JP2004502752A5 - - Google Patents
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- Publication number
- JP2004502752A5 JP2004502752A5 JP2002509074A JP2002509074A JP2004502752A5 JP 2004502752 A5 JP2004502752 A5 JP 2004502752A5 JP 2002509074 A JP2002509074 A JP 2002509074A JP 2002509074 A JP2002509074 A JP 2002509074A JP 2004502752 A5 JP2004502752 A5 JP 2004502752A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- compound according
- pharmaceutically acceptable
- minocycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960004023 minocycline Drugs 0.000 description 8
- -1 minocycline compound Chemical class 0.000 description 8
- 208000035143 Bacterial infection Diseases 0.000 description 5
- 125000003282 alkyl amino group Chemical group 0.000 description 5
- 208000022362 bacterial infectious disease Diseases 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000000651 prodrug Substances 0.000 description 4
- 229940002612 prodrug Drugs 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000004098 Tetracycline Substances 0.000 description 3
- 229960002180 tetracycline Drugs 0.000 description 3
- 229930101283 tetracycline Natural products 0.000 description 3
- 235000019364 tetracycline Nutrition 0.000 description 3
- 150000003522 tetracyclines Chemical class 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000004663 dialkyl amino group Chemical group 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical class C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 125000004894 pentylamino group Chemical group C(CCCC)N* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21665900P | 2000-07-07 | 2000-07-07 | |
| US60/216,659 | 2000-07-07 | ||
| US27562101P | 2001-03-13 | 2001-03-13 | |
| US60/275,621 | 2001-03-13 | ||
| PCT/US2001/020721 WO2002004406A2 (en) | 2000-07-07 | 2001-06-29 | 9-substituted minocycline compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008157219A Division JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004502752A JP2004502752A (ja) | 2004-01-29 |
| JP2004502752A5 true JP2004502752A5 (enExample) | 2008-08-07 |
| JP4925549B2 JP4925549B2 (ja) | 2012-04-25 |
Family
ID=26911221
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002509074A Expired - Lifetime JP4925549B2 (ja) | 2000-07-07 | 2001-06-29 | ９−置換ミノサイクリン化合物 |
| JP2008157219A Expired - Lifetime JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
| JP2012034839A Pending JP2012107045A (ja) | 2000-07-07 | 2012-02-21 | ９−置換ミノサイクリン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008157219A Expired - Lifetime JP5037436B2 (ja) | 2000-07-07 | 2008-06-16 | ９−置換ミノサイクリン化合物 |
| JP2012034839A Pending JP2012107045A (ja) | 2000-07-07 | 2012-02-21 | ９−置換ミノサイクリン化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US6846939B2 (enExample) |
| EP (4) | EP3461808A1 (enExample) |
| JP (3) | JP4925549B2 (enExample) |
| KR (2) | KR100674047B1 (enExample) |
| CN (2) | CN1690047B (enExample) |
| AT (2) | ATE336481T1 (enExample) |
| AU (4) | AU2001286388B2 (enExample) |
| BR (1) | BRPI0112269B8 (enExample) |
| CA (1) | CA2415178C (enExample) |
| CY (1) | CY1107524T1 (enExample) |
| CZ (2) | CZ303702B6 (enExample) |
| DE (1) | DE60122341T2 (enExample) |
| DK (2) | DK1679305T3 (enExample) |
| EA (3) | EA013908B1 (enExample) |
| ES (2) | ES2701599T3 (enExample) |
| HR (1) | HRP20030091B1 (enExample) |
| HU (1) | HU229577B1 (enExample) |
| IL (2) | IL153639A0 (enExample) |
| MX (1) | MXPA03000055A (enExample) |
| PT (1) | PT1301467E (enExample) |
| SI (1) | SI1301467T1 (enExample) |
| TW (2) | TWI299038B (enExample) |
| WO (1) | WO2002004406A2 (enExample) |
| ZA (1) | ZA200300749B (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| AU2466099A (en) * | 1998-01-23 | 1999-08-09 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| EP1666453A1 (en) * | 1999-09-14 | 2006-06-07 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| CA2397863A1 (en) * | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| ES2288945T3 (es) * | 2000-03-31 | 2008-02-01 | Trustees Of Tufts College | Compuestos de tetraciclina 7 y 9-carbamato, urea, tiourea, tiocarbamato y heteroaril-amino sustituidos. |
| DE60102815D1 (de) * | 2000-05-15 | 2004-05-19 | Paratek Pharm Innc | 7-substituierte kondensierte ring-tetrazyclin- verbindungen |
| AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| SI1301467T1 (sl) * | 2000-07-07 | 2007-02-28 | Tufts College | 9-substituirane minociklinske spojine |
| EP1241160A1 (en) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| US6683068B2 (en) * | 2001-03-13 | 2004-01-27 | Paratek Pharmaceuticals, Inc. | 7, 9-substituted tetracycline compounds |
| AU2002250331A1 (en) * | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| CA2440757A1 (en) | 2001-03-14 | 2002-09-19 | Michael Draper | Substituted tetracycline compounds as synergistic antifungal agents |
| US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| US20040063674A1 (en) | 2001-07-13 | 2004-04-01 | Levy Stuart B. | Tetracycline compounds having target therapeutic activities |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| AU2002365120A1 (en) | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
| JP2005514410A (ja) * | 2002-01-08 | 2005-05-19 | パラテック ファーマシューティカルズ インコーポレイテッド | ４−デジメチルアミノテトラサイクリン化合物 |
| JP2005526754A (ja) * | 2002-03-08 | 2005-09-08 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノメチル置換されたテトラサイクリン化合物 |
| AU2003218242A1 (en) * | 2002-03-21 | 2003-10-08 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| JP2005520846A (ja) * | 2002-03-21 | 2005-07-14 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換されたテトラサイクリン化合物。 |
| EP1534300A4 (en) * | 2002-07-12 | 2008-04-23 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS SUBSTITUTED IN 3, 10, AND 12A |
| AU2003287218C1 (en) * | 2002-10-24 | 2010-07-15 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| EP1562608A4 (en) * | 2002-10-24 | 2010-09-01 | Paratek Pharm Innc | METHOD OF USE OF SUBSTITUTED TETRACYCLINE COMPOUNDS FOR MODULATING THE RNA |
| WO2004091513A2 (en) * | 2003-04-10 | 2004-10-28 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| CA2531732C (en) * | 2003-07-09 | 2012-04-10 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP2319828A3 (en) * | 2003-07-09 | 2011-07-06 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US8691258B2 (en) * | 2003-12-12 | 2014-04-08 | Medtronic, Inc. | Anti-infective medical device |
| EP2332904A3 (en) | 2004-01-15 | 2012-04-11 | Paratek Pharmaceuticals, Inc. | Derivatives of tetracycline compounds |
| CN103214409B (zh) | 2004-05-21 | 2015-10-21 | 哈佛大学校长及研究员协会 | 四环素及其类似物的合成 |
| TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
| EP1805134B1 (en) * | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP2287148A3 (en) * | 2004-10-25 | 2011-10-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| JP2008530023A (ja) * | 2005-02-04 | 2008-08-07 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の１１ａ，１２−誘導体 |
| AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
| AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
| AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
| WO2007014154A2 (en) * | 2005-07-21 | 2007-02-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
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| EP1991236A2 (en) | 2006-01-24 | 2008-11-19 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| AU2007235279B2 (en) * | 2006-04-07 | 2012-12-06 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| AU2007249695A1 (en) | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| EP2479169B1 (en) | 2006-10-11 | 2014-12-03 | President and Fellows of Harvard College | Synthesis of Enone Intermediate |
| WO2008045507A2 (en) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
| SI2120963T1 (sl) | 2006-12-21 | 2019-02-28 | Paratek Pharmaceuticals, Inc. | Substituirane spojine tetraciklina za zdravljenje vnetnih kožnih motenj |
| PT2109602E (pt) * | 2006-12-21 | 2014-05-23 | Paratek Pharm Innc | Derivados de tetraciclina para o tratamento de infecções bacterianas, virais e parasitárias |
| US7935687B2 (en) * | 2007-04-12 | 2011-05-03 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| CA2688662A1 (en) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| ATE555079T1 (de) * | 2007-07-06 | 2012-05-15 | Paratek Pharm Innc | Verfahren zur synthese von 9-substituiertem minocyclin |
| AU2008331163B2 (en) | 2007-11-29 | 2014-01-30 | Viatris Asia Pacific Pte. Ltd. | Phosphonic acid derivates and their use as P2Y12 receptor antagonists |
| CN102015602A (zh) | 2008-03-05 | 2011-04-13 | 帕拉特克药品公司 | 米诺环素化合物及其使用方法 |
| PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| US20100022483A1 (en) * | 2008-04-14 | 2010-01-28 | Paratek Pharmaceuticals, Inc. | Substituted Tetracycline Compounds |
| TW202021946A (zh) * | 2008-05-19 | 2020-06-16 | 美商派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| CN103936645B (zh) * | 2008-08-08 | 2016-03-09 | 四相制药公司 | C7-氟取代的四环素化合物 |
| JP5443720B2 (ja) * | 2008-09-05 | 2014-03-19 | 住友化学株式会社 | 組成物、光学フィルム及びその製造方法、光学部材ならびに表示装置 |
| CN101759598B (zh) * | 2008-09-12 | 2011-11-09 | 山东轩竹医药科技有限公司 | 具有氨基烷基脒的四环素化合物 |
| CN101684080B (zh) * | 2008-09-16 | 2011-12-14 | 山东轩竹医药科技有限公司 | 含有甲酰肼基的四环素化合物 |
| CN101684083B (zh) * | 2008-09-16 | 2011-10-05 | 山东轩竹医药科技有限公司 | 胍基烷酰胺基取代的四环素衍生物 |
| CN101759599B (zh) * | 2008-09-17 | 2012-05-30 | 山东轩竹医药科技有限公司 | 具有氨基肟基的四环素类化合物 |
| AP2011005631A0 (en) * | 2008-09-19 | 2011-04-30 | Paratek Pharmaceuticals Ind | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment. |
| EP2424834B1 (en) | 2009-04-30 | 2018-07-11 | President and Fellows of Harvard College | Synthesis of tetracyclines and intermediates thereof |
| CA2761241C (en) | 2009-05-08 | 2018-02-27 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| US9624166B2 (en) | 2009-08-28 | 2017-04-18 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| EP2738156B1 (en) * | 2011-07-26 | 2018-01-03 | Kbp Biosciences Usa Inc. | 9-aminomethyl substituted tetracycline compounds |
| AU2013289892A1 (en) * | 2012-07-13 | 2015-02-19 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds for treating neurodegenerative disorders |
| HUE042600T2 (hu) | 2012-08-31 | 2019-07-29 | Tetraphase Pharmaceuticals Inc | Tetraciklin vegyületek |
| WO2014152332A1 (en) | 2013-03-15 | 2014-09-25 | Melinta Therapeutics, Inc. | Methods of treating infections in overweight and obese patients using antibiotics |
| TW201615222A (zh) * | 2014-10-24 | 2016-05-01 | 朗齊生物醫學股份有限公司 | 免疫疾病用藥臨床新應用 |
| MX389771B (es) | 2015-03-24 | 2025-03-20 | Paratek Pharm Innc | Compuestos de minociclina para biodefensas. |
| SG10201913559VA (en) * | 2016-03-24 | 2020-02-27 | Paratek Pharm Innc | Methods for treating and preventing c. difficile infection |
| EP3529236B1 (en) | 2016-10-19 | 2024-02-07 | Tetraphase Pharmaceuticals, Inc. | Crystalline forms of eravacycline |
| CN110087655A (zh) | 2016-11-01 | 2019-08-02 | 帕拉特克药品公司 | 9-氨基甲基米诺环素化合物及其在治疗社区获得性细菌性肺炎(cabp)中的用途 |
| JP7466544B2 (ja) * | 2018-09-04 | 2024-04-12 | パラテック ファーマシューティカルズ，インコーポレイテッド | テトラサイクリン化合物を使用してマイコバクテリア感染症を処置する方法 |
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-
2001
- 2001-06-29 SI SI200130646T patent/SI1301467T1/sl unknown
- 2001-06-29 EP EP18187132.8A patent/EP3461808A1/en not_active Withdrawn
- 2001-06-29 US US09/895,857 patent/US6846939B2/en not_active Expired - Lifetime
- 2001-06-29 CZ CZ20090877A patent/CZ303702B6/cs not_active IP Right Cessation
- 2001-06-29 EP EP01965828A patent/EP1301467B1/en not_active Expired - Lifetime
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- 2001-06-29 HR HR20030091A patent/HRP20030091B1/xx not_active IP Right Cessation
- 2001-06-29 HU HU0301169A patent/HU229577B1/hu unknown
- 2001-06-29 AU AU2001286388A patent/AU2001286388B2/en not_active Expired
- 2001-06-29 CN CN2005100530441A patent/CN1690047B/zh not_active Expired - Fee Related
- 2001-06-29 DK DK06007501.7T patent/DK1679305T3/da active
- 2001-06-29 AT AT01965828T patent/ATE336481T1/de active
- 2001-06-29 AT AT06007501T patent/ATE544745T1/de active
- 2001-06-29 KR KR1020037000160A patent/KR100674047B1/ko not_active Expired - Lifetime
- 2001-06-29 IL IL15363901A patent/IL153639A0/xx unknown
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- 2001-06-29 CN CNB01815087XA patent/CN100473644C/zh not_active Expired - Lifetime
- 2001-06-29 ES ES10182900T patent/ES2701599T3/es not_active Expired - Lifetime
- 2001-06-29 DK DK01965828T patent/DK1301467T3/da active
- 2001-06-29 EA EA200401579A patent/EA013908B1/ru not_active IP Right Cessation
- 2001-06-29 MX MXPA03000055A patent/MXPA03000055A/es active IP Right Grant
- 2001-06-29 WO PCT/US2001/020721 patent/WO2002004406A2/en not_active Ceased
- 2001-06-29 ES ES01965828T patent/ES2271070T3/es not_active Expired - Lifetime
- 2001-06-29 CZ CZ2003344A patent/CZ2003344A3/cs unknown
- 2001-06-29 JP JP2002509074A patent/JP4925549B2/ja not_active Expired - Lifetime
- 2001-06-29 EA EA201000496A patent/EA201000496A1/ru unknown
- 2001-06-29 DE DE60122341T patent/DE60122341T2/de not_active Expired - Lifetime
- 2001-06-29 EA EA200300135A patent/EA009175B1/ru not_active IP Right Cessation
- 2001-06-29 CA CA2415178A patent/CA2415178C/en not_active Expired - Lifetime
- 2001-06-29 KR KR1020057025319A patent/KR100699390B1/ko not_active Expired - Fee Related
- 2001-06-29 BR BRPI0112269A patent/BRPI0112269B8/pt not_active IP Right Cessation
- 2001-06-29 EP EP10182900.0A patent/EP2308832B8/en not_active Expired - Lifetime
- 2001-06-29 AU AU8638801A patent/AU8638801A/xx active Pending
- 2001-07-06 TW TW090116602A patent/TWI299038B/zh not_active IP Right Cessation
- 2001-07-06 TW TW093140806A patent/TWI305528B/zh not_active IP Right Cessation
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2004
- 2004-05-04 US US10/839,023 patent/US8048867B2/en not_active Expired - Fee Related
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2005
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2008
- 2008-06-16 JP JP2008157219A patent/JP5037436B2/ja not_active Expired - Lifetime
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2009
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