JP2005511642A5 - - Google Patents
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- Publication number
- JP2005511642A5 JP2005511642A5 JP2003546936A JP2003546936A JP2005511642A5 JP 2005511642 A5 JP2005511642 A5 JP 2005511642A5 JP 2003546936 A JP2003546936 A JP 2003546936A JP 2003546936 A JP2003546936 A JP 2003546936A JP 2005511642 A5 JP2005511642 A5 JP 2005511642A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- formula
- compound
- pharmaceutically acceptable
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical group COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 10
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 8
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 7
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 7
- 229960002216 methylparaben Drugs 0.000 claims description 7
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 4
- 229960003415 propylparaben Drugs 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000004067 bulking agent Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000003085 diluting agent Substances 0.000 claims 4
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims 4
- 239000003755 preservative agent Substances 0.000 claims 4
- 230000002335 preservative effect Effects 0.000 claims 4
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims 3
- 241000282472 Canis lupus familiaris Species 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims 1
- 229960001950 benzethonium chloride Drugs 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 229960004217 benzyl alcohol Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 210000001635 urinary tract Anatomy 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 7
- 244000005700 microbiome Species 0.000 description 4
- 159000000000 sodium salts Chemical class 0.000 description 4
- 239000007979 citrate buffer Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33853601P | 2001-11-30 | 2001-11-30 | |
| US60/338,536 | 2001-11-30 | ||
| US39893202P | 2002-07-26 | 2002-07-26 | |
| US60/398,932 | 2002-07-26 | ||
| PCT/IB2002/004743 WO2003045435A1 (en) | 2001-11-30 | 2002-11-13 | Formulations comprising a cephalosporin compound and their use treating bacterial infections in cats and dogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005511642A JP2005511642A (ja) | 2005-04-28 |
| JP2005511642A5 true JP2005511642A5 (enExample) | 2006-01-12 |
| JP4689959B2 JP4689959B2 (ja) | 2011-06-01 |
Family
ID=26991236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003546936A Expired - Lifetime JP4689959B2 (ja) | 2001-11-30 | 2002-11-13 | セファロスポリン化合物を含む処方物ならびにイヌおよびネコにおける細菌感染の治療におけるその使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7378408B2 (enExample) |
| EP (1) | EP1448234B1 (enExample) |
| JP (1) | JP4689959B2 (enExample) |
| KR (1) | KR100621291B1 (enExample) |
| CN (1) | CN100502873C (enExample) |
| AR (1) | AR037595A1 (enExample) |
| AT (1) | ATE406916T1 (enExample) |
| AU (1) | AU2002348986B2 (enExample) |
| BR (1) | BRPI0214583B1 (enExample) |
| CA (1) | CA2468708C (enExample) |
| CY (1) | CY1108437T1 (enExample) |
| DE (1) | DE60228749D1 (enExample) |
| DK (1) | DK1448234T3 (enExample) |
| EA (1) | EA008503B1 (enExample) |
| ES (1) | ES2307800T3 (enExample) |
| HR (1) | HRP20040487A2 (enExample) |
| IL (2) | IL161851A0 (enExample) |
| IS (1) | IS7214A (enExample) |
| MA (1) | MA27085A1 (enExample) |
| MX (1) | MXPA04003724A (enExample) |
| NO (1) | NO334818B1 (enExample) |
| NZ (1) | NZ532208A (enExample) |
| PL (1) | PL212683B1 (enExample) |
| PT (1) | PT1448234E (enExample) |
| TN (1) | TNSN04097A1 (enExample) |
| TW (1) | TWI248363B (enExample) |
| WO (1) | WO2003045435A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20021725A1 (it) | 2002-08-01 | 2002-10-31 | Zambon Spa | Composizioni farmaceutiche ad attivita' antibiotica. |
| BRPI0509992A (pt) * | 2004-04-22 | 2007-10-16 | Pfizer Prod Inc | método de estabilização de sal de sódio de cefovecina desordenado |
| EP1656930A1 (en) * | 2004-11-10 | 2006-05-17 | Basilea Pharmaceutica AG | Stabilized freeze-dried formulation for cephalosporin derivatives |
| CA2591157C (en) * | 2004-12-17 | 2012-06-12 | Venus Remedies Limited | Antibiotic combinations for providing total solution to the treatment of infections |
| KR20070085674A (ko) * | 2005-02-14 | 2007-08-27 | 비너스 레머디스 리미티드 | 약제 내성균에 의한 감염 질환을 위한 비경구 병용 요법 |
| CA2626273C (en) * | 2005-10-29 | 2013-05-14 | Intervet International Bv | Cefquinome compositions and methods of their use |
| US20080103121A1 (en) * | 2006-10-30 | 2008-05-01 | Gole Dilip J | Cephalosporin derivative formulation |
| KR20100137439A (ko) * | 2008-03-04 | 2010-12-30 | 엘란 파마 인터내셔널 리미티드 | 항감염제의 안정성 액체 포뮬레이션 및 항감염제의 조정된 용량투여 요법 |
| CN101352422B (zh) * | 2008-09-17 | 2011-04-20 | 厦门朝阳生物工程有限公司 | 河豚毒素冻干粉针制剂及其制备方法 |
| US9050251B2 (en) | 2008-10-31 | 2015-06-09 | The Invention Science Fund I, Llc | Compositions and methods for delivery of frozen particle adhesives |
| US9060934B2 (en) | 2008-10-31 | 2015-06-23 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US9060931B2 (en) | 2008-10-31 | 2015-06-23 | The Invention Science Fund I, Llc | Compositions and methods for delivery of frozen particle adhesives |
| US9072688B2 (en) | 2008-10-31 | 2015-07-07 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US8603496B2 (en) | 2008-10-31 | 2013-12-10 | The Invention Science Fund I, Llc | Compositions and methods for biological remodeling with frozen particle compositions |
| US20100111857A1 (en) | 2008-10-31 | 2010-05-06 | Boyden Edward S | Compositions and methods for surface abrasion with frozen particles |
| US8731841B2 (en) | 2008-10-31 | 2014-05-20 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US8788211B2 (en) * | 2008-10-31 | 2014-07-22 | The Invention Science Fund I, Llc | Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition |
| US8849441B2 (en) | 2008-10-31 | 2014-09-30 | The Invention Science Fund I, Llc | Systems, devices, and methods for making or administering frozen particles |
| US8731840B2 (en) | 2008-10-31 | 2014-05-20 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US8725420B2 (en) | 2008-10-31 | 2014-05-13 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US8793075B2 (en) | 2008-10-31 | 2014-07-29 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US9060926B2 (en) | 2008-10-31 | 2015-06-23 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US9050317B2 (en) | 2008-10-31 | 2015-06-09 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
| US9050070B2 (en) | 2008-10-31 | 2015-06-09 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US9072799B2 (en) | 2008-10-31 | 2015-07-07 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US8721583B2 (en) | 2008-10-31 | 2014-05-13 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
| US8762067B2 (en) | 2008-10-31 | 2014-06-24 | The Invention Science Fund I, Llc | Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data |
| US9040087B2 (en) | 2008-10-31 | 2015-05-26 | The Invention Science Fund I, Llc | Frozen compositions and methods for piercing a substrate |
| US20140274997A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Cephalosporin pharmaceutical compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| UA121298C2 (uk) * | 2013-03-15 | 2020-05-12 | Мерк Шарп І Доум Корп. | Антибіотична композиція на основі цефтолозану і тазобактаму |
| MX389290B (es) * | 2015-07-09 | 2025-03-20 | Uniwell Laboratories Llc | Composiciones farmacéuticas. |
| CN108135928B (zh) | 2015-09-07 | 2021-06-08 | 持田制药株式会社 | 藻酸冻结干燥制剂 |
| WO2019064065A1 (en) * | 2017-09-27 | 2019-04-04 | F. Hoffmann-La Roche Ag | PHARMACEUTICAL FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| CA3076959C (en) | 2017-09-27 | 2025-02-11 | Meiji Seika Pharma Co., Ltd. | CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND THEIR PRODUCTION PROCESS |
| KR102844744B1 (ko) | 2017-09-27 | 2025-08-11 | 메이지 세이카 파루마 가부시키가이샤 | 디아자비시클로옥탄 유도체의 약제학적 형태 및 그의 제조방법 |
| GB2575261B (en) | 2018-07-02 | 2022-03-09 | Norbrook Lab Ltd | Intermediates in the synthesis of C3-substituted cephalosporins |
| CN109393004A (zh) * | 2018-09-28 | 2019-03-01 | 上海锦立保鲜科技有限公司 | 一种利用冻品自由水升华实现真空解冻的方法 |
| EP4438062A1 (en) * | 2021-11-26 | 2024-10-02 | Astellas Pharma Inc. | Indocyanine compound-containing solid pharmaceutical composition |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4002748A (en) | 1976-01-19 | 1977-01-11 | Eli Lilly And Company | Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral administration |
| JPS5711909A (en) | 1980-06-23 | 1982-01-21 | Shionogi & Co Ltd | Stable freeze-dried preparation of beta-lactam |
| JPS6045514A (ja) | 1983-08-22 | 1985-03-12 | Shionogi & Co Ltd | 安定な抗菌性凍結乾燥製剤 |
| SE8500273D0 (sv) * | 1985-01-22 | 1985-01-22 | Leo Ab | Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder |
| US5138066A (en) | 1987-08-14 | 1992-08-11 | Hoffmann-La Roche, Inc. | Intermediates for cephalosporins with sulfur-containing oxyimino side chain |
| KR890012960A (ko) | 1988-02-05 | 1989-09-20 | 매리 앤 터커 | 결정성 β-락탐 용매화물 |
| CA2024587A1 (en) * | 1989-09-05 | 1991-03-06 | Bernard Ecanow | Drug delivery compositions based on biological cells or components thereof and methods |
| MY106399A (en) * | 1990-07-24 | 1995-05-30 | Pfizer | Cephalosporins and homologeus, preparation and pharmaceutical composition |
| US6020329A (en) | 1990-07-24 | 2000-02-01 | Pzifer Inc. | Cephaloporins and homologues, preparations and pharmaceutical compositions |
| US6001997A (en) | 1990-07-24 | 1999-12-14 | Bateson; John Hargreaves | Cephalosporins and homologues, preparations and pharmaceutical compositions |
| US5401842A (en) | 1992-09-08 | 1995-03-28 | Bristol-Myers Squibb Company | Injectable compositions of a cephalosporin dihydrate salt |
| EP0664117A1 (de) * | 1994-01-25 | 1995-07-26 | F. Hoffmann-La Roche Ag | Liposomenlösungen |
| US5665760A (en) * | 1995-09-18 | 1997-09-09 | Sanofi Winthrop, Inc. | Lyophilized thioxanthenone antitumor agents |
| KR100312622B1 (ko) * | 1998-11-03 | 2002-02-28 | 김송배 | 생약을주성분으로한안정화된항암제조성물및그제조방법 |
| JP2001199889A (ja) * | 1999-11-11 | 2001-07-24 | Takeda Chem Ind Ltd | 縮合ピリダジン誘導体を含有してなる点鼻用剤 |
| EP1246668B1 (en) | 1999-12-01 | 2005-11-30 | Natco Pharma Limited | An rapid acting freeze dired oral pharmaceutical composition for treating migraine |
| GB0002835D0 (en) * | 2000-02-09 | 2000-03-29 | Melvin William T | Drug resistance in cancer |
| GB0019124D0 (en) | 2000-08-03 | 2000-09-27 | Pfizer | Novel process |
| BR0115870A (pt) * | 2000-12-04 | 2004-02-03 | Pfizer Prod Inc | Processos de acoplamento e intermediários úteis para preparação de cefalosporinas |
-
2002
- 2002-11-12 US US10/292,343 patent/US7378408B2/en not_active Expired - Lifetime
- 2002-11-13 HR HR20040487A patent/HRP20040487A2/hr not_active Application Discontinuation
- 2002-11-13 EA EA200400489A patent/EA008503B1/ru unknown
- 2002-11-13 KR KR1020047008097A patent/KR100621291B1/ko not_active Expired - Lifetime
- 2002-11-13 DK DK02781499T patent/DK1448234T3/da active
- 2002-11-13 WO PCT/IB2002/004743 patent/WO2003045435A1/en not_active Ceased
- 2002-11-13 EP EP02781499A patent/EP1448234B1/en not_active Expired - Lifetime
- 2002-11-13 DE DE60228749T patent/DE60228749D1/de not_active Expired - Lifetime
- 2002-11-13 IL IL16185102A patent/IL161851A0/xx unknown
- 2002-11-13 ES ES02781499T patent/ES2307800T3/es not_active Expired - Lifetime
- 2002-11-13 AU AU2002348986A patent/AU2002348986B2/en not_active Expired
- 2002-11-13 PL PL370083A patent/PL212683B1/pl unknown
- 2002-11-13 AT AT02781499T patent/ATE406916T1/de active
- 2002-11-13 CA CA002468708A patent/CA2468708C/en not_active Expired - Lifetime
- 2002-11-13 MX MXPA04003724A patent/MXPA04003724A/es active IP Right Grant
- 2002-11-13 JP JP2003546936A patent/JP4689959B2/ja not_active Expired - Lifetime
- 2002-11-13 CN CNB028229258A patent/CN100502873C/zh not_active Expired - Lifetime
- 2002-11-13 BR BRPI0214583A patent/BRPI0214583B1/pt active IP Right Grant
- 2002-11-13 NZ NZ532208A patent/NZ532208A/en not_active IP Right Cessation
- 2002-11-13 PT PT02781499T patent/PT1448234E/pt unknown
- 2002-11-19 TW TW091133707A patent/TWI248363B/zh not_active IP Right Cessation
- 2002-11-28 AR ARP020104594A patent/AR037595A1/es not_active Application Discontinuation
-
2004
- 2004-04-07 IS IS7214A patent/IS7214A/is unknown
- 2004-05-06 IL IL161851A patent/IL161851A/en active IP Right Grant
- 2004-05-20 MA MA27689A patent/MA27085A1/fr unknown
- 2004-05-28 TN TNP2004000097A patent/TNSN04097A1/fr unknown
- 2004-06-01 NO NO20042271A patent/NO334818B1/no not_active IP Right Cessation
-
2008
- 2008-10-21 CY CY20081101180T patent/CY1108437T1/el unknown
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