JP2004504295A - 安定化１α−ヒドロキシビタミンＤ - Google Patents

安定化１α−ヒドロキシビタミンＤ Download PDF

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JP2004504295A
JP2004504295A JP2002512124A JP2002512124A JP2004504295A JP 2004504295 A JP2004504295 A JP 2004504295A JP 2002512124 A JP2002512124 A JP 2002512124A JP 2002512124 A JP2002512124 A JP 2002512124A JP 2004504295 A JP2004504295 A JP 2004504295A
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shvd
hydroxyvitamin
stabilized
composition
vitamin
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JP2004504295A5 (cg-RX-API-DMAC10.html
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ナットソン　ジョイス　シー
マゼス　リチャード　ビー
ビショップ　チャールズ　ダブリュー
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ボーン　ケア　インターナショナル　インコーポレイテッド
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Publication of JP2004504295A5 publication Critical patent/JP2004504295A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2002512124A 2000-07-18 2001-07-18 安定化１α−ヒドロキシビタミンＤ Pending JP2004504295A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21906800P 2000-07-18 2000-07-18
PCT/US2001/022729 WO2002006218A2 (en) 2000-07-18 2001-07-18 STABILIZED 1α-HYDROXY VITAMIN D

Publications (2)

Publication Number Publication Date
JP2004504295A true JP2004504295A (ja) 2004-02-12
JP2004504295A5 JP2004504295A5 (cg-RX-API-DMAC10.html) 2008-09-04

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ID=22817719

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JP2002512124A Pending JP2004504295A (ja) 2000-07-18 2001-07-18 安定化１α−ヒドロキシビタミンＤ

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US (2) US6903083B2 (cg-RX-API-DMAC10.html)
EP (2) EP1301479A2 (cg-RX-API-DMAC10.html)
JP (1) JP2004504295A (cg-RX-API-DMAC10.html)
AU (2) AU7895601A (cg-RX-API-DMAC10.html)
CA (1) CA2414407A1 (cg-RX-API-DMAC10.html)
IL (2) IL153378A0 (cg-RX-API-DMAC10.html)
WO (1) WO2002006218A2 (cg-RX-API-DMAC10.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005247803A (ja) * 2004-03-08 2005-09-15 Zeria Pharmaceut Co Ltd 点眼剤及びその容器
JP2014062131A (ja) * 2008-03-12 2014-04-10 Cytochroma Inc 安定化１，２５−ジヒドロキシビタミンｄ２及びその製造方法
JP2018172299A (ja) * 2017-03-31 2018-11-08 ナガセ医薬品株式会社 マキサカルシトール含有水溶液製剤

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
JP2004504295A (ja) * 2000-07-18 2004-02-12 ボーン　ケア　インターナショナル　インコーポレイテッド 安定化１α−ヒドロキシビタミンＤ
CN100391464C (zh) * 2001-12-03 2008-06-04 诺瓦西股份有限公司 含活性维生素d化合物的药物组合物
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20050101576A1 (en) * 2003-11-06 2005-05-12 Novacea, Inc. Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes
US7351869B2 (en) * 2002-11-18 2008-04-01 Teva Pharmaceutical Industries Ltd Crystallization method for purification of calcipotriene
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
DE602005020842D1 (de) * 2004-11-22 2010-06-02 Wisconsin Alumni Res Found 17,20(e)-dehydro-vitamin-d-analoga und deren verwendungen
US20070122477A1 (en) * 2005-10-12 2007-05-31 Cytochroma, Inc. Methods and articles for treating 25-hydroxyvitamin D insufficiency and deficiency
PT3095447T (pt) 2006-02-03 2022-01-24 Opko Renal Llc Tratamento da insuficiência e deficiência de vitamina d com 25-hidroxivitamina d2 e 25-hidroxivitamina d3
RU2412165C2 (ru) 2006-03-17 2011-02-20 Лео Фарма А/С Изомеризация фармацевтических интермедиатов
DK2037936T3 (da) 2006-06-21 2014-09-22 Opko Renal Llc Fremgangsmåde til behandling og forebyggelse af sekundær hyperparathyroidisme
JP5645408B2 (ja) * 2006-11-16 2014-12-24 カイ ファーマシューティカルズ インコーポレーティッド 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド
EP2148685A4 (en) * 2007-04-25 2010-07-28 Cytochroma Inc METHODS AND COMPOUNDS FOR THERAPY BASED ON VITAMIN D
KR101691876B1 (ko) 2007-04-25 2017-01-02 사이토크로마 인코포레이티드 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
CA2683628C (en) * 2007-04-25 2018-03-06 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
ES3047207T3 (en) * 2007-04-25 2025-12-03 Opko Renal Llc Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
JP2011508744A (ja) * 2007-12-28 2011-03-17 ウィスコンシン アラムナイ リサーチ ファンデーション （２０ｒ）−２３，２３−ジフルオロ−２−メチレン−１９−ノル−ビスホモプレグナカルシフェロール−ビタミンｄ類縁体
AU2008345082B2 (en) * 2007-12-28 2014-03-06 Wisconsin Alumni Research Foundation (20S)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs
ES2593356T3 (es) 2008-04-02 2016-12-07 Opko Ireland Global Holdings, Ltd. Métodos, composiciones, usos y kits útiles para la deficiencia de la vitamina D y trastornos relacionados
US8013176B2 (en) * 2008-09-11 2011-09-06 Alphora Research Inc. Paricalcitol purification
CN102264751A (zh) * 2008-11-26 2011-11-30 赛特克罗公司 合成维生素d类似物的方法
EP2459208B1 (en) 2009-07-29 2016-09-28 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels
US11672809B2 (en) 2010-03-29 2023-06-13 Eirgen Pharma Ltd. Methods and compositions for reducing parathyroid levels
CA2698160C (en) * 2010-03-30 2017-07-25 Alphora Research Inc. Stabilized doxercalciferol and process for manufacturing the same
US20120108554A1 (en) * 2010-10-28 2012-05-03 Formosa Laboratories, Inc. PROCESS FOR PREPARING HIGH PURITY 1alpha-HYDROXY VITAMIN D2
PT2717896T (pt) 2011-06-08 2016-12-23 Kai Pharmaceuticals Inc Agentes terapêuticos para a regulação do fósforo sérico
MX355063B (es) 2011-11-10 2018-04-04 Kai Pharmaceuticals Inc Calcimiméticos y métodos para su uso.
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
CN105348164B (zh) * 2015-10-29 2017-03-29 无锡福祈制药有限公司 一种1α‑羟基维生素D2的制备方法
KR20180123100A (ko) 2016-03-28 2018-11-14 옵코 아일랜드 글로벌 홀딩스 리미티드 비타민 d 치료 방법
CN106748942B (zh) * 2016-11-28 2018-06-29 无锡福祈制药有限公司 度骨化醇类似物wxfq-65及其合成方法
CN106748642B (zh) * 2016-11-28 2019-11-05 无锡福祈制药有限公司 一种度骨化醇类似物wxfq-65的合成方法
CN113666858A (zh) * 2021-08-20 2021-11-19 江苏四环生物制药有限公司 一种度骨化醇及其制备方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58126862A (ja) * 1981-11-02 1983-07-28 リサ−チ・インステイチユ−ト・フオア・メデイスン・アンド・ケミストリ−・インコ−ポレ−テツド １−ヒドロキシル化ビタミンｄ化合物の製法
JPS62298572A (ja) * 1986-06-19 1987-12-25 Chugai Pharmaceut Co Ltd １α−ヒドロキシビタミンＤ３の精製法
JPS63126862A (ja) * 1987-10-30 1988-05-30 Nisshin Flour Milling Co Ltd １α−ヒドロキシビタミンＤ↓２の製造方法
JPS63126891A (ja) * 1986-11-14 1988-05-30 Nisshin Flour Milling Co Ltd ステロイド誘導体およびその製造方法
JPH01246276A (ja) * 1988-03-25 1989-10-02 Teikoku Chem Ind Corp Ltd １α−ヒドロキシ―６―（１，３−ベンゾジチオール−２−イル）オキシー３，５−シクロビタミンＤ↓３
JPH02270860A (ja) * 1988-03-25 1990-11-05 Teikoku Chem Ind Corp Ltd １α―ヒドロキシ―ビタミンＤ↓３の製造方法
JPH05279260A (ja) * 1991-04-09 1993-10-26 Takeda Chem Ind Ltd 安定化されたビタミンｄ類製剤
JPH05320127A (ja) * 1992-03-27 1993-12-03 Nisshin Flour Milling Co Ltd 活性型ビタミンｄ誘導体
JPH05339230A (ja) * 1992-03-12 1993-12-21 Nisshin Flour Milling Co Ltd 活性型ビタミンｄ２及びその誘導体の製造法
JPH06256301A (ja) * 1992-11-04 1994-09-13 Wisconsin Alumni Res Found １α，２４−ジヒドロキシビタミンＤ類似体の製造方法
JP2002535307A (ja) * 1999-01-20 2002-10-22 ウィスコンシン・アルムニ・リサーチ・ファウンデーション 結晶１α−ヒドロキシビタミンＤ２とその精製方法

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2383446A (en) 1941-06-04 1945-08-28 Du Pont Antirachitic materials and processes for their production
US3697559A (en) 1971-02-25 1972-10-10 Wisconsin Alumni Res Found 1,25-dihydroxycholecalciferol
US3741996A (en) 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol
US5472957A (en) * 1973-01-10 1995-12-05 Research Institute For Medicine And Chemistry Chemical compounds and process
US3907843A (en) 1974-06-14 1975-09-23 Wisconsin Alumni Res Found 1{60 -Hydroxyergocalciferol and processes for preparing same
JPS5452717A (en) 1977-09-29 1979-04-25 Chugai Pharmaceut Co Ltd Stable oily pharmaceuticals containing 1alpha-hydroxyvitamin d
US4202829A (en) 1978-01-05 1980-05-13 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4195027A (en) 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4260549A (en) 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4160803A (en) 1978-03-23 1979-07-10 Corning Glass Works Self packaged test kit
US4225596A (en) 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4234495A (en) 1979-09-10 1980-11-18 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxyvitamin D compounds from 1α-hydroxy-3,5-cyclovitamin D compounds
US4362710A (en) 1980-07-04 1982-12-07 Nissan Gosei Kogyo Co., Ltd. Feeds for baby pigs, process for preparing the same and method of breeding baby pigs
JPS57149224A (en) 1981-03-13 1982-09-14 Chugai Pharmaceut Co Ltd Tumor-suppressing agent
US4508651A (en) 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
WO1984004527A1 (en) 1983-05-09 1984-11-22 Wisconsin Alumni Res Found PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS
US4689180A (en) 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4588716A (en) 1984-05-04 1986-05-13 Wisconsin Alumni Research Foundation Method for treating metabolic bone disease in mammals
US4555364A (en) 1984-11-01 1985-11-26 Wisconsin Alumni Research Foundation Method for preparing 1-hydroxyvitamin D compounds
US4554106A (en) * 1984-11-01 1985-11-19 Wisconsin Alumni Research Foundation Method for preparing 1α-hydroxyvitamin D compounds
US4728643A (en) 1984-11-02 1988-03-01 The General Hospital Corporation Method of treating psoriasis
US5037816A (en) 1984-11-02 1991-08-06 The General Hospital Corporation Method of treating psoriasis
US4717721A (en) 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity
US4661294A (en) 1985-03-18 1987-04-28 The General Hospital Corporation Biologically active 1-thio derivatives of vitamin D
IL78342A (en) 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
WO1987000834A1 (en) 1985-08-02 1987-02-12 Leo Pharmaceutical Products Ltd. A/S Novel vitamin d analogues
US5554386A (en) 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
US5338532A (en) 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
US5527524A (en) 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US4833125A (en) 1986-12-05 1989-05-23 The General Hospital Corporation Method of increasing bone mass
US4902481A (en) 1987-12-11 1990-02-20 Millipore Corporation Multi-well filtration test apparatus
US5087619A (en) 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US5145846A (en) 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5232836A (en) 1988-05-04 1993-08-03 Ire-Medgenix S.A. Vitamin D derivatives: therapeutic applications and applications to assays of metabolites of vitamin D
US5602116A (en) 1988-08-02 1997-02-11 Bone Care International, Inc. Method for treating and preventing secondary hyperparathyroidism
US5104864A (en) 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
US5098899A (en) 1989-03-06 1992-03-24 Trustees Of Boston University Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites
US5321018A (en) 1989-03-09 1994-06-14 Wisconsin Alumni Research Foundation Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
CA1333616C (en) 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5372996A (en) 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
US4948789A (en) 1989-03-28 1990-08-14 Chugai Seiyaku Kabushiki Kaisha Suppression of parathyroid hormone synthesis and secretion
JP2645130B2 (ja) 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
GB2229921B (en) 1989-04-05 1992-12-16 Chugai Pharmaceutical Co Ltd Treatment for hyperparathyroidism with use of vitamin d derivatives
US5219528A (en) 1989-07-28 1993-06-15 Pierce Chemical Company Apparatus for rapid immunoassays
DE3933034A1 (de) 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
US5260290A (en) 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5194248A (en) 1990-06-21 1993-03-16 Trustees Of Boston University Compositions comprising vitamin D analog precursors and the use thereof
US5141719A (en) 1990-07-18 1992-08-25 Bio-Rad Laboratories, Inc. Multi-sample filtration plate assembly
US5763428A (en) 1990-09-21 1998-06-09 Bone Care International, Inc. Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof
US5798345A (en) 1990-09-21 1998-08-25 Bone Care International, Inc. Method of inhibiting the hyperproliferation of malignant cells
PL170447B1 (en) 1990-09-21 1996-12-31 Lunar Corp Method of obtaining novel 1 alpha-hydroxyvitamin d4 and novel transition and analog compounds
DE69233074T2 (de) 1991-01-08 2004-03-18 Bone Care International Inc., Madison Verfahren zur Herstellung von 1-alpha-24-dihydroxy-Vitamin D2
US6251883B1 (en) 1991-01-08 2001-06-26 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
JP3030157B2 (ja) 1991-03-13 2000-04-10 株式会社クラレ シクロヘキサントリオール誘導体
US5264184A (en) 1991-03-19 1993-11-23 Minnesota Mining And Manufacturing Company Device and a method for separating liquid samples
US5417923A (en) 1991-04-24 1995-05-23 Pfizer Inc. Assay tray assembly
WO1992021355A1 (en) 1991-05-28 1992-12-10 The Procter & Gamble Company Calcium, trace mineral, vitamin d and drug therapy combinations
DE69213844T2 (de) 1991-07-05 1997-04-10 Duphar Int Res Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür
US5205989A (en) 1991-09-18 1993-04-27 Minnesota Mining And Manufacturing Company Multi-well filtration apparatus
JP2823959B2 (ja) 1991-10-24 1998-11-11 アイシス・ファーマシューティカルス・インコーポレーテッド 改良された取り込みおよびその他の性質を持つ誘導化オリゴヌクレオチド
DE69318142T2 (de) 1992-01-29 1998-09-17 Bone Care Int Inc 1 alpha-HYDROXY-24-(EPI)-VITAMIN D4
EP0562497A1 (en) 1992-03-27 1993-09-29 Nisshin Flour Milling Co., Ltd. 1 alpha-hydroxy vitamins D7 and D4' processes for the preparation thereof and pharmaceutical compositions
US6113946A (en) 1992-04-03 2000-09-05 The Regents Of The University Of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
US5962731A (en) 1992-04-22 1999-10-05 Ligand Pharmaceuticals Incorporated Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5795882A (en) 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
DK0600079T3 (da) 1992-06-22 2002-04-15 Bone Care Int Inc Oral 1alpha-hydroxyprævitamin D
DE4221961A1 (de) 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
WO1994005630A1 (en) 1992-08-28 1994-03-17 Lunar Corporation 1α,24(S)-DIHYDROXY VITAMIN D2, ITS FORMATION AND USE
IL103224A (en) * 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
US5753638A (en) 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5350745A (en) 1993-01-29 1994-09-27 Lunar Corporation Treatment of myocardial failure
US5366965A (en) 1993-01-29 1994-11-22 Boehringer Mannheim Gmbh Regimen for treatment or prophylaxis of osteoporosis
US5478816A (en) 1993-07-02 1995-12-26 Bristol-Myers Squibb Company Liquid vitamin formulations containing vitamin D esters
SK279913B6 (sk) 1993-09-01 1999-05-07 Teijin Limited Farmaceutický prostriedok vo forme krému
US5763429A (en) 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US6103709A (en) 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
DE69503394T2 (de) 1994-01-20 1999-03-11 Duphar International Research B.V., Weesp Vitamin-D-Derivate und Verfahren zu deren Herstellung
US5597575A (en) 1994-06-06 1997-01-28 Breitbarth; Richard Composition for stimulating and inducing hair growth
AU700668B2 (en) * 1994-07-18 1999-01-14 Bone Care International, Inc. Synthesis of 1alpha-hydroxy vitamin D
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US6221911B1 (en) 1995-06-07 2001-04-24 Karo Bio Ab Uses for thyroid hormone compounds or thyroid hormone-like compounds
US5739271A (en) 1995-06-07 1998-04-14 Gen-Probe Incorporated Thiocationic lipids
US5952317A (en) 1995-09-21 1999-09-14 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
WO1997013518A1 (en) 1995-10-10 1997-04-17 Marilyn Strube Treatment of pruritus with vitamin d and analogs thereof
DE69606680T2 (de) 1995-10-30 2000-08-17 F. Hoffmann-La Roche Ag, Basel 1-Alpha, 26-dihydroxy-D-homo-vitamin D3
US5691328A (en) 1996-02-02 1997-11-25 Clarion Pharmaceuticals Inc. Phosphoethanolamine conjugates of vitamin D compounds
AU710931B2 (en) 1996-02-28 1999-09-30 Sumitomo Pharmaceuticals Company, Limited Crystalline vitamin D derivative
AU2588297A (en) 1996-04-04 1997-10-29 Ortho Pharmaceutical Corporation Liposome-based topical vitamin d formulation
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US5976784A (en) 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US6599513B2 (en) 1997-05-27 2003-07-29 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
US6372234B1 (en) 1997-05-27 2002-04-16 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
US6359152B2 (en) 1997-07-21 2002-03-19 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US6087350A (en) 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
JP2002509888A (ja) 1998-03-27 2002-04-02 オレゴン ヘルス サイエンシーズ ユニバーシティー 腫瘍および他の過増殖性疾患の治療におけるビタミンｄおよびその類似体
US6114317A (en) 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
US5972917A (en) 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US20010002396A1 (en) 1998-07-16 2001-05-31 Charles Achkar Compositions and methods of treating skin conditions
US6552009B2 (en) 1998-07-16 2003-04-22 Gentrix Llc Compositions and methods of treating abnormal cell proliferation
US6218430B1 (en) 1998-08-24 2001-04-17 Ligand Pharmaceuticals Incorporated Vitamin D3 mimics
EP1123921A4 (en) 1998-10-23 2003-08-20 Teijin Ltd VITAMIN D 3 DERIVATIVES? AND MEDICINES FOR INFLAMMATORY RESPIRATORY DISEASES CONTAINING THEM
US6548789B1 (en) * 1999-04-22 2003-04-15 Malden Mills Industries, Inc. Electric resistance heating/warming fabric articles
US6524594B1 (en) 1999-06-23 2003-02-25 Johnson & Johnson Consumer Companies, Inc. Foaming oil gel compositions
US6362350B1 (en) 1999-07-01 2002-03-26 Wisconsin Alumni Research Foundation Crystalline 1α, 24(S)-dihydroxyvitamin D2 and method of purification thereof
ATE277889T1 (de) 1999-07-16 2004-10-15 Leo Pharma As Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
PT1210320E (pt) 1999-07-16 2005-01-31 Leo Pharma As Aminobenzofenonas como inibidores de il-1beta e tnf-alfa
DE19935771A1 (de) 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
FR2798855B1 (fr) 1999-09-28 2003-04-25 Oreal Utilisation de complexes inorganiques-organiques dans une composition a usage topique
AU7995300A (en) 1999-10-05 2001-05-10 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
KR20020071876A (ko) 1999-12-06 2002-09-13 레오 파마 에이/에스 ＩＬ-1β 및 ＴＮＦ-α의 억제제로서의 아미노벤조페논
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
JP4803939B2 (ja) 2000-04-19 2011-10-26 中外製薬株式会社 ビタミンｄ誘導体
US6251608B1 (en) * 2000-04-20 2001-06-26 Technion Research & Development Foundation, Ltd. Method of determining a potential of a hyperglycemic patients of developing vascular complications
CN1239485C (zh) 2000-05-22 2006-02-01 里奥制药有限公司 作为IL－1β和TNF－α抑制剂的二苯酮类
US6395784B1 (en) 2000-06-07 2002-05-28 Bristol-Myers Squibb Company Benzamide ligands for the thyroid receptor
CN100469764C (zh) 2000-06-15 2009-03-18 中外制药株式会社 维生素d衍生物
JP2004504295A (ja) * 2000-07-18 2004-02-12 ボーン　ケア　インターナショナル　インコーポレイテッド 安定化１α−ヒドロキシビタミンＤ
BR0114102A (pt) * 2000-09-22 2005-04-19 Bristol Myers Squibb Pharma Co Processo eficiente para a preparação de um inibidor do fator xa
US20030149005A1 (en) 2001-08-22 2003-08-07 Posner Gary H. 24-sulfur-substituted analogs of 1alpha, 25-dihydroxy vitamin D3
DK1436257T3 (da) 2001-10-12 2007-06-25 Univ Johns Hopkins Oxim-analogica af 1-alpha, 25-dihydroxy-vitamin-D3 med ringe kalcemisk virkning
DE10156596A1 (de) 2001-11-13 2003-05-28 Schering Ag Vitamin D-Derivate mit Acyloxygruppen in der Seitenkette, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6924400B2 (en) 2001-12-10 2005-08-02 Galderma Research & Development, Snc Triaromatic vitamin D analogues
WO2003086415A1 (en) 2002-04-05 2003-10-23 Merck & Co., Inc. Method for inhibiting bone resorption with an alendronate and vitamin d formulation

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58126862A (ja) * 1981-11-02 1983-07-28 リサ−チ・インステイチユ−ト・フオア・メデイスン・アンド・ケミストリ−・インコ−ポレ−テツド １−ヒドロキシル化ビタミンｄ化合物の製法
JPS62298572A (ja) * 1986-06-19 1987-12-25 Chugai Pharmaceut Co Ltd １α−ヒドロキシビタミンＤ３の精製法
JPS63126891A (ja) * 1986-11-14 1988-05-30 Nisshin Flour Milling Co Ltd ステロイド誘導体およびその製造方法
JPS63126862A (ja) * 1987-10-30 1988-05-30 Nisshin Flour Milling Co Ltd １α−ヒドロキシビタミンＤ↓２の製造方法
JPH01246276A (ja) * 1988-03-25 1989-10-02 Teikoku Chem Ind Corp Ltd １α−ヒドロキシ―６―（１，３−ベンゾジチオール−２−イル）オキシー３，５−シクロビタミンＤ↓３
JPH02270860A (ja) * 1988-03-25 1990-11-05 Teikoku Chem Ind Corp Ltd １α―ヒドロキシ―ビタミンＤ↓３の製造方法
JPH05279260A (ja) * 1991-04-09 1993-10-26 Takeda Chem Ind Ltd 安定化されたビタミンｄ類製剤
JPH05339230A (ja) * 1992-03-12 1993-12-21 Nisshin Flour Milling Co Ltd 活性型ビタミンｄ２及びその誘導体の製造法
JPH05320127A (ja) * 1992-03-27 1993-12-03 Nisshin Flour Milling Co Ltd 活性型ビタミンｄ誘導体
JPH06256301A (ja) * 1992-11-04 1994-09-13 Wisconsin Alumni Res Found １α，２４−ジヒドロキシビタミンＤ類似体の製造方法
JP2002535307A (ja) * 1999-01-20 2002-10-22 ウィスコンシン・アルムニ・リサーチ・ファウンデーション 結晶１α−ヒドロキシビタミンＤ２とその精製方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005247803A (ja) * 2004-03-08 2005-09-15 Zeria Pharmaceut Co Ltd 点眼剤及びその容器
JP2014062131A (ja) * 2008-03-12 2014-04-10 Cytochroma Inc 安定化１，２５−ジヒドロキシビタミンｄ２及びその製造方法
JP2018172299A (ja) * 2017-03-31 2018-11-08 ナガセ医薬品株式会社 マキサカルシトール含有水溶液製剤

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