JP2004516104A - 注入装置の投与手段 - Google Patents

注入装置の投与手段 Download PDF

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JP2004516104A
JP2004516104A JP2002552614A JP2002552614A JP2004516104A JP 2004516104 A JP2004516104 A JP 2004516104A JP 2002552614 A JP2002552614 A JP 2002552614A JP 2002552614 A JP2002552614 A JP 2002552614A JP 2004516104 A JP2004516104 A JP 2004516104A
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ナイジェル ラングレイ クリストファー
アリステア デイ シェーン
フレデリック ヴィーゼイ ロバート
ウルストン ロバート
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ディーシーエー デザイン インターナショナル リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/21—General characteristics of the apparatus insensitive to tilting or inclination, e.g. spill-over prevention
    • A61M2205/215—Tilt detection, e.g. for warning or shut-off
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6018—General characteristics of the apparatus with identification means providing set-up signals for the apparatus configuration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31546—Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/01—Motorized syringe

Abstract

供給する薬剤の量を決める投与ダイヤル手段６，８を備える薬剤供給装置が開示されている。
薬剤供給装置には、供給する薬剤の量を、第一分量単位の倍数と決めるか、又は第二分量単位の倍数と決めるかを選択する選択手段を備えている。

Description

【０００１】
本発明は薬剤供給装置に関し、具体的には患者が薬剤を自己管理するための薬剤供給装置に関する。上記の装置は、限定されるものではないが、とりわけ糖尿病の治療に適応される。
【０００２】
薬剤供給装置には、輸液装置およびペン式注入装置などがある。このような薬剤供給装置は、典型的には、交換式薬剤カートリッジから一定量の薬剤を押し出す。薬剤供給装置は、好都合には、供給する薬剤の必要量を選択する手段を備えている。
【０００３】
既知の薬剤供給装置は、患者の必要性に応じて、ある注入装置では１単位の倍数として、他の注入装置では半単位の倍数として、薬剤の量を選択するようになっている。これは、上記の薬剤供給装置には柔軟性がないことを示している。
【０００４】
本発明の利点は、上記の問題を解消するところにあり、薬剤の量を柔軟に選択できるようになした薬剤供給装置を提供するものである。
【０００５】
本発明の第一態様によると、供給する薬剤の量を決める投与ダイヤル手段を具備する薬剤供給装置は、供給する薬剤の量を、第一分量単位の倍数と決めるか、又は第二分量単位の倍数と決めるかを選択する選択手段も備えている。
【０００６】
第一分量単位は１単位であり、第二分量単位は半単位であることが好ましい。
【０００７】
選択手段は、使用者により操作されるスイッチ又はスイッチの組み合わせを具備していることが好ましい。
【０００８】
あるいは、薬剤供給装置は、さらにマイクロプロセッサおよび表示部を具備しており、選択手段は、表示部に設けられる使用者により選択されるオプション機能から構成される。
【０００９】
薬剤供給装置は、供給する薬剤の量を第一分量単位の倍数とするか、又は第二分量単位の倍数とするかを決める投与ダイヤル手段を作動させる選択手段が操作可能かどうかを使用者に表示する手段を備えていることが好ましい。
【００１０】
以下では、実施例のみに基づいて、添付図面を参照しながら本発明を説明する。
【００１１】
図１には、薬剤供給装置の平面図が示されており、図示された実施例には、ペン式注入装置２が示されている。注入装置２には、投与ダイヤル手段６，８、表示部１０、針ユニット１２および投与供給ボタン１４を有する本体ハウジング４が備えられている。表示部は、選択された薬剤の注入量等の情報を使用者に伝達するように適合されている。
【００１２】
使用者は、投与ダイヤル手段６，８を操作することにより薬剤供給装置を作動し、注入する薬剤の必要量を選択する。投与承認ボタン１６を押すことによって、この量を承認できる。投与供給ボタン１４の操作において、マイクロプロセッサ２０はハウジング４内の駆動手段２２を作動させ、望む薬剤量を排出する。
【００１３】
投与ダイヤル手段６，８は、好都合には、供給する薬剤の量を増やすボタンと供給する薬剤の量を減らすボタンの二つのボタンを備える。いずれにおいても、それぞれのボタンが一回押されることにより、薬剤の量は１単位ごとに変化し、１単位となるか又は半単位となるかは、操作モードに応じて決まる。それぞれのボタンを押し続けることによりダイヤルされた投与を連続して変化させることができる機能を薬剤供給装置が備えてもよい。
【００１４】
図２に示された実施例によると、操作モードの選択は、両方の投与ダイヤルボタン６，８を同時に押すことにより、部分単位変更から１単位変更の間で変えることができる。
【００１５】
供給する薬剤の量を１単位の倍数とするか、又は半単位の倍数とするかを決めるための投与ダイヤル手段６，８を作動させるための選択手段が操作可能かどうかをが使用者に伝達されるように、表示部１０を適合させてもよい。
【００１６】
図３の実施例では、同じ部分には同じ参照番号を付し、選択手段は追加専用ボタン３０を備える
【００１７】
本発明の一つの実施例では、選択手段は、薬剤供給装置の寿命の間のあらかじめ決められた期間中に、一度しか操作できない。これにより、あらかじめ決められた期間以降における選択手段の不慮の操作を防ぐことができる。
【００１８】
更なる実施例では、追加的に又は代替的に、選択手段は、製造者のみが操作するようにしてもよく、供給する薬剤の量を決める単位の分量は、使用者が装置を所有する前に選択される。これは、好都合には、製造工程の一部として行われる。これにより、異なる操作構成を有する各種の薬剤供給装置が一つの製造ラインで生産可能になる。
【図面の簡単な説明】
【図１】本発明による薬剤供給装置の平面図である。
【図２】本発明による供給装置の操作のための第一制御配置を概略的に示した図である。
【図３】本発明による供給装置の操作のための第二制御装置を概略的に示した図である。

Claims (8)

  1. 供給する薬剤の量を決める投与ダイヤル手段６，８を具備する薬剤供給装置であって、供給する薬剤の量を、第一分量単位の倍数と決めるか、又は第二分量単位の倍数と決めるかを選択する選択手段を備えていることを特徴とする薬剤供給装置。
  2. 前記第一分量単位は１単位であり、前記第二分量単位は半単位であることを特徴とする請求項１に記載の薬剤供給装置。
  3. 前記選択手段は、使用者により操作されるスイッチ又はスイッチの組み合わせを具備していることを特徴とする請求項１又は２に記載の薬剤供給装置。
  4. 前記薬剤供給装置は、さらにマイクロプロセッサ２０および表示部１０を具備しており、前記選択手段は、前記表示部１０に設けられる使用者により選択されるオプション機能から構成されることを特徴とする請求項１に記載の薬剤供給装置。
  5. 前記薬剤供給装置は、供給する薬剤の量を前記第一分量単位の倍数とするか、又は前記第二分量単位の倍数とするかを決める投与ダイヤル手段を作動させる前記選択手段が操作可能かどうかを使用者に表示する手段を具備していることを特徴とする請求項１〜４の何れか１項に記載の薬剤供給装置。
  6. 前記第一又は第二分量単位のいずれかが半単位であることを特徴とする請求項１〜５の何れか１項に記載の薬剤供給装置。
  7. 前記選択手段は、前記薬剤供給装置の寿命の間のあらかじめ決められた期間中に、一度しか操作できないようにされていることを特徴とする請求項１〜６の何れか１項に記載の薬剤供給装置。
  8. 前記選択手段が製造者のみに操作され、供給する薬剤の量を決める単位の分量は、使用者が装置を保有する前に選択されることを特徴とする請求項１〜７の何れか１項に記載の薬剤供給装置。
JP2002552614A 2000-12-22 2001-12-21 注入装置の投与手段 Expired - Lifetime JP4150589B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0031466.6A GB0031466D0 (en) 2000-12-22 2000-12-22 Improvements in and relating to an injection device
PCT/GB2001/005721 WO2002051473A1 (en) 2000-12-22 2001-12-21 Dosing means for an injection device

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JP2004516104A true JP2004516104A (ja) 2004-06-03
JP4150589B2 JP4150589B2 (ja) 2008-09-17

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JP2002552621A Expired - Lifetime JP4676674B2 (ja) 2000-12-22 2001-12-21 電子制御ユニットを具備するペン型注入装置
JP2002552617A Expired - Lifetime JP4436043B2 (ja) 2000-12-22 2001-12-21 電子制御ユニットを具備するペン型注入装置
JP2002552614A Expired - Lifetime JP4150589B2 (ja) 2000-12-22 2001-12-21 注入装置の投与手段
JP2002552613A Expired - Lifetime JP4308524B2 (ja) 2000-12-22 2001-12-21 注入装置のための駆動機構
JP2002559097A Expired - Lifetime JP4287148B2 (ja) 2000-12-22 2001-12-21 電子制御ユニットを具備するペン型注入装置
JP2002552618A Expired - Lifetime JP4676673B2 (ja) 2000-12-22 2001-12-21 電子制御ユニットを具備するペン型注入装置
JP2002552620A Expired - Lifetime JP4694095B2 (ja) 2000-12-22 2001-12-21 電子制御ユニットを具備するペン型注入装置
JP2002552615A Expired - Lifetime JP4308525B2 (ja) 2000-12-22 2001-12-21 注入装置のための駆動機構
JP2002552612A Expired - Lifetime JP4308523B2 (ja) 2000-12-22 2001-12-21 注入装置のための駆動機構
JP2002552616A Expired - Lifetime JP4614621B2 (ja) 2000-12-22 2001-12-21 交換可能なカートリッジを備えた注入装置
JP2002552619A Pending JP2004516109A (ja) 2000-12-22 2001-12-21 電子制御ユニットを具備するペン型注入装置
JP2002552622A Expired - Lifetime JP4287145B2 (ja) 2000-12-22 2001-12-21 薬剤カートリッジ保持機構を具備するペン型注入装置
JP2002559098A Expired - Lifetime JP4164362B2 (ja) 2000-12-22 2001-12-21 電子制御ユニットを具備するペン型注入装置
JP2008256767A Expired - Lifetime JP4955637B2 (ja) 2000-12-22 2008-10-01 電子制御ユニットを具備するペン型注入装置
JP2009188006A Expired - Lifetime JP5054739B2 (ja) 2000-12-22 2009-08-14 電子制御ユニットを具備する携帯型注入装置の制御方法
JP2010258513A Expired - Lifetime JP5461368B2 (ja) 2000-12-22 2010-11-19 識別手段を有する薬剤カートリッジ

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JP2002552619A Pending JP2004516109A (ja) 2000-12-22 2001-12-21 電子制御ユニットを具備するペン型注入装置
JP2002552622A Expired - Lifetime JP4287145B2 (ja) 2000-12-22 2001-12-21 薬剤カートリッジ保持機構を具備するペン型注入装置
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JP2008256767A Expired - Lifetime JP4955637B2 (ja) 2000-12-22 2008-10-01 電子制御ユニットを具備するペン型注入装置
JP2009188006A Expired - Lifetime JP5054739B2 (ja) 2000-12-22 2009-08-14 電子制御ユニットを具備する携帯型注入装置の制御方法
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KR20040023580A (ko) 2004-03-18
MXPA03005595A (es) 2004-05-17
DE60110636D1 (de) 2005-06-09
ES2240343T3 (es) 2005-10-16
CA2430940A1 (en) 2002-07-04
CN1482928A (zh) 2004-03-17
DE60127303T2 (de) 2007-12-20
CN1505534A (zh) 2004-06-16
KR100788321B1 (ko) 2007-12-27
JP4308525B2 (ja) 2009-08-05
ES2246289T3 (es) 2006-02-16
US6969370B2 (en) 2005-11-29
JP4676674B2 (ja) 2011-04-27
CN100400117C (zh) 2008-07-09
CN1248746C (zh) 2006-04-05
KR20030066738A (ko) 2003-08-09
DK1353715T3 (da) 2005-08-22
US8469922B2 (en) 2013-06-25
AU2007202032B2 (en) 2009-11-05
CA2430928A1 (en) 2002-07-04
AU2002216232B2 (en) 2005-08-18
US8128603B2 (en) 2012-03-06
US20040030296A1 (en) 2004-02-12
CA2430920C (en) 2009-04-07
JP4694095B2 (ja) 2011-06-01
MXPA03005589A (es) 2004-05-14
DE60110636T2 (de) 2006-01-19
IL156270A0 (en) 2004-01-04
JP2004516105A (ja) 2004-06-03
JP2004516112A (ja) 2004-06-03
CA2430940C (en) 2009-11-24
EP1349595A1 (en) 2003-10-08
EP1349595B1 (en) 2005-07-27
MXPA03005591A (es) 2004-05-14
JP2009000557A (ja) 2009-01-08
MXPA03005584A (es) 2004-05-17
CN1482931A (zh) 2004-03-17
ES2283375T3 (es) 2007-11-01
HK1059585A1 (en) 2004-07-09
IL156270A (en) 2009-02-11
KR20030066728A (ko) 2003-08-09
PT1349591E (pt) 2005-11-30
US20040044317A1 (en) 2004-03-04
HK1059580A1 (en) 2004-07-09
JP2004516106A (ja) 2004-06-03
KR100788319B1 (ko) 2007-12-27
ATE294002T1 (de) 2005-05-15
DK1353713T3 (da) 2006-08-28
KR100788317B1 (ko) 2007-12-27
AU2007201951A1 (en) 2007-05-24
JP2010005414A (ja) 2010-01-14
CA2430922A1 (en) 2002-07-04
DK1349594T3 (da) 2005-08-29
DE60119164D1 (de) 2006-06-01
DE60110639T2 (de) 2006-01-19
GB0031466D0 (en) 2001-02-07
IL156238A (en) 2009-02-11
ES2272411T3 (es) 2007-05-01
ES2240341T3 (es) 2005-10-16
US6942646B2 (en) 2005-09-13
DE60110639D1 (de) 2005-06-09
EP1353712B1 (en) 2006-10-11
JP2004516102A (ja) 2004-06-03
JP2004516107A (ja) 2004-06-03
MXPA03005594A (es) 2004-05-17
HK1059582A1 (en) 2004-07-09
BR0116279B1 (pt) 2009-12-01
IL156245A (en) 2007-12-03
DE60119164T2 (de) 2007-02-01
WO2002051476A1 (en) 2002-07-04
WO2002051474A1 (en) 2002-07-04
EP1349593B2 (en) 2018-04-04
US20040030298A1 (en) 2004-02-12
KR100788318B1 (ko) 2007-12-27
EP1353715B1 (en) 2005-05-04
US20040097873A1 (en) 2004-05-20
EP1349594B1 (en) 2005-05-04
WO2002051475A1 (en) 2002-07-04
KR100788316B1 (ko) 2007-12-27
KR100826218B1 (ko) 2008-04-30
EP1353712A1 (en) 2003-10-22
HK1059904A1 (en) 2004-07-23
CA2430925A1 (en) 2002-07-04
IL156251A0 (en) 2004-01-04
WO2002051472A1 (en) 2002-07-04
JP4308523B2 (ja) 2009-08-05
US20040078001A1 (en) 2004-04-22
AU2002217288B2 (en) 2005-08-04
MXPA03005578A (es) 2004-05-17
IL156240A (en) 2007-12-03
DK1349592T3 (da) 2005-08-29
CN1325127C (zh) 2007-07-11
DE60110638T2 (de) 2006-01-19
DK1349595T3 (da) 2005-11-21
EP1349588B1 (en) 2005-05-18
AU2002216231B2 (en) 2005-08-04
AU2002217283B2 (en) 2007-01-25
WO2002051478A1 (en) 2002-07-04
KR20030066740A (ko) 2003-08-09
IL156251A (en) 2009-02-11
JP4614621B2 (ja) 2011-01-19
BR0116275A (pt) 2003-12-30
ATE324131T1 (de) 2006-05-15
ATE295749T1 (de) 2005-06-15
BR0116273A (pt) 2003-12-30
DK1349591T3 (da) 2005-11-28
US20040122355A1 (en) 2004-06-24
AU2007201951B2 (en) 2009-07-16
IL156238A0 (en) 2004-01-04
IL156243A (en) 2008-11-03
KR20030066743A (ko) 2003-08-09
KR100826221B1 (ko) 2008-04-30
HK1059586A1 (en) 2004-07-09
AU2002216254B2 (en) 2007-01-25
CN1482932A (zh) 2004-03-17
ATE294599T1 (de) 2005-05-15
BR0116296A (pt) 2004-08-17
KR20030066742A (ko) 2003-08-09
EP1349596A1 (en) 2003-10-08
ES2240348T3 (es) 2005-10-16
EP1349593B1 (en) 2007-03-14
IL156239A (en) 2008-11-26
BR0116280B1 (pt) 2009-12-01
IL156242A0 (en) 2004-01-04
BR0116294A (pt) 2004-08-17
DE60112326T2 (de) 2006-04-20
EP1353713A1 (en) 2003-10-22
KR20030066726A (ko) 2003-08-09

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