WO2021251965A1 - Automated injection device for administering antigens to animals - Google Patents

Automated injection device for administering antigens to animals Download PDF

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Publication number
WO2021251965A1
WO2021251965A1 PCT/US2020/037125 US2020037125W WO2021251965A1 WO 2021251965 A1 WO2021251965 A1 WO 2021251965A1 US 2020037125 W US2020037125 W US 2020037125W WO 2021251965 A1 WO2021251965 A1 WO 2021251965A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
groove
injection device
injection
push block
Prior art date
Application number
PCT/US2020/037125
Other languages
French (fr)
Inventor
Jun Zhou
Xiangwei ZHAO
Chunmei LONG
Original Assignee
Bioworld Technology, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioworld Technology, Inc filed Critical Bioworld Technology, Inc
Priority to PCT/US2020/037125 priority Critical patent/WO2021251965A1/en
Publication of WO2021251965A1 publication Critical patent/WO2021251965A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M2005/14573—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for quick connection/disconnection with a driving system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2414—Ampoule inserted into the ampoule holder from the side
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A61M2205/505—Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

Definitions

  • This invention relates to automatic injector devices for injecting medications.
  • antigens are injected into experimental animals to provoke an immune response.
  • the antigen is injected via a syringe.
  • the antigen is solubilized in water and then emulsified in an oil phase as a water-in-oil (w/o) emulsion.
  • w/o water-in-oil
  • the antigen emulsion When properly prepared, the antigen emulsion is thick (viscous). Because of this, injection of the antigen emulsion into the animals can be difficult. Thus, the currently used syringes must be gripped and pushed with two fingers to administer the injection. Moreover, the amount of pushing force needed increases towards the end of the injection process.
  • the invention provides an injection device that can perform automatic injections with controlled volumes of injection.
  • the invention is a syringe injection device comprising an upper module and a lower module that are locked together.
  • On the upper module there is a syringe groove for receiving a syringe comprising an injection plunger.
  • Above the syringe groove there is a syringe pressing plate that has an open configuration to allow loading of the syringe into the syringe groove, and a closed configuration to hold down the syringe.
  • Proximal to the syringe groove there is a push block for urging against the injection plunger of the syringe.
  • Beneath the push block there is a screw nut that is attached to the push block.
  • An electric motor is connected to the screw drive for spinning the screw drive.
  • There is a control panel comprising a display screen and one or more injection volume controls.
  • a circuit board controls the electric motor according to the injection volume control settings made on the control panel.
  • the syringe injection device further comprises an up button and a down button on the control panel. In some embodiments, the syringe injection device further comprises a reset button on the control panel that resets the position of push block. In some embodiments, the syringe pressing plate is configured to twist to an open position away from the syringe groove and to a closed position over the syringe groove. In some embodiments, the screw nut moves back-and-forth along the screw drive, causing the push block to move back- and-forth.
  • the invention is a method for injecting an animal using an injection device of the present invention.
  • the animal is injected with a needle syringe containing an emulsion liquid comprising an antigen for eliciting an immune reaction in the animal.
  • the emulsion liquid may be relatively viscous.
  • the emulsion liquid has a viscosity of at least 5 mPa-s, or at least 10 mPa-s.
  • the syringe is loaded into the syringe groove distal to the push block.
  • the syringe is locked into the syringe groove by closing the syringe pressing plate onto the syringe.
  • the desired injection volume is set.
  • the animal is penetrated with the needle of the syringe.
  • the animal is injected by triggering the syringe activation.
  • the syringe pressing plate prior to loading the syringe into the syringe groove, the syringe pressing plate is turned to an open position away from the syringe groove.
  • the syringe pressing plate is turned to a closed position over the syringe.
  • FIG. 1 shows a perspective view of the injection device.
  • FIG. 2 shows a bottom view of the injection device.
  • FIG. 3 shows a side, internal view of the injection device.
  • FIG. 4 shows transverse, cross-section view of the injection device.
  • FIGS. 1-4 show one particular example of this invention.
  • FIG. 1 shows an injection device that has a compact design suitable for use by one hand. As seen here, the injection device has an upper module 101 and a lower module 102 that are locked together with screws. For designating orientation, the injection device has a proximal end designated by "P" and a distal end designated by "D.” The proximal/distal designation follows the direction of injection flow from the syringe to the subject animal.
  • the upper module 101 and the lower module 102 are combined together and locked together with screws.
  • a button switch 110 is fixed to the upper cover 101, and the back is locked by a nut. Button switch 110 it is located at the front and is very convenient to operate.
  • the upper module 101 has a syringe groove 130 for receiving a screw syringe 103, which is positioned in the groove 130 and is held down by a syringe pressing plate 104.
  • the syringe pressing plate 104 is attached to a guide post 107. One end of the guide post 107 is threaded and fixed on the upper module 101.
  • the guide post 107 has a cap 105, which is attached to the syringe pressing plate 104. As shown in FIG. 4, the syringe pressing plate 104 is in fixed attachment with the guide post 107. The guide post 107 guides the up-and-down movement of the syringe pressing plate 104.
  • a compression spring 106 that provides the pre-tension.
  • the syringe pressing plate 104 is turned away to allow access to the syringe groove 130.
  • a syringe 103 containing the antigen emulsion liquid is loaded into the syringe groove 130.
  • the syringe pressing plate 104 is then turned 90° to position over the syringe 103 and press down on the syringe 103. Downward compression force is provided by compression spring 106.
  • FIG. 3 shows the mechanical operation of the injection device.
  • a drive screw 121 is located in the upper module 101, and each end is fixed by bearings 120, bearing pressure plates 119, and nuts 118.
  • the two bearings 120 prevent radial movement of the drive screw 121.
  • the bearing pressure plate 119 is located between the bearings 120 and nuts 118.
  • the pressure plate 119 and the nut 118 are fixed.
  • the screw nut 122 is fixed on the push block 109 with screws.
  • the preload force is transmitted between nuts 118.
  • the nut 118 at both ends provides the axial preload force to prevent the axial movement of the drive screw 121.
  • the coupling 117 works to couple the drive screw 121 with the electric motor 108.
  • the final speed and torque provided by the electric motor 108 are transmitted to the drive screw 121 through the coupling 117.
  • the drive screw 121 is engaged with a push block 109 through the screw nut 122. Rotation of the drive screw 121 through screw nut 122 causes the push block 109 to move forward. With this forward movement, push block 109 pushes against the injection plunger of the syringe 103.
  • Forward displacement of the push block 109 can be precisely and quantitatively controlled by controlling the rotation of the electric motor 108.
  • a screw guide groove 124 is fixed to the upper module 101 and is located on the other side of the drive screw 121 in parallel.
  • the limit switches 123 control the stroke of the screw nut 122. When the screw nut 122 touches either limit switch 123, it prevents the screw nut 122 from exceeding the stroke range.
  • the function of limit switches 123 is to prevent spinning of screw nut 122 while drive screw 121 spins. As such, screw nut 122 moves only back-and-forth without spinning. In other words, drive screw 121 spins and causes screw nut 122 to move back-and-forth in linear motion.
  • the screw guide groove 124 keeps all these components in alignment.
  • FIGS. S and 4 there is a screw baffle 125 located in the slot of the upper module 101.
  • the screw baffle 125 can move forward-and-backward following the motion of push block 109.
  • the screw baffle 125 works to expose less of the inner workings of the injection device, which reduces dust penetration and improves overall appearance.
  • the button switch 110 on the upper cover 101 is for activating the injector device.
  • the display 111 is on the lower module 102, as fixed by the display pressure plate 112 located in the lower module 102.
  • the membrane switch panel 113 is located at the proximal end of the lower module 102. The back is glued to the outer wall of the lower module 102.
  • a lithium battery 114 is located in the lower module 102 and is adhered to the inner wall by an adhesive.
  • the battery charging connector 115 is located at the seam of the upper module 101 and the lower module 102.
  • the lower module 102 is clamped closed.
  • the control circuit board 116 is located in the lower module 102 and is locked by screws.
  • the board 116 is located in the slot of the upper module 101.
  • the display 111 is fixed to the lower module 102, and a membrane switch panel 113 is attached to the outside.
  • the membrane switch panel 113 is provided with an up button and a down button, which are used to increase and decrease the single-actuation injection volume, respectively.
  • any use of the word “or” herein is intended to be inclusive and is equivalent to the expression “and/or,” unless the context clearly dictates otherwise.
  • the expression “A or B” means A, or B, or both A and B.
  • the expression “A, B, or C” means A, or B, or C, or any combination thereof.

Abstract

An syringe injection device for performing automated injections of antigen emulsions into animals to provoke an immune response. The injection device comprises an upper module and a lower module that are locked together. On the upper module, there is a syringe groove for receiving a syringe. The syringe injection device works by electric motor actuation, which spins a screw drive. The internal mechanism causes a push block to urge against the injection plunger of the syringe. This expels the antigen emulsion out of the syringe for injection into the animal.

Description

Automated Injection Device for Administering Antigens to Animals
Technical Field
This invention relates to automatic injector devices for injecting medications.
Background
In comparative immunology experiments, antigens are injected into experimental animals to provoke an immune response. The antigen is injected via a syringe. Typically, the antigen is solubilized in water and then emulsified in an oil phase as a water-in-oil (w/o) emulsion. The reason for this is to enhance the immune response to the antigen.
When properly prepared, the antigen emulsion is thick (viscous). Because of this, injection of the antigen emulsion into the animals can be difficult. Thus, the currently used syringes must be gripped and pushed with two fingers to administer the injection. Moreover, the amount of pushing force needed increases towards the end of the injection process.
Commonly, the same medication-loaded syringe is used to make injections in multiple animals. In this situation, the operator needs to closely observe the amount injected to ensure that a consistent amount is administered across the multiple injections. Overall, this process is time-consuming and labor-intensive. Thus, there is a need for an automated quantitative injection instrument for animal immunization experiments.
Summary
This invention provides an injection device that can perform automatic injections with controlled volumes of injection. In one aspect, the invention is a syringe injection device comprising an upper module and a lower module that are locked together. On the upper module, there is a syringe groove for receiving a syringe comprising an injection plunger. Above the syringe groove, there is a syringe pressing plate that has an open configuration to allow loading of the syringe into the syringe groove, and a closed configuration to hold down the syringe. Proximal to the syringe groove, there is a push block for urging against the injection plunger of the syringe. Beneath the push block, there is a screw nut that is attached to the push block. There is further a screw drive that is engaged with the screw nut. An electric motor is connected to the screw drive for spinning the screw drive. There is a control panel comprising a display screen and one or more injection volume controls. A circuit board controls the electric motor according to the injection volume control settings made on the control panel.
In some embodiments, the syringe injection device further comprises an up button and a down button on the control panel. In some embodiments, the syringe injection device further comprises a reset button on the control panel that resets the position of push block. In some embodiments, the syringe pressing plate is configured to twist to an open position away from the syringe groove and to a closed position over the syringe groove. In some embodiments, the screw nut moves back-and-forth along the screw drive, causing the push block to move back- and-forth.
In another aspect, the invention is a method for injecting an animal using an injection device of the present invention. The animal is injected with a needle syringe containing an emulsion liquid comprising an antigen for eliciting an immune reaction in the animal. The emulsion liquid may be relatively viscous. In some embodiments, the emulsion liquid has a viscosity of at least 5 mPa-s, or at least 10 mPa-s.
The syringe is loaded into the syringe groove distal to the push block. The syringe is locked into the syringe groove by closing the syringe pressing plate onto the syringe. The desired injection volume is set. The animal is penetrated with the needle of the syringe. The animal is injected by triggering the syringe activation. In some embodiments, prior to loading the syringe into the syringe groove, the syringe pressing plate is turned to an open position away from the syringe groove. In some embodiments, after loading the syringe into the syringe groove, the syringe pressing plate is turned to a closed position over the syringe.
Brief Description of the Drawings
FIG. 1 shows a perspective view of the injection device.
FIG. 2 shows a bottom view of the injection device. FIG. 3 shows a side, internal view of the injection device.
FIG. 4 shows transverse, cross-section view of the injection device.
Description of an Example Embodiment
To assist in understanding the invention, reference is made to the accompanying drawings to show by way of illustration specific embodiments in which the invention may be practiced. The drawings herein are not necessarily made to scale or actual proportions. For example, lengths and widths of the components may be adjusted to accommodate the page size.
FIGS. 1-4 show one particular example of this invention. FIG. 1 shows an injection device that has a compact design suitable for use by one hand. As seen here, the injection device has an upper module 101 and a lower module 102 that are locked together with screws. For designating orientation, the injection device has a proximal end designated by "P" and a distal end designated by "D." The proximal/distal designation follows the direction of injection flow from the syringe to the subject animal.
The upper module 101 and the lower module 102 are combined together and locked together with screws. A button switch 110 is fixed to the upper cover 101, and the back is locked by a nut. Button switch 110 it is located at the front and is very convenient to operate. The upper module 101 has a syringe groove 130 for receiving a screw syringe 103, which is positioned in the groove 130 and is held down by a syringe pressing plate 104. The syringe pressing plate 104 is attached to a guide post 107. One end of the guide post 107 is threaded and fixed on the upper module 101.
The guide post 107 has a cap 105, which is attached to the syringe pressing plate 104. As shown in FIG. 4, the syringe pressing plate 104 is in fixed attachment with the guide post 107. The guide post 107 guides the up-and-down movement of the syringe pressing plate 104.
Within guide post 107, there is a compression spring 106 that provides the pre-tension. With the injection device empty, the syringe pressing plate 104 is turned away to allow access to the syringe groove 130. A syringe 103 containing the antigen emulsion liquid is loaded into the syringe groove 130. The syringe pressing plate 104 is then turned 90° to position over the syringe 103 and press down on the syringe 103. Downward compression force is provided by compression spring 106.
FIG. 3 shows the mechanical operation of the injection device. A drive screw 121 is located in the upper module 101, and each end is fixed by bearings 120, bearing pressure plates 119, and nuts 118. The two bearings 120 prevent radial movement of the drive screw 121. The bearing pressure plate 119 is located between the bearings 120 and nuts 118. The pressure plate 119 and the nut 118 are fixed. The screw nut 122 is fixed on the push block 109 with screws. The preload force is transmitted between nuts 118. The nut 118 at both ends provides the axial preload force to prevent the axial movement of the drive screw 121.
There is an electric motor 108 fixed in the upper module 101. The coupling 117 works to couple the drive screw 121 with the electric motor 108. The final speed and torque provided by the electric motor 108 are transmitted to the drive screw 121 through the coupling 117. The drive screw 121 is engaged with a push block 109 through the screw nut 122. Rotation of the drive screw 121 through screw nut 122 causes the push block 109 to move forward. With this forward movement, push block 109 pushes against the injection plunger of the syringe 103.
This advances the injection plunger of the syringe 103 forward within the syringe 103, causing the emulsion liquid to travel through the syringe needle and be expelled out. Forward displacement of the push block 109 can be precisely and quantitatively controlled by controlling the rotation of the electric motor 108.
As shown in FIG. 2, a screw guide groove 124 is fixed to the upper module 101 and is located on the other side of the drive screw 121 in parallel. There are two limit switches 123 that are fixed on the upper module 101 on each side of the drive screw 121. The limit switches 123 control the stroke of the screw nut 122. When the screw nut 122 touches either limit switch 123, it prevents the screw nut 122 from exceeding the stroke range. The function of limit switches 123 is to prevent spinning of screw nut 122 while drive screw 121 spins. As such, screw nut 122 moves only back-and-forth without spinning. In other words, drive screw 121 spins and causes screw nut 122 to move back-and-forth in linear motion. The screw guide groove 124 keeps all these components in alignment. As shown in FIGS. S and 4, there is a screw baffle 125 located in the slot of the upper module 101. The screw baffle 125 can move forward-and-backward following the motion of push block 109. The screw baffle 125 works to expose less of the inner workings of the injection device, which reduces dust penetration and improves overall appearance.
The button switch 110 on the upper cover 101 is for activating the injector device. The display 111 is on the lower module 102, as fixed by the display pressure plate 112 located in the lower module 102. The membrane switch panel 113 is located at the proximal end of the lower module 102. The back is glued to the outer wall of the lower module 102.
A lithium battery 114 is located in the lower module 102 and is adhered to the inner wall by an adhesive. The battery charging connector 115 is located at the seam of the upper module 101 and the lower module 102. The lower module 102 is clamped closed. The control circuit board 116 is located in the lower module 102 and is locked by screws. The board 116 is located in the slot of the upper module 101.
The display 111 is fixed to the lower module 102, and a membrane switch panel 113 is attached to the outside. The membrane switch panel 113 is provided with an up button and a down button, which are used to increase and decrease the single-actuation injection volume, respectively. There is also an "INIT" button, which works to reset the position of push block 109.
The descriptions and examples given herein are intended merely to illustrate the invention and are not intended to be limiting. Each of the disclosed aspects and embodiments of the invention may be considered individually or in combination with other aspects, embodiments, and variations of the invention. In addition, unless otherwise specified, the steps of the methods of the invention are not confined to any particular order of performance. Modifications of the disclosed embodiments incorporating the spirit and substance of the invention may occur to persons skilled in the art, and such modifications are within the scope of the invention.
Any use of the word "or" herein is intended to be inclusive and is equivalent to the expression "and/or," unless the context clearly dictates otherwise. As such, for example, the expression "A or B" means A, or B, or both A and B. Similarly, for example, the expression "A, B, or C" means A, or B, or C, or any combination thereof.

Claims

1. A syringe injection device comprising: an upper module (101) and a lower module (102) that are locked together; on the upper module (101), a syringe groove (130) for receiving a syringe (103) comprising an injection plunger; above the syringe groove (130), a syringe pressing plate (104) that has an open configuration to allow loading of the syringe (103) into the syringe groove (130), and a closed configuration to hold down the syringe (103); proximal to the syringe groove, a push block (109) for urging against the injection plunger of the syringe (103); beneath the push block (109), a screw nut (122) that is attached to the push block (109); a screw drive (121) that is engaged with the screw nut (122); an electric motor connected to the screw drive (121) for spinning the screw drive (121); a control panel comprising a display screen and one or more injection volume controls; a circuit board for controlling the electric motor according to the injection volume control settings made on the control panel.
2. The injection device of claim 1, further comprising an up button and a down button on the control panel.
3. The injection device of claim 1, further comprising a reset button on the control panel that resets the position of push block 109.
4. The injection device of claim 1, wherein the syringe pressing plate (104) is configured to twist to an open position away from the syringe groove (130) and to a closed position over the syringe groove (130).
5. The injection device of claim 1, wherein the screw nut (122) moves back-and-forth along the screw drive (121), causing the push block 109 to move back-and-forth.
6. A method for injecting an animal, comprising: having a syringe (103) containing an emulsion liquid comprising an antigen for eliciting an immune reaction in the animal, wherein the syringe (103) has a needle. having a syringe injection device of claim 1: loading the syringe (103) into the syringe groove (130) distal to the push block (109); closing the syringe pressing plate (104) to lock the syringe (103) in the syringe groove
(130); setting the injection volume; injecting the animal with the preset volume of emulsion liquid containing the antigen.
7. The method of claim 6, further comprising: prior to loading the syringe (103) into the syringe groove (130), turning the syringe pressing plate (104) to an open position away from the syringe groove (130); after loading the syringe (103) into the syringe groove (130), turning the syringe pressing plate (104) to an closed position over the syringe (103).
PCT/US2020/037125 2020-06-11 2020-06-11 Automated injection device for administering antigens to animals WO2021251965A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2020/037125 WO2021251965A1 (en) 2020-06-11 2020-06-11 Automated injection device for administering antigens to animals

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Application Number Priority Date Filing Date Title
PCT/US2020/037125 WO2021251965A1 (en) 2020-06-11 2020-06-11 Automated injection device for administering antigens to animals

Publications (1)

Publication Number Publication Date
WO2021251965A1 true WO2021251965A1 (en) 2021-12-16

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040054328A1 (en) * 2000-12-22 2004-03-18 Langley Christopher Nigel Pen-type injector having an electronic control unit
US20110224613A1 (en) * 2004-06-09 2011-09-15 D Antonio Nicholas F Hypodermic injection system
US20120056019A1 (en) * 2009-03-03 2012-03-08 Dieter Hölze Technik-Projekte Gmbh Injection device having injection volume adjustment
US9737253B2 (en) * 2007-08-29 2017-08-22 Brighter Ab Portable medical apparatus including sampling, determining and injecting components
US20180117265A1 (en) * 2012-05-04 2018-05-03 Sofia Eleni Armes Electromechanical manipulating device for medical needle and syringe with sensory biofeedback and pain suppression capability
US20190038837A1 (en) * 2012-07-05 2019-02-07 Unl Holdings Llc Drive Control Mechanisms And Automatic Injectors For Injectable Cartridges

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040054328A1 (en) * 2000-12-22 2004-03-18 Langley Christopher Nigel Pen-type injector having an electronic control unit
US20110224613A1 (en) * 2004-06-09 2011-09-15 D Antonio Nicholas F Hypodermic injection system
US9737253B2 (en) * 2007-08-29 2017-08-22 Brighter Ab Portable medical apparatus including sampling, determining and injecting components
US20120056019A1 (en) * 2009-03-03 2012-03-08 Dieter Hölze Technik-Projekte Gmbh Injection device having injection volume adjustment
US20180117265A1 (en) * 2012-05-04 2018-05-03 Sofia Eleni Armes Electromechanical manipulating device for medical needle and syringe with sensory biofeedback and pain suppression capability
US20190038837A1 (en) * 2012-07-05 2019-02-07 Unl Holdings Llc Drive Control Mechanisms And Automatic Injectors For Injectable Cartridges

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Title
KD SCIENTIFIC INC, MODEL 100 SERIES USER'S MANUAL, 30 July 2014 (2014-07-30), XP055887464, Retrieved from the Internet <URL:https://www.kdscientific.com/media/manuals/KDS%20Model%20100%20Series_5600-001REVG.pdf> [retrieved on 20200813] *

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