BR0114102A - Processo eficiente para a preparação de um inibidor do fator xa - Google Patents

Processo eficiente para a preparação de um inibidor do fator xa

Info

Publication number
BR0114102A
BR0114102A BR0114102-3A BR0114102A BR0114102A BR 0114102 A BR0114102 A BR 0114102A BR 0114102 A BR0114102 A BR 0114102A BR 0114102 A BR0114102 A BR 0114102A
Authority
BR
Brazil
Prior art keywords
preparing
inhibitor
factor
efficient process
efficient
Prior art date
Application number
BR0114102-3A
Other languages
English (en)
Inventor
Hari Babu Sunkara
Yali Yang
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of BR0114102A publication Critical patent/BR0114102A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

"PROCESSO EFICIENTE PARA A PREPARAçãO DE UM INIBIDOR DO FATOR XA". A presente invenção refere-se ao processo para a preparação do composto da Fórmula I, a partir do seu 3-ciano-4-flúor-fenil-pirazol e intermediários correspondentes, útil para o uso em questão.
BR0114102-3A 2000-09-22 2001-09-12 Processo eficiente para a preparação de um inibidor do fator xa BR0114102A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23462200P 2000-09-22 2000-09-22
PCT/US2001/028406 WO2002024690A2 (en) 2000-09-22 2001-09-12 Efficient process for the preparation of a factor xa inhibitor

Publications (1)

Publication Number Publication Date
BR0114102A true BR0114102A (pt) 2005-04-19

Family

ID=22882119

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114102-3A BR0114102A (pt) 2000-09-22 2001-09-12 Processo eficiente para a preparação de um inibidor do fator xa

Country Status (23)

Country Link
US (3) US6667332B2 (pt)
EP (1) EP1366045A2 (pt)
JP (1) JP2004529853A (pt)
KR (1) KR20040043089A (pt)
CN (1) CN1610679A (pt)
AU (1) AU2001292612A1 (pt)
BG (1) BG107813A (pt)
BR (1) BR0114102A (pt)
CA (1) CA2424576A1 (pt)
CZ (1) CZ2003835A3 (pt)
EE (1) EE200300116A (pt)
HR (1) HRP20030316A2 (pt)
HU (1) HUP0500133A2 (pt)
IL (1) IL155043A0 (pt)
IS (1) IS6754A (pt)
MX (1) MXPA03002493A (pt)
NO (1) NO20031308L (pt)
PL (1) PL366027A1 (pt)
RU (1) RU2003111464A (pt)
SK (1) SK4892003A3 (pt)
TW (1) TW593314B (pt)
WO (1) WO2002024690A2 (pt)
ZA (1) ZA200302971B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
CA2414407A1 (en) * 2000-07-18 2002-01-24 Bone Care International, Inc. Stabilized 1.alpha.-hydroxy vitamin d
TW200302225A (en) * 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
AU2003270861A1 (en) 2002-10-02 2004-04-23 Bristol-Myers Squibb Company Novel combination of a factor xa inhibitor and clopidogrel
EP1564181A1 (en) * 2002-11-06 2005-08-17 Matsushita Electric Industrial Co., Ltd. Microactuator provided with diplacement detection function, and deformable mirror provided with this microactuator
US7429581B2 (en) * 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
US20050059719A1 (en) * 2003-09-16 2005-03-17 Badawy Sherif Ibrahim Farag Solid dosage formulation containing a Factor Xa inhibitor and method
AU2015226855C1 (en) 2014-03-07 2021-02-11 Biocryst Pharmaceuticals, Inc. Human plasma kallikrein inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors

Also Published As

Publication number Publication date
CN1610679A (zh) 2005-04-27
HUP0500133A2 (hu) 2005-04-28
CA2424576A1 (en) 2002-03-28
SK4892003A3 (en) 2004-04-06
IS6754A (is) 2003-03-21
TW593314B (en) 2004-06-21
BG107813A (bg) 2004-01-30
EE200300116A (et) 2005-04-15
US20040198787A1 (en) 2004-10-07
US6667332B2 (en) 2003-12-23
KR20040043089A (ko) 2004-05-22
RU2003111464A (ru) 2004-10-27
ZA200302971B (en) 2005-05-09
WO2002024690A3 (en) 2003-09-25
MXPA03002493A (es) 2004-09-10
CZ2003835A3 (cs) 2003-12-17
US6747158B2 (en) 2004-06-08
US20030212117A1 (en) 2003-11-13
EP1366045A2 (en) 2003-12-03
NO20031308L (no) 2003-05-07
PL366027A1 (en) 2005-01-24
NO20031308D0 (no) 2003-03-21
IL155043A0 (en) 2003-10-31
WO2002024690A8 (en) 2002-08-08
US20020061917A1 (en) 2002-05-23
WO2002024690A2 (en) 2002-03-28
HRP20030316A2 (en) 2005-02-28
AU2001292612A1 (en) 2002-04-02
JP2004529853A (ja) 2004-09-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 1964 DE 26/08/2008 E CONSIDERANDO A AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS.