BG107813A - Ефективен метод за получаване на фактор xа инхибитор - Google Patents

Ефективен метод за получаване на фактор xа инхибитор Download PDF

Info

Publication number
BG107813A
BG107813A BG107813A BG10781303A BG107813A BG 107813 A BG107813 A BG 107813A BG 107813 A BG107813 A BG 107813A BG 10781303 A BG10781303 A BG 10781303A BG 107813 A BG107813 A BG 107813A
Authority
BG
Bulgaria
Prior art keywords
compound
formula
solvent
reacting
water
Prior art date
Application number
BG107813A
Other languages
Bulgarian (bg)
English (en)
Inventor
Luigi Anzalone
Fuqiang Jin
David J. Meloni
Jung-Hui Sun
Christopher A. Teleha
Jiacheng Zhou
Thomas E. Smyser
Hui-Yin Li
Original Assignee
Bristol-Myers Squibb Pharma Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Pharma Company filed Critical Bristol-Myers Squibb Pharma Company
Publication of BG107813A publication Critical patent/BG107813A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
BG107813A 2000-09-22 2003-05-13 Ефективен метод за получаване на фактор xа инхибитор BG107813A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23462200P 2000-09-22 2000-09-22
PCT/US2001/028406 WO2002024690A2 (en) 2000-09-22 2001-09-12 Efficient process for the preparation of a factor xa inhibitor

Publications (1)

Publication Number Publication Date
BG107813A true BG107813A (bg) 2004-01-30

Family

ID=22882119

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107813A BG107813A (bg) 2000-09-22 2003-05-13 Ефективен метод за получаване на фактор xа инхибитор

Country Status (23)

Country Link
US (3) US6667332B2 (pt)
EP (1) EP1366045A2 (pt)
JP (1) JP2004529853A (pt)
KR (1) KR20040043089A (pt)
CN (1) CN1610679A (pt)
AU (1) AU2001292612A1 (pt)
BG (1) BG107813A (pt)
BR (1) BR0114102A (pt)
CA (1) CA2424576A1 (pt)
CZ (1) CZ2003835A3 (pt)
EE (1) EE200300116A (pt)
HR (1) HRP20030316A2 (pt)
HU (1) HUP0500133A2 (pt)
IL (1) IL155043A0 (pt)
IS (1) IS6754A (pt)
MX (1) MXPA03002493A (pt)
NO (1) NO20031308L (pt)
PL (1) PL366027A1 (pt)
RU (1) RU2003111464A (pt)
SK (1) SK4892003A3 (pt)
TW (1) TW593314B (pt)
WO (1) WO2002024690A2 (pt)
ZA (1) ZA200302971B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
WO2002006218A2 (en) * 2000-07-18 2002-01-24 Bone Care International, Inc. STABILIZED 1α-HYDROXY VITAMIN D
TW200302225A (en) * 2001-12-04 2003-08-01 Bristol Myers Squibb Co Substituted amino methyl factor Xa inhibitors
AU2003270861A1 (en) 2002-10-02 2004-04-23 Bristol-Myers Squibb Company Novel combination of a factor xa inhibitor and clopidogrel
WO2004041710A1 (ja) * 2002-11-06 2004-05-21 Matsushita Electric Industrial Co., Ltd. 変位検出機能を備えたマイクロアクチュエータ、および当該マイクロアクチュエータを備えた可変形ミラー
US7429581B2 (en) * 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
US20050059719A1 (en) * 2003-09-16 2005-03-17 Badawy Sherif Ibrahim Farag Solid dosage formulation containing a Factor Xa inhibitor and method
SG11201607267SA (en) 2014-03-07 2016-09-29 Biocryst Pharm Inc Human plasma kallikrein inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors

Also Published As

Publication number Publication date
SK4892003A3 (en) 2004-04-06
KR20040043089A (ko) 2004-05-22
NO20031308L (no) 2003-05-07
IS6754A (is) 2003-03-21
CN1610679A (zh) 2005-04-27
PL366027A1 (en) 2005-01-24
MXPA03002493A (es) 2004-09-10
RU2003111464A (ru) 2004-10-27
WO2002024690A8 (en) 2002-08-08
NO20031308D0 (no) 2003-03-21
US6667332B2 (en) 2003-12-23
BR0114102A (pt) 2005-04-19
WO2002024690A3 (en) 2003-09-25
EP1366045A2 (en) 2003-12-03
CZ2003835A3 (cs) 2003-12-17
US20030212117A1 (en) 2003-11-13
WO2002024690A2 (en) 2002-03-28
JP2004529853A (ja) 2004-09-30
CA2424576A1 (en) 2002-03-28
EE200300116A (et) 2005-04-15
US6747158B2 (en) 2004-06-08
HUP0500133A2 (hu) 2005-04-28
TW593314B (en) 2004-06-21
US20020061917A1 (en) 2002-05-23
ZA200302971B (en) 2005-05-09
AU2001292612A1 (en) 2002-04-02
HRP20030316A2 (en) 2005-02-28
IL155043A0 (en) 2003-10-31
US20040198787A1 (en) 2004-10-07

Similar Documents

Publication Publication Date Title
RU2257381C2 (ru) Диазепановое производное, фармацевтическая композиция, его содержащая, и ингибитор активированного фактора x коагуляции крови
JP4053597B2 (ja) 置換ｎ―［（アミノイミノメチル又はアミノメチル）フェニル］プロピルアミド
WO2002042270A1 (fr) Derives de benzene substitues ou leurs sels
US20100113391A1 (en) Bicyclic heterocyclic compound
JP2001502326A (ja) マトリクス金属プロテナイーゼおよびＴＡＣＥに対する阻害薬としてのβ―スルホンアミドヒドロキサム酸
JP5266053B2 (ja) ＴＡＦＩａのインヒビターとしてのイミダゾール誘導体
PT1369419E (pt) Composto de n-fenilarilsulfonamida, fármaco contendo o composto como ingrediente activo, produtos intermédios para a produção do composto e processos para a produção do composto
RU2709810C2 (ru) ПРОИЗВОДНЫЕ ПИРАЗОЛО[3,4-с]ПИРИДИНА
JP4390024B2 (ja) 新規なジアゼパン誘導体又はその塩
US6750225B2 (en) 1,4,5,6-tetrahydropyrazolo-[3,4,-c]-pyridin-7-ones useful as factor Xa inhibitors
BG107813A (bg) Ефективен метод за получаване на фактор xа инхибитор
CN103420984B (zh) 作为前药的达比加群酯衍生物及其制备方法和用途
US20030022916A1 (en) 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors
JP2002520401A (ja) ピペラジノン誘導体及びその利用
JPS59118746A (ja) ベンゼン誘導体
KR20130131775A (ko) 인자 ＸＩａ 억제 활성을 갖는 다이펩타이드 유도체