JP2004505046A5 - - Google Patents
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- JP2004505046A5 JP2004505046A5 JP2002515252A JP2002515252A JP2004505046A5 JP 2004505046 A5 JP2004505046 A5 JP 2004505046A5 JP 2002515252 A JP2002515252 A JP 2002515252A JP 2002515252 A JP2002515252 A JP 2002515252A JP 2004505046 A5 JP2004505046 A5 JP 2004505046A5
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- Prior art keywords
- pharmaceutical composition
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- hydroxyethyl
- disease
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 description 28
- 239000011701 zinc Substances 0.000 description 17
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 15
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 9
- 206010039083 rhinitis Diseases 0.000 description 6
- 210000002345 respiratory system Anatomy 0.000 description 5
- 229960003232 troxerutin Drugs 0.000 description 5
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 4
- 208000035143 Bacterial infection Diseases 0.000 description 4
- 201000007100 Pharyngitis Diseases 0.000 description 4
- 208000036142 Viral infection Diseases 0.000 description 4
- 208000022362 bacterial infectious disease Diseases 0.000 description 4
- 229930003935 flavonoid Natural products 0.000 description 4
- 150000002215 flavonoids Chemical class 0.000 description 4
- 235000017173 flavonoids Nutrition 0.000 description 4
- 206010041232 sneezing Diseases 0.000 description 4
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229940050410 gluconate Drugs 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000711573 Coronaviridae Species 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 241000709661 Enterovirus Species 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000000112 Myalgia Diseases 0.000 description 2
- 206010028748 Nasal obstruction Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 241000725643 Respiratory syncytial virus Species 0.000 description 2
- 206010039101 Rhinorrhoea Diseases 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 208000013465 muscle pain Diseases 0.000 description 2
- 208000010753 nasal discharge Diseases 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 description 1
- 241000712891 Arenavirus Species 0.000 description 1
- 0 COC1=C(c(cc2)cc(OCCO)c2OCC*)Oc2cc(OCC*)cc(*)c2C1=O Chemical compound COC1=C(c(cc2)cc(OCCO)c2OCC*)Oc2cc(OCC*)cc(*)c2C1=O 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 241001466953 Echovirus Species 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- 229940123424 Neuraminidase inhibitor Drugs 0.000 description 1
- 241000709664 Picornaviridae Species 0.000 description 1
- 241000125945 Protoparvovirus Species 0.000 description 1
- 241000702263 Reovirus sp. Species 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 229940068682 chewable tablet Drugs 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- PGZUMBJQJWIWGJ-ONAKXNSWSA-N oseltamivir phosphate Chemical compound OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 PGZUMBJQJWIWGJ-ONAKXNSWSA-N 0.000 description 1
- KQOXLKOJHVFTRN-UHFFFAOYSA-N pleconaril Chemical compound O1N=C(C)C=C1CCCOC1=C(C)C=C(C=2N=C(ON=2)C(F)(F)F)C=C1C KQOXLKOJHVFTRN-UHFFFAOYSA-N 0.000 description 1
- 229960000471 pleconaril Drugs 0.000 description 1
- 229950004693 polaprezinc Drugs 0.000 description 1
- 108700035912 polaprezinc Proteins 0.000 description 1
- 229960000888 rimantadine Drugs 0.000 description 1
- 239000002911 sialidase inhibitor Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229940061367 tamiflu Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- IUWLTSZHVYHOHY-FJXQXJEOSA-L zinc;(2s)-2-(3-azanidylpropanoylazanidyl)-3-(1h-imidazol-5-yl)propanoate Chemical group [Zn+2].[NH-]CCC(=O)[N-][C@H](C([O-])=O)CC1=CN=CN1 IUWLTSZHVYHOHY-FJXQXJEOSA-L 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001152 | 2000-07-28 | ||
| DKPA200001316 | 2000-09-04 | ||
| DKPA200001935 | 2000-12-23 | ||
| DKPA200100007 | 2001-01-03 | ||
| DKPA200100827 | 2001-05-22 | ||
| PCT/DK2001/000515 WO2002009699A2 (en) | 2000-07-28 | 2001-07-23 | Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004505046A JP2004505046A (ja) | 2004-02-19 |
| JP2004505046A5 true JP2004505046A5 (enExample) | 2008-09-04 |
Family
ID=27512989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002515252A Withdrawn JP2004505046A (ja) | 2000-07-28 | 2001-07-23 | 感冒、アレルギー性鼻炎および気道に関連した感染症の症状の処置方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7166640B2 (enExample) |
| EP (1) | EP1307189B1 (enExample) |
| JP (1) | JP2004505046A (enExample) |
| KR (1) | KR100824075B1 (enExample) |
| CN (1) | CN100411617C (enExample) |
| AT (1) | ATE325612T1 (enExample) |
| AU (2) | AU7958701A (enExample) |
| BR (1) | BR0112818A (enExample) |
| CA (1) | CA2416899C (enExample) |
| DE (1) | DE60119534T2 (enExample) |
| DK (1) | DK1307189T3 (enExample) |
| EA (1) | EA008612B1 (enExample) |
| ES (1) | ES2263643T3 (enExample) |
| IL (2) | IL154144A0 (enExample) |
| MX (1) | MXPA03000848A (enExample) |
| NO (1) | NO20030337L (enExample) |
| NZ (1) | NZ524121A (enExample) |
| PL (1) | PL203216B1 (enExample) |
| WO (1) | WO2002009699A2 (enExample) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10122714A1 (de) * | 2001-05-10 | 2002-11-21 | Brench Ag | Verwendung von Rutinen und Aescinen zur Behandlung okulärer Durchblutungsstörungen |
| US7972632B2 (en) | 2003-02-28 | 2011-07-05 | Unigen Pharmaceuticals, Inc. | Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors |
| US7108868B2 (en) | 2002-03-22 | 2006-09-19 | Unigen Pharmaceuticals, Inc. | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia |
| US8945518B2 (en) | 2002-04-30 | 2015-02-03 | Unigen, Inc. | Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions |
| US8034387B2 (en) | 2002-04-30 | 2011-10-11 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| CA2703698C (en) | 2002-04-30 | 2016-11-22 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent |
| FR2845597B1 (fr) * | 2002-10-11 | 2005-03-11 | Innothera Lab Sa | Formulation orale seche contenant de la diosmine sous forme pharmaceutique de comprime a croquer |
| EP1556021B1 (en) | 2002-10-24 | 2007-12-19 | Immupharm A/S | Pharmaceutical compositions comprising flavonoids and menthol |
| DE602004022635D1 (de) * | 2003-01-21 | 2009-10-01 | Wei-Wei Su | Verwendung von naringenin, naringin und salzen daraus als schleimlöser bei der behandlung von husten sowie zusammensetzungen daraus |
| WO2004089392A1 (en) | 2003-04-04 | 2004-10-21 | Unigen Pharmaceuticals, Inc. | Formulation of dual cycloxygenase (cox) and lipoxygenase (lox) inhibitors for mammal skin care |
| ES2542985T3 (es) | 2003-07-22 | 2015-08-13 | Kyowa Hakko Bio Co., Ltd | Composición preventiva o terapéutica para una enfermedad infecciosa vírica |
| DE10361444A1 (de) * | 2003-12-23 | 2005-07-21 | Axaron Bioscience Ag | Verfahren zur in vitro Differenzierung neuronaler Stammzellen oder von neuronalen Stammzellen abgeleiteter Zellen |
| JP4571952B2 (ja) | 2004-02-05 | 2010-10-27 | アクセス ビジネス グループ インターナショナル リミテッド ライアビリティ カンパニー | 抗アレルギー組成物及び関連方法 |
| KR101531116B1 (ko) | 2004-04-28 | 2015-06-23 | 누트리션 사이언스 파트너스 리미티드 | 천심련으로부터의 조추출물 |
| US20060030550A1 (en) * | 2004-08-04 | 2006-02-09 | Lithgow Theodore L | Pharmaceutical formulations |
| TW200630102A (en) * | 2004-10-19 | 2006-09-01 | Unigen Pharmaceuticals Inc | Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions |
| EP1843782A1 (en) * | 2005-02-04 | 2007-10-17 | ViraNative AB | Method and use of interferon compositions for the treatment of avian influenza |
| CA2601028C (en) * | 2005-03-11 | 2014-05-27 | Howard Florey Institute Of Experimental Physiology And Medecine | Flavonoid compounds and uses thereof |
| US7910620B2 (en) * | 2005-04-22 | 2011-03-22 | Broadhurst Iii Jack J | Uses of neuraminidase inhibitors in infectious diseases |
| DK1976532T3 (en) * | 2006-01-27 | 2016-02-01 | Univ Yale | FAST-ACTING INHIBITOR of gastric acid secretion |
| US20070202164A1 (en) * | 2006-02-28 | 2007-08-30 | Hutchison Medipharma Enterprises Limited | Andrographis Extract Formulations |
| JP2009531342A (ja) * | 2006-03-24 | 2009-09-03 | ゲオルギオス パンダリス | かぜの予防および治療用組成物 |
| JPWO2007125731A1 (ja) * | 2006-04-28 | 2009-09-10 | 株式会社メニコン | ソフトコンタクトレンズ用溶液及びそれを用いて得られる薬剤徐放性ソフトコンタクトレンズ並びにその製造方法 |
| KR100792626B1 (ko) * | 2006-05-30 | 2008-01-09 | 프로테온 주식회사 | 카테킨 유도체 화합물을 유효성분으로 하는 독감 바이러스감염성 질환 예방 및 치료제 |
| KR100770746B1 (ko) * | 2006-06-15 | 2007-10-30 | 제주대학교 산학협력단 | 항염활성을 갖는 감귤 유래 노빌레틴과 그 분리.정제방법 |
| US8846757B2 (en) | 2006-07-31 | 2014-09-30 | The Trustees Of Columbia University In The City Of New York | Bioactive depside and anthocyanin compounds, compositions, and methods of use |
| RU2315593C1 (ru) * | 2006-08-02 | 2008-01-27 | Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" | Липосомальная композиция антиоксидантов для ингаляций при заболеваниях легких и верхних дыхательных путей |
| US8465782B2 (en) * | 2006-09-21 | 2013-06-18 | Immune Guard, LLC | Methods and materials for reducing risk of cold and/or flu |
| CA2669138A1 (en) * | 2006-11-09 | 2008-12-04 | University Of Maryland, Baltimore | Use of 5,6-dimethylxanthenone-4-acetic acid as an antimicrobial agent |
| EA015930B1 (ru) | 2006-12-05 | 2011-12-30 | Мариномед Биотехнологи Гмбх | Применение йота-каррагинана для лечения риновирусной инфекции и фармацевтическая композиция для лечения риновирусной инфекции, содержащая йота-каррагинан |
| WO2008106979A2 (en) * | 2007-03-02 | 2008-09-12 | Immupharm A/S | Pharmaceutical compositions comprising flavonoids and xylitol |
| KR100853442B1 (ko) * | 2007-08-21 | 2008-08-21 | 프로테온 주식회사 | 카테킨 유도체 화합물을 유효성분으로 하는 독감 바이러스감염성 질환 예방용 건강식품 |
| US20090117209A1 (en) * | 2007-11-02 | 2009-05-07 | Hutchison Medipharma Enterprises Limited | Andrographis paniculata extract |
| KR100999872B1 (ko) * | 2008-06-12 | 2010-12-09 | 한국생명공학연구원 | 홍경천 추출물, 홍경천 분획물, 이로부터 분리한플라보노이드계 화합물, 이의 유도체 화합물 또는 이의약학적으로 허용 가능한 염을 유효성분으로 함유하는바이러스 질환의 예방 및 치료용 약학적 조성물 |
| WO2009151173A1 (en) * | 2008-06-12 | 2009-12-17 | Korea Research Institute Of Bioscience And Biotechnology | Pharmaceutical compositions for prevention and treatment of viral diseases containing rhodiola extracts, fractions, the isolated flavonoid compounds therefrom, derivatives compounds thereof or the pharmaceutically acceptable salts as an active ingredient |
| US20100009012A1 (en) * | 2008-07-11 | 2010-01-14 | Zukkoor N David | Chewable pharyngeal inflammation symptom relief composition |
| US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US20150005325A1 (en) * | 2009-06-16 | 2015-01-01 | Biocopea Limited | Drug Combinations and Uses in Treating a Coughing Condition |
| JP5617097B2 (ja) * | 2010-05-13 | 2014-11-05 | 敏彦 四宮 | 亜鉛錯体とプロスタグランジン等からなる外用剤 |
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| AT510585B1 (de) * | 2010-11-18 | 2012-05-15 | Apeptico Forschung & Entwicklung Gmbh | Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase |
| CN102048726A (zh) * | 2011-01-10 | 2011-05-11 | 华东理工大学 | 川陈皮素的应用 |
| EP2694046A1 (en) * | 2011-04-08 | 2014-02-12 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods and pharmaceutical compositions for inhibiting influenza viruses replication |
| CN102343083A (zh) * | 2011-10-17 | 2012-02-08 | 中国科学院成都生物研究所 | 一种抗病毒的组合药物 |
| US20210260144A1 (en) * | 2012-01-27 | 2021-08-26 | The Trustees Of The University Of Pennsylvania | Quinine and its use to generate innate immune response |
| CN104684923B (zh) | 2012-07-13 | 2018-09-28 | 株式会社新日本科学 | 手性核酸佐剂 |
| JP2016512262A (ja) | 2013-03-13 | 2016-04-25 | インフラマトリー・レスポンス・リサーチ・インコーポレイテッド | 血管炎の処置におけるレボセチリジン及びモンテルカストの使用 |
| KR20150135339A (ko) | 2013-03-13 | 2015-12-02 | 인플래머토리 리스폰스 리서치, 아이엔씨. | 레보세티리진 및 몬테루카스트의 외상성 손상의 치료 용도 |
| ES2745041T3 (es) | 2013-03-13 | 2020-02-27 | Inflammatory Response Res Inc | Uso de levocetirizina y montelukast en el tratamiento de trastornos autoinmunitarios |
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法 |
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| EP3037132B1 (en) * | 2014-12-23 | 2018-10-31 | Farma-Derma S.R.L. | Zinc salt and polyphenol composition |
| DE102015115876A1 (de) * | 2015-09-21 | 2017-03-23 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Substanz zur Prophylaxe und Behandlung von Infektionen durch Influenzaviren |
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| WO2018081059A1 (en) * | 2016-10-24 | 2018-05-03 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| CN106667996B (zh) * | 2017-02-27 | 2019-04-09 | 吉林大学 | 桑色素在制备抗猪链球菌病药物中的应用 |
| CN106667997A (zh) * | 2017-02-27 | 2017-05-17 | 吉林大学 | 表没食子儿茶素没食子酸酯抑制肺炎链球菌致病力及应用 |
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| CN108704074A (zh) * | 2018-06-27 | 2018-10-26 | 陶燃 | 一种治疗慢性鼻炎的药物组合物及其应用 |
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2001
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- 2001-07-23 JP JP2002515252A patent/JP2004505046A/ja not_active Withdrawn
- 2001-07-23 EA EA200300190A patent/EA008612B1/ru not_active IP Right Cessation
- 2001-07-23 IL IL15414401A patent/IL154144A0/xx active IP Right Grant
- 2001-07-23 EP EP01957764A patent/EP1307189B1/en not_active Expired - Lifetime
- 2001-07-23 DE DE60119534T patent/DE60119534T2/de not_active Expired - Fee Related
- 2001-07-23 MX MXPA03000848A patent/MXPA03000848A/es active IP Right Grant
- 2001-07-23 CN CNB018165729A patent/CN100411617C/zh not_active Expired - Fee Related
- 2001-07-23 DK DK01957764T patent/DK1307189T3/da active
- 2001-07-23 AU AU7958701A patent/AU7958701A/xx active Pending
- 2001-07-23 US US10/363,430 patent/US7166640B2/en not_active Expired - Fee Related
- 2001-07-23 WO PCT/DK2001/000515 patent/WO2002009699A2/en not_active Ceased
- 2001-07-23 CA CA2416899A patent/CA2416899C/en not_active Expired - Fee Related
- 2001-07-23 KR KR1020037001218A patent/KR100824075B1/ko not_active Expired - Fee Related
- 2001-07-23 PL PL360140A patent/PL203216B1/pl not_active IP Right Cessation
- 2001-07-23 AT AT01957764T patent/ATE325612T1/de active
- 2001-07-23 AU AU2001279587A patent/AU2001279587B2/en not_active Ceased
- 2001-07-23 NZ NZ524121A patent/NZ524121A/en unknown
- 2001-07-23 ES ES01957764T patent/ES2263643T3/es not_active Expired - Lifetime
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2003
- 2003-01-22 NO NO20030337A patent/NO20030337L/no not_active Application Discontinuation
- 2003-01-27 IL IL154144A patent/IL154144A/en not_active IP Right Cessation
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2005
- 2005-07-05 US US11/172,878 patent/US8003688B2/en not_active Expired - Fee Related
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