (zh) * | 2013-11-22 | 2018-10-30 | 威海迪素制药有限公司 | 一种降压组合物 |
| CN112826806A (zh) * | 2021-01-20 | 2021-05-25 | 海南皇隆制药股份有限公司 | 一种缬沙坦片制备方法和缬沙坦片 |
| CN112807286A (zh) * | 2021-01-20 | 2021-05-18 | 海南皇隆制药股份有限公司 | 一种缬沙坦分散片制备方法和缬沙坦分散片 |
| EP4295839A1 (en) | 2022-06-20 | 2023-12-27 | KRKA, d.d., Novo mesto | Combination of valsartan and indapamide |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59107440D1 (de) | 1990-02-19 | 1996-04-04 | Ciba Geigy Ag | Acylverbindungen |
| SK117996A3 (en) | 1994-03-17 | 1997-03-05 | Ciba Geigy Ag | Pharmaceutical composition for treatment of diabetic nephropathy |
| ATE209047T1 (de) * | 1995-06-07 | 2001-12-15 | Searle & Co | Epoxysteroide aldosteronantagonist und angiotensin ii rezeptor antagonist kombinationstherapie zur behandlung von congestivem herzversagen |
| CA2232663C (en) * | 1995-10-06 | 2008-04-08 | Novartis Ag | At1-receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys |
| AU1791497A (en) * | 1996-02-29 | 1997-09-16 | Novartis Ag | At1 receptor antagonist for the stimulation of apoptosis |
| CN1165291C (zh) * | 1996-05-20 | 2004-09-08 | 詹森药业有限公司 | 具有改进的生物利用度的抗真菌组合物 |
| GB9613470D0 (en) | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| US6541669B1 (en) * | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| SE9802973D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
| CZ297795B6 (cs) * | 1998-12-23 | 2007-03-28 | Novartis Ag | Tablety obsahující valsartan |
| SK14642002A3 (sk) * | 2000-04-12 | 2003-05-02 | Novartis Ag | Kombinované farmaceutické prostriedky obsahujúce antagonistu AT1-receptora a/alebo inhibítor HMG-CoA reduktázy a/alebo ACE inhibítor |
-
2001
- 2001-06-20 AU AU8576801A patent/AU8576801A/xx active Pending
- 2001-06-20 SK SK1806-2002A patent/SK18062002A3/sk unknown
- 2001-06-20 KR KR1020057013346A patent/KR100659644B1/ko not_active Expired - Fee Related
- 2001-06-20 HU HU0301390A patent/HUP0301390A3/hu not_active Application Discontinuation
- 2001-06-20 EP EP09004205A patent/EP2072049A3/en not_active Withdrawn
- 2001-06-20 PL PL01358290A patent/PL358290A1/xx not_active Application Discontinuation
- 2001-06-20 NZ NZ540748A patent/NZ540748A/en not_active IP Right Cessation
- 2001-06-20 SG SG200501782-7A patent/SG162605A1/en unknown
- 2001-06-20 CN CNB018115527A patent/CN1221256C/zh not_active Expired - Fee Related
- 2001-06-20 EP EP01965014A patent/EP1296677A2/en not_active Ceased
- 2001-06-20 RU RU2003100507/15A patent/RU2333757C2/ru not_active IP Right Cessation
- 2001-06-20 JP JP2002503289A patent/JP2003535895A/ja not_active Withdrawn
- 2001-06-20 HK HK03104842.9A patent/HK1052868A1/zh unknown
- 2001-06-20 AU AU2001285768A patent/AU2001285768B2/en not_active Ceased
- 2001-06-20 MX MXPA02012683A patent/MXPA02012683A/es active IP Right Grant
- 2001-06-20 BR BR0111868-4A patent/BR0111868A/pt not_active Application Discontinuation
- 2001-06-20 IL IL15342801A patent/IL153428A0/xx unknown
- 2001-06-20 CA CA2411882A patent/CA2411882C/en not_active Expired - Fee Related
- 2001-06-20 WO PCT/EP2001/006983 patent/WO2001097805A2/en not_active Ceased
- 2001-06-20 CZ CZ20024180A patent/CZ20024180A3/cs unknown
- 2001-06-20 CN CNB2005100510503A patent/CN100450478C/zh not_active Expired - Fee Related
- 2001-06-20 NZ NZ522953A patent/NZ522953A/en not_active IP Right Cessation
- 2001-06-20 KR KR10-2002-7017469A patent/KR100525341B1/ko not_active Expired - Fee Related
-
2002
- 2002-12-12 EC EC2002004389A patent/ECSP024389A/es unknown
- 2002-12-12 IL IL153428A patent/IL153428A/en not_active IP Right Cessation
- 2002-12-19 NO NO20026123A patent/NO20026123L/no unknown
- 2002-12-20 ZA ZA200210359A patent/ZA200210359B/xx unknown
-
2007
- 2007-01-11 JP JP2007003546A patent/JP2007091758A/ja not_active Withdrawn
-
2012
- 2012-08-02 JP JP2012172246A patent/JP2012211200A/ja active Pending
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