JP2004538468A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004538468A5 JP2004538468A5 JP2003519572A JP2003519572A JP2004538468A5 JP 2004538468 A5 JP2004538468 A5 JP 2004538468A5 JP 2003519572 A JP2003519572 A JP 2003519572A JP 2003519572 A JP2003519572 A JP 2003519572A JP 2004538468 A5 JP2004538468 A5 JP 2004538468A5
- Authority
- JP
- Japan
- Prior art keywords
- hybrid
- group
- monolithic material
- surface modifier
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 claims 75
- 239000003607 modifier Substances 0.000 claims 38
- 239000002245 particle Substances 0.000 claims 29
- 239000011148 porous material Substances 0.000 claims 16
- 239000000126 substance Substances 0.000 claims 14
- 125000005372 silanol group Chemical group 0.000 claims 13
- 238000004587 chromatography analysis Methods 0.000 claims 11
- 229920000642 polymer Polymers 0.000 claims 11
- 239000011248 coating agent Substances 0.000 claims 10
- 238000000576 coating method Methods 0.000 claims 10
- 125000000962 organic group Chemical group 0.000 claims 10
- 229910004298 SiO 2 Inorganic materials 0.000 claims 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- PYJJCSYBSYXGQQ-UHFFFAOYSA-N trichloro(octadecyl)silane Chemical compound CCCCCCCCCCCCCCCCCC[Si](Cl)(Cl)Cl PYJJCSYBSYXGQQ-UHFFFAOYSA-N 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 claims 6
- 125000000524 functional group Chemical group 0.000 claims 6
- 239000000377 silicon dioxide Substances 0.000 claims 4
- RCHUVCPBWWSUMC-UHFFFAOYSA-N trichloro(octyl)silane Chemical group CCCCCCCC[Si](Cl)(Cl)Cl RCHUVCPBWWSUMC-UHFFFAOYSA-N 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 2
- 238000005349 anion exchange Methods 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 238000005341 cation exchange Methods 0.000 claims 2
- 229910010293 ceramic material Inorganic materials 0.000 claims 2
- GZGREZWGCWVAEE-UHFFFAOYSA-N chloro-dimethyl-octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[Si](C)(C)Cl GZGREZWGCWVAEE-UHFFFAOYSA-N 0.000 claims 2
- DBKNGKYVNBJWHL-UHFFFAOYSA-N chloro-dimethyl-octylsilane Chemical compound CCCCCCCC[Si](C)(C)Cl DBKNGKYVNBJWHL-UHFFFAOYSA-N 0.000 claims 2
- -1 cyano, amino Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 150000002009 diols Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical group CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000005504 styryl group Chemical group 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims 2
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 229920002554 vinyl polymer Chemical group 0.000 claims 2
- 229910001928 zirconium oxide Inorganic materials 0.000 claims 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 1
- 125000000923 (C1-C30) alkyl group Chemical group 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- SLYCYWCVSGPDFR-UHFFFAOYSA-N octadecyltrimethoxysilane Chemical compound CCCCCCCCCCCCCCCCCC[Si](OC)(OC)OC SLYCYWCVSGPDFR-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31144501P | 2001-08-09 | 2001-08-09 | |
| PCT/US2002/025193 WO2003014450A1 (en) | 2001-08-09 | 2002-08-08 | Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008236842A Division JP5089543B2 (ja) | 2001-08-09 | 2008-09-16 | クロマトグラフィー分離用多孔質有機・無機ハイブリッドモノリス状物質、およびその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004538468A JP2004538468A (ja) | 2004-12-24 |
| JP2004538468A5 true JP2004538468A5 (enExample) | 2006-01-05 |
| JP4216716B2 JP4216716B2 (ja) | 2009-01-28 |
Family
ID=23206890
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003519572A Expired - Fee Related JP4216716B2 (ja) | 2001-08-09 | 2002-08-08 | クロマトグラフィー分離用多孔質有機・無機ハイブリッドモノリス状物質、およびその製造方法 |
| JP2008236842A Expired - Lifetime JP5089543B2 (ja) | 2001-08-09 | 2008-09-16 | クロマトグラフィー分離用多孔質有機・無機ハイブリッドモノリス状物質、およびその製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008236842A Expired - Lifetime JP5089543B2 (ja) | 2001-08-09 | 2008-09-16 | クロマトグラフィー分離用多孔質有機・無機ハイブリッドモノリス状物質、およびその製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US7250214B2 (enExample) |
| EP (1) | EP1417366A4 (enExample) |
| JP (2) | JP4216716B2 (enExample) |
| WO (1) | WO2003014450A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6686035B2 (en) * | 1999-02-05 | 2004-02-03 | Waters Investments Limited | Porous inorganic/organic hybrid particles for chromatographic separations and process for their preparation |
| US6528167B2 (en) * | 2001-01-31 | 2003-03-04 | Waters Investments Limited | Porous hybrid particles with organic groups removed from the surface |
| US7250214B2 (en) | 2001-08-09 | 2007-07-31 | Waters Investments Limited | Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation |
| WO2004041398A2 (en) | 2002-10-30 | 2004-05-21 | Waters Investments Limited | Porous inorganic/organic hybrid materials and preparation thereof |
| EP1562700A1 (de) * | 2002-10-31 | 2005-08-17 | MERCK PATENT GmbH | Mit organischen polymeren beschichtete anorganische monolithische formk rper |
| JP4791352B2 (ja) * | 2003-02-07 | 2011-10-12 | ウオーターズ・テクノロジーズ・コーポレイシヨン | クロマトグラフィーナノカラム用ポリマー固体支持体 |
| DE112004000244T5 (de) * | 2003-02-10 | 2006-02-09 | Waters Investments Ltd., New Castle | Siloxan-immobilisierte partikuläre stationäre Phasen für chromatographische Auftrennungen und Extraktionen |
| DE112004000906T5 (de) * | 2003-05-28 | 2006-10-19 | Waters Investments Ltd., New Castle | Neue Nanoverbundstoffe und ihre Anwendung als Monolithsäulen |
| WO2005007264A2 (en) * | 2003-07-14 | 2005-01-27 | Waters Investments Limited | Separation device with integral guard column |
| DE10351798A1 (de) * | 2003-11-06 | 2005-06-09 | Merck Patent Gmbh | Verfahren zur Herstellung von monolithischen Formkörpern |
| US20050127002A1 (en) * | 2003-12-12 | 2005-06-16 | Zare Richard N. | Immobilized-enzyme microreactor devices for characterization of biomolecular analytes and associated methods |
| DE112005000269T5 (de) * | 2004-02-17 | 2007-01-25 | Waters Investments Ltd., New Castle | Poröse Hybridmonolithmaterialien mit von der Oberfläche entfernten organischen Gruppen |
| GB2428393B (en) | 2004-03-05 | 2008-10-01 | Waters Investments Ltd | Frit for high pressure liquid chromotography |
| US7309426B2 (en) * | 2004-04-23 | 2007-12-18 | Agilent Technologies, Inc. | Composition and method for high efficiency chromatography |
| JP4558382B2 (ja) * | 2004-06-04 | 2010-10-06 | ジーエルサイエンス株式会社 | アフィニティクロマトグラフィ用デバイス及びその製法 |
| US10773186B2 (en) | 2004-07-30 | 2020-09-15 | Waters Technologies Corporation | Porous inorganic/organic hybrid materials with ordered domains for chromatographic separations and processes for their preparation |
| US8658277B2 (en) * | 2004-07-30 | 2014-02-25 | Waters Technologies Corporation | Porous inorganic/organic hybrid materials with ordered domains for chromatographic separations and processes for their preparation |
| GB2437420B (en) * | 2004-11-16 | 2010-07-28 | Waters Investments Ltd | Device for performing separations and methods of making and using same |
| US7439272B2 (en) * | 2004-12-20 | 2008-10-21 | Varian, Inc. | Ultraporous sol gel monoliths |
| US7582214B2 (en) * | 2005-06-20 | 2009-09-01 | Mcmaster University | Methods for forming macroporous monolithic methylsilsesquioxanes |
| US20070014699A1 (en) * | 2005-06-23 | 2007-01-18 | Beckman Coulter, Inc, | Methods and apparatus for improving the sensitivity of capillary zone electrophoresis |
| US20070181479A1 (en) * | 2005-11-21 | 2007-08-09 | Pentax Corporation | Column and method of manufacturing the column |
| US7947579B2 (en) * | 2006-02-13 | 2011-05-24 | Stc.Unm | Method of making dense, conformal, ultra-thin cap layers for nanoporous low-k ILD by plasma assisted atomic layer deposition |
| JP4962490B2 (ja) * | 2006-03-29 | 2012-06-27 | ダイソー株式会社 | 修飾シリカゲル及びその利用 |
| ES2593478T3 (es) * | 2006-04-07 | 2016-12-09 | Merck Patent Gmbh | Fabricación de columnas de separación monolíticas |
| US8680311B2 (en) * | 2006-11-07 | 2014-03-25 | Waters Technologies Corporation | Monolithic electrokinetic pump fabrication |
| EP2102316A1 (en) * | 2006-11-07 | 2009-09-23 | Sued-Chemie AG | Method for purification of biodiesel |
| EP1920829A1 (en) * | 2006-11-07 | 2008-05-14 | Süd-Chemie Ag | Amorphous adsorbent, method of obtaining the same and its use in the bleaching of fats and/or oils |
| WO2008085435A1 (en) | 2007-01-12 | 2008-07-17 | Waters Investments Limited | Porous carbon-heteroatom-silicon hybrid inorganic/organic materials for chromatographic separations and process for the preparation thereof |
| WO2008103423A1 (en) * | 2007-02-21 | 2008-08-28 | Waters Investments Limited | Porous inorganic/organic hybrid particles having high organic content and enhanced pore geometry for chromatographic separations |
| US7651762B2 (en) * | 2007-03-13 | 2010-01-26 | Varian, Inc. | Methods and devices using a shrinkable support for porous monolithic materials |
| US20100278695A1 (en) * | 2007-05-08 | 2010-11-04 | Waters Technologies Corporation | Chromatographic And Electrophoretic Separation Media And Apparatus |
| CN101918312A (zh) * | 2007-06-04 | 2010-12-15 | 全技术联合公司 | 二氧化硅颗粒及其制备方法和使用方法 |
| WO2008156199A1 (ja) * | 2007-06-18 | 2008-12-24 | Gl Sciences Incorporated | モノリス吸着剤及びそれによる試料吸着方法及び装置 |
| US8596468B2 (en) * | 2007-06-27 | 2013-12-03 | J.M. Huber Corporation | Composite caustic silica gel manufacturing method and gels made thereby |
| US7803343B2 (en) * | 2007-06-27 | 2010-09-28 | J.M. Huber Corporation | Silica gel manufacturing method and gels made thereby |
| WO2009102363A2 (en) * | 2007-11-15 | 2009-08-20 | Stc.Unm | Ultra-thin microporous/hybrid materials |
| DE102007063297A1 (de) * | 2007-12-27 | 2009-07-02 | Merck Patent Gmbh | Poröse monolithische Materialien |
| JP5597191B2 (ja) * | 2008-04-08 | 2014-10-01 | ウオーターズ・テクノロジーズ・コーポレイシヨン | ナノ粒子含有複合材料およびこのクロマトグラフィーでの使用 |
| US7915318B2 (en) * | 2008-09-09 | 2011-03-29 | General Electric Company | Aqueous ROMP-based monolith materials and methods for making |
| DE102009017943A1 (de) | 2009-04-17 | 2010-10-21 | Merck Patent Gmbh | Poröse, magnetische Kieselgelformkörper, deren Herstellung und Anwendung |
| US11439977B2 (en) | 2009-06-01 | 2022-09-13 | Waters Technologies Corporation | Hybrid material for chromatographic separations comprising a superficially porous core and a surrounding material |
| EP2437882A4 (en) * | 2009-06-01 | 2016-11-23 | Waters Technologies Corp | HYBRID MATERIAL FOR CHROMATOGRAPHY SEPARATIONS |
| IN2012DN00363A (enExample) | 2009-08-04 | 2015-08-21 | Waters Technologies Corp | |
| FR2957276A1 (fr) * | 2010-03-15 | 2011-09-16 | Francois Parmentier | Monolithe multicapillaire |
| CN101806787B (zh) * | 2010-04-02 | 2012-01-04 | 北京化工大学 | 一种耐碱性高效液相色谱整体柱及其制备方法 |
| WO2011128338A1 (en) * | 2010-04-12 | 2011-10-20 | Universite Claude Bernard Lyon I | Method for preparing hybrid materials obtained by fast condensation of an organosilicon sol |
| WO2012018598A1 (en) | 2010-07-26 | 2012-02-09 | Waters Technologies Corporation | Superficially porous materials comprising a substantially nonporous core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations |
| EP2709754B1 (en) * | 2011-05-20 | 2021-01-27 | Waters Technologies Corporation | Porous materials for solid phase extraction and chromatography |
| WO2012170755A1 (en) | 2011-06-09 | 2012-12-13 | Waters Technologies Corporation | A porous material and devices for performing separations, filtrations, and catalysis and ek pumps, and methods of making and using the same |
| EP2570183A1 (en) * | 2011-09-15 | 2013-03-20 | InstrAction GmbH | Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules |
| US10185057B2 (en) | 2011-11-11 | 2019-01-22 | Ppg Industries Ohio, Inc. | Coated articles having abrasion resistant, glass-like coatings |
| CN107754776B (zh) | 2012-05-15 | 2021-09-21 | 沃特世科技公司 | 色谱材料 |
| CN102755880B (zh) * | 2012-07-16 | 2014-04-02 | 北京化工大学 | 一种溶胶-凝胶法制备高纯硅胶色谱柱填料的方法 |
| RU2015114177A (ru) * | 2012-09-17 | 2016-11-10 | У.Р. Грейс Энд Ко.-Конн. | Функционализированный, состоящий из частиц материал носителя и способы его получения и применения |
| BR112015005937A2 (pt) | 2012-09-17 | 2017-07-04 | Grace W R & Co | meios e dispositivos cromatográficos |
| US9610576B2 (en) | 2012-09-27 | 2017-04-04 | Agilent Technologies, Inc. | Hydrolytically stable ion-exchange stationary phases and uses thereof |
| US9702856B2 (en) * | 2012-10-03 | 2017-07-11 | Waters Technologies Corporation | System and method for rapid analysis of polymer additives |
| US9518960B2 (en) * | 2013-10-02 | 2016-12-13 | Waters Technologies Corporation | System and method for rapid analysis of polycyclic aromatic hydrocarbons |
| SG11201604198YA (en) | 2013-12-30 | 2016-07-28 | Curevac Ag | Methods for rna analysis |
| EP3540060A1 (en) | 2013-12-30 | 2019-09-18 | CureVac AG | Methods for rna analysis |
| ES2887110T3 (es) | 2014-01-16 | 2021-12-21 | Grace W R & Co | Medios para cromatografía de afinidad y dispositivos para cromatografía |
| US11389783B2 (en) | 2014-05-02 | 2022-07-19 | W.R. Grace & Co.-Conn. | Functionalized support material and methods of making and using functionalized support material |
| FR3026312B1 (fr) | 2014-09-29 | 2018-07-13 | Francois Parmentier | Procede de chromatographie sur un gel ou un liquide organique |
| US20180126298A1 (en) | 2015-05-22 | 2018-05-10 | Merck Patent Gmbh | Device for substance separation |
| PL3302784T3 (pl) | 2015-06-05 | 2022-01-17 | W.R. Grace & Co.-Conn. | Adsorbentowe środki klarujące do bioprzetwarzania oraz sposoby ich wytwarzania i stosowania |
| EP4239080A3 (en) | 2015-07-01 | 2023-11-01 | CureVac Manufacturing GmbH | Method for analysis of an rna molecule |
| US20190049414A1 (en) | 2016-02-15 | 2019-02-14 | Curevac Ag | Method for analyzing by-products of rna in vitro transcription |
| US20190015815A1 (en) | 2016-03-06 | 2019-01-17 | Waters Technologies Corporation | Superficially porous materials comprising a coated core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations |
| CN117054585A (zh) | 2016-04-24 | 2023-11-14 | 沃特世科技公司 | 用于对用两亲强碱性部分改性的聚糖进行分析的带电表面反相色谱材料方法 |
| CN107519850B (zh) * | 2016-06-22 | 2020-06-02 | 中国科学院大连化学物理研究所 | 用于色谱分离的杂化硅胶整体材料的制备及材料和应用 |
| EP3491374B1 (en) | 2016-07-28 | 2024-10-09 | Waters Technologies Corporation | Encapsulated pre-analytic workflow reagents for flow-through devices, liquid chromatography and mass spectrometric analysis |
| EP3596091B1 (en) | 2017-03-16 | 2021-08-25 | Waters Technologies Corporation | Chromatographic compositions |
| US11709156B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved analytical analysis |
| US12180581B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US12181452B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709155B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| WO2019067637A1 (en) | 2017-09-26 | 2019-04-04 | Waters Technologies Corporation | HIGH-PURITY CHROMATOGRAPHIC MATERIALS COMPRISING AN IONIZABLE MODIFIER FOR RETENTION OF ACID ANALYTES |
| WO2019067632A1 (en) | 2017-09-26 | 2019-04-04 | Waters Technologies Corporation | LIQUID CHROMATOGRAPHY SEPARATION OF GLUCIDIC TAUTOMERS |
| CN113507971A (zh) | 2019-02-27 | 2021-10-15 | 沃特世科技公司 | 用于最大程度减少分析物吸附的色谱密封件和经涂覆的流动路径 |
| JP7372043B2 (ja) * | 2019-03-29 | 2023-10-31 | 旭化成株式会社 | 修飾多孔質体、修飾多孔質体の製造方法、反射材、多孔質シート |
| US11918936B2 (en) | 2020-01-17 | 2024-03-05 | Waters Technologies Corporation | Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding |
| CN116391122A (zh) | 2020-09-24 | 2023-07-04 | 沃特世科技公司 | 用于反应性分子分离的色谱硬件改进 |
| CN116618032B (zh) * | 2023-05-15 | 2025-07-08 | 江南大学 | 一种三氟甲基共价有机骨架基气相色谱柱制备方法及应用 |
| WO2025181770A2 (en) | 2024-02-28 | 2025-09-04 | Waters Technologies Corporation | Methods for the separation of nucleic acids with slalom chromatography |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3935299A (en) | 1972-05-11 | 1976-01-27 | Andrei Vladimirovich Kiselev | Process for preparation of wide-pore adsorbent for use in chromatography |
| DE2236862C2 (de) | 1972-07-27 | 1974-09-05 | Istvan Prof. Dr. 6600 Saarbruecken Halasz | Sorptionsmittel für die Chromatographie |
| DE2357184A1 (de) * | 1973-11-16 | 1975-05-22 | Merck Patent Gmbh | Verfahren zur herstellung von organisch modifizierten siliciumdioxiden |
| US4029583A (en) * | 1975-02-28 | 1977-06-14 | Purdue Research Foundation | Chromatographic supports and methods and apparatus for preparing the same |
| CS179184B1 (en) | 1975-07-25 | 1977-10-31 | Stanislav Vozka | Method for preparation of precisely spherical particles of silica gel with controlled size and controled size pores. |
| DE2642032C2 (de) | 1976-09-18 | 1987-04-30 | Rupprecht, Herbert, Prof. Dr., 8400 Regensburg | Verfahren zur Inkorporierung von Wirkstoffen in siliciumdioxidhaltige Trägermaterialien und eine siliciumdioxidhaltige Zubereitung |
| US4177647A (en) | 1977-10-06 | 1979-12-11 | Lewis Refrigeration Co. | Air slide freezer system |
| FR2464967A1 (fr) | 1979-09-07 | 1981-03-20 | Rhone Poulenc Ind | Preparation de resines echangeuses d'anions par bromation de polymeres vinylaromatiques |
| US4324689A (en) | 1980-02-26 | 1982-04-13 | Shah Ramesh M | High carbon content chromatographic packing and method for making same |
| US4334118A (en) | 1981-06-01 | 1982-06-08 | Chevron Research | Solid phosphoric acid catalyzed olefin polymerization process |
| JPS58120525A (ja) | 1982-01-05 | 1983-07-18 | Asahi Glass Co Ltd | 珪酸塩中空球の製造方法 |
| JPS5954619A (ja) | 1982-09-24 | 1984-03-29 | Asahi Glass Co Ltd | 珪酸塩粒状体の製造方法 |
| US4724207A (en) | 1984-02-02 | 1988-02-09 | Cuno Incorporated | Modified siliceous chromatographic supports |
| JPS60257358A (ja) * | 1984-06-05 | 1985-12-19 | Daicel Chem Ind Ltd | 分離用充填剤 |
| US5177128A (en) | 1985-07-10 | 1993-01-05 | Sequa Chemicals, Inc. | Paper coating composition |
| DE3616133A1 (de) | 1985-09-25 | 1987-11-19 | Merck Patent Gmbh | Kugelfoermige sio(pfeil abwaerts)2(pfeil abwaerts)-partikel |
| US5108595A (en) | 1985-11-01 | 1992-04-28 | E. I. Du Pont De Nemours And Company | Porous silica microspheres having silanol-enriched and silanized surfaces |
| GB8618322D0 (en) | 1986-07-28 | 1986-09-03 | 3I Res Expl Ltd | Bonded chromotographic stationary phase |
| US5256386A (en) | 1987-06-29 | 1993-10-26 | Eka Nobel Ab | Method for preparation of silica particles |
| US4889632A (en) * | 1987-12-10 | 1989-12-26 | Ceskoslovenska Akademie Ved | Macroporous polymeric membranes for the separation of polymers and a method of their application |
| EP0386926A3 (en) | 1989-03-02 | 1991-12-18 | Supelco, Inc. | Silica gel supports suitable for chromatographic separations |
| US5403908A (en) | 1989-10-06 | 1995-04-04 | Idemitsu Kosan Company, Limited | Aryl styrene-based copolymer |
| US6022902A (en) | 1989-10-31 | 2000-02-08 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Porous article with surface functionality and method for preparing same |
| US4983369A (en) | 1989-11-22 | 1991-01-08 | Allied-Signal Inc. | Process for forming highly uniform silica spheres |
| US5068387A (en) | 1989-12-01 | 1991-11-26 | Dow Corning Corporation | Production of organofunctional alkoxysilanes |
| JP2874297B2 (ja) | 1989-12-18 | 1999-03-24 | 東ソー株式会社 | 逆相クロマトグラフィー用充填剤及びその製造方法 |
| US5271833A (en) | 1990-03-22 | 1993-12-21 | Regents Of The University Of Minnesota | Polymer-coated carbon-clad inorganic oxide particles |
| JP2646150B2 (ja) | 1990-08-27 | 1997-08-25 | 出光興産 株式会社 | 撥水性シリカゾルおよびその製造方法 |
| JPH0617476B2 (ja) | 1990-09-04 | 1994-03-09 | 工業技術院長 | 有機基修飾シリカ粒子、その製造方法および該粒子をフィラーとする樹脂組成物 |
| JP3026594B2 (ja) | 1990-11-20 | 2000-03-27 | 旭光学工業株式会社 | 分離材及び分離器 |
| US5071565A (en) | 1991-02-04 | 1991-12-10 | Iowa State University Research Foundation, Inc. | Modified resins for solid-phase extraction |
| DE69211010T2 (de) | 1991-10-21 | 1997-01-23 | Cornell Res Foundation Inc | Chromographiesäule mit makroporöser Polymerfüllung |
| US5734020A (en) | 1991-11-20 | 1998-03-31 | Cpg, Inc. | Production and use of magnetic porous inorganic materials |
| US5565142A (en) | 1992-04-01 | 1996-10-15 | Deshpande; Ravindra | Preparation of high porosity xerogels by chemical surface modification. |
| CA2135875A1 (en) | 1992-05-20 | 1993-11-25 | Kenneth G. Sharp | Process for making inorganic gels |
| JP3440486B2 (ja) | 1992-06-19 | 2003-08-25 | 旭硝子株式会社 | 球状シリカの製造方法 |
| US5298833A (en) | 1992-06-22 | 1994-03-29 | Copytele, Inc. | Black electrophoretic particles for an electrophoretic image display |
| US5374755A (en) | 1992-07-17 | 1994-12-20 | Millipore Corporation | Liquid chromatography stationary phases with reduced silanol interactions |
| US5378790A (en) | 1992-09-16 | 1995-01-03 | E. I. Du Pont De Nemours & Co. | Single component inorganic/organic network materials and precursors thereof |
| US5498678A (en) | 1992-12-21 | 1996-03-12 | Rohm And Haas Company | Suspension polymerization process for water-soluble monomers |
| JP2585671Y2 (ja) * | 1993-03-24 | 1998-11-25 | 株式会社ニッソー | 観賞魚水槽用濾過装置 |
| WO1995003256A1 (en) | 1993-07-19 | 1995-02-02 | Merck Patent Gmbh | Inorganic porous material and process for making same |
| US5425930A (en) | 1993-09-17 | 1995-06-20 | Alliedsignal Inc. | Process for forming large silica spheres by low temperature nucleation |
| JPH07120450A (ja) | 1993-10-22 | 1995-05-12 | Sumika Bunseki Center:Kk | 多孔質体クロマトグラフィー用カラム |
| DE69425473T3 (de) * | 1993-11-05 | 2005-11-03 | Shin-Etsu Chemical Co., Ltd. | Verfahren zur Herstellung von Organo-funktionelle Gruppen enthaltenden Organopolysiloxanen und daraus hergestellte Organopolysiloxane, Mercapto- und Alkoxygruppen enthaltende Organopolysiloxane und Verfahren zu deren Herstellung |
| JP2893104B2 (ja) * | 1994-03-14 | 1999-05-17 | 直弘 曽我 | 有機官能基の結合した無機系多孔質体の製造方法 |
| US5728457A (en) * | 1994-09-30 | 1998-03-17 | Cornell Research Foundation, Inc. | Porous polymeric material with gradients |
| US5868966A (en) * | 1995-03-30 | 1999-02-09 | Drexel University | Electroactive inorganic organic hybrid materials |
| US5691898A (en) * | 1995-09-27 | 1997-11-25 | Immersion Human Interface Corp. | Safe and low cost computer peripherals with force feedback for consumer applications |
| US5637135A (en) | 1995-06-26 | 1997-06-10 | Capillary Technology Corporation | Chromatographic stationary phases and adsorbents from hybrid organic-inorganic sol-gels |
| US5667674A (en) | 1996-01-11 | 1997-09-16 | Minnesota Mining And Manufacturing Company | Adsorption medium and method of preparing same |
| JP3818689B2 (ja) | 1996-01-16 | 2006-09-06 | 富士写真フイルム株式会社 | コロイド状シリカをコアとし、有機ポリマーをシェルとするコア／シェル状複合粒子の水性分散物及びその製造方法 |
| US5869152A (en) * | 1996-03-01 | 1999-02-09 | The Research Foundation Of State University Of New York | Silica materials |
| JPH09278485A (ja) | 1996-04-11 | 1997-10-28 | Tosoh Corp | 耐アルカリ性球状ガラスとその製造方法 |
| US5965202A (en) | 1996-05-02 | 1999-10-12 | Lucent Technologies, Inc. | Hybrid inorganic-organic composite for use as an interlayer dielectric |
| US6313219B1 (en) | 1996-05-02 | 2001-11-06 | Lucent Technologies, Inc. | Method for hybrid inorganic/organic composite materials |
| JPH1062401A (ja) | 1996-06-10 | 1998-03-06 | Toyota Central Res & Dev Lab Inc | 液体クロマトグラフ用充填剤 |
| US5853886A (en) * | 1996-06-17 | 1998-12-29 | Claytec, Inc. | Hybrid nanocomposites comprising layered inorganic material and methods of preparation |
| US6201570B1 (en) * | 1996-09-13 | 2001-03-13 | Hitachi Denshi Kabushiki Kaisha | Digital television camera apparatus provided with camera head unit and camera control unit, independently |
| AU7533696A (en) | 1996-12-13 | 1998-06-18 | Ciba-Geigy Ag | New materials |
| US6207098B1 (en) * | 1996-12-26 | 2001-03-27 | Merck Patent Gmbh | Method for producing porous inorganic materials |
| US5976479A (en) | 1996-12-30 | 1999-11-02 | Uop Llc | Hydrothermal process for preparing a unimodal large pore silica |
| US5935429A (en) | 1997-01-03 | 1999-08-10 | Bio-Rad Laboratories, Inc. | Chromatography columns with continuous beds formed in situ from aqueous solutions |
| JP4291415B2 (ja) | 1997-02-25 | 2009-07-08 | バイエル・アクチエンゲゼルシヤフト | 有機−無機ハイブリッド材料 |
| JP3410634B2 (ja) | 1997-05-30 | 2003-05-26 | 株式会社豊田中央研究所 | 球状メソ多孔体及びその製造方法 |
| AU7965698A (en) * | 1997-06-13 | 1998-12-30 | California Institute Of Technology | Porous silica having spatially organized organic functionalities |
| JP2002505006A (ja) | 1997-06-18 | 2002-02-12 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 分取クロマトグラフィーによる分離のためのモノリシック吸着剤の使用 |
| US6027643A (en) * | 1997-09-04 | 2000-02-22 | Dionex Corporation | Ion chromatographic method and apparatus using a combined suppressor and eluent generator |
| EP1023463A4 (en) * | 1997-10-09 | 2003-01-02 | Transgenomic Inc | MODIFICATION OF DOUBLE-STRANDED DNA TO IMPROVE CHROMATOGRAPHIC SEPARATIONS OF MATCHED ION POLYNUCLEOTIDES |
| JPH11199351A (ja) * | 1997-10-30 | 1999-07-27 | Asahi Chem Ind Co Ltd | 多孔性無機有機複合体およびその製造方法 |
| US6136187A (en) | 1997-12-09 | 2000-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | Separation column containing porous matrix and method of packing column |
| ATE275600T1 (de) | 1997-12-09 | 2004-09-15 | Sba Materials Inc | Blockcopolymerverarbeitung für mesostrukturierte anorganische oxidmaterialien |
| DE19756831A1 (de) | 1997-12-19 | 1999-07-01 | Wacker Chemie Gmbh | Siliciumdioxid, das an seiner Oberfläche teil- oder vollständig silylierte Polykieselsäureketten trägt |
| US6281257B1 (en) * | 1998-04-27 | 2001-08-28 | The Regents Of The University Of Michigan | Porous composite materials |
| JP3899733B2 (ja) * | 1998-07-03 | 2007-03-28 | 株式会社豊田中央研究所 | 多孔材料及び多孔材料の製造方法 |
| JP3953649B2 (ja) | 1998-07-17 | 2007-08-08 | オリヱント化学工業株式会社 | 有機−無機ハイブリッド成分傾斜高分子材料、及びその製造方法 |
| US6210570B1 (en) * | 1998-08-21 | 2001-04-03 | Agilent Technologies, Inc. | Monolithic silica column |
| US6138187A (en) * | 1998-08-21 | 2000-10-24 | International Business Machines Corporation | Method and system for increasing spatial reuse in a serial storage architecture subsystem |
| US6090477A (en) * | 1998-09-11 | 2000-07-18 | Ut-Battelle, Llc | Gas storage carbon with enhanced thermal conductivity |
| US6238565B1 (en) * | 1998-09-16 | 2001-05-29 | Varian, Inc. | Monolithic matrix for separating bio-organic molecules |
| DE19856000A1 (de) | 1998-12-04 | 2000-06-15 | Bayer Ag | Hybridlack-Zubereitung |
| US6686035B2 (en) | 1999-02-05 | 2004-02-03 | Waters Investments Limited | Porous inorganic/organic hybrid particles for chromatographic separations and process for their preparation |
| EP1163050B1 (en) | 1999-02-05 | 2007-01-03 | Waters Investments Limited | Preparation of porous inorganic/organic hybrid particles for chromatographic separations |
| US6227304B1 (en) | 1999-03-01 | 2001-05-08 | Case Corporation | Upper hitch link |
| JP4214203B2 (ja) | 1999-05-18 | 2009-01-28 | オリヱント化学工業株式会社 | 有機−無機複合材料およびその製造方法 |
| US20060194919A1 (en) | 1999-08-04 | 2006-08-31 | Lichtenhan Joseph D | Porosity control with polyhedral oligomeric silsesquioxanes |
| US6649083B1 (en) | 1999-08-12 | 2003-11-18 | Board Of Trustees Of Michigan State University | Combined porous organic and inorganic oxide materials prepared by non-ionic surfactant templating route |
| SE9903223L (sv) | 1999-09-09 | 2001-05-08 | Ericsson Telefon Ab L M | Förfarande och anordning i telekommunikationssystem |
| US6251280B1 (en) | 1999-09-15 | 2001-06-26 | University Of Tennessee Research Corporation | Imprint-coating synthesis of selective functionalized ordered mesoporous sorbents for separation and sensors |
| TW588072B (en) | 2000-10-10 | 2004-05-21 | Shipley Co Llc | Antireflective porogens |
| US6528167B2 (en) | 2001-01-31 | 2003-03-04 | Waters Investments Limited | Porous hybrid particles with organic groups removed from the surface |
| US7250214B2 (en) | 2001-08-09 | 2007-07-31 | Waters Investments Limited | Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation |
| WO2004041398A2 (en) | 2002-10-30 | 2004-05-21 | Waters Investments Limited | Porous inorganic/organic hybrid materials and preparation thereof |
| DE112005000269T5 (de) | 2004-02-17 | 2007-01-25 | Waters Investments Ltd., New Castle | Poröse Hybridmonolithmaterialien mit von der Oberfläche entfernten organischen Gruppen |
| US8658277B2 (en) * | 2004-07-30 | 2014-02-25 | Waters Technologies Corporation | Porous inorganic/organic hybrid materials with ordered domains for chromatographic separations and processes for their preparation |
| US7439272B2 (en) | 2004-12-20 | 2008-10-21 | Varian, Inc. | Ultraporous sol gel monoliths |
| WO2008085435A1 (en) | 2007-01-12 | 2008-07-17 | Waters Investments Limited | Porous carbon-heteroatom-silicon hybrid inorganic/organic materials for chromatographic separations and process for the preparation thereof |
| WO2008103423A1 (en) | 2007-02-21 | 2008-08-28 | Waters Investments Limited | Porous inorganic/organic hybrid particles having high organic content and enhanced pore geometry for chromatographic separations |
-
2002
- 2002-08-08 US US10/216,674 patent/US7250214B2/en not_active Expired - Lifetime
- 2002-08-08 JP JP2003519572A patent/JP4216716B2/ja not_active Expired - Fee Related
- 2002-08-08 EP EP02759304A patent/EP1417366A4/en not_active Withdrawn
- 2002-08-08 WO PCT/US2002/025193 patent/WO2003014450A1/en not_active Ceased
-
2006
- 2006-12-21 US US11/644,279 patent/US8404346B2/en not_active Expired - Fee Related
-
2008
- 2008-09-16 JP JP2008236842A patent/JP5089543B2/ja not_active Expired - Lifetime
-
2013
- 2013-03-25 US US13/850,212 patent/US9089836B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004538468A5 (enExample) | ||
| JP2010519542A5 (enExample) | ||
| JP4216716B2 (ja) | クロマトグラフィー分離用多孔質有機・無機ハイブリッドモノリス状物質、およびその製造方法 | |
| JP2005502061A5 (enExample) | ||
| Hoffmann et al. | Silica‐based mesoporous organic–inorganic hybrid materials | |
| US11071969B1 (en) | Porous carbon-heteroatom-silicon inorganic/organic materials for chromatographic separations and process for the preparation thereof | |
| JP2874297B2 (ja) | 逆相クロマトグラフィー用充填剤及びその製造方法 | |
| Schubert | New materials by sol–gel processing: design at the molecular level | |
| JP2003531269A (ja) | パターン化された機能性ナノストラクチャーのプロトタイピング | |
| US10335767B2 (en) | Sol-gel polymeric stationary phases for high-performance liquid chromatography and solid phase extraction: their method of making | |
| JP2005539112A5 (enExample) | ||
| EP1191066A3 (en) | Room temperature-curing organopolysiloxane composition | |
| El Kadib et al. | Dendrimer–silica hybrid mesoporous materials | |
| JP2007510644A5 (enExample) | ||
| Bourlinos et al. | “Side chain” modification of MCM-41 silica through the exchange of the surfactant template with charged functionalized organosiloxanes: an efficient route to valuable reconstructed MCM-41 derivatives | |
| Albela et al. | Surface molecular engineering in the confined space of templated porous silica | |
| JP2008521658A5 (enExample) | ||
| JP2007500323A5 (enExample) | ||
| JP2018503713A5 (enExample) | ||
| CN108743951A (zh) | 一种pH响应可降解中空介孔有机硅纳米粒子的制备方法 | |
| JP2011241331A (ja) | 有機シリカ系材料 | |
| JP2008530312A5 (enExample) | ||
| Hüsing | Design of inorganic and inorganic–organic hybrid materials by sol–gel processing–from nanostructures to hierarchical networks | |
| Hüsing et al. | Synthesis and Functionalization of Mesostructured Silica‐Based Films | |
| Morancais et al. | Reinforcement of Very Porous Sic Ceramics Prepared by SHS by Adding Nanometric Sic Powder in the Reactive Compact |